Membrane and matrix localization of proteinases: a common theme in tumor cell invasion and angiogenesis

Plasminogen Activators, Tissue Degradation, and Cancer

1985 • 2,584 citations

Metastatic potential correlates with enzymatic degradation of basement membrane collagen

1980 • 1,778 citations

Kinetics of the activation of plasminogen by human tissue plasminogen activator. Role of fibrin.

1982 • 1,300 citations

Migration and proliferation of endothelial cells in preformed and newly formed blood vessels during tumor angiogenesis

1977 • 1,286 citations

Macrophage-induced angiogenesis is mediated by tumour necrosis factor-α

1987 • 1,210 citations

Tumor invasion and the extracellular matrix.

1983 • 960 citations

Heparin Affinity: Purification of a Tumor-Derived Capillary Endothelial Cell Growth Factor

1984 • 937 citations

Isolation and characterization of angiogenin, an angiogenic protein from human carcinoma cells

1985 • 911 citations

Transforming Growth Factor-α: a More Potent Angiogenic Mediator than Epidermal Growth Factor

1986 • 856 citations

Purification and characterization of the plasminogen activator secreted by human melanoma cells in culture.

1981 • 792 citations

Tumor invasion through the human amniotic membrane: Requirement for a proteinase cascade

1986 • 764 citations

A cellular binding site for the Mr 55,000 form of the human plasminogen activator, urokinase.

1985 • 731 citations

Proteinases in mammalian cells and tissues

1978 • 701 citations

Endogenous Activation of Latent Collagenase by Rheumatoid Synovial Cells

1977 • 686 citations

Rat Transforming Growth Factor Type 1: Structure and Relation to Epidermal Growth Factor

1984 • 666 citations

Antibodies to plasminogen activator inhibit human tumor metastasis

1983 • 651 citations

Biochemical and immunological characterization of the secreted forms of human neutrophil gelatinase.

1985 • 625 citations

Effect of plasminogen activator (urokinase), plasmin, and thrombin on glycoprotein and collagenous components of basement membrane.

1981 • 587 citations

Endothelial cells produce a latent inhibitor of plasminogen activators that can be activated by denaturants.

1985 • 555 citations

Secretion of metalloproteinases by stimulated capillary endothelial cells. II. Expression of collagenase and stromelysin activities is regulated by endogenous inhibitors.

1986 • 531 citations

Elastase secretion by stimulated macrophages. Characterization and regulation.

1975 • 522 citations

Stromelysin, a connective tissue-degrading metalloendopeptidase secreted by stimulated rabbit synovial fibroblasts in parallel with collagenase. Biosynthesis, isolation, characterization, and substrates.

1985 • 506 citations

Proteolytic degradation of extracellular matrix in tumor invasion

1987 • 484 citations

Epidermal growth factor-like transforming growth factor. II. Interaction with epidermal growth factor receptors in human placenta membranes and A431 cells.

1983 • 484 citations

The receptor-binding sequence of urokinase. A biological function for the growth-factor module of proteases.

1987 • 479 citations

Stromelysin is an activator of procollagenase. A study with natural and recombinant enzymes

1987 • 474 citations

Tumor-promoting phorbol esters induce angiogenesis in vitro

1985 • 470 citations

The plasminogen system and cell surfaces: evidence for plasminogen and urokinase receptors on the same cell type.

1986 • 466 citations

Localization of type IV collagen, laminin, heparan sulfate proteoglycan, and fibronectin to the basal lamina of basement membranes.

1982 • 464 citations

Purification of an inhibitor of plasminogen activator (antiactivator) synthesized by endothelial cells.

1984 • 455 citations

Enhanced production and extracellular deposition of the endothelial-type plasminogen activator inhibitor in cultured human lung fibroblasts by transforming growth factor-beta.

