The C-terminal Region of Membrane Type Matrix Metalloproteinase Is a Functional Transmembrane Domain Required for Pro-gelatinase A Activation

Cancer metastasis and angiogenesis: An imbalance of positive and negative regulation

1991 • 2,774 citations

A matrix metalloproteinase expressed on the surface of invasive tumour cells

1994 • 2,561 citations

Tumor Cell Interactions with the Extracellular Matrix During Invasion and Metastasis

1993 • 1,523 citations

The cysteine switch: a principle of regulation of metalloproteinase activity with potential applicability to the entire matrix metalloproteinase gene family.

1990 • 1,423 citations

Biology and biochemistry of proteinases in tumor invasion

1993 • 1,264 citations

The plasminogen activator/plasmin system.

1991 • 1,196 citations

A novel metalloproteinase gene specifically expressed in stromal cells of breast carcinomas

1990 • 1,140 citations

Molecular cloning and expression of cDNAs for the human interleukin-2 receptor

1984 • 858 citations

Sequence of human tissue inhibitor of metalloproteinases and its identity to erythroid-potentiating activity

1985 • 702 citations

Biochemical and immunological characterization of the secreted forms of human neutrophil gelatinase.

1985 • 625 citations

Cloning and expression of the receptor for human urokinase plasminogen activator, a central molecule in cell surface, plasmin dependent proteolysis.

1990 • 624 citations

Arg-X-Lys/Arg-Arg motif as a signal for precursor cleavage catalyzed by furin within the constitutive secretory pathway

1991 • 590 citations

Tissue cooperation in a proteolytic cascade activating human interstitial collagenase.

1989 • 579 citations

Biosynthesis, cleavage, and degradation of the human immunodeficiency virus 1 envelope glycoprotein gp160.

1988 • 442 citations

Mechanisms of activation of tissue procollagenase by matrix metalloproteinase 3 (stromelysin)

1990 • 431 citations

Matrix metalloproteinase 2 from human rheumatoid synovial fibroblasts

1990 • 428 citations

Stepwise activation mechanisms of the precursor of matrix metalloproteinase 3 (stromelysin) by proteinases and (4-aminophenyl)mercuric acetate

1990 • 381 citations

Independent expression and cellular processing of Mr 72,000 type IV collagenase and interstitial collagenase in human tumorigenic cell lines.

1990 • 379 citations

Structural biochemistry and activation of matrix metalloproteases

1993 • 347 citations

Plasma membrane-dependent activation of the 72-kDa type IV collagenase is prevented by complex formation with TIMP-2

1993 • 338 citations

v-Src activates the expression of 92-kDa type IV collagenase gene through the AP-1 site and the GT box homologous to retinoblastoma control elements. A mechanism regulating gene expression independent of that by inflammatory cytokines.

1993 • 291 citations

Concanavalin A produces a matrix-degradative phenotype in human fibroblasts. Induction and endogenous activation of collagenase, 72-kDa gelatinase, and Pump-1 is accompanied by the suppression of the tissue inhibitor of matrix metalloproteinases.

1990 • 235 citations

Association of MMP-2 Activation Potential With Metastatic Progression in Human Breast Cancer Cell Lines Independent of MMP-2 Production

1993 • 216 citations

Tissue inhibitor of metalloproteinases-2 inhibits the activation of 72 kDa progelatinase by fibroblast membranes

1991 • 201 citations

Binding and localization of M(r) 72,000 matrix metalloproteinase at cell surface invadopodia.

1993 • 182 citations

Effects of deletions in the cytoplasmic domain on biological functions of human immunodeficiency virus type 1 envelope glycoproteins

1992 • 182 citations

Collagen-induced activation of the M(r) 72,000 type IV collagenase in normal and malignant human fibroblastoid cells.

1992 • 154 citations

Tumor cell surface-associated binding site for the M(r) 72,000 type IV collagenase.

1992 • 153 citations

Inhibition by retinoic acid of type IV collagenolysis and invasion through reconstituted basement membrane by metastatic rat mammary adenocarcinoma cells.

1989 • 151 citations

Reconstitution of functional receptor for human interleukin-2 in mouse cells

1985 • 150 citations

Cellular activation of the 72 kDa type IV procollagenase/TIMP-2 complex

1993 • 138 citations

DOUBLE-STRANDED AND SINGLE-STRANDED RNA VIRUSES OF SACCHAROMYCES CEREVISIAE

1992 • 125 citations

Tissue inhibitor of metalloproteinase 1 is a negative regulator of the metastatic ability of a human gastric cancer cell line, KKLS, in the chick embryo.

1993 • 108 citations

Stability analysis of latent and active 72-kDa type IV collagenase: The role of tissue inhibitor of metalloproteinases-2 (TIMP-2)

1993 • 89 citations

Secretion of human epidermal growth factor from Saccharomyces cerevisiae using synthetic leader sequences

1991 • 53 citations

Metastatic mouse melanoma cells release collagen-gelatin degrading metalloproteinases as components of shed membrane vesicles

1987 • 51 citations

Prohormone convertase-1 will process prorelaxin, a member of the insulin family of hormones.

1992 • 49 citations

Modulation of translation by the 5' leader sequence of the mRNA encoding murine tissue inhibitor of metalloproteinases.

1990 • 31 citations

Processing of Kex2 pro‐region at two interchangeable cleavage sites

1993 • 7 citations