A novel metalloproteinase gene specifically expressed in stromal cells of breast carcinomas

A new method for predicting signal sequence cleavage sites

1986 • 4,629 citations

CLUSTAL: a package for performing multiple sequence alignment on a microcomputer

1988 • 3,446 citations

Detection of mRNAs in sea urchin embryos by in situ hybridization using asymmetric RNA probes

1984 • 1,638 citations

Metalloproteinases and their inhibitors in matrix remodeling

1990 • 1,627 citations

The cysteine switch: a principle of regulation of metalloproteinase activity with potential applicability to the entire matrix metalloproteinase gene family.

1990 • 1,423 citations

SV40-transformed Human Lung Fibroblasts Secrete a 92-kDa Type IV Collagenase Which Is Identical to That Secreted by Normal Human Macrophages

1989 • 1,122 citations

H-ras oncogene-transformed human bronchial epithelial cells (TBE-1) secrete a single metalloprotease capable of degrading basement membrane collagen.

1988 • 1,050 citations

Oncogenes, antioncogenes, and the molecular bases of multistep carcinogenesis.

1989 • 961 citations

Tissue Inhibitor of Metalloproteinase (TIMP-2)

1989 • 899 citations

Tumor invasion through the human amniotic membrane: Requirement for a proteinase cascade

1986 • 764 citations

BIOCHEMICAL INTERACTIONS OF TUMOR CELLS WITH THE BASEMENT MEMBRANE

1986 • 693 citations

Human fibroblast collagenase. Complete primary structure and homology to an oncogene transformation-induced rat protein.

1986 • 645 citations

Mechanisms of Tumor Progression

2010 • 608 citations

Tenascin: An Extracellular Matrix Protein Prominent in Specialized Embryonic Tissues and Tumors

1989 • 604 citations

Tumor interactions with the vasculature: angiogenesis and tumor metastasis

1990 • 598 citations

Human 72-kilodalton type IV collagenase forms a complex with a tissue inhibitor of metalloproteases designated TIMP-2.

1989 • 594 citations

Tumor Suppressor Genes: The Puzzle and the Promise

1989 • 488 citations

Identification of an Inhibitor of Neovascularization from Cartilage

1990 • 481 citations

The search for the causes of breast and colon cancer

1989 • 479 citations

Tumor-promoting phorbol esters induce angiogenesis in vitro

1985 • 470 citations

Antisense RNA-Induced Reduction in Murine TIMP Levels Confers Oncogenicity on Swiss 3T3 Cells

1989 • 459 citations

Comparison of human stromelysin and collagenase by cloning and sequence analysis

1986 • 443 citations

The collagenase gene family in humans consists of at least four members

1988 • 364 citations

Isolation of the oncogene and epidermal growth factor-induced transin gene: complex control in rat fibroblasts.

1986 • 339 citations

Human skin fibroblast stromelysin: structure, glycosylation, substrate specificity, and differential expression in normal and tumorigenic cells.

1987 • 323 citations

Immunohistochemical distribution of type IV collagenase in normal, benign, and malignant breast tissue.

1990 • 323 citations

Specific expression of the pS2 gene in subclasses of breast cancers in comparison with expression of the estrogen and progesterone receptors and the oncogene ERBB2.

1987 • 279 citations

Tenascin is a stromal marker for epithelial malignancy in the mammary gland.

1987 • 273 citations

Purification of two astroglial growth factors from bovine brain

1985 • 235 citations

Stromal Involvement In Malignant Growth

1988 • 225 citations

Cancer as a dynamic developmental disorder.

1985 • 216 citations

Purification and Characterization of Two Related but Distinct Metalloproteinase Inhibitors Secreted by Bovine Aortic Endothelial Cells

1989 • 193 citations

Molecular aspects of the metastatic cascade

1989 • 193 citations

Breast Cancer: Cellular and Molecular Biology

1988 • 182 citations

Cell-type-specific cDNA probes and the murine I region: the localization and orientation of Ad alpha.

1984 • 167 citations

Purification of the migration stimulating factor produced by fetal and breast cancer patient fibroblasts.

1989 • 153 citations

Mechanisms of Growth Control in Normal and Malignant Breast Epithelium

1989 • 131 citations

Persistence of responsiveness of adult mouse mammary gland to induction by embryonic mesenchyme

1979 • 106 citations

Detection of inapparent nodule-transformed cells in the mammary gland tissues of virgin female BALB/cfC3H mice.

1978 • 90 citations

Origin and biology of cancer metastasis

1989 • 86 citations

Stromal aspects of breast carcinoma

1979 • 80 citations

Tenascin distribution in the normal human breast is altered during the menstrual cycle and in carcinoma

1990 • 63 citations

Immunohistochemical distribution of the 52-kDa protein in mammary tumors: A marker associated with cell proliferation rather than with hormone responsiveness

1987 • 45 citations

An efficient approach for the selective isolation of specific transcripts from complex brain mRNA populations

1986 • 43 citations

Growth factors and oncogenes in breast cancer

1990 • 42 citations

Tumor-associated growth factors in malignant rodent and human mammary epithelial cells

1988 • 30 citations