Absence of host plasminogen activator inhibitor 1 prevents cancer invasion and vascularization

The urokinase-type plasminogen activator system in cancer metastasis: A review

1997 • 1,561 citations

Biology and biochemistry of proteinases in tumor invasion

1993 • 1,264 citations

The serpin PAI-1 inhibits cell migration by blocking integrin αvβ3 binding to vitronectin

1996 • 680 citations

Plasminogen activators, integrins, and the coordinated regulation of cell adhesion and migration

1997 • 472 citations

Is plasminogen activator inhibitor-1 the molecular switch that governs urokinase receptor-mediated cell adhesion and release?

1996 • 460 citations

Increased proteolytic activity is responsible for the aberrant morphogenetic behavior of endothelial cells expressing the middle T oncogene

1990 • 452 citations

Halting angiogenesis suppresses carcinoma cell invasion

1997 • 430 citations

The keratinocyte handbook

1995 • 428 citations

Urokinase and urokinase receptor: A paracrine/autocrine system regulating cell migration and invasiveness

1993 • 402 citations

Plasminogen activator inhibitor-1 gene-deficient mice. II. Effects on hemostasis, thrombosis, and thrombolysis.

1993 • 399 citations

High levels of urokinase-type plasminogen activator and its inhibitor PAI-1 in cytosolic extracts of breast carcinomas are associated with poor prognosis.

1993 • 396 citations

Plasminogen activator inhibitor-1 gene-deficient mice. I. Generation by homologous recombination and characterization.

1993 • 344 citations

Prognostic impact of urokinase, urokinase receptor, and type 1 plasminogen activator inhibitor in squamous and large cell lung cancer tissue.

1994 • 296 citations

Plasmin and plasminogen activator inhibitor type 1 promote cellular motility by regulating the interaction between the urokinase receptor and vitronectin.

1997 • 288 citations

The Urokinase Receptor Is a Major Vitronectin-Binding Protein on Endothelial Cells

1996 • 252 citations

Inhibitory Role of Plasminogen Activator Inhibitor-1 in Arterial Wound Healing and Neointima Formation

1997 • 250 citations

The Role of Plasmhogen Activators in the Regulation of Connective Tissue Metalloproteinasesa

1992 • 243 citations

Plasminogen activator inhibitor-1 and prognosis in primary breast cancer.

1994 • 230 citations

The Keratinocyte handbook

1994 • 229 citations

c-Ha-ras oncogene expression in immortalized human keratinocytes (HaCaT) alters growth potential in vivo but lacks correlation with malignancy.

1990 • 212 citations

Prognostic impact of urokinase-type plasminogen activator and its inhibitor PAI-1 in completely resected gastric cancer.

1994 • 205 citations

Impaired arterial neointima formation in mice with disruption of the plasminogen gene.

1997 • 196 citations

In vivo patterns of expression of urokinase and its inhibitor PAI-1 suggest a concerted role in regulating physiological angiogenesis.

1992 • 187 citations

Inhibition of urokinase-type plasminogen activator by antibodies: the effect on dissemination of a human tumor in the nude mouse.

1991 • 179 citations

Plasminogen Activator Inhibitor 1 and Plasminogen Activator Inhibitor 2 in Various Disease States

1988 • 165 citations

In situ analysis of changes in telomere size during replicative aging and cell transformation.

1996 • 152 citations

The plasminogen activation system in human colon cancer: messenger RNA for the inhibitor PAI-1 is located in endothelial cells in the tumor stroma.

1991 • 147 citations

Co‐expression of urokinase, urokinase receptor and PAI‐1 is necessary for optimum invasiveness of cultured lung cancer cells

1995 • 146 citations

The c-myc-regulated gene mrl encodes plasminogen activator inhibitor 1.

1990 • 143 citations

Urokinase (uPA) and PAI-1 Predict Survival in Advanced Ovarian Cancer Patients (FIGO III) after Radical Surgery and Platinum-Based Chemotherapy

1994 • 140 citations

Tumor-associated proteolysis and prognosis: new functional risk factors in gastric cancer defined by the urokinase-type plasminogen activator system.

1995 • 116 citations

Plasminogen activator inhibitor‐1 is induced in migrating endothelial cells

1992 • 115 citations

Two alternatively spliced mouse urokinase receptor mRNAs with different histological localization in the gastrointestinal tract.

1991 • 110 citations

Immunoassay of Murine t-PA, u-PA and PAI-1 Using Monoclonal Antibodies Raised in Gene-inactivated Mice

1995 • 100 citations

Relationship between secreted urokinase plasminogen activator activity and metastatic potential in murine B16 cells transfected with human urokinase sense and antisense genes.

1990 • 99 citations

Differential protease expression by cutaneous squamous and basal cell carcinomas.

1991 • 95 citations

Plasminogen activators augment endothelial cell organization in vitro by two distinct pathways

1995 • 91 citations

Plasminogen activator inhibitor-type 1 in Lewis lung carcinoma

1990 • 74 citations

Characteristics of chemically transformed mouse epidermal cells in vitro and in vivo.

1978 • 72 citations

Inactive urokinase and increased levels of its inhibitor type 1 in colorectal cancer liver metastasis

1994 • 66 citations

Immunohistochemical localization of the plasminogen activator inhibitor‐1 in breast cancer

1995 • 63 citations

Possible role of plasminogen activator inhibitor 2 in the prevention of the metastasis of gastric cancer tissues

1992 • 54 citations

Biological Effects of Combined Inactivation of Plasminogen Activator and Plasminogen Activator Inhibitor-1 Gene Function in Mice

1995 • 23 citations

Expression of plasminogen activators and plasminogen activator inhibitors in cutaneous melanomas of transgenic melanoma-susceptible mice.

1995 • 19 citations