Tissue Inhibitor of Metalloproteinase (TIMP-2)

Improved tools for biological sequence comparison.

1988 • 11,455 citations

Metastatic potential correlates with enzymatic degradation of basement membrane collagen

1980 • 1,778 citations

H-ras oncogene-transformed human bronchial epithelial cells (TBE-1) secrete a single metalloprotease capable of degrading basement membrane collagen.

1988 • 1,050 citations

Sequence of human tissue inhibitor of metalloproteinases and its identity to erythroid-potentiating activity

1985 • 702 citations

Endogenous Activation of Latent Collagenase by Rheumatoid Synovial Cells

1977 • 686 citations

Secretion of metalloproteinases by stimulated capillary endothelial cells. II. Expression of collagenase and stromelysin activities is regulated by endogenous inhibitors.

1986 • 531 citations

A metalloproteinase from human rheumatoid synovial fibroblasts that digests connective tissue matrix components. Purification and characterization.

1986 • 515 citations

Stromelysin, a connective tissue-degrading metalloendopeptidase secreted by stimulated rabbit synovial fibroblasts in parallel with collagenase. Biosynthesis, isolation, characterization, and substrates.

1985 • 506 citations

Stromelysin is an activator of procollagenase. A study with natural and recombinant enzymes

1987 • 474 citations

Antisense RNA-Induced Reduction in Murine TIMP Levels Confers Oncogenicity on Swiss 3T3 Cells

1989 • 459 citations

Comparison of human stromelysin and collagenase by cloning and sequence analysis

1986 • 443 citations

Purification of rabbit bone inhibitor of collagenase

1981 • 352 citations

The Activation of Human Type IV Collagenase Proenzyme

1989 • 347 citations

Basement Membrane Collagen: Degradation by Migrating Endothelial Cells

1983 • 345 citations

Molecular characterization and expression of the gene encoding human erythroid-potentiating activity

1985 • 279 citations

Primary structure and cDNA cloning of human fibroblast collagenase inhibitor.

1986 • 274 citations

Human skin fibroblast collagenase inhibitor. Purification and biochemical characterization.

1983 • 259 citations

Partial purification and characterization of a neutral protease which cleaves type IV collagen

1981 • 241 citations

Secretion of type IV collagenolytic protease and metastatic phenotype: induction by transfection with c-Ha-ras but not c-Ha-ras plus Ad2-E1a.

1987 • 226 citations

Evidence that latent collagenases are enzyme-inhibitor complexes

1977 • 223 citations

Ras oncogene mediated induction of a 92kDa metalloproteinase; strong correlation with the malignant phenotype

1988 • 209 citations

Human alveolar macrophages produce a fibroblast-like collagenase and collagenase inhibitor.

1985 • 199 citations

Purification and characterization of a bone metalloproteinase that degrades gelatin and types IV and V collagen

1985 • 195 citations

Regulation of the Mammalian Collagenases

1984 • 194 citations

The activation of human skin fibroblast procollagenase. Sequence identification of the major conversion products.

1987 • 173 citations

Human tissues and cells in carcinogenesis research.

1987 • 173 citations

The interaction of purified rabbit bone collagenase with purified rabbit bone metalloproteinase inhibitor

1983 • 172 citations

Human Skin Fibroblast Collagenase: Interaction with Substrate and Inhibitor

1985 • 167 citations

Human fibroblast collagenase: glycosylation and tissue-specific levels of enzyme synthesis.

1986 • 125 citations

Evidence that human rheumatoid synovial matrix metalloproteinase 3 is an endogenous activator of procollagenase

1988 • 120 citations

Expression pattern of a gene for a secreted metalloproteinase during late stages of tumor progression

1988 • 112 citations

Invasive and Metastatic Potential of a v-Ha-ras-Transformed Human Bronchial Epithelial Cell Line

1989 • 103 citations

K562 cells produce and respond to human erythroid-potentiating activity

1988 • 99 citations

The detection and characterization of collagenase inhibitors from rabbit tissues in culture

1977 • 90 citations

Monocyte procollagenase and tissue inhibitor of metalloproteinases. Identification, characterization, and regulation of secretion.

1987 • 79 citations

Characterization and expression of a murine gene homologous to human EPA/TIMP: a virus-induced gene in the mouse.

1987 • 79 citations

Production of collagenase and inhibitor (TIMP) by intracranial tumors and dura in vitro

1983 • 75 citations

A fibrosarcoma model derived from mouse embryo cells: Growth properties and secretion of collagenase and metalloproteinase inhibitor (TIMP) by tumour cell lines

1984 • 74 citations

Purification and partial amino acid sequence of a bovine cartilage-derived collagenase inhibitor.

1986 • 61 citations

Malignant conversion of murine squamous papilloma cell lines by transfection with the fos oncogene

1988 • 59 citations

Tissue inhibitor of metalloproteinases. Identification of precursor forms synthetized by human fibroblasts in culture

1985 • 33 citations

The Collagenase Inhibitor from Human Polymorphonuclear Leukocytes

1983 • 30 citations

Characterisation of β₁‐Anticollagenase from Human Plasma and Its Reaction with Polymorphonuclear Leukocyte Collagenase by Disulfide/Thiol Interchange

1983 • 21 citations