Cortical Neuropathology in Aging and Dementing Disorders

Neuropathological stageing of Alzheimer-related changes

1991 • 14,533 citations

A synaptic model of memory: long-term potentiation in the hippocampus

1993 • 11,303 citations

Distributed Hierarchical Processing in the Primate Cerebral Cortex

1991 • 7,706 citations

Glutamate neurotoxicity and diseases of the nervous system

1988 • 7,257 citations

Long‐lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path

1973 • 7,118 citations

Handbook of Chemical Neuroanatomy

1986 • 4,276 citations

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

1991 • 4,120 citations

Motor Neuron Degeneration in Mice that Express a Human Cu,Zn Superoxide Dismutase Mutation

1994 • 3,959 citations

Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB)

1996 • 3,940 citations

Oxidative Stress, Glutamate, and Neurodegenerative Disorders

1993 • 3,746 citations

Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5

1986 • 3,586 citations

Interneurons of the hippocampus

1998 • 3,399 citations

Preface: Cerebral Cortex Has Come of Age

1991 • 3,393 citations

Segregation of Form, Color, Movement, and Depth: Anatomy, Physiology, and Perception

1988 • 3,293 citations

The Medial Temporal Lobe Memory System

1991 • 3,239 citations

Object vision and spatial vision: two cortical pathways

1983 • 2,807 citations

Borders of Multiple Visual Areas in Humans Revealed by Functional Magnetic Resonance Imaging

1995 • 2,681 citations

Excitatory Amino Acids as a Final Common Pathway for Neurologic Disorders

1994 • 2,668 citations

Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease

1992 • 2,520 citations

The Role of Glutamate Neurotoxicity in Hypoxic-Ischemic Neuronal Death

1990 • 2,204 citations

Alzheimer's Disease: Cell-Specific Pathology Isolates the Hippocampal Formation

1984 • 2,199 citations

Synapse loss in frontal cortex biopsies in Alzheimer's disease: Correlation with cognitive severity

1990 • 2,131 citations

Calbindin D-28k and parvalbumin in the rat nervous system

1990 • 2,068 citations

Observations on the brains of demented old people

1970 • 2,066 citations

Progressive Supranuclear Palsy

1964 • 1,864 citations

Excitatory amino acid neurotoxicity and neurodegenerative disease

1990 • 1,781 citations

Profound Loss of Layer II Entorhinal Cortex Neurons Occurs in Very Mild Alzheimer’s Disease

1996 • 1,734 citations

Metabolic reduction in the posterior cingulate cortex in very early Alzheimer's disease

1997 • 1,680 citations

Retinotopic organization in human visual cortex and the spatial precision of functional MRI

1997 • 1,627 citations

beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

1992 • 1,602 citations

RNA editing in brain controls a determinant of ion flow in glutamate-gated channels

1991 • 1,465 citations

Functional analysis of human MT and related visual cortical areas using magnetic resonance imaging

1995 • 1,421 citations

Dissociation of Object and Spatial Processing Domains in Primate Prefrontal Cortex

1993 • 1,420 citations

Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease

1997 • 1,395 citations

The Topographical and Neuroanatomical Distribution of Neurofibrillary Tangles and Neuritic Plaques in the Cerebral Cortex of Patients with Alzheimer's Disease

1991 • 1,344 citations

Life and Death of Neurons in the Aging Brain

1997 • 1,323 citations

Calcium-binding proteins in the nervous system

1992 • 1,321 citations

Preclinical Evidence of Alzheimer's Disease in Persons Homozygous for the ε4 Allele for Apolipoprotein E

1996 • 1,320 citations

Clinical and neuropathological criteria for frontotemporal dementia. The Lund and Manchester Groups.

