Nonenzymatic Interactions between Proteinases and the Cell Surface: Novel Roles in Normal and Malignant Cell Physiology

Matrix metalloproteinases and their inhibitors in connective tissue remodeling

1991 • 3,309 citations

Plasminogen Activators, Tissue Degradation, and Cancer

1985 • 2,584 citations

A matrix metalloproteinase expressed on the surface of invasive tumour cells

1994 • 2,561 citations

THE CAVEOLAE MEMBRANE SYSTEM

1998 • 1,947 citations

Fundamentals of molecular evolution

1991 • 1,721 citations

Metalloproteinases and their inhibitors in matrix remodeling

1990 • 1,627 citations

Fos and jun: The AP-1 connection

1988 • 1,597 citations

Mechanism Of Cell Surface Activation Of 72-kDa Type IV Collagenase

1995 • 1,576 citations

The urokinase-type plasminogen activator system in cancer metastasis: A review

1997 • 1,561 citations

Localization of Matrix Metalloproteinase MMP-2 to the Surface of Invasive Cells by Interaction with Integrin αvβ3

1996 • 1,555 citations

Tissue inhibitors of metalloproteinases: structure, regulation and biological functions.

1997 • 1,510 citations

Caveolins, a Family of Scaffolding Proteins for Organizing “Preassembled Signaling Complexes” at the Plasma Membrane

1998 • 1,502 citations

ECM and Cell Surface Proteolysis: Regulating Cellular Ecology

1997 • 1,311 citations

Biology and biochemistry of proteinases in tumor invasion

1993 • 1,264 citations

Transforming growth factor beta modulates the expression of collagenase and metalloproteinase inhibitor.

1987 • 1,243 citations

Cloning and expression of human tissue-type plasminogen activator cDNA in E. coli

1983 • 1,241 citations

A novel metalloproteinase gene specifically expressed in stromal cells of breast carcinomas

1990 • 1,140 citations

SV40-transformed Human Lung Fibroblasts Secrete a 92-kDa Type IV Collagenase Which Is Identical to That Secreted by Normal Human Macrophages

1989 • 1,122 citations

Physiological consequences of loss of plasminogen activator gene function in mice

1994 • 1,051 citations

H-ras oncogene-transformed human bronchial epithelial cells (TBE-1) secrete a single metalloprotease capable of degrading basement membrane collagen.

1988 • 1,050 citations

Recent developments in the cell biology of basic fibroblast growth factor.

1989 • 1,049 citations

Proteolytic activation of latent transforming growth factor-beta from fibroblast-conditioned medium.

1988 • 962 citations

Membrane Type 1 Matrix Metalloproteinase Digests Interstitial Collagens and Other Extracellular Matrix Macromolecules

1997 • 926 citations

Matrix Metalloproteinase-2 Is an Interstitial Collagenase

1995 • 917 citations

Inhibition of endothelial cell movement by pericytes and smooth muscle cells: activation of a latent transforming growth factor-beta 1-like molecule by plasmin during co-culture.

1989 • 914 citations

Tissue Inhibitor of Metalloproteinase (TIMP-2)

1989 • 899 citations

Biological Roles of Fibroblast Growth Factor-2*

1997 • 892 citations

Cell-Associated Plasminogen Activation: Regulation and Physiological Functions

1988 • 826 citations

Molecular cloning and expression of collagenase-3, a novel human matrix metalloproteinase produced by breast carcinomas

1994 • 769 citations

EMERGING ROLES FOR CYSTEINE PROTEASES IN HUMAN BIOLOGY

1997 • 767 citations

Matrix metalloproteinases: structures, evolution, and diversification

1998 • 759 citations

Cellular Mechanisms for Human Procollagenase-3 (MMP-13) Activation

1996 • 741 citations

Regulation of Integrin Function by the Urokinase Receptor

1996 • 734 citations

A cellular binding site for the Mr 55,000 form of the human plasminogen activator, urokinase.

1985 • 731 citations

Matrix Metalloproteinases Regulate Neovascularization by Acting as Pericellular Fibrinolysins

1998 • 716 citations

Scatter factor induces blood vessel formation in vivo.

1993 • 704 citations

Multiple modes of activation of latent human fibroblast collagenase: evidence for the role of a Cys73 active-site zinc complex in latency and a "cysteine switch" mechanism for activation.

1990 • 699 citations

Endogenous Activation of Latent Collagenase by Rheumatoid Synovial Cells

1977 • 686 citations

Absence of host plasminogen activator inhibitor 1 prevents cancer invasion and vascularization

1998 • 683 citations

The serpin PAI-1 inhibits cell migration by blocking integrin αvβ3 binding to vitronectin

1996 • 680 citations

Extensive Vasculogenesis, Angiogenesis, and Organogenesis Precede Lethality in Mice Lacking All αv Integrins

1998 • 649 citations

Human fibroblast collagenase. Complete primary structure and homology to an oncogene transformation-induced rat protein.

1986 • 645 citations

Cloning and expression of the receptor for human urokinase plasminogen activator, a central molecule in cell surface, plasmin dependent proteolysis.

1990 • 624 citations

Furin-dependent intracellular activation of the human stromelysin-3 zymogen

1995 • 620 citations

Matrix metalloproteinase 3 (stromelysin) activates the precursor for the human matrix metalloproteinase 9.

1992 • 620 citations

Disruption of Angiogenesis by PEX, a Noncatalytic Metalloproteinase Fragment with Integrin Binding Activity

1998 • 618 citations

The Matrix Metalloproteinases and Their Inhibitors

1992 • 604 citations

Requirement for fos gene expression in the transcriptional activation of collagenase by other oncogenes and phorbol esters

1988 • 597 citations

Developmental roles of HGF/SF and its receptor, the c-Met tyrosine kinase

1998 • 595 citations

Human 72-kilodalton type IV collagenase forms a complex with a tissue inhibitor of metalloproteases designated TIMP-2.

