Matrix metalloproteinase 2 from human rheumatoid synovial fibroblasts

“Western Blotting”: Electrophoretic transfer of proteins from sodium dodecyl sulfate-polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A

1981 • 8,657 citations

Sequence from picomole quantities of proteins electroblotted onto polyvinylidene difluoride membranes.

1987 • 5,066 citations

Protein and cell membrane iodinations with a sparingly soluble chloroamide, 1,3,4,6-tetrachloro-3a,6a-diphenylglycoluril

1978 • 4,673 citations

A rapid, sensitive method for detection of alkaline phosphatase-conjugated anti-antibody on Western blots

1984 • 2,189 citations

Transforming growth factor beta modulates the expression of collagenase and metalloproteinase inhibitor.

1987 • 1,243 citations

SV40-transformed Human Lung Fibroblasts Secrete a 92-kDa Type IV Collagenase Which Is Identical to That Secreted by Normal Human Macrophages

1989 • 1,122 citations

H-ras oncogene-transformed human bronchial epithelial cells (TBE-1) secrete a single metalloprotease capable of degrading basement membrane collagen.

1988 • 1,050 citations

Tissue Inhibitor of Metalloproteinase (TIMP-2)

1989 • 899 citations

Independent Regulation of Collagenase, 72-kDa Progelatinase, and Metalloendoproteinase Inhibitor Expression in Human Fibroblasts by Transforming Growth Factor-β

1989 • 649 citations

Human fibroblast collagenase. Complete primary structure and homology to an oncogene transformation-induced rat protein.

1986 • 645 citations

Biochemical and immunological characterization of the secreted forms of human neutrophil gelatinase.

1985 • 625 citations

Human 72-kilodalton type IV collagenase forms a complex with a tissue inhibitor of metalloproteases designated TIMP-2.

1989 • 594 citations

Production of collagenase and prostaglandins by isolated adherent rheumatoid synovial cells.

1976 • 555 citations

Human leukocyte granule elastase: rapid isolation and characterization

1976 • 550 citations

A metalloproteinase from human rheumatoid synovial fibroblasts that digests connective tissue matrix components. Purification and characterization.

1986 • 515 citations

Stromelysin, a connective tissue-degrading metalloendopeptidase secreted by stimulated rabbit synovial fibroblasts in parallel with collagenase. Biosynthesis, isolation, characterization, and substrates.

1985 • 506 citations

Stromelysin is an activator of procollagenase. A study with natural and recombinant enzymes

1987 • 474 citations

Comparison of human stromelysin and collagenase by cloning and sequence analysis

1986 • 443 citations

Mechanisms of activation of tissue procollagenase by matrix metalloproteinase 3 (stromelysin)

1990 • 431 citations

Stepwise activation mechanisms of the precursor of matrix metalloproteinase 3 (stromelysin) by proteinases and (4-aminophenyl)mercuric acetate

1990 • 381 citations

Self-assembly of basement membrane collagen

1984 • 347 citations

The Activation of Human Type IV Collagenase Proenzyme

1989 • 347 citations

Human skin fibroblast stromelysin: structure, glycosylation, substrate specificity, and differential expression in normal and tumorigenic cells.

1987 • 323 citations

An endopeptidase from rheumatoid synovial tissue culture

1972 • 252 citations

Expression of a metalloproteinase that degrades native type V collagen and denatured collagens by cultured human alveolar macrophages.

1987 • 235 citations

The complete primary structure of human matrix metalloproteinase-3. Identity with stromelysin.