1994 • 1,291 citations

The inflammatory response system of brain: implications for therapy of Alzheimer and other neurodegenerative diseases

1995 • 1,290 citations

Area V5 of the Human Brain: Evidence from a Combined Study Using Positron Emission Tomography and Magnetic Resonance Imaging

1993 • 1,254 citations

Widespread Peroxynitrite-Mediated Damage in Alzheimer’s Disease

1997 • 1,241 citations

Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease

1994 • 1,213 citations

Neocortical neuron number in humans: Effect of sex and age

1997 • 1,197 citations

Clinical, pathological, and neurochemical changes in dementia: A subgroup with preserved mental status and numerous neocortical plaques

1988 • 1,186 citations

Unbiased stereological estimation of the number of neurons in the human hippocampus

1990 • 1,146 citations

Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob disease

1991 • 1,133 citations

Concurrent processing streams in monkey visual cortex

1988 • 1,127 citations

Occurrence of neuropathological changes and dementia of Alzheimer's disease in Down's syndrome

1985 • 1,125 citations

The functional logic of cortical connections

1988 • 1,071 citations

The Lewy body variant of Alzheimer's disease

1990 • 1,057 citations

Mapping striate and extrastriate visual areas in human cerebral cortex.

1996 • 1,050 citations

Alzheimer's Disease: X-Ray Spectrometric Evidence of Aluminum Accumulation in Neurofibrillary Tangle-Bearing Neurons

1980 • 995 citations

Anatomical correlates of the distribution of the pathological changes in the neocortex in Alzheimer disease.

1985 • 979 citations

Assembly of microtubule-associated protein tau into Alzheimer-like filaments induced by sulphated glycosaminoglycans

1996 • 974 citations

Hierarchical organization and functional streams in the visual cortex

1983 • 962 citations

Paired Helical Filaments in Electron Microscopy of Alzheimer's Disease

1963 • 956 citations

Age‐associated memory impairment: Proposed diagnostic criteria and measures of clinical change — report of a national institute of mental health work group

1986 • 928 citations

Effects on visual recognition of combined and separate ablations of the entorhinal and perirhinal cortex in rhesus monkeys

1993 • 908 citations

Guam Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Linked to a Plant Excitant Neurotoxin

1987 • 881 citations

The `subcortical dementia' of progressive supranuclear palsy

1974 • 872 citations

Structural Determinants of Ion Flow Through Recombinant Glutamate Receptor Channels

1991 • 827 citations

The aftermath of boxing

1973 • 812 citations

Some morphometric aspects of the brain in senile dementia of the alzheimer type

1981 • 803 citations

The distribution of tangles, plaques and related immunohistochemical markers in healthy aging and Alzheimer's disease

1991 • 801 citations

Neuron numbers and dendritic extent in normal aging and Alzheimer's disease

1987 • 769 citations

Lesions of perirhinal and parahippocampal cortex that spare the amygdala and hippocampal formation produce severe memory impairment

1989 • 763 citations

Posterior Cortical Atrophy

1988 • 729 citations

Advanced Maillard reaction end products are associated with Alzheimer disease pathology.

1994 • 712 citations

PUNCH DRUNK

1928 • 710 citations

Calcium-binding proteins: selective markers of nerve cells

1993 • 699 citations

Transgenic mice expressing an altered murine superoxide dismutase gene provide an animal model of amyotrophic lateral sclerosis.

1995 • 694 citations

Calcium‐binding protein (calbindin‐D_28k) and parvalbumin immunocytochemistry: Localization in the rat hippocampus with specific reference to the selective vulnerability of hippocampal neurons to seizure activity

1989 • 689 citations

Intraneuronal Aluminum Accumulation in Amyotrophic Lateral Sclerosis and Parkinsonism-Dementia of Guam

1982 • 678 citations

Neocortical cell counts in normal human adult aging

1987 • 676 citations

Cerebral hypoxia: some new approaches and unanswered questions

1990 • 674 citations

Perforant pathway changes and the memory impairment of Alzheimer's disease

1986 • 665 citations

Optic-Nerve Degeneration in Alzheimer's Disease

1986 • 658 citations

Observations on the brains of non-demented old people

1968 • 656 citations

Architectonic subdivision of the orbital and medial prefrontal cortex in the macaque monkey