1989 • 594 citations

Identification of the urokinase receptor as an adhesion receptor for vitronectin.

1994 • 593 citations

Tissue cooperation in a proteolytic cascade activating human interstitial collagenase.

1989 • 579 citations

Cellular receptor for urokinase plasminogen activator. Carboxyl-terminal processing and membrane anchoring by glycosyl-phosphatidylinositol

1991 • 578 citations

Impaired wound healing in mice with a disrupted plasminogen gene

1996 • 568 citations

The Soluble Catalytic Domain of Membrane Type 1 Matrix Metalloproteinase Cleaves the Propeptide of Progelatinase A and Initiates Autoproteolytic Activation

1996 • 564 citations

Endothelial cells produce a latent inhibitor of plasminogen activators that can be activated by denaturants.

1985 • 555 citations

Molecular Cloning and Characterization of Human Tissue Inhibitor of Metalloproteinase 4

1996 • 547 citations

Role of cell-surface lysines in plasminogen binding to cells: identification of .alpha.-enolase as a candidate plasminogen receptor

1991 • 544 citations

Two distinct phases of apoptosis in mammary gland involution: proteinase-independent and -dependent pathways

1996 • 538 citations

Secretion of metalloproteinases by stimulated capillary endothelial cells. II. Expression of collagenase and stromelysin activities is regulated by endogenous inhibitors.

1986 • 531 citations

Cellular activation of latent transforming growth factor beta requires binding to the cation-independent mannose 6-phosphate/insulin-like growth factor type II receptor.

1991 • 521 citations

A metalloproteinase from human rheumatoid synovial fibroblasts that digests connective tissue matrix components. Purification and characterization.

1986 • 515 citations

Plasminogen activation by receptor-bound urokinase. A kinetic study with both cell-associated and isolated receptor

1991 • 509 citations

An endothelial cell receptor for plasminogen/tissue plasminogen activator. I. Identity with annexin II.

1994 • 509 citations

Stromelysin, a connective tissue-degrading metalloendopeptidase secreted by stimulated rabbit synovial fibroblasts in parallel with collagenase. Biosynthesis, isolation, characterization, and substrates.

1985 • 506 citations

Matrix metalloproteinase 9 (92-kDa gelatinase/type IV collagenase) from HT 1080 human fibrosarcoma cells. Purification and activation of the precursor and enzymic properties.

1992 • 502 citations

Tissue inhibitor of metalloproteinases-3 (TIMP-3) is an extracellular matrix-associated protein with a distinctive pattern of expression in mouse cells and tissues.

1994 • 485 citations

Synthesis of fibrinolytic activator and inhibitor by endothelial cells

1977 • 484 citations

The receptor for urokinase type plasminogen activator polarizes expression of the protease to the leading edge of migrating monocytes and promotes degradation of enzyme inhibitor complexes.

1990 • 480 citations

The receptor-binding sequence of urokinase. A biological function for the growth-factor module of proteases.

1987 • 479 citations

Cloning and characterization of a unique elastolytic metalloproteinase produced by human alveolar macrophages.

1993 • 479 citations

Structure and Biological Role of Vitronectin

1991 • 477 citations

Identification of the Second Membrane-type Matrix Metalloproteinase (MT-MMP-2) Gene from a Human Placenta cDNA Library

1995 • 474 citations

Plasminogen activators, integrins, and the coordinated regulation of cell adhesion and migration

1997 • 472 citations

The plasminogen system and cell surfaces: evidence for plasminogen and urokinase receptors on the same cell type.

1986 • 466 citations

Transforming growth factor-beta 1 modulates basic fibroblast growth factor-induced proteolytic and angiogenic properties of endothelial cells in vitro.

1990 • 466 citations

Purified alpha 2-macroglobulin receptor/LDL receptor-related protein binds urokinase.plasminogen activator inhibitor type-1 complex. Evidence that the alpha 2-macroglobulin receptor mediates cellular degradation of urokinase receptor-bound complexes.

1992 • 464 citations

Is plasminogen activator inhibitor-1 the molecular switch that governs urokinase receptor-mediated cell adhesion and release?

1996 • 460 citations

Matrix metalloproteinase degradation of elastin, type IV collagen and proteoglycan. A quantitative comparison of the activities of 95 kDa and 72 kDa gelatinases, stromelysins-1 and -2 and punctuated metalloproteinase (PUMP)

1991 • 454 citations

Preferential digestion of basement membrane collagen by an enzyme derived from a metastatic murine tumor.

1979 • 452 citations

Differentiation-enhanced binding of the amino-terminal fragment of human urokinase plasminogen activator to a specific receptor on U937 monocytes.

1985 • 450 citations

TGF-β1 inhibition of transin/stromelysin gene expression is mediated through a fos binding sequence

1990 • 444 citations

Plasminogen deficiency causes severe thrombosis but is compatible with development and reproduction.

1995 • 440 citations

Membrane‐Type Matrix Metalloproteinases 1 and 2 Exhibit Broad‐Spectrum Proteolytic Capacities Comparable to Many Matrix Metalloproteinases

1997 • 434 citations

Tissue inhibitor of metalloproteinases-2 (TIMP-2) mRNA expression in tumor cell lines and human tumor tissues.

1990 • 428 citations

Matrix metalloproteinase 2 from human rheumatoid synovial fibroblasts

1990 • 428 citations

Control of type IV collagenase activity by components of the urokinase-plasmin system: a regulatory mechanism with cell-bound reactants

1997 • 427 citations

Protease-nexin: A cellular component that links thrombin and plasminogen activator and mediates their binding to cells

1980 • 424 citations

Transmembrane/cytoplasmic domain-mediated membrane type 1-matrix metalloprotease docking to invadopodia is required for cell invasion

1997 • 419 citations

Human neutrophil collagenase. A distinct gene product with homology to other matrix metalloproteinases.