1986 • 443 citations

Inhibition of Endothelial Regeneration by Type-Beta Transforming Growth Factor from Platelets

1986 • 439 citations

Plasminogen activation and regulation of pericellular proteolysis

1985 • 439 citations

STUDIES ON INFLAMMATION. III. GROWING CAPILLARIES: THEIR STRUCTURE AND PERMEABILITY.

1963 • 430 citations

Biology of Endothelial Cells

1984 • 426 citations

Heparin Binds Endothelial Cell Growth Factor, the Principal Endothelial Cell Mitogen in Bovine Brain

1984 • 391 citations

Further studies on the activation of procollagenase, the latent precursor of bone collagenase. Effects of lysosomal cathepsin B, plasmin and kallikrein, and spontaneous activation

1977 • 389 citations

Human skin collagenase: isolation of precursor and active forms from both fibroblast and organ cultures

1977 • 387 citations

The opposing effects of basic fibroblast growth factor and transforming growth factor beta on the regulation of plasminogen activator activity in capillary endothelial cells.

1987 • 378 citations

Cultured bovine endothelial cells produce both urokinase and tissue-type plasminogen activators.

1982 • 362 citations

Autocrine saturation of pro-urokinase receptors on human A431 cells

1986 • 361 citations

Inhibition of tumor angiogenesis mediated by cartilage.

1975 • 361 citations

Factors involved in the modulation of cell proliferation in vivo and in vitro: The role of fibroblast and epidermal growth factors in the proliferative response of mammalian cells

1978 • 360 citations

Amino acid sequence of human tumor derived angiogenin

1985 • 357 citations

Characteristic ribonucleolytic activity of human angiogenin

1986 • 354 citations

Heparan Sulfate Degradation: Relation to Tumor Invasive and Metastatic Properties of Mouse B16 Melanoma Sublines

1983 • 350 citations

Basement Membrane Collagen: Degradation by Migrating Endothelial Cells

1983 • 345 citations

Basic and acidic fibroblast growth factors interact with the same cell surface receptors.

1986 • 340 citations

Brain-Derived Acidic Fibroblast Growth Factor: Complete Amino Acid Sequence and Homologies

1985 • 335 citations

The Neutral Proteases of Human Granulocytes

1974 • 316 citations

Transforming growth factor-beta inhibits endothelial cell proliferation

1986 • 313 citations

Inhibition of endothelial cell proliferation by type β-transforming growth factor: Interactions with acidic and basic fibroblast growth factors

1986 • 312 citations

Binding and activation of plasminogen on the platelet surface.

1985 • 312 citations

Ultrastructural localization of plasma membrane-associated urokinase-type plasminogen activator at focal contacts.

1988 • 312 citations

Control of proliferation of human vascular endothelial cells. Characterization of the response of human umbilical vein endothelial cells to fibroblast growth factor, epidermal growth factor, and thrombin

1978 • 312 citations

Binding of plasminogen to cultured human endothelial cells.

1986 • 311 citations

Isolations of a Cartilage Factor That Inhibits Tumor Neovascularization

1976 • 308 citations

Studies on inflammation

1963 • 306 citations

Isolation of the pericellular matrix of human fibroblast cultures.

1979 • 302 citations

Purification of two distinct growth factors from bovine neural tissue by heparin affinity chromatography

1984 • 298 citations

The role of proteinase in cellular invasiveness

1983 • 297 citations

Distinct localizations of urokinase-type plasminogen activator and its type 1 inhibitor under cultured human fibroblasts and sarcoma cells

1987 • 295 citations

Urokinase-type plasminogen activator is induced in migrating capillary endothelial cells.

1987 • 286 citations

Identification of the fibroblast growth factor receptor of Swiss 3T3 cells and mouse skeletal muscle myoblasts

1986 • 285 citations

Human endothelial cells are chemotactic to endothelial cell growth factor and heparin.

1985 • 282 citations

Plasminogen activator and collagenase production by cultured capillary endothelial cells

1982 • 279 citations

Degradation of type IV (basement membrane) collagen by a proteinase isolated from human polymorphonuclear leukocyte granules.