1994 • 656 citations

Amyloid A4 Protein and Its Precursor in Down's Syndrome and Alzheimer's Disease

1989 • 651 citations

Presymptomatic hippocampal atrophy in Alzheimer's disease

1996 • 630 citations

Triggering and execution of neuronal death in brain ischaemia: two phases of glutamate release by different mechanisms

1994 • 630 citations

Neuronal loss, neurofibrillary tangles and granulovacuolar degeneration in the hippocampus with ageing and dementia

1977 • 628 citations

Frontotemporal dementia and parkinsonism linked to chromosome 17: A consensus conference

1997 • 626 citations

Identification of normal and pathological aging in prospectively studied nondemented elderly humans

1992 • 625 citations

Organization of the cerebral cortex. III. A study of aging in the human cerebral cortex

1955 • 624 citations

Distribution of Alzheimer‐type pathologic changes in nondemented elderly individuals matches the pattern in Alzheimer's disease

1992 • 617 citations

Regionally specific loss of neurons in the aging human hippocampus

1993 • 612 citations

Semantic memory impairment in Alzheimer's disease: Failure of access or degraded knowledge?

1992 • 611 citations

Corticodentatonigral Degeneration With Neuronal Achromasia

1968 • 610 citations

Plaques, tangles and dementia

1982 • 603 citations

Evidence of neuronal oxidative damage in Alzheimer's disease.

1996 • 602 citations

Cortical-basal ganglionic degeneration

1990 • 574 citations

Senile dementia of Lewy body type

1990 • 573 citations

Immunohistochemical evidence for apoptosis in Alzheimerʼs disease

1994 • 569 citations

Laminar and regional distributions of neurofibrillary tangles and neuritic plaques in Alzheimer's disease: a quantitative study of visual and auditory cortices

1987 • 569 citations

Clinico‐pathologic studies in dementia

1988 • 567 citations

Beta amyloid protein deposition in the brain after severe head injury: implications for the pathogenesis of Alzheimer's disease.

1994 • 563 citations

Biopsy-derived adult human brain tau is phosphorylated at many of the same sites as Alzheimer's disease paired helical filament tau

1994 • 561 citations

Glycated tau protein in Alzheimer disease: a mechanism for induction of oxidant stress.

1994 • 558 citations

Increased expression of neurofilament subunit NF-L produces morphological alterations that resemble the pathology of human motor neuron disease

1993 • 550 citations

Progressive neuronopathy in transgenic mice expressing the human neurofilament heavy gene: A mouse model of amyotrophic lateral sclerosis

1993 • 549 citations

Lesions of the perirhinal and parahippocampal cortices in the monkey produce long-lasting memory impairment in the visual and tactual modalities

1993 • 548 citations

Loss of the Presynaptic Vesicle Protein Synaptophysin in Hippocampus Correlates with Cognitive Decline in Alzheimer Disease

1997 • 535 citations

Prevalence of Alzheimer's disease and other dementias in an elderly urban population

1991 • 527 citations

The occult aftermath of boxing.

1990 • 522 citations

Two classes of cortical GABA neurons defined by differential calcium binding protein immunoreactivities

1989 • 514 citations

Volume and number of neurons of the human hippocampal formation in normal aging and Alzheimer's disease

1997 • 505 citations

Local circuit neurons immunoreactive for calretinin, calbindin D‐28k or parvalbumin in monkey prefronatal cortex: Distribution and morphology

1994 • 505 citations

Size, laminar and columnar distribution of efferent cells in the sensory‐motor cortex of monkeys

1977 • 497 citations

Neurodegenerative Diseases

1994 • 492 citations

Functional Brain Imaging Studies of Cortical Mechanisms for Memory

1995 • 492 citations

Neocortical Neurofibrillary Tangles Correlate With Dementia Severity in Alzheimer's Disease

1995 • 488 citations

Excitatory amino acids and Alzheimer's disease

1989 • 485 citations

Very mild Alzheimer's disease

1991 • 473 citations

βA4 amyloid protein deposition in brain after head trauma

1991 • 465 citations

Seelenlähmung des “Schauens”, optische Ataxie, räumliche Störung der Aufmerksamkeit. pp. 51–66