1990 • 406 citations

Transmembrane-deletion Mutants of the Membrane-type Matrix Metalloproteinase-1 Process Progelatinase A and Express Intrinsic Matrix-degrading Activity

1996 • 392 citations

Regulation of matrix metalloproteinase expression in human vein and microvascular endothelial cells. Effects of tumour necrosis factor α, interleukin 1 and phorbol ester

1993 • 388 citations

Enzymatic Degradation of GlycosaminogIycans

1995 • 387 citations

α1-Antitrypsin and the serpins: variation and countervariation

1985 • 384 citations

The opposing effects of basic fibroblast growth factor and transforming growth factor beta on the regulation of plasminogen activator activity in capillary endothelial cells.

1987 • 378 citations

Receptor-mediated internalization and degradation of urokinase is caused by its specific inhibitor PAI-1.

1990 • 374 citations

Tissue inhibitor of metalloproteinases‐2 inhibits bFGF‐induced human microvascular endothelial cell proliferation

1993 • 362 citations

Purification of a factor from human placenta that stimulates capillary endothelial cell protease production, DNA synthesis, and migration.

1986 • 354 citations

Membrane and matrix localization of proteinases: a common theme in tumor cell invasion and angiogenesis

1988 • 354 citations

Fundamentals of molecular evolution

1991 • 353 citations

Cathepsin B efficiently activates the soluble and the tumor cell receptor-bound form of the proenzyme urokinase-type plasminogen activator (Pro-uPA).

1991 • 347 citations

Structural biochemistry and activation of matrix metalloproteases

1993 • 347 citations

An endothelial cell receptor for plasminogen/tissue plasminogen activator (t-PA). II. Annexin II-mediated enhancement of t-PA-dependent plasminogen activation.

1994 • 341 citations

Cellular consequences of thrombin-receptor activation

1996 • 341 citations

Deduced primary structure of rat hepatocyte growth factor and expression of the mRNA in rat tissues.

1990 • 333 citations

Focalized proteolysis: spatial and temporal regulation of extracellular matrix degradation at the cell surface

1996 • 331 citations

Molecular cloning of a novel membrane-type matrix metalloproteinase from a human breast carcinoma.

1996 • 330 citations

Activation of progelatinase B (MMP-9) by gelatinase A (MMP-2).

1995 • 324 citations

Human skin fibroblast stromelysin: structure, glycosylation, substrate specificity, and differential expression in normal and tumorigenic cells.

1987 • 323 citations

cDNA Sequence and mRNA Tissue Distribution of a Novel Human Matrix Metalloproteinase with a Potential Transmembrane Segment

1995 • 319 citations

Degradation of connective tissue matrices by macrophages. I. Proteolysis of elastin, glycoproteins, and collagen by proteinases isolated from macrophages.

1980 • 314 citations

Binding and activation of plasminogen on the platelet surface.

1985 • 312 citations

Ultrastructural localization of plasma membrane-associated urokinase-type plasminogen activator at focal contacts.

1988 • 312 citations

The role of the C-terminal domain in collagenase and stromelysin specificity.

1992 • 311 citations

Binding of plasminogen to cultured human endothelial cells.

1986 • 311 citations

Structure and function of hepatocyte growth factor

1991 • 307 citations

Recycling of the urokinase receptor upon internalization of the uPA:serpin complexes

1997 • 304 citations

Relating matrix metalloproteinase structure to function: Why the “hemopexin” domain?

1997 • 300 citations

Growth Factors Regulate Transin Gene Expression by c- fos -Dependent and c- fos -Independent Pathways

1988 • 290 citations

Matrix Metalloproteinase 7 (Matrilysin) from Human Rectal Carcinoma Cells

1995 • 290 citations

Plasmin and plasminogen activator inhibitor type 1 promote cellular motility by regulating the interaction between the urokinase receptor and vitronectin.

1997 • 288 citations

Tissue Inhibitor of Metalloproteinase-2 (TIMP-2) Binds to the Catalytic Domain of the Cell Surface Receptor, Membrane Type 1-Matrix Metalloproteinase 1 (MT1-MMP)

1998 • 285 citations

Expression and tissue localization of membrane-types 1, 2, and 3 matrix metalloproteinases in human invasive breast carcinomas.

1997 • 281 citations

Urokinase Receptor (CD87) Regulates Leukocyte Recruitment via β2 Integrins In Vivo

1998 • 279 citations

The human receptor for urokinase plasminogen activator. NH2-terminal amino acid sequence and glycosylation variants.

1990 • 278 citations

A 55,000-60,000 Mr receptor protein for urokinase-type plasminogen activator. Identification in human tumor cell lines and partial purification.

1988 • 275 citations

Urokinase-type plasminogen activator is effective in fibrin clearance in the absence of its receptor or tissue-type plasminogen activator.

1996 • 271 citations

The C-terminal Region of Membrane Type Matrix Metalloproteinase Is a Functional Transmembrane Domain Required for Pro-gelatinase A Activation

1995 • 269 citations

Vascular Endothelial Growth Factor Increases Urokinase Receptor Expression in Vascular Endothelial Cells

1995 • 269 citations

The C-terminal domain of 72 kDa gelatinase A is not required for catalysis, but is essential for membrane activation and modulates interactions with tissue inhibitors of metalloproteinases

1992 • 268 citations

Induction of cell migration by pro-urokinase binding to its receptor: possible mechanism for signal transduction in human epithelial cells.

1994 • 266 citations

Identification and Characterization of the Fifth Membrane-type Matrix Metalloproteinase MT5-MMP

1999 • 261 citations

Human skin fibroblast collagenase inhibitor. Purification and biochemical characterization.