1980 • 279 citations

Effect of fibroblast growth factor and lipoproteins on the proliferation of endothelial cells derived from bovine adrenal cortex, brain cortex, and corpus luteum capillaries

1986 • 273 citations

Cloning and sequencing of the intronless gene for angiogenin, a human angiogenesis factor

1985 • 273 citations

Purification from a human hepatoma cell line of a basic fibroblast growth factor-like molecule that stimulates capillary endothelial cell plasminogen activator production, DNA synthesis, and migration.

1986 • 272 citations

Metastatic melanoma cell heparanase. Characterization of heparan sulfate degradation fragments produced by B16 melanoma endoglucuronidase.

1984 • 269 citations

Transforming growth factor-beta induction of type-1 plasminogen activator inhibitor. Pericellular deposition and sensitivity to exogenous urokinase.

1987 • 263 citations

Purification and characterization of heparin-binding endothelial cell growth factors.

1986 • 263 citations

The angiogenic activity of the fibroblast and epidermal growth factor

1979 • 261 citations

Corpus Luteum Angiogenic Factor Is Related to Fibroblast Growth Factor*

1985 • 260 citations

Mouse macrophage elastase. Purification and characterization as a metalloproteinase

1981 • 260 citations

Lymphoma cell-mediated degradation of sulfated proteoglycans in the subendothelial extracellular matrix: relationship to tumor cell metastasis.

1983 • 259 citations

Relationship between tissue plasminogen activator and the activators in blood and vascular wall

1980 • 254 citations

Purification and characterization of a murine basement membrane collagen-degrading enzyme secreted by metastatic tumor cells.

1983 • 245 citations

Proteolysis by Neutrophils

1982 • 244 citations

Partial purification and characterization of a neutral protease which cleaves type IV collagen

1981 • 241 citations

Macrophage fibrinolytic activity: Identification of two pathways of plasmin formation by intact cells and of a plasminogen activator inhibitor

1982 • 225 citations

Endothelial cell mitogens derived from retina and hypothalamus: biochemical and biological similarities.

1984 • 224 citations

Binding of tissue plasminogen activator to cultured human endothelial cells.

1987 • 223 citations

Solubilization and degradation of subendothelial matrix glycoproteins and proteoglycans by metastatic tumor cells.

1982 • 222 citations

Destruction of extracellular matrices containing glycoproteins, elastin, and collagen by metastatic human tumor cells.

1980 • 221 citations

Secretion of metalloproteinases by stimulated capillary endothelial cells. I. Production of procollagenase and prostromelysin exceeds expression of proteolytic activity.

1986 • 215 citations

Primary structure of bovine brain acidic fibroblast growth factor (FGF)

1985 • 213 citations

Partial purification of collagenase and gelatinase from human polymorphonuclear leucocytes. Analysis of their actions on soluble and insoluble collagens

1982 • 203 citations

Angiogenesis is stimulated by a tumor‐derived endothelial cell growth factor

1985 • 203 citations

Secretion of basement membrane collagen degrading enzyme and plasminogen activator by transformed cells – role in metastasis

1982 • 195 citations

Regulation of the Mammalian Collagenases

1984 • 194 citations

Extracellular matrix of cultured bovine aortic endothelial cells contains functionally active type 1 plasminogen activator inhibitor

1987 • 188 citations

Expression of transformation-associated protease(s) that degrade fibronectin at cell contact sites.

1984 • 184 citations

Plasminogen activator dependent pathways inthe dissemination of human tumor cells in the chick embryo

1988 • 181 citations

Induction of angiogenesis by bovine brain derived class 1 heparin-binding growth factor

1985 • 180 citations

Acidic fibroblast growth factor (FGF) from bovine brain: amino-terminal sequence and comparison with basic FGF.

1985 • 178 citations

Binding of plasminogen to extracellular matrix.

