Muscle-specific Pparg deletion causes insulin resistance

An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ)

1995 • 3,603 citations

Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor

1994 • 3,477 citations

Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators

1990 • 3,462 citations

The RXR heterodimers and orphan receptors

1995 • 3,168 citations

Obesity and insulin resistance

2000 • 3,076 citations

Prevalence of Diabetes, Impaired Fasting Glucose, and Impaired Glucose Tolerance in U.S. Adults: The Third National Health and Nutrition Examination Survey, 1988–1994

1998 • 2,780 citations

mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer.

1994 • 2,176 citations

Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat.

1996 • 2,130 citations

Pathogenesis of NIDDM: A Balanced Overview

1992 • 2,111 citations

PPARγ Is Required for the Differentiation of Adipose Tissue In Vivo and In Vitro

1999 • 1,963 citations

PPARγ Is Required for Placental, Cardiac, and Adipose Tissue Development

1999 • 1,904 citations

Oxidized LDL Regulates Macrophage Gene Expression through Ligand Activation of PPARγ

1998 • 1,819 citations

The PPARs: From Orphan Receptors to Drug Discovery

2000 • 1,792 citations

PPAR-gamma: adipogenic regulator and thiazolidinedione receptor.

1998 • 1,728 citations

INFLUENCES OF GLUCOSE LOADING AND OF INJECTED INSULIN ON HEPATIC GLUCOSE OUTPUT*

1959 • 1,674 citations

Differential expression and activation of a family of murine peroxisome proliferator-activated receptors.

1994 • 1,410 citations

Adipogenesis and Obesity: Rounding Out the Big Picture

1996 • 1,268 citations

The Organization, Promoter Analysis, and Expression of the Human PPARγ Gene

1997 • 1,183 citations

A Muscle-Specific Insulin Receptor Knockout Exhibits Features of the Metabolic Syndrome of NIDDM without Altering Glucose Tolerance

1998 • 1,173 citations

The peroxisome proliferator activated receptors (PPARs) and their effects on lipid metabolism and adipocyte differentiation

1996 • 1,036 citations

Thiazolidinediones in the Treatment of Insulin Resistance and Type II Diabetes

1996 • 1,004 citations

Improvement in Glucose Tolerance and Insulin Resistance in Obese Subjects Treated with Troglitazone

1994 • 935 citations

Peroxisome proliferator-activated receptor gene expression in human tissues. Effects of obesity, weight loss, and regulation by insulin and glucocorticoids.

1997 • 789 citations

Liver Peroxisome Proliferator-activated Receptor γ Contributes to Hepatic Steatosis, Triglyceride Clearance, and Regulation of Body Fat Mass

2003 • 733 citations

Tissue Distribution and Quantification of the Expression of mRNAs of Peroxisome Proliferator–Activated Receptors and Liver X Receptor-α in Humans: No Alteration in Adipose Tissue of Obese and NIDDM Patients

1997 • 697 citations

Expression of Putative Fatty Acid Transporter Genes Are Regulated by Peroxisome Proliferator-activated Receptor α and γ Activators in a Tissue- and Inducer-specific Manner

1998 • 526 citations

Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2

2000 • 499 citations

Metabolic Syndrome

2002 • 498 citations

Characterization of New Oral Antidiabetic Agent CS-045: Studies in KK and ob/ob Mice and Zucker Fatty Rats

1988 • 459 citations

Third national health and nutrition examination survey

1985 • 444 citations

Expression and Function of PPARγ in Rat and Human Vascular Smooth Muscle Cells

2000 • 439 citations

Protamine-Cre recombinase transgenes efficiently recombine target sequences in the male germ line of mice, but not in embryonic stem cells

1997 • 438 citations

Metabolic Effects of New Oral Hypoglycemic Agent CS-045 in NIDDM Subjects

1992 • 423 citations

c-Jun N-terminal Kinase (JNK) Mediates Feedback Inhibition of the Insulin Signaling Cascade

2003 • 422 citations

Improved insulin-sensitivity in mice heterozygous for PPAR-γ deficiency

2000 • 401 citations

PPARgamma induces the insulin-dependent glucose transporter GLUT4 in the absence of C/EBPalpha during the conversion of 3T3 fibroblasts into adipocytes.

1998 • 349 citations

Comprehensive Messenger Ribonucleic Acid Profiling Reveals That Peroxisome Proliferator-Activated Receptor γ Activation Has Coordinate Effects on Gene Expression in Multiple Insulin-Sensitive Tissues

2001 • 334 citations

Differentiation-Dependent Expression of the Brown Adipocyte Uncoupling Protein Gene: Regulation by Peroxisome Proliferator-Activated Receptor γ

1996 • 271 citations

Troglitazone, an insulin action enhancer, improves metabolic control in NIDDM patients

1996 • 239 citations

EPIDEMIOLOGY OF THE METABOLIC SYNDROME

2002 • 179 citations

Distribution of peroxisome proliferator-activated receptors (PPARs) in human skeletal muscle and adipose tissue: relation to insulin action

2000 • 175 citations

Skeletal muscle triacylglycerol in the rat: methods for sampling and measurement, and studies of biological variability.

1980 • 174 citations

In vitro studies on the action of CS-045, a new antidiabetic agent

1990 • 165 citations

Repeat Treatment of Obese Mice With BRL 49653, a New Potent Insulin Sensitizer, Enhances Insulin Action in White Adipocytes: Association With Increased Insulin Binding and Cell-Surface GLUT4 as Measured by Photoaffinity Labeling

1995 • 139 citations

Influence of hyperglycemia on insulin's in vivo effects in type II diabetes.

1984 • 117 citations

In vivo glucose metabolism in the awake rat: Tracer and insulin clamp studies

1987 • 102 citations

Localization of a pioglitazone response element in the adipocyte fatty acid-binding protein gene.

1994 • 74 citations

The effect of CP 68,722, a thiozolidinedione derivative, on insulin sensitivity in lean and obese Zucker rats

1991 • 56 citations

Regulation of glucose transport by pioglitazone in cultured muscle cells

1994 • 52 citations

Reduced insulin-stimulated glucose transport in denervated muscle is associated with impaired Akt-α activation

2000 • 15 citations