1983 • 259 citations

Palmitylation of an amino-terminal cysteine motif of protein tyrosine kinases p56lck and p59fyn mediates interaction with glycosyl-phosphatidylinositol-anchored proteins.

1993 • 259 citations

The ligand-binding domain of the cell surface receptor for urokinase-type plasminogen activator.

1991 • 256 citations

Identification and Characterization of a Novel Human Matrix Metalloproteinase with Unique Structural Characteristics, Chromosomal Location, and Tissue Distribution

1997 • 254 citations

Urokinase plasminogen activator cleaves its cell surface receptor releasing the ligand-binding domain.

1992 • 253 citations

Inhibitory Role of Plasminogen Activator Inhibitor-1 in Arterial Wound Healing and Neointima Formation

1997 • 250 citations

Rat collagenase. Cloning, amino acid sequence comparison, and parathyroid hormone regulation in osteoblastic cells.

1990 • 249 citations

Purification and characterization of a plasminogen activator inhibitor from the histiocytic lymphoma cell line U-937.

1986 • 249 citations

Characterization of the Cellular Binding Site for the Urokinase-type Plasminogen Activator

1989 • 248 citations

Biological Activation of pro-HGF (Hepatocyte Growth Factor) by Urokinase Is Controlled by a Stoichiometric Reaction

1995 • 248 citations

Matrix metalloproteinases

1997 • 247 citations

Purification and characterization of a murine basement membrane collagen-degrading enzyme secreted by metastatic tumor cells.

1983 • 245 citations

cDNA Sequence and mRNA Tissue Distribution of a Novel Human Matrix Metalloproteinase with a Potential Transmembrane Segment

1995 • 244 citations

Requirement of Receptor-bound Urokinase-type Plasminogen Activator for Integrin αvβ5-directed Cell Migration

1996 • 244 citations

Structure and expression of the human gene for the matrix metalloproteinase matrilysin.

1994 • 243 citations

Role of Vitronectin and Its Receptors in Haemostasis and Vascular Remodeling

1998 • 237 citations

One-chain urokinase-type plasminogen activator from human sarcoma cells is a proenzyme with little or no intrinsic activity.

1988 • 237 citations

Plasminogen Activator Inhibitor-1 Represses Integrin- and Vitronectin-Mediated Cell Migration Independently of Its Function as an Inhibitor of Plasminogen Activation

1997 • 234 citations

Tissue Plasminogen Activator Binding to the Annexin II Tail Domain

1998 • 233 citations

Membrane-type matrix metalloproteinase 1 is a gelatinolytic enzyme and is secreted in a complex with tissue inhibitor of metalloproteinases 2.

1996 • 232 citations

The Receptor for Urokinase-type Plasminogen Activator Is Not Essential for Mouse Development or Fertility

1995 • 230 citations

Identification and primary sequence of an unspliced human urokinase poly(A)+ RNA.

1984 • 229 citations

Cloning and Characterization of Human MMP-23, a New Matrix Metalloproteinase Predominantly Expressed in Reproductive Tissues and Lacking Conserved Domains in Other Family Members

1999 • 226 citations

Urokinase-type plasminogen activator receptors associate with beta1 and beta3 integrins of fibrosarcoma cells: dependence on extracellular matrix components.

1997 • 222 citations

Serotonin 5-HT2a and 5-HT2c Receptors Stimulate Amyloid Precursor Protein Ectodomain Secretion

1996 • 221 citations

Extracellular Matrix Binding Properties of Recombinant Fibronectin Type II-like Modules of Human 72-kDa Gelatinase/Type IV Collagenase

1995 • 221 citations

Identification and Structural and Functional Characterization of Human Enamelysin (MMP-20)^,

1997 • 220 citations

Purification and properties of a small latent matrix metalloproteinase of the rat uterus.

1988 • 220 citations

Activation of plasminogen by human plasma kallikrein

1969 • 219 citations

Hepatocyte growth factor increases urokinase-type plasminogen activator (u-PA) and u-PA receptor expression in Madin-Darby canine kidney epithelial cells.

1992 • 219 citations

Expression and localization of matrilysin, a matrix metalloproteinase, in human endometrium during the reproductive cycle

1993 • 218 citations

Secretion of metalloproteinases by stimulated capillary endothelial cells. I. Production of procollagenase and prostromelysin exceeds expression of proteolytic activity.

1986 • 215 citations

Plasminogen

1992 • 214 citations

Pump-1 cDNA codes for a protein with characteristics similar to those of classical collagenase family members

1989 • 212 citations

Hageman factor substrates. Human plasma prekallikrein: mechanism of activation by Hageman factor and participation in hageman factor-dependent fibrinolysis.

1977 • 210 citations

Matrix metalloproteinases as stromal effectors of human carcinoma progression: Therapeutic implications

1997 • 207 citations

Binding of Urokinase-type Plasminogen Activator to Its Receptor in MCF-7 Cells Activates Extracellular Signal-regulated Kinase 1 and 2 Which Is Required for Increased Cellular Motility

1998 • 203 citations

Tissue inhibitor of metalloproteinase‐2 (TIMP‐2) has erythroid‐potentiating activity

1992 • 200 citations

Impaired arterial neointima formation in mice with disruption of the plasminogen gene.

1997 • 196 citations

The urokinase-type plasminogen activator receptor, a GPI-linked protein, is localized in caveolae.

1995 • 196 citations

alpha-2 Macroglobulin receptor/Ldl receptor-related protein(Lrp)-dependent internalization of the urokinase receptor.

1995 • 194 citations

Interaction of heparin with plasminogen activators and plasminogen: effects on the activation of plasminogen

1986 • 191 citations

The glycophosphatidylinositol-anchored Thy-1 molecule interacts with the p60fyn protein tyrosine kinase in T cells.