1988 • 227 citations

Purification and characterization of a rabbit bone metalloproteinase that degrades proteoglycan and other connective-tissue components

1983 • 222 citations

Ras oncogene mediated induction of a 92kDa metalloproteinase; strong correlation with the malignant phenotype

1988 • 209 citations

Human skin fibroblast procollagenase: mechanisms of activation by organomercurials and trypsin

1983 • 208 citations

Analysis of protein and peptide mixtures

1981 • 207 citations

Purification and characterization of a bone metalloproteinase that degrades gelatin and types IV and V collagen

1985 • 195 citations

Purification and Characterization of Two Related but Distinct Metalloproteinase Inhibitors Secreted by Bovine Aortic Endothelial Cells

1989 • 193 citations

Human α-1-antichymotrypsin: interaction with chymotrypsin-like proteinases

1978 • 174 citations

The activation of human skin fibroblast procollagenase. Sequence identification of the major conversion products.

1987 • 173 citations

Cleavage of type II and III collagens with mammalian collagenase: site of cleavage and primary structure at the amino-terminal portion of the smaller fragment released from both collagens

1976 • 171 citations

The role of polar and hydrophobic interactions for the molecular packing of type I collagen: A three-dimensional evaluation of the amino acid sequence

1978 • 163 citations

Cleavage of type VII collagen by interstitial collagenase and type IV collagenase (gelatinase) derived from human skin

1989 • 151 citations

Neutral metallo-proteinases of rabbit bone. Separation in latent forms of distinct enzymes that when activated degrade collagen, gelatin and proteoglycans

1978 • 149 citations

The precursor of a metalloendopeptidase from human rheumatoid synovial fibroblasts. Purification and mechanisms of activation by endopeptidases and 4-aminophenylmercuric acetate

1988 • 142 citations

Metalloproteinases from rabbit bone culture medium degrade types IV and V collagens, laminin and fibronectin

1981 • 138 citations

Purification of an endogenous activator of procollagenase from rabbit synovial fibroblast culture medium.

1983 • 134 citations

Coordinate regulation of stromelysin and collagenase genes determined with cDNA probes.

1987 • 129 citations

Evidence that human rheumatoid synovial matrix metalloproteinase 3 is an endogenous activator of procollagenase

1988 • 120 citations

Gelatinases of metastatic cell lines of murine colonic carcinoma as detected by substrate-gel electrophoresis

1988 • 117 citations

Type X collagen contains two cleavage sites for a vertebrate collagenase.

1986 • 106 citations

IMMUNOCHEMICAL AND COLLAGEN-BINDING PROPERTIES OF FIBRONECTIN

1978 • 101 citations

Degradation of type IX collagen by matrix metalloproteinase 3 (stromelysin) from human rheumatoid synovial cells

1989 • 98 citations

Purification of a Type V Collagen Degrading Metalloproteinase from Rabbit Alveolar Macrophages

1984 • 98 citations

Human plasma kallikrein. A rapid purification method with high yield

1981 • 96 citations

Gelatinase (type iv collagenase) immunolocalization in cells and tissues: Use of an antiserum to rabbit bone gelatinase that identifies high and low M r forms

1989 • 87 citations

Cloning of a complementary dna for rabbit proactivator. a metalloproteinase that activates synovial cell collagenase, shares homology with stromelysin and transin, and is coordinately regulated with collagenase

1987 • 86 citations

An improved assay for proteases and polysaccharidases employing a cartilage proteoglycan substrate entrapped in polyacrylamide particles

1980 • 83 citations

Degradation of basement membranes by human matrix metalloproteinase 3 (stromelysin)

1988 • 63 citations

Covalent structure of collagen: amino acid sequence of .alpha.2-CB5 of chick skin collagen containing the animal collagenase cleavage site

1979 • 34 citations

Procollagenase activator produced by rabbit uterine cervical fibroblasts

1987 • 28 citations

Proactivator-dependent activation of procollagenase induced by treatment with EGTA

1986 • 24 citations

<b>MECHANISM OF COLLAGEN DEGRADATION BY COLLAGENASE: A TRANSITION PROCESS OF THE COLLAGEN MOLECULE FROM COLLAGENASE-SUBSTRATE TO </b><b>GELATINASE-SUBSTRATE </b>

1983 • 21 citations

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