Proteases and Protease Inhibitors in Tumor Progression

Matrix Metalloproteinases: A Review

1993 • 2,998 citations

Metastatic potential correlates with enzymatic degradation of basement membrane collagen

1980 • 1,778 citations

Mechanism Of Cell Surface Activation Of 72-kDa Type IV Collagenase

1995 • 1,576 citations

Growth‐promoting activity of tissue inhibitor of metalloproteinases‐1 (TIMP‐1) for a wide range of cells A possible new growth factor in serum

1992 • 705 citations

Furin-dependent intracellular activation of the human stromelysin-3 zymogen

1995 • 620 citations

Human 72-kilodalton type IV collagenase forms a complex with a tissue inhibitor of metalloproteases designated TIMP-2.

1989 • 594 citations

Identification of the urokinase receptor as an adhesion receptor for vitronectin.

1994 • 593 citations

Interaction of 92-kDa type IV collagenase with the tissue inhibitor of metalloproteinases prevents dimerization, complex formation with interstitial collagenase, and activation of the proenzyme with stromelysin.

1992 • 519 citations

Cell growth-promoting activity of tissue inhibitor of metalloproteinases-2 (TIMP-2)

1994 • 456 citations

Metalloproteinases and cancer invasion.

1990 • 399 citations

Transmembrane-deletion Mutants of the Membrane-type Matrix Metalloproteinase-1 Process Progelatinase A and Express Intrinsic Matrix-degrading Activity

1996 • 392 citations

A synthetic matrix metalloproteinase inhibitor decreases tumor burden and prolongs survival of mice bearing human ovarian carcinoma xenografts.

1993 • 383 citations

Biological and clinical aspects of plasminogen activator inhibitor type 2

1995 • 324 citations

Tissue inhibitor of metalloproteinases (TIMP, aka EPA): Structure, control of expression and biological functions

1993 • 270 citations

Matrix metalloproteinase inhibitor BB-94 (batimastat)inhibits human colon tumor growth and spread in a patient-like orthotopic model in nude mice.

1994 • 254 citations

In vitro degradation of extracellular matrix with Mr 52,000 cathepsin D secreted by breast cancer cells.

1988 • 242 citations

Suppression of the Tumorigenic and Metastatic Abilities of Murine B16-F10 Melanoma Cells In Vivo by the Overexpression of the Tissue Inhibitor of the Metalloproteinases-1

1994 • 221 citations

Hydrolytic inactivation of a breast carcinoma cell-derived serpin by human stromelysin-3.

1994 • 217 citations

Cathepsin B and cystatins: evidence for a role in cancer progression.

1990 • 206 citations

Tissue inhibitor of metalloproteinase‐2 (TIMP‐2) has erythroid‐potentiating activity

1992 • 200 citations

Drug Resistance in Oncology

1994 • 173 citations

Metalloproteinase inhibition and erythroid potentiation are independent activities of tissue inhibitor of metalloproteinases-1

1995 • 172 citations

Effect of tissue inhibitor of the matrix metalloproteinases-2 expression on the growth and spontaneous metastasis of a human melanoma cell line.

1994 • 168 citations

Identification of Cysteine 354 of β-Tubulin as Part of the Binding Site for the A Ring of Colchicine

1996 • 160 citations

Drug Resistance in Oncology

1997 • 160 citations

Overexpression of metalloproteinase inhibitor in B16F10 cells does not affect extravasation but reduces tumor growth.

1994 • 160 citations

Inhibition of autoproteolytic activation of interstitial procollagenase by recombinant metalloproteinase inhibitor MI/TIMP-2

1991 • 156 citations

Physiological mechanisms for metalloproteinase activation.

1992 • 142 citations

Cytokines induce urokinase-dependent adhesion of human myeloid cells. A regulatory role for plasminogen activator inhibitors.

1993 • 138 citations

Protease inhibitors: Role and potential therapeutic use in human cancer

1994 • 134 citations

Overexpression of tissue inhibitor of metalloproteinases-2 retroviral-mediated gene transfer in vivo inhibits tumor growth and invasion.

1996 • 134 citations

Overexpression of plasminogen activator inhibitor 2 in human melanoma cells inhibits spontaneous metastasis in scid/scid mice.

1995 • 131 citations

Melanoma-mediated dissolution of extracellular matrix: contribution of urokinase-dependent and metalloproteinase-dependent proteolytic pathways.

1993 • 106 citations

Urokinase/urokinase receptor system: internalization/degradation of urokinase-serpin complexes: mechanism and regulation.

1995 • 102 citations

Effects of membrane-associated cathepsin B on the activation of receptor-bound prourokinase and subsequent invasion of reconstituted basement membranes

1993 • 98 citations

Activation of precursors for matrix metalloproteinases 1 (interstitial collagenase) and 3 (stromelysin) by rat mast-cell proteinases I and II

1995 • 93 citations

Immunohistochemical analysis of cathepsins D, B, and L in human breast cancer

1994 • 92 citations

Increased expression of cathepsins L and B and decreased activity of their inhibitors in metastatic, ras‐transformed NIH 3T3 cells

1992 • 91 citations

Plasminogen activator inhibitor type 2 prevents programmed cell death of human macrophages infected with Mycobacterium avium, serovar 4.

1995 • 79 citations

Characterization of the functional domain of tissue inhibitor of metalloproteinases-2 (TIMP-2)

1993 • 64 citations

Cathepsins B, H and L in human breast carcinoma.

1992 • 61 citations

Independent regulation of matrix metalloproteinases and plasminogen activators in human fibrosarcoma cells

1996 • 36 citations

Immunoradiometric assay of pro-cathepsin D in breast cancer cytosol: Relative prognostic value versus total cathepsin D

1993 • 33 citations

Cathepsin-D in human breast cancer: correlation with vascular invasion and other clinical and histopathological characteristics.

1993 • 14 citations