1992 • 191 citations

Tissue Inhibitor of Metalloproteinase-2 Stimulates Fibroblast Proliferation via a cAMP-dependent Mechanism

1995 • 188 citations

Low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor mediates cellular uptake of pro-urokinase.

1993 • 186 citations

Matrix metalloproteinase-9 (92 kDa gelatinase/type IV collagenase) from U937 monoblastoid cells: correlation with cellular invasion

1993 • 186 citations

Mac-1 (CD11b/CD18) and the urokinase receptor (CD87) form a functional unit on monocytic cells

1996 • 183 citations

Extracellular Matrix Remodeling during Morphogenesis^a

1998 • 181 citations

The Jak/Stat Pathway and Urokinase Receptor Signaling in Human Aortic Vascular Smooth Muscle Cells

1998 • 179 citations

Urokinase Receptor Is Associated with the Components of the JAK1/STAT1 Signaling Pathway and Leads to Activation of This Pathway upon Receptor Clustering in the Human Kidney Epithelial Tumor Cell Line TCL-598

1997 • 179 citations

Expression of the urokinase receptor in vascular endothelial cells is stimulated by basic fibroblast growth factor.

1991 • 178 citations

An amino-terminal fragment of urokinase isolated from a prostate cancer cell line (PC-3) is mitogenic for osteoblast-like cells

1990 • 177 citations

Requirement for receptor‐bound urokinase in plasmin‐dependent cellular conversion of latent TGF‐β to TGF‐β

1994 • 176 citations

Human skin fibroblast collagenase: chemical properties of precursor and active forms

1978 • 175 citations

Cloning, sequencing, and expression of human macrophage stimulating protein (MSP, MST1) confirms MSP as a member of the family of kringle proteins and locates the MSP gene on chromosome 3

1993 • 174 citations

Macrophage stimulating protein: purification, partial amino acid sequence, and cellular activity.

1991 • 171 citations

The primary plasminogen-activator inhibitors in endothelial cells, platelets, serum, and plasma are immunologically related.

1985 • 171 citations

Cleavage of type II and III collagens with mammalian collagenase: site of cleavage and primary structure at the amino-terminal portion of the smaller fragment released from both collagens

1976 • 171 citations

Epidermal Growth Factor Stimulation of Stromelysin mRNA in Rat Fibroblasts Requires Induction of Proto-Oncogenes c-fos and c-jun and Activation of Protein Kinase C

1990 • 170 citations

Structure-function relationships in the collagenase family member transin.

1988 • 169 citations

Association of a protease (plasminogen activator) with a specific membrane fraction isolated from transformed cells.

1976 • 163 citations

The Urokinase-type Plasminogen Activator Receptor Mediates Tyrosine Phosphorylation of Focal Adhesion Proteins and Activation of Mitogen-activated Protein Kinase in Cultured Endothelial Cells

1998 • 162 citations

Purification of a Specific Placental Plasminogen Activator Inhibitor by Monoclonal Antibody and Its Complex Formation with Plasminogen Activator

1985 • 161 citations

Identification of Cysteine 354 of β-Tubulin as Part of the Binding Site for the A Ring of Colchicine

1996 • 160 citations

The role of urokinase-type plasminogen activator in aggressive tumor cell behavior

1990 • 158 citations

Linkage of extracellular plasminogen activator to the fibroblast cytoskeleton: colocalization of cell surface urokinase with vinculin.

1988 • 158 citations

Reduction in Surface Urokinase Receptor Forces Malignant Cells into a Protracted State of Dormancy

1997 • 158 citations

A specific inhibitor of vertebrate collagenase produced by human skin fibroblasts.

1979 • 157 citations

Effective activation of the proenzyme form of the urokinase‐type plasminogen activator (pro‐uPA) by the cysteine protease cathepsin L

1992 • 157 citations

Binding of urokinase to its receptor promotes migration and invasion of human melanoma cells in vitro.

1994 • 155 citations

Cleavage of type VII collagen by interstitial collagenase and type IV collagenase (gelatinase) derived from human skin

1989 • 151 citations

Identification and characterization of human endothelial cell membrane binding sites for tissue plasminogen activator and urokinase.

1990 • 150 citations

Receptor‐mediated endocytosis of plasminogen activators and activator/inhibitor complexes

1994 • 148 citations

The intact urokinase receptor is required for efficient vitronectin binding: receptor cleavage prevents ligand interaction

1997 • 146 citations

Regulation of urokinase receptors in monocytelike U937 cells by phorbol ester phorbol myristate acetate.

1989 • 142 citations

High Affinity Binding of Latent Matrix Metalloproteinase-9 to the α2(IV) Chain of Collagen IV

1998 • 138 citations

Mannose 6-Phosphate/Insulin-like Growth Factor–II Receptor Targets the Urokinase Receptor to Lysosomes via a Novel Binding Interaction

1998 • 138 citations

Degradation of entactin by matrix metalloproteinases. Susceptibility to matrilysin and identification of cleavage sites.

1993 • 138 citations

Partial Purification and Properties of Urokinase Inhibitor from Human Placenta

1970 • 136 citations

Regions involved in binding of urokinase-type-1 inhibitor complex and pro-urokinase to the endocytic alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein. Evidence that the urokinase receptor protects pro-urokinase against binding to the endocytic receptor.

1994 • 135 citations

Immunological identity of heparin-dependent plasma and urinary protein C inhibitor and plasminogen activator inhibitor-3.

1987 • 135 citations

Purification of human fibroblast urokinase proenzyme and analysis of its regulation by proteases and protease nexin.

1984 • 134 citations

Urokinase-type plasminogen activator receptor reversibly dissociates from complement receptor type 3 (alpha M beta 2' CD11b/CD18) during neutrophil polarization.

