Physiological consequences of loss of plasminogen activator gene function in mice

Plasminogen Activators, Tissue Degradation, and Cancer

1985 • 2,584 citations

The fibrin plate method for estimating fibrinolytic activity

1952 • 1,708 citations

Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene

1991 • 1,317 citations

The plasminogen activator/plasmin system.

1991 • 1,196 citations

Cell-Associated Plasminogen Activation: Regulation and Physiological Functions

1988 • 826 citations

SECRETION OF PLASMINOGEN ACTIVATOR BY STIMULATED MACROPHAGES

1974 • 719 citations

Basic and clinical aspects of fibrinolysis and thrombolysis

1991 • 653 citations

Urokinase-type plasminogen activator: proenzyme, receptor, and inhibitors

1987 • 625 citations

Plasminogen activator in early embryogenesis: Enzyme production by trophoblast and parietal endoderm

1976 • 590 citations

Mammary plasminogen activator: correlation with involution, hormonal modulation and comparison between normal and neoplastic tissue

1979 • 437 citations

Plasminogen activator inhibitor-1 gene-deficient mice. II. Effects on hemostasis, thrombosis, and thrombolysis.

1993 • 399 citations

Membrane and matrix localization of proteinases: a common theme in tumor cell invasion and angiogenesis

1988 • 354 citations

Evidence for the Occurrence of a Fast-Acting Inhibitor for Tissue-Type Plasminogen Activator in Human Plasma

1984 • 345 citations

Plasminogen activator inhibitor-1 gene-deficient mice. I. Generation by homologous recombination and characterization.

1993 • 344 citations

Two different mechanisms in patients with venous thrombosis and defective fibrinolysis: low concentration of plasminogen activator or increased concentration of plasminogen activator inhibitor.

1985 • 341 citations

Local abnormalities in coagulation and fibrinolytic pathways predispose to alveolar fibrin deposition in the adult respiratory distress syndrome.

1989 • 325 citations

Plasminogen activators in tissue remodeling and invasion: mRNA localization in mouse ovaries and implanting embryos.

1989 • 287 citations

Mechanisms of trophoblast invasiveness and their control: the role of proteases and protease inhibitors

1990 • 267 citations

Secretion of plasminogen activator by human polymorphonuclear leukocytes. Modulation by glucocorticoids and other effectors.

1977 • 246 citations

Implantation. The role of proteinases, and blockage of implantation by proteinase inhibitors.

1977 • 193 citations

Glomerular matrix accumulation is linked to inhibition of the plasmin protease system

1992 • 189 citations

Plasminogen activator in mouse and rat oocytes: Induction during meiotic maturation

1985 • 163 citations

Molecular cloning of complementary DNA to mouse tissue plasminogen activator mRNA and its expression during F9 teratocarcinoma cell differentiation.

1988 • 156 citations

Migrating Keratinocytes Express Urokinase-Type Plasminogen Activator

1987 • 134 citations

Suppression of Ovulation Rate by Antibodies to Tissue-Type Plasminogen Activator and α₂-Antiplasmin*

1989 • 131 citations

Plasminogen activator and mouse spermatozoa: urokinase synthesis in the male genital tract and binding of the enzyme to the sperm cell surface.

1987 • 125 citations

Inhibition of cancer cell urokinase plasminogen activator by its specific inhibitor PAI-2 and subsequent effects on extracellular matrix degradation.

1990 • 112 citations

Mouse ovarian granulosa cells produce urokinase-type plasminogen activator, whereas the corresponding rat cells produce tissue-type plasminogen activator.

1987 • 76 citations

Tissue-type plasminogen activator (t-PA) : physiological and clinical aspects

1988 • 72 citations

On the role of coagulation and fibrinolysis in atherosclerosis

1992 • 68 citations

The structure of the TATA-less rat tissue-type plasminogen activator gene. Species-specific sequence divergences in the promoter predict differences in regulation of gene expression.

1990 • 64 citations

Purification and characterization of glycogen synthase from a glycogen-deficient strain of Saccharomyces cerevisiae.

1990 • 62 citations

The murine urokinase-type plasminogen activator gene

1987 • 54 citations

Plasminogen activators in the mouse mammary gland

1989 • 39 citations

A hamster pulmonary embolism model for the evaluation of the thrombolytic and pharmacokinetic properties of thrombolytic agents

1990 • 36 citations

Localization of urokinase-type and tissue-type plasminogen activator mRNA during organogenesis in the mouse

1989 • 20 citations

EMBO medal review. On transferring genes into stem cells and mice.

1990 • 20 citations

[Tissue-type plasminogen activator (t-PA)].

1987 • 17 citations

Rat peritoneal macrophage procoagulant and fibrinolytic activities. An expression of the local inflammatory response

1991 • 15 citations

Dual peptidergic innervation of the blowfly hindgut : a light and electron microscopic study of FMRFamide and proctolin immunoreactive fibers

1991 • 10 citations