1909 • 465 citations

The pattern of acquisition of plaques and tangles in the brains of patients under 50 years of age with Down's syndrome

1989 • 463 citations

Memory‐related neural systems in Alzheimer's disease

1990 • 450 citations

Validity and Reliability of the Preliminary NINDS Neuropathologic Criteria for Progressive Supranuclear Palsy and Related Disorders

1996 • 446 citations

Neurobiology of Cingulate Cortex and Limbic Thalamus

1993 • 446 citations

Topographically specific hippocampal projections target functionally distinct prefrontal areas in the rhesus monkey

1995 • 443 citations

ALZHEIMER’S DISEASE —AN ELECTRON MICROSCOPICAL STUDY

1964 • 440 citations

Frontal lobe dementia and motor neuron disease.

1990 • 437 citations

Processing of the β‐Amyloid Precursor Protein and Its Regulation in Alzheimer's Disease

1995 • 431 citations

Motor neurons are selectively vulnerable to AMPA/kainate receptor-mediated injury in vitro.

1996 • 420 citations

Heme oxygenase-1 is associated with the neurofibrillary pathology of Alzheimer's disease.

1994 • 420 citations

Occurrence of neuropil threads in the senile human brain and in Alzheimer's disease: A third location of paired helical filaments outside of neurofibrillary tangles and neuritic plaques

1986 • 419 citations

THE USE OF ANIMAL MODELS TO STUDY THE EFFECTS OF AGING ON COGNITION

1997 • 414 citations

Quantitative morphology and regional and laminar distributions of senile plaques in Alzheimer's disease

1985 • 414 citations

Changes in Ca2+-binding proteins in human neurodegenerative disorders

1992 • 413 citations

PARKINSONISM-DEMENTIA COMPLEX, AN ENDEMIC DISEASE ON THE ISLAND OF GUAM

1961 • 412 citations

Specific Hippocampal Volume Reductions in Individuals at Risk for Alzheimer’s Disease

1997 • 412 citations

Quantitative synaptic alterations in the human neocortex during normal aging

1993 • 408 citations

Making the diagnosis of Alzheimer's disease. A primer for practicing pathologists.

1993 • 408 citations

Corticobasal degeneration: A clinical study of 36 cases

1994 • 400 citations

Occipital cortex in man: Organization of callosal connections, related myelo‐ and cytoarchitecture, and putative boundaries of functional visual areas

1990 • 399 citations

Switch in glutamate receptor subunit gene expression in CA1 subfield of hippocampus following global ischemia in rats.

1992 • 399 citations

Transgenic mice carrying a human mutant superoxide dismutase transgene develop neuronal cytoskeletal pathology resembling human amyotrophic lateral sclerosis lesions.

1996 • 397 citations

Alzheimer's Neurofibrillary Changes

1962 • 396 citations

Frontal lobe degeneration of non-Alzheimer type. I. Neuropathology

1987 • 389 citations

Genetic evidence for the involvement of τ in progressive supranuclear palsy

1997 • 387 citations

A potential role for apoptosis in neurodegeneration and Alzheimer's disease

1995 • 382 citations

Specific reduction of calcium-binding protein (28-kilodalton calbindin-D) gene expression in aging and neurodegenerative diseases.

1990 • 382 citations

Dementia lacking distinctive histologie features

1990 • 380 citations

Differential Regulation of NMDAR1 mRNA and Protein by Estradiol in the Rat Hippocampus

1996 • 376 citations

Temporal Lobe Regions on Magnetic Resonance Imaging Identify Patients With Early Alzheimer's Disease

1993 • 376 citations

Frontal lobe degeneration of non-Alzheimer type. II. Clinical picture and differential diagnosis

1987 • 376 citations

Neuropsychological deficits in symptomatic minor head injury patients after concussion and mild concussion.

