Plasminogen Activator Inhibitor-1 Represses Integrin- and Vitronectin-Mediated Cell Migration Independently of Its Function as an Inhibitor of Plasminogen Activation

Integrins: Versatility, modulation, and signaling in cell adhesion

1992 • 9,986 citations

Cell Migration: A Physically Integrated Molecular Process

1996 • 3,909 citations

Binding of soluble form of fibroblast surface protein, fibronectin, to collagen

1977 • 1,972 citations

Biology and biochemistry of proteinases in tumor invasion

1993 • 1,264 citations

The serpin superfamily of proteinase inhibitors: structure, function, and regulation.

1994 • 879 citations

Regulation of Integrin Function by the Urokinase Receptor

1996 • 734 citations

The serpin PAI-1 inhibits cell migration by blocking integrin αvβ3 binding to vitronectin

1996 • 680 citations

Influence of stereochemistry of the sequence Arg-Gly-Asp-Xaa on binding specificity in cell adhesion.

1987 • 653 citations

Identification of the urokinase receptor as an adhesion receptor for vitronectin.

1994 • 593 citations

The receptor for urokinase type plasminogen activator polarizes expression of the protease to the leading edge of migrating monocytes and promotes degradation of enzyme inhibitor complexes.

1990 • 480 citations

Structure and Biological Role of Vitronectin

1991 • 477 citations

Is plasminogen activator inhibitor-1 the molecular switch that governs urokinase receptor-mediated cell adhesion and release?

1996 • 460 citations

Plasminogen activator inhibitors: hormonally regulated serpins

1990 • 409 citations

Plasminogen activator inhibitor-1 gene-deficient mice. II. Effects on hemostasis, thrombosis, and thrombolysis.

1993 • 399 citations

High levels of urokinase-type plasminogen activator and its inhibitor PAI-1 in cytosolic extracts of breast carcinomas are associated with poor prognosis.

1993 • 396 citations

Proteases as prognostic markers in cancer.

1996 • 319 citations

Proteolytic cleavage of the urokinase receptor substitutes for the agonist-induced chemotactic effect.

1996 • 306 citations

Directed Plasminogen Activation at the Surface of Normal and Malignant Cells

1991 • 291 citations

Upregulation of urokinase receptor expression on migrating endothelial cells

1993 • 277 citations

Induction of cell migration by pro-urokinase binding to its receptor: possible mechanism for signal transduction in human epithelial cells.

1994 • 266 citations

FIBRINOLYSIS ASSOCIATED WITH ONCOGENIC TRANSFORMATION

1973 • 261 citations

The Urokinase Receptor Is a Major Vitronectin-Binding Protein on Endothelial Cells

1996 • 252 citations

Transforming growth factor-beta is a strong and fast acting positive regulator of the level of type-1 plasminogen activator inhibitor mRNA in WI-38 human lung fibroblasts.

1987 • 247 citations

Requirement of the integrin beta 3 subunit for carcinoma cell spreading or migration on vitronectin and fibrinogen

1992 • 239 citations

Purification and functional characterization of integrin alpha v beta 5. An adhesion receptor for vitronectin.

1990 • 238 citations

Reversible cellular adhesion to vitronectin linked to urokinase receptor occupancy.

1994 • 216 citations

Cell‐induced potentiation of the plasminogen activation system is abolished by a monoclonal antibody that recognizes the NH₂‐terminal domain of the urokinase receptor

1991 • 194 citations

Vitronectin is not essential for normal mammalian development and fertility.

1995 • 188 citations

Urokinase‐type plasminogen activator mediates basic fibroblast growth factor‐induced bovine endothelial cell migration independent of its proteolytic activity

1992 • 183 citations

Specific roles of the αVβ1, αVβ3 and αVβ5 integrins in avian neural crest cell adhesion and migration on vitronectin

1994 • 161 citations

Multimeric vitronectin. Identification and characterization of conformation-dependent self-association of the adhesive protein.

1993 • 155 citations

Binding of urokinase to its receptor promotes migration and invasion of human melanoma cells in vitro.

1994 • 155 citations

Urokinase-type plasminogen activator and its receptor: new targets for anti-metastatic therapy?

1994 • 139 citations

An autocrine role for urokinase in phorbol ester-mediated differentiation of myeloid cell lines.