1986 • 175 citations

Plasminogen and tissue-type plasminogen activator bind to immobilized fibronectin.

1985 • 174 citations

Receptor Mediated Binding of the Fibrinolytic Components, Plasminogen and Urokinase, to Peripheral Blood Cells

1987 • 165 citations

Effect of Thrombin on the Production of Plasminogen Activators and PA Inhibitor-1 by Human Foreskin Microvascular Endothelial Cells

1987 • 164 citations

Association of a protease (plasminogen activator) with a specific membrane fraction isolated from transformed cells.

1976 • 163 citations

Activation of human breast carcinoma collagenase through plasminogen activator

1980 • 160 citations

Invasion of reconstituted basement membrane matrix by metastatic human tumor cells.

1986 • 160 citations

Plasminogen activator inhibitor is associated with the extracellular matrix of cultured bovine smooth muscle cells.

1987 • 158 citations

Linkage of extracellular plasminogen activator to the fibroblast cytoskeleton: colocalization of cell surface urokinase with vinculin.

1988 • 158 citations

Human endothelial cells contain one type of plasminogen activator

1984 • 156 citations

Proteolytic Enzymes in Cancer Invasion and Metastasis

1986 • 154 citations

Rat mammary carcinoma cells secrete active collagenase and activate latent enzyme in the stroma via plasminogen activator

1981 • 149 citations

Glycosidases in cancer and invasion

1985 • 149 citations

Collagenolytic mechanisms in tumor cell invasion

1984 • 146 citations

Tumor Cell Collagenase and Its Inhibition by a Cartilage-Derived Protease Inhibitor

1977 • 143 citations

Plasminogen, the Serum Proenzyme Activated by Factors from Cells Transformed by Oncogenic Viruses

1974 • 139 citations

The resistance of certain tissues to invasion: penetrability of explanted tissues by vascularized mesenchyme.

1973 • 135 citations

Association of a plasminogen activator inhibitor (PAI-1) with the growth substratum and membrane of human endothelial cells.

1987 • 135 citations

Purification of an endogenous activator of procollagenase from rabbit synovial fibroblast culture medium.

1983 • 134 citations

Fibronectin-degrading proteases from the membranes of transformed cells

1987 • 134 citations

Proliferation of a human epidermal tumor cell line stimulated by urokinase

1987 • 132 citations

Quantitation and properties of the active and latent plasminogen activator inhibitors in cultures of human endothelial cells

1986 • 130 citations

The resistance of certain tissues to invasion. II. Evidence for extractable factors in cartilage which inhibit invasion by vascularized mesenchyme.

1975 • 130 citations

Isolation of Elastase-Like and Chymotrypsin-Like Neutral Proteases from Human Granulocytes

1974 • 129 citations

[7] Elastase

1970 • 125 citations

Human lysosomal elastase. Catalytic and immunological properties

1976 • 124 citations

Phorbol ester induces cultured endothelial cells to invade a fibrin matrix in the presence of fibrinolytic inhibitors

1987 • 121 citations

Tetradecanoyl phorbol acetate stimulates latent collagenase production by cultured human endothelial cells

1980 • 117 citations

A gene for rabbit synovial cell collagenase: member of a family of metalloproteinases that degrades the connective tissue matrix

1987 • 115 citations

The extracellular matrix of normal chick embryo fibroblasts: its effect on transformed chick fibroblasts and its proteolytic degradation by the transformants.

1985 • 114 citations

Human brain-derived acidic and basic fibroblast growth factors: Amino terminal sequences and specific mitogenic activities

1986 • 112 citations

Production of a fibrinolytic inhibitor by cultured endothelial cells derived from human umbilical vein

1978 • 111 citations

A form of human basic fibroblast growth factor with an extended amino terminus

1987 • 110 citations

Phorbol esters induce angiogenesis in vitro from large‐vessel endothelial cells

1987 • 109 citations

An inhibitor of plasminogen activator in rabbit endothelial cells.