1990 • 376 citations

Motor Neurons Are Selectively Vulnerable to AMPA/Kainate Receptor-Mediated InjuryIn Vitro

1996 • 368 citations

AMYOTROPHIC LATERAL SCLEROSIS AND ITS ASSOCIATION WITH DEMENTIA, PARKINSONISM AND OTHER NEUROLOGICAL DISORDERS: A REVIEW

1981 • 368 citations

Quantitative analysis of a vulnerable subset of pyramidal neurons in Alzheimer's disease: I. Superior frontal and inferior temporal cortex

1990 • 367 citations

Regional distribution of iron and iron‐regulatory proteins in the brain in aging and Alzheimer's disease

1992 • 367 citations

Monoclonal antibody to neurofilament protein (SMI‐32) labels a subpopulation of pyramidal neurons in the human and monkey neocortex

1989 • 366 citations

Clinical Neurology of Aging

2010 • 361 citations

A mutant neurofilament subunit causes massive, selective motor neuron death: Implications for the pathogenesis of human motor neuron disease

1994 • 356 citations

Is senile dementia "age-related" or "ageing-related"? —evidence from meta-analysis of dementia prevalence in the oldest old

1995 • 353 citations

Epitope mapping of monoclonal antibodies to the paired helical filaments of Alzheimer's disease: identification of phosphorylation sites in tau protein

1994 • 349 citations

Pick’s Disease

1974 • 349 citations

Early detection of axonal injury after human head trauma using immunocytochemistry for ?-amyloid precursor protein

1994 • 348 citations

The development of the pathologic changes of Alzheimer's disease and senile dementia in patients with Down's syndrome.

1973 • 340 citations

Regional, cellular, and ultrastructural distribution of N-methyl-D-aspartate receptor subunit 1 in monkey hippocampus.

1994 • 339 citations

Calcium‐binding protein (calbindin‐D28K) and parvalbumin immunocytochemistry in the normal and epileptic human hippocampus

1991 • 338 citations

Alterations in L-Glutamate Binding in Alzheimer's and Huntington's Diseases

1985 • 334 citations

The pathological association between down syndrome and Alzheimer disease

1988 • 334 citations

Familial multiple system tauopathy with presenile dementia: A disease with abundant neuronal and glial tau filaments

1997 • 334 citations

Enduring memory impairment in monkeys after ischemic damage to the hippocampus

1992 • 329 citations

Complex visual disturbances in Alzheimer's disease

1990 • 328 citations

Pattern of brain destruction in Parkinson's and Alzheimer's diseases

1996 • 325 citations

Down's Syndrome and Alzheimer's disease: a review

1986 • 316 citations

The Organization of Connections between Areas V5 and V1 in Macaque Monkey Visual Cortex

1989 • 311 citations

Pathological changes in olfactory neurons in patients with Alzheimer's disease

1989 • 310 citations

Altered glutamatergic transmission in neurological disorders: From high extracellular glutamate to excessive synaptic efficacy

1997 • 308 citations

The N-methyl-d-aspartate antagonists phencyclidine, ketamine and dizocilpine as both behavioral and anatomical models of the dementias

1995 • 306 citations

Amygdalohippocampal MR volume measurements in the early stages of Alzheimer disease.

1994 • 302 citations

Quantitative analysis of a vulnerable subset of pyramidal neurons in Alzheimer's disease: II. Primary and secondary visual cortex

1990 • 302 citations

The Oldest Old.

1993 • 302 citations

Abnormal neuronal development in the visual cortex of the human fetus and infant with down's syndrome. A quantitative and qualitative golgi study

1981 • 300 citations

Head injury as a risk factor for Alzheimer's disease

1985 • 300 citations

Uber die Beziehungen der senilen Hirnatrophie zur Aphasie

1892 • 299 citations

The fine structure of some intraganglionic alterations. Neurofibrillary tangles, granulovacuolar bodies and "rod-like" structures as seen in Guam amyotrophic lateral sclerosis and parkinsonism-dementia complex.