1991 • 137 citations

An anti-αv-integrin antibody that blocks integrin function inhibits the development of a human melanoma in nude mice

1995 • 134 citations

Identification of vitronectin as a major plasma protein adsorbed on polymer surfaces of different copolymer composition

1989 • 123 citations

Monoclonal Antibodies to Human 54,000 Molecular Weight Plasminogen Activator Inhibitor from Fibrosarcoma Cells - Inhibitor Neutralization and One-Step Affinity Purification

1986 • 120 citations

Immunohistochemical localization of urokinase-type plasminogen activator, type-1 plasminogen-activator inhibitor, urokinase receptor and α2-macroglobulin receptor in human breast carcinomas

1996 • 102 citations

Distribution and lateral mobility of the urokinase-receptor complex at the cell surface.

1993 • 98 citations

Interaction of urokinase with specific receptors stimulates mobilization of bovine adrenal capillary endothelial cells*1

1988 • 98 citations

Tumor necrosis factor and epidermal growth factor modulate migration of human microvascular endothelial cells and production of tissue-type plasminogen activator and its inhibitor

1991 • 96 citations

Interconversions between active, inert and substrate forms of denatured/refolded type-1 plasminogen activator inhibitor

1993 • 92 citations

Human urokinase-type plasminogen activator stimulates chemotaxis of human neutrophils

1987 • 92 citations

Quantitation of cytokine-stimulated migration of endothelium and epithelium by a new assay using microcarrier beads

1990 • 90 citations

How do cells move along surfaces?

1993 • 87 citations

Vitronectin-driven human keratinocyte locomotion is mediated by the alpha v beta 5 integrin receptor.

1994 • 86 citations

Urokinase receptor in breast cancer tissue extracts. Enzyme-linked immunosorbent assay with a combination of mono- and polyclonal antibodies

1995 • 79 citations

Plasminogen activator inhibitor type I stabilizes vitronectin-dependent adhesions in HT-1080 cells.

1990 • 78 citations

The PAI-1/Vitronectin Interaction: Two Cats in a Bag?

1995 • 70 citations

Role of Specific Membrane Receptors in Urokinase-Dependent Migration of Human Keratinocytes

1990 • 70 citations

Monoclonal antibody to human 66,000 molecular weight plasminogen activator from melanoma cells. Specific enzyme inhibition and one-step affinity purification.

1983 • 64 citations

Role of Urokinase Type Plasminogen Activator (u-PA) in Corneal Epithelial Migration

1993 • 61 citations

Type‐1 inhibitor of plasminogen activators

1991 • 54 citations

Plasmin Abrogates αvβ5-Mediated Adhesion of a Human Keratinocyte Cell Line (HaCaT) to Vitronectin

1995 • 49 citations

Inhibition of urokinase synthesis and cell surface binding alters the motile behavior of embryonic endocardial-derived mesenchymal cells in vitro

1993 • 48 citations

Integrin-type Extracellular Matrix Receptors in Cancer and Inflammation

1993 • 40 citations

Conformational Changes of the Reactive‐Centre Loop and β‐Strand 5A Accompany Temperature‐Dependent Inhibitor‐Substrate Transition of Plasminogen‐Activator Inhibitor 1

1996 • 38 citations

Plasminogen activators are involved in keratinocyte and fibroblast migration in wounded cultures in vitro

1994 • 34 citations

The Versatility of Adhesion Receptor Ligands in Haemostasis: Morpho-Regulatory Functions of Vitronectin

1995 • 34 citations

Urokinase-type Plasminogen Activator-induced Monocyte Adhesion Requires a Carboxyl-terminal Lysine and cAMP-dependent Signal Transduction

1995 • 31 citations

The EGF-inducible protein EIP-1 of migrating normal and malignant rat liver epithelial cells is identical to plasminogen activator inhibitor 1 and is a component of the ECM migration tracks

1992 • 25 citations

Separation of Active and Inactive Forms of Recombinant Human Plasminogen Activator Inhibitor Type 1 (PAI-1) Expressed in Chinese Hamster Ovary Cells: Comparison with Native Human PAI-1

1994 • 21 citations

Cell-associated proteases affect tumour cell migration in vitro

1979 • 18 citations

Differential regulation of urokinase-type-1 inhibitor complex endocytosis by phorbol esters in different cell lines is associated with differential regulation of α2-macroglobulin receptor and urokinase receptor expression

1995 • 17 citations

Willam Paton (1917–1993)

1994 • 4 citations