RXR activators molecular signalling: involvement of a PPARα‐dependent pathway in the liver and kidney, evidence for an alternative pathway in the heart
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References (50)
The nuclear receptor superfamily: The second decade
1995 • 6,929 citations
Chapter 4 Preparation of Isolated Rat Liver Cells
1976 • 5,335 citations
Mechanisms of Neuroprotective Action of Vitamin D3
2004 • 5,057 citations
The RXR heterodimers and orphan receptors
1995 • 3,168 citations
Thyroid Hormone and the Cardiovascular System
2001 • 2,227 citations
Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat.
1996 • 2,130 citations
Targeted Disruption of the α Isoform of the Peroxisome Proliferator-Activated Receptor Gene in Mice Results in Abolishment of the Pleiotropic Effects of Peroxisome Proliferators
1995 • 1,626 citations
Nuclear Hormone Receptors and Gene Expression
2001 • 1,538 citations
Differential expression and activation of a family of murine peroxisome proliferator-activated receptors.
1994 • 1,410 citations
Genetic analysis of RXRα developmental function: Convergence of RXR and RAR signaling pathways in heart and eye morphogenesis
1994 • 684 citations
RXR alpha mutant mice establish a genetic basis for vitamin A signaling in heart morphogenesis.
1994 • 632 citations
Unique response pathways are established by allosteric interactions among nuclear hormone receptors
1995 • 629 citations
Sensitization of diabetic and obese mice to insulin by retinoid X receptor agonists
1997 • 614 citations
Peroxisome Proliferator-activated Receptor α-Isoform Deficiency Leads to Progressive Dyslipidemia with Sexually Dimorphic Obesity and Steatosis
1998 • 395 citations
Reduction of atherosclerosis in apolipoprotein E knockout mice by activation of the retinoid X receptor
2001 • 288 citations
Regulation of Pyruvate Dehydrogenase Kinase Expression by Peroxisome Proliferator–Activated Receptor-α Ligands, Glucocorticoids, and Insulin
2002 • 249 citations
Hepatocyte-Specific Mutation Establishes Retinoid X Receptor α as a Heterodimeric Integrator of Multiple Physiological Processes in the Liver
2000 • 226 citations
Adaptive Increase in Pyruvate Dehydrogenase Kinase 4 during Starvation Is Mediated by Peroxisome Proliferator-Activated Receptor α
2001 • 203 citations
Identification and characterization of DNA elements implicated in the regulation of CYP4A1 transcription
1995 • 185 citations
Peroxisome proliferation due to di(2-ethylhexyl) phthalate (DEHP): species differences and possible mechanisms.
1986 • 178 citations
Role of peroxisome proliferator-activated receptor alpha in altered cell cycle regulation in mouse liver
1998 • 160 citations
Peroxisome proliferator-activated receptor alpha required for gene induction by dehydroepiandrosterone-3 beta-sulfate.
1996 • 139 citations
The role of the peroxisome proliferator-activated receptor α (PPARα) in the control of cardiac lipid metabolism
1999 • 133 citations
Therapeutic Applications for Ligands of Retinoid Receptors
2000 • 128 citations
Recent Developments in Receptor-Selective Retinoids
2000 • 112 citations
A Phase I study of LGD1069 in adults with advanced cancer.
1999 • 104 citations
Fuel-sensing mechanisms integrating lipid and carbohydrate utilization
2001 • 101 citations
Metabolic Effects of Rexinoids: Tissue-Specific Regulation of Lipoprotein Lipase Activity
2001 • 91 citations
RXR Agonists Activate PPARα-Inducible Genes, Lower Triglycerides, and Raise HDL Levels In Vivo
1998 • 87 citations
The RXR agonist LG100268 causes hepatomegaly, improves glycaemic control and decreases cardiovascular risk and cachexia in diabetic mice suffering from pancreatic beta-cell dysfunction
1999 • 86 citations
Biochemical functionality and recovery of hepatocytes after deep freezing storage
1984 • 85 citations
Selective ablation of retinoid X receptor α in hepatocytes impairs their lifespan and regenerative capacity
2001 • 85 citations
Apoptosis and proliferation in nongenotoxic carcinogenesis: species differences and role of PPARα
2000 • 77 citations
Functional Evidence for Retinoid X Receptor (RXR) as a Nonsilent Partner in the Thyroid Hormone Receptor/RXR Heterodimer
2002 • 72 citations
Role of Peroxisome Proliferator-Activated Receptor-α in the Mechanism Underlying Changes in Renal Pyruvate Dehydrogenase Kinase Isoform 4 Protein Expression in Starvation and after Refeeding
2001 • 66 citations
Evaluation of the role of peroxisome-proliferator-activated receptor α in the regulation of cardiac pyruvate dehydrogenase kinase 4 protein expression in response to starvation, high-fat feeding and hyperthyroidism
2002 • 64 citations
Up-regulation of pyruvate dehydrogenase kinase isoform 4 (PDK4) protein expression in oxidative skeletal muscle does not require the obligatory participation of peroxisome-proliferator-activated receptor α (PPARα)
2002 • 63 citations
Selective Modification of Pyruvate Dehydrogenase Kinase Isoform Expression in Rat Pancreatic Islets Elicited by Starvation and Activation of Peroxisome Proliferator–Activated Receptor-α
2001 • 61 citations
Retinoid-Induced Hypertriglyceridemia in Rats Is Mediated by Retinoic Acid Receptors
1996 • 60 citations
Fenofibrate and human liver
1983 • 56 citations
Morphometric study of human hepatic cell modifications induced by fenofibrate
1987 • 52 citations
Expression of five forms of microsomal cytochrome P-450 in primary cultures of rabbit hepatocytes treated with various classes of inducers
1987 • 51 citations
Section Review: Retinoids: Biological Function and Use in the Treatment of Dermatological Diseases: Pulmonary-Allergy, Dermatological, Gastrointestinal & Arthritis
1995 • 51 citations
Bexarotene ligand pharmaceuticals.
2000 • 43 citations
Hepatic expression of acute-phase protein genes during carcinogenesis induced by peroxisome proliferators
1999 • 42 citations
Fuel-sensing mechanisms integrating lipid and carbohydrate utilization
2001 • 34 citations
Effects of the peroxisome proliferator mono(2-ethylhexyl)phthalate in primary hepatocyte cultures derived from rat, guinea pig, rabbit and monkey
1993 • 34 citations
Retinoid X receptor agonist elevation of serum triglycerides in rats by potentiation of retinoic acid receptor agonist induction or by action as single agents 2 2Abbreviations: RARs, retinoic acid receptors; and RXRs, retinoid X receptors.
2001 • 31 citations
Mitogenic effect of retinoid X receptor agonists in rat liver
1997 • 25 citations
[LGD1069: an antagonist to the X retinoid receptor].
2000 • 1 citations