1996 • 134 citations

Proliferation of a human epidermal tumor cell line stimulated by urokinase

1987 • 132 citations

The 28-kDa N-terminal domain of mouse stromelysin-3 has the general properties of a weak metalloproteinase

1993 • 132 citations

Localization of the disulfide bonds in the NH2-terminal domain of the cellular receptor for human urokinase-type plasminogen activator. A domain structure belonging to a novel superfamily of glycolipid-anchored membrane proteins

1993 • 130 citations

Coordinate regulation of stromelysin and collagenase genes determined with cDNA probes.

1987 • 129 citations

Plasminogen deficiency accelerates vessel wall disease in mice predisposed to atherosclerosis

1997 • 125 citations

Specific cleavage of the native Type III collagen molecule with trypsin

1976 • 125 citations

Proteases and Protease Inhibitors in Tumor Progression

1997 • 124 citations

Proteases Associated with Invadopodia, and Their Role in Degradation of Extracellular Matrix

1996 • 123 citations

Identification of MMP-18, a Putative Novel Human Matrix Metalloproteinase

1996 • 123 citations

A ligand-free, soluble urokinase receptor is present in the ascitic fluid from patients with ovarian cancer.

1993 • 122 citations

The endothelial cell tissue plasminogen activator receptor. Specific interaction with plasminogen.

1991 • 122 citations

Differential susceptibility of type X collagen to cleavage by two mammalian interstitial collagenases and 72-kDa type IV collagenase.

1990 • 121 citations

Cell‐Surface Acceleration of Urokinase‐Catalyzed Receptor Cleavage

1997 • 120 citations

The AP-1 site Is required for basal expression but is not necessary for TPA-response of the human stromelysin gene

1991 • 120 citations

Identification of the rat Heymann nephritis autoantigen (GP330) as a receptor site for plasminogen

1991 • 119 citations

Urokinase-receptor biosynthesis, mRNA level and gene transcription are increased by transforming growth factor beta 1 in human A549 lung carcinoma cells.

1991 • 117 citations

Ovulation efficiency is reduced in mice that lack plasminogen activator gene function: functional redundancy among physiological plasminogen activators.

1995 • 116 citations

Vitronectin Concentrates Proteolytic Activity on the Cell Surface and Extracellular Matrix by Trapping Soluble Urokinase Receptor-Urokinase Complexes

1998 • 114 citations

Growth and Dissemination of Lewis Lung Carcinoma in Plasminogen-Deficient Mice

1997 • 113 citations

A polyomavirus enhancer A-binding protein-3 site and Ets-2 protein have a major role in the 12-O-tetradecanoylphorbol-13-acetate response of the human stromelysin gene.

1993 • 112 citations

Membrane-Type Matrix Metalloproteinases (MT-MMPs) in Cell Invasion

1997 • 112 citations

Urokinase receptor mRNA level and gene transcription are strongly and rapidly increased by phorbol myristate acetate in human monocyte-like U937 cells.

1991 • 111 citations

Molecules in focus Thrombin

1998 • 111 citations

Binding of urokinase to plasminogen activator inhibitor type-1 mediates cell adhesion and spreading

1997 • 107 citations

The association between glycosylphosphatidylinositol-anchored proteins and heterotrimeric G protein alpha subunits in lymphocytes.

1996 • 107 citations

Domains in human plasminogen

1984 • 107 citations

Transforming growth factor beta 1 and cAMP inhibit transcription of epidermal growth factor- and oncogene-induced transin RNA.

1988 • 107 citations

Type X collagen contains two cleavage sites for a vertebrate collagenase.

1986 • 106 citations

Downstream targets of urokinase‐type plasminogen‐activator‐mediated signal transduction

1998 • 105 citations

Structural and Functional Analysis of the Plasminogen Activator Inhibitor-1 Binding Motif in the Somatomedin B Domain of Vitronectin

1996 • 103 citations

Ligand Interaction between Urokinase-Type Plasminogen Activator and Its Receptor Probed with 8-Anilino-1-naphthalenesulfonate. Evidence for a Hydrophobic Binding Site Exposed Only on the Intact Receptor

1994 • 102 citations

IFN-gamma, tumor necrosis factor-alpha, and urokinase regulate the expression of urokinase receptors on human monocytes.

1988 • 101 citations

Identification of soluble type of membrane-type matrix metalloproteinase-3 formed by alternatively spliced mRNA

1997 • 100 citations

K562 cells produce and respond to human erythroid-potentiating activity

1988 • 99 citations

Receptor-mediated endocytosis of tissue-type plasminogen activator by low density lipoprotein receptor-related protein on human hepatoma HepG2 cells

1993 • 99 citations

Interaction of urokinase with specific receptors stimulates mobilization of bovine adrenal capillary endothelial cells*1

1988 • 98 citations

Human and rat malignant-tumor-associated mRNAs encode stromelysin-like metalloproteinases

1989 • 97 citations

Tumor-promoting phorbol esters and cell proliferation stimulate secretion of basement membrane (type IV) collagen-degrading metalloproteinase by human fibroblasts.

1985 • 96 citations

Activation of the 92 kDa type IV collagenase by tissue kallikrein

1993 • 95 citations

Integrin-dependent induction of functional urokinase receptors in primary T lymphocytes.

1996 • 95 citations

Collagen-stimulated induction of keratinocyte collagenase is mediated via tyrosine kinase and protein kinase C activities.

1994 • 94 citations

Embryonic Fibroblasts That Are Genetically Deficient in Low Density Lipoprotein Receptor-related Protein Demonstrate Increased Activity of the Urokinase Receptor System and Accelerated Migration on Vitronectin

1997 • 93 citations

Phorbol ester-induced cell surface association of matrix metalloproteinase-9 in human MCF10A breast epithelial cells.