1981 • 108 citations

Synthesis of biologically active rat transforming growth factor I

1984 • 102 citations

Comparative studies of the fibrinolytic activity of cultured vascular cells

1979 • 101 citations

Activation of immobilized plasminogen by tissue activator. Multimolecular complex formation.

1985 • 97 citations

Tumor necrosis factor inhibits the proliferation of cultured capillary endothelial cells

1987 • 91 citations

Plasminogen Is Present in the Basal Layer of the Epidermis

1983 • 91 citations

Proteinase inhibitors of bovine nasal cartilage

1978 • 90 citations

Cloning of a complementary dna for rabbit proactivator. a metalloproteinase that activates synovial cell collagenase, shares homology with stromelysin and transin, and is coordinately regulated with collagenase

1987 • 86 citations

A latent form of collagenase in the involuting rat uterus and its activation by a serine proteinase

1977 • 84 citations

Degradation of native type IV procollagen by human neutrophil elastase. Implications for leukocyte-mediated degradation of basement membranes

1987 • 79 citations

Activation of alveolar macrophage collagenase by a neutral protease secreted by the same cell

1976 • 78 citations

Isolation and characterization of a urokinase-type plasminogen activator (Mr = 54,000) from cultured human endothelial cells indistinguishable from urinary urokinase.

1984 • 77 citations

Sequential degradation of heparan sulfate in the subendothelial extracellular matrix by highly metastatic lymphoma cells

1985 • 75 citations

Properties of a plasma membrane-associated cathepsin B-like cysteine proteinase in metastatic B16 melanoma variants.

1987 • 73 citations

Identification of plasma kallikrein as an activator of latent collagenase in rheumatoid synovial fluid

1982 • 73 citations

Co-operation between plasmin and elastase in elastin degradation by intact murine macrophages

1984 • 72 citations

Mesosecrin: a secreted glycoprotein produced in abundance by human mesothelial, endothelial, and kidney epithelial cells in culture.

1987 • 72 citations

Cryptic urokinase binding sites on human foreskin fibroblasts

1985 • 71 citations

Localization of protease nexin‐1 on the fibroblast extracellular matrix

1988 • 69 citations

Involvement of both heparanase and plasminogen activator in lymphoma cell‐mediated degradation of heparan sulfate in the subendothelial extracellular matrix

1986 • 67 citations

The isolation and purification of two anionic endothelial cell growth factors from human brain

1984 • 66 citations

Isolation of a Protease Inhibitor from Tissues Resistant to Tumor Invasion

1977 • 66 citations

Proteinase inhibitor activity in connective tissues

1974 • 64 citations

Metalloproteinase inhibitors from bovine cartilage and body fluids

1984 • 62 citations

The regulation of tissue plasminogen activator activity by human fibroblasts

1983 • 61 citations

Purification and partial amino acid sequence of a bovine cartilage-derived collagenase inhibitor.

1986 • 61 citations

Cathepsin B-like enzymes. Subcellular distribution and properties in neoplastic and control cells from human ectocervix.

1981 • 61 citations

Amino acid sequence of bovine brain derived class 1 heparin-binding growth factor

1986 • 60 citations

Enrichment of collagen and gelatin degrading activities in the plasma membranes of human cancer cells.

1987 • 60 citations

Immunological identification and comparison of plasminogen activator forms in cultured normal human endothelial cells and smooth muscle cells

1981 • 57 citations

Anchorage independent growth and plasminogen activator production by bovine endothelial cells.

1980 • 56 citations

Interaction of plasmin with endothelial cells

1984 • 54 citations

Metastatic mouse melanoma cells release collagen-gelatin degrading metalloproteinases as components of shed membrane vesicles

1987 • 51 citations

Urokinase‐type and tissue‐type plasminogen activators have different distributions in cultured bovine capillary endothelial cells

1986 • 48 citations

New functions of epidermal growth factor: Stimulation of capillary endothelial cell migration and matrix dependent proliferation

1985 • 46 citations

Inhibition of proteolytic enzymes in the in vitro amnion model for basement membrane invasion.