1968 • 298 citations

Pathological alterations of the cerebral microvasculature in Alzheimer's disease and related dementing disorders

1994 • 297 citations

Retinal ganglion cells in Alzheimer's disease and aging

1993 • 294 citations

Cortical neuronal counts in normal elderly controls and demented patients

1983 • 293 citations

Alzheimer's Disease, Other Dementias, Depression and Pseudo-dementia: Prevalence, Incidence and Three-Year Outcome in Liverpool

1992 • 293 citations

Cortical and subcortical patterns of synaptophysinlike immunoreactivity in Alzheimer's disease.

1991 • 292 citations

Risk of dementia among relatives of Alzheimer's disease patients in the MIRAGE study

1996 • 287 citations

Individual differences in the cognitive and neurobiological consequences of normal aging

1992 • 287 citations

Excitatory amino acid receptors, neural membrane phospholipid metabolism and neurological disorders

1991 • 286 citations

Alzheimer Disease and Frontotemporal Dementias

1996 • 280 citations

Alzheimer neurofibrillary tangles in diseases other than senile and presenile dementia

1979 • 279 citations

The visual variant of Alzheimer's disease

1993 • 279 citations

The clinical and pathological spectrum of Steele-Richardson-Olszewski syndrome (progressive supranuclear palsy): a reappraisal

1995 • 277 citations

On areas of transition between entorhinal allocortex and temporal isocortex in the human brain. Normal morphology and lamina-specific pathology in Alzheimer's disease

1985 • 276 citations

Regional Distribution of Neurofibrillary Tangles and Senile Plaques in the Cerebral Cortex of Elderly Patients: A Quantitative Evaluation of a One-Year Autopsy Population from a Geriatric Hospital

1994 • 275 citations

CORTICAL AND SUBCORTICAL ARGYROPHILIC GRAINS CHARACTERIZE A DISEASE ASSOCIATED WITH ADULT ONSET DEMENTIA

1989 • 273 citations

Progressive language disorder due to lobar atrophy

1992 • 271 citations

Widespread cytoskeletal pathology characterizes corticobasal degeneration.

1995 • 271 citations

Pattern in the laminar origin of corticocortical connections

1986 • 269 citations

Neurofilament protein defines regional patterns of cortical organization in the macaque monkey visual system: A quantitative immunohistochemical analysis

1995 • 269 citations

Advanced glycation endproducts in ageing and Alzheimer's disease

1997 • 267 citations

ALZHEIMERʼS DISEASE

1953 • 267 citations

Somatostatin immunoreactivity in neuritic plaques of Alzheimer's patients

1985 • 263 citations

CLINICAL AND PATHOLOGICAL FEATURES OF DIFFUSE CORTICAL LEWY BODY DISEASE (LEWY BODY DEMENTIA)

1987 • 261 citations

Handbook of the Biology of Aging

1991 • 259 citations

Anatomical Evidence for MT and Additional Cortical Visual Areas in Humans

1995 • 256 citations

Neuropathological Indexes of Alzheimer's Disease in Demented and Nondemented Persons Aged 80 Years and Older

1993 • 254 citations

Somatostatin immunoreactive neurons in the human hippocampus and cortex shown by immunogold/silver intensification on vibratome sections: Coexistence with neuropeptide Y neurons, and effects alzheimer‐type dementia

1987 • 252 citations

THE ASSOCIATION BETWEEN HEAD TRAUMA AND ALZHEIMER'S DISEASE

1990 • 251 citations

The role of cortical connectivity in Alzheimer's disease pathogenesis: A review and model system

1993 • 251 citations

Preferential labeling of Alzheimer neurofibrillary tangles with antisera for tau protein kinase (TPK) I/glycogen synthase kinase-3β and cyclin-dependent kinase 5, a component of TPK II

1996 • 246 citations

Imaging of calcium and aluminum in neurofibrillary tangle-bearing neurons in parkinsonism-dementia of Guam.