1997 • 93 citations

Matrix Metalloproteinase MMP-19 (RASI-1) is Expressed on the Surface of Activated Peripheral Blood Mononuclear Cells and is Detected as an Autoantigen in Rheumatoid Arthritis

1998 • 91 citations

Functional inhibition of endogenously produced urokinase decreases cell proliferation in a human melanoma cell line.

1989 • 91 citations

The Involvement of the Fibronectin Type II-like Modules of Human Gelatinase A in Cell Surface Localization and Activation

1998 • 89 citations

The extracellular matrix proteins laminin and fibronectin contain binding domains for human plasminogen and tissue plasminogen activator.

1993 • 89 citations

Cooperation between Matrix Metalloproteinases and the Plasminogen Activator-Plasmin System in Tumor Progression

1996 • 88 citations

The gelatin-binding site of human 72 kDa type IV collagenase (gelatinase A)

1994 • 88 citations

Degradation of Cross-Linked Fibrin by Matrix Metalloproteinase 3 (Stromelysin 1): Hydrolysis of the γ Gly 404−Ala 405 Peptide Bond

1996 • 88 citations

Proteolytic conversion of single chain precursor macrophage-stimulating protein to a biologically active heterodimer by contact enzymes of the coagulation cascade.

1994 • 86 citations

The Propeptide Domain of Membrane Type 1 Matrix Metalloproteinase Is Required for Binding of Tissue Inhibitor of Metalloproteinases and for Activation of Pro-gelatinase A

1998 • 85 citations

N-linked glycosylation of the ligand-binding domain of the human urokinase receptor contributes to the affinity for its ligand

1993 • 85 citations

Protease nexin-1-urokinase complexes are internalized and degraded through a mechanism that requires both urokinase receptor and alpha 2-macroglobulin receptor.

1994 • 85 citations

Regulation of collagenase gene expression by IL–1β requires transcriptional and post-transcriptional mechanisms

1994 • 85 citations

An alternatively spliced variant of mRNA for the human receptor for urokinase plasminogen activator

1993 • 85 citations

Melanoma cell migration on vitronectin: Regulation by components of the plasminogen activation system

1997 • 84 citations

Healing of corneal epithelial defects in plasminogen- and fibrinogen-deficient mice.

1998 • 84 citations

Coordinated expression of the vitronectin receptor and the urokinase-type plasminogen activator receptor in metastatic melanoma cells.

1995 • 83 citations

Urokinase-Urokinase Receptor Interaction: Non-Mitogenic Signal Transduction in Human Epidermal Cells

1993 • 79 citations

Monocyte procollagenase and tissue inhibitor of metalloproteinases. Identification, characterization, and regulation of secretion.

1987 • 79 citations

Multiple members of the plasminogen-apolipoprotein(a) gene family associated with thrombosis

1992 • 78 citations

A soluble form of the glycolipid‐anchored receptor for urokinase‐type plasminogen activator is secreted from peripheral blood leukocytes from patients with paroxysmal nocturnal hemoglobinuria

1992 • 75 citations

Contribution of the C-terminal domain of metalloproteinases to binding by tissue inhibitor of metalloproteinases. C-terminal truncated stromelysin and matrilysin exhibit equally compromised binding affinities as compared to full-length stromelysin.

1994 • 75 citations

Human hepatoma cells produce an 85 kDa gelatinase regulated by phorbol 12-myristate 13-acetate

1990 • 75 citations

Glucocorticoid Receptor Mediated Inhibition of Interleukin-1 Stimulated Neutral Metalloprotease Synthesis in Normal Human Chondrocytes*

1991 • 74 citations

The urokinase receptor

1998 • 74 citations

Interaction of a 39 kDa protein with the low-density-lipoprotein-receptor-related protein (LRP) on rat hepatoma cells

1993 • 73 citations

Co-operation between plasmin and elastase in elastin degradation by intact murine macrophages

1984 • 72 citations

Isolation of cDNA sequences coding for a part of human tissue plasminogen activator.

1983 • 71 citations

Determinants of binding and internalization of tissue-type plasminogen activator by human vascular smooth muscle and endothelial cells

1993 • 71 citations

Negative regulation of gene expression by TGF‐β

1992 • 71 citations

Role of Specific Membrane Receptors in Urokinase-Dependent Migration of Human Keratinocytes

1990 • 70 citations

Photoaffinity Labeling of the Human Receptor for Urokinase-Type Plasminogen Activator Using a Decapeptide Antagonist. Evidence for a Composite Ligand-Binding Site and a Short Interdomain Separation

1998 • 68 citations

Cloning and Characterization of a Novel Matrix Metalloproteinase (MMP), CMMP, from Chicken Embryo Fibroblasts

1998 • 67 citations

Competition between plasminogen and tissue plasminogen activator for cellular binding sites

1993 • 65 citations

Correction: LDL receptor-related protein internalizes and degrades uPA-PAI-1 complexes and is essential for embryo implantation

1993 • 65 citations

Induction of c‐fos gene expression by urokinase‐type plasminogen activator in human ovarian cancer cells

1994 • 63 citations

Mitogenic Effects of Urokinase on Melanoma Cells Are Independent of High Affinity Binding to the Urokinase Receptor

1998 • 61 citations

Cell Surface Dynamics of GPI-Anchored Proteins

1997 • 58 citations

Identification of Specific Sites Involved in Ligand Binding by Photoaffinity Labeling of the Receptor for the Urokinase-Type Plasminogen Activator. Residues Located at Equivalent Positions in uPAR Domains I and III Participate in the Assembly of a Composite Ligand-Binding Site

1998 • 57 citations

A Novel Matrix Metalloproteinase Gene (XMMP) Encoding Vitronectin-like Motifs Is Transiently Expressed in Xenopus laevis Early Embryo Development

1997 • 57 citations

Production of Second Messengers Following Chemotactic and Mitogenic Urokinase-Receptor Interaction in Human Fibroblasts and Mouse Fibroblasts Transfected with Human Urokinase Receptor

1994 • 55 citations

Binding of tissue plasminogen activator to human monocytes and monocytoid cells

1991 • 55 citations

Plasminogen receptors in the mediation of pericellular proteolysis

1990 • 55 citations

Proteolytic activation of single-chain precursor macrophage-stimulating protein by nerve growth factor-gamma and epidermal growth factor-binding protein, members of the kallikrein family.