1986 • 46 citations

Heparan sulfate endoglycosidase and metastatic potential in murine fibrosarcoma and melanoma.

1986 • 45 citations

The activation of latent pig synovial collagenase

1981 • 45 citations

A pathway of coagulation on endothelial cells

1985 • 42 citations

Production of latent collagenase by human umbilical vein endothelial cells in response to angiogenic preparations

1985 • 38 citations

Inhibition of type I collagen film degradation by tumour cells using a specific antibody to collagenase and the specific tissue inhibitor of metalloproteinases (TIMP)

1985 • 38 citations

Heparin potentiation of 3T3‐adipocyte stimulated angiogenesis: Mechanisms of action on endothelial cells

1986 • 37 citations

Role of Plasminogen in Matrix Breakdown by Neoplastic Cells<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>

1983 • 37 citations

Diversity of human pancreatic cancer cell proteinases: role of cell membrane metalloproteinases in collagenolysis and cytolysis.

1985 • 36 citations

Characterization of a plasminogen activator secreted by cultured bovine aortic endothelial cells

1982 • 35 citations

Degradation of endothelial basement membrane by human breast cancer cell lines.

1986 • 35 citations

Endothelial Cells Degrade Extracellular Matrix Proteins Produced In Vitro

1985 • 34 citations

Substrate hydrolysis by immune complex-activated neutrophils: effect of physical presentation of complexes and protease inhibitors.

1981 • 32 citations

Plasminogen activator activity by cultured bovine aortic endothelial cells

1980 • 27 citations

Characterization of an extracellular matrix-degrading protease derived from a highly metastatic tumor cell line

1985 • 27 citations

A trypsin-like neutral protease on Ehrlich ascites cell surfaces: its role in the activation of tumour-cell zymogen of collagenase

1980 • 27 citations

Human urokinase and porcine tissue plasminogen activator. A comparative study of the mechanism of fibrinolysis, and the effect of natural proteinase inhibitors and omega-aminocarboxylic acids.

1977 • 27 citations

Changes in proteoglycan biosynthesis following leukocyte elastase treatment of bovine articular cartilage in culture

1984 • 26 citations

Human placental tissue stimulates bovine capillary endothelial cell growth, migration and protease production

1985 • 24 citations

Tissue culture : studies in experimental morphology and general physiology of tissue cells in vitro

1925 • 23 citations

Clearing and release of basement membrane proteins from substrates by metastatic tumor cell variants.

1986 • 22 citations

Comparison of human and bovine brain derived heparin-binding growth factors

1985 • 22 citations

Inhibition of tumor cell collagenolytic activity by bovine endothelial cells.

1986 • 20 citations

Stimulation of motility in cultured bovine capillary endothelial cells by angiogenic preparations

1984 • 20 citations

Serine proteinase activation of latent human skin collagenase

1984 • 17 citations

Cell surface-associated and released proteolytic activities of bovine aorta endothelial cells

1976 • 15 citations

Comparison of basement membrane matrix degradation by purified proteases and by metastatic tumor cells

1987 • 11 citations

Inhibition by Bovine Endothelial Cells of Degradation by HT-1080 Fibrosarcoma Cells of Extracellular Matrix Proteins<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>

1983 • 11 citations

Tissue Culture. Studies in Experimental Morphology and General Physiology of Tissue Cells in Vitro.

1925 • 10 citations

A vertebrate interstitial collagenase inhibitor from bovine scapular cartilage: purification and characterization

1987 • 8 citations

Plasminogen activator activity of isolated cardiac muscle microvessel endothelial cells

1980 • 7 citations

Binding sites for elastase on cultured human fibroblasts that do not mediate internalization

1987 • 4 citations