1994 • 51 citations

Domain structure and domain-domain interactions of recombinant tissue plasminogen activator

1991 • 51 citations

Induction in human osteoblastic cells (SaOS2) of the early response genesfos, jun, andmyc by the amino terminal fragment (ATF) of urokinase

1997 • 51 citations

Phosphorylation of Human Pro-Urokinase on Ser138/303 Impairs Its Receptor-dependent Ability to Promote Myelomonocytic Adherence and Motility

1997 • 50 citations

Plasminogen binding to cell surfaces

1998 • 48 citations

Cleavage specificity of type IV collagenase (gelatinase) from human skin

1989 • 47 citations

Binding of tissue-type plasminogen activator with human endothelial cell monolayers. Characterization of the high affinity interaction with plasminogen activator inhibitor-1.

1990 • 47 citations

Characterization of plasminogen activation by glycosylphosphatidylinositol-anchored urokinase.

1994 • 43 citations

Growth factor-like effect of urokinase type plasminogen activator in human renal cells

1991 • 43 citations

Interaction of wild-type and catalytically inactive mutant forms of tissue-type plasminogen activator with human umbilical vein endothelial cell monolayers.

1990 • 42 citations

Plasminogen Activators and Angiogenesis

1996 • 42 citations

Growth stimulation of human epidermal cells by urokinase is restricted to the intact active enzyme

1989 • 42 citations

The Mechanism of Inhibition of Collagenase by TIMP-1

1996 • 40 citations

Identification of determinants involved in binding of tissue-type plasminogen activator-plasminogen activator inhibitor type 1 complexes to HepG2 cells.

1990 • 39 citations

Vascular Smooth Muscle Cells Potentiate Plasmin Generation by Both Urokinase and Tissue Plasminogen Activator-Dependent Mechanisms: Evidence for a Specific Tissue-Type Plasminogen Activator Receptor on These Cells

1997 • 39 citations

Urokinase Receptor-Dependent Upregulation of Smooth Muscle Cell Adhesion to Vitronectin by Urokinase

1998 • 37 citations

Parallel induction of fibrinolysis and receptors for plasminogen and urokinase by interferon gamma on U937 cells

1988 • 36 citations

A virgin enzyme derived from human plasminogen. Specific cleavage of the Arg560-Val peptide bond in the DIP-virgin enzyme by plasminogen activators

1982 • 35 citations

Soluble Human Urokinase Receptor Is Composed of Two Active Units

1997 • 35 citations

Human Alveolar Macrophages Secrete an Inhibitor of Metalloproteinase Elastase^1–4

1987 • 34 citations

Preimplantation mouse embryos express a cell surface receptor for tissue-plasminogen activator

1993 • 33 citations

Effect of urokinase on the proliferation of primary cultures of human prostatic cells

1987 • 33 citations

Vascular Smooth Muscle Cells Potentiate Plasmin Generation by Both Urokinase and Tissue Plasminogen Activator-Dependent Mechanisms: Evidence for a Specific Tissue-Type Plasminogen Activator Receptor on These Cells

1997 • 32 citations

Plasminogen and Plasminogen Activator Assembly on the Human Endothelial Cell

1993 • 31 citations

Mitogenic effect of urokinase on malignant and unaffected adjacent human renal cells

1988 • 30 citations

Binding of tissue‐type plasminogen activator to human melanoma cells

1993 • 28 citations

Deficiency of factor XII-dependent plasminogen proactivator in prekallikrein-deficient plasma.

1978 • 28 citations

Modulation of tissue plasminogen activator-catalyzed plasminogen activation by synthetic peptides derived from the amino-terminal heparin binding domain of fibronectin.

1993 • 26 citations

Transformation-dependent activation of urokinase-type plasminogen activator by a plasmin-independent mechanism: involvement of cell surface membranes.

1991 • 24 citations

The GPI-anchored adhesion molecule F3 induces tyrosine phosphorylation: involvement of the FNIII repeats

1996 • 24 citations

Urokinase-mediated transactivation of the plasminogen activator inhibitor type 2 (PAI-2 ) gene promoter in HT-1080 cells utilises AP-1 binding sites and potentiates phorbol ester-mediated induction of endogenous PAI-2 mRNA

1997 • 23 citations

Interaction of urokinase a chain with the receptor of human keratinocytes stimulates release of urokinase-like plasminogen activator

1990 • 20 citations

Proteinases in Human Polymorphonuclear Leukocytes

1983 • 20 citations

Transmembrane interactions at cell adhesion and invasion sites

1990 • 19 citations

Selective localization of receptors for urokinase amino-terminal fragment at substratum contact sites of an in vitro-established line of human epidermal cells

1992 • 18 citations

Interaction of Urokinase-Type Plasminogen Activator with Its Receptor Rapidly Induces Activation of Glucose Transporters

1997 • 18 citations

Effect of Peptides on the Inactivation of Tissue Plasminogen Activator by Plasminogen Activator Inhibitor-1 and on the Binding of Tissue Plasminogen Activator to Endothelial Cells

1990 • 10 citations

Expression in non-lens tissues of an enzyme activity related to the ‘lensspecific’ protein, δ crystallin

1991 • 4 citations

The C-terminal domain of 72 kDa gelatinase A is not required for catalysis, but is essential for membrane activation and modulates interactions with tissue inhibitors of metalloproteinases

1992 • 2 citations

Additions and Corrections

1990 • 1 citations