1984 • 244 citations

PARKINSONISM-DEMENTIA COMPLEX, AN ENDEMIC DISEASE ON THE ISLAND OF GUAM

1961 • 244 citations

A CASE-CONTROL STUDY OF DEMENTIA OF THE ALZHEIMER TYPE

1985 • 244 citations

Chapter 9 Neuronal development in human prefrontal cortex in prenatal and postnatal stages

1991 • 243 citations

Cognitive and neurobiologic markers of early Alzheimer disease

1996 • 242 citations

THE FINE STRUCTURE OF SOME INTRAGANGLIONIC ALTERATIONS

1968 • 239 citations

Alz-50, Ubiquitin and Tau Immunoreactivity of Neurofibrillary Tangles, Pick Bodies and Lewy Bodies

1988 • 238 citations

Some morphometric observations on the cerebral cortex and hippocampus in presenile Alzheimer's disease, senile dementia of Alzheimer type and Down's syndrome in middle age

1985 • 238 citations

Frontal lobe degeneration of non-Alzheimer type.

1992 • 237 citations

Segregation of a Missense Mutation in the Microtubule-Associated Protein Tau Gene with Familial Frontotemporal Dementia and Parkinsonism

1998 • 236 citations

Abnormal Tau proteins in progressive supranuclear palsy

1991 • 235 citations

Atypical form of Alzheimer's disease with prominent posterior cortical atrophy: A review of lesion distribution and circuit disconnection in cortical visual pathways

1997 • 235 citations

Cortical Pyramidal Neurone Loss May Cause Glutamatergic Hypoactivity and Cognitive Impairment in Alzheimer's Disease: Investigative and Therapeutic Perspectives

1993 • 233 citations

Down patients: Extracellular preamyloid deposits precede neuritic degeneration and senile plaques

1989 • 233 citations

Synapses of double bouquet cells in monkey cerebral cortex visualized by calbindin immunoreactivity

1989 • 232 citations

Motor and cognitive function in Lewy body dementia: comparison with Alzheimer's and Parkinson's diseases.

1997 • 232 citations

Assessment of Visual Impairment in Patients With Alzheimer's Disease

1987 • 228 citations

SUBCORTICAL DEMENTIA

1985 • 228 citations

Age-Related Distribution of Neuropathologic Changes in the Cerebral Cortex of Patients With Down's Syndrome

1995 • 227 citations

Amyotrophic Lateral Sclerosis and Parkinsonism-Dementia Complex on Guam

1966 • 226 citations

Progress in neuropathology

1971 • 225 citations

Argyrophilic grains: characteristic pathology of cerebral cortex in cases of adult onset dementia without Alzheimer changes

1987 • 225 citations

Selective Disconnection of Specific Visual Association Pathways in Cases of Alzheimer's Disease Presenting with Balint's Syndrome

1990 • 223 citations

Heterogeneity of chandelier neurons in monkey neocortex: Corticotropin‐releasing factor‐and parvalbumin‐immunoreactive populations

1990 • 221 citations

Alzheimer's disease: Glutamate depletion in the hippocampal perforant pathway zone

1987 • 221 citations

Spectrum of morphological appearance of amyloid deposits in Alzheimer's disease

1989 • 219 citations

Immunohistochemical detection of 4-hydroxy-2-nonenal adducts in Alzheimer's disease is associated with inheritance of APOE4.

1997 • 219 citations

Cortical somatostatin, neuropeptide Y, and NADPH diaphorase neurons: Normal anatomy and alterations in alzheimer's disease

1988 • 219 citations

Specific Pathological Tau Protein Variants Characterize Pickʼs Disease

1996 • 218 citations

Progressive Supranuclear Palsy

2005 • 218 citations

Altered Tau and Neurofilament Proteins in Neuro‐Degenerative Diseases: Diagnostic Implications for Alzheimer's Disease and Lewy Body Dementias

1993 • 216 citations

Corticobasal degeneration

1997 • 216 citations

Spindle neurons of the human anterior cingul. Ate cortex

1995 • 214 citations

Constant neurofibrillary changes in the neocortex in progressive supranuclear palsy. Basic differences with Alzheimer's disease and aging

1990 • 214 citations

LHRH systems in the brain of platyfish

1981 • 214 citations

Rapidly progressing atrophy of medial temporal lobe in Alzheimer's disease

1994 • 213 citations

Distribution of clusterin in Alzheimer brain tissue

1992 • 212 citations

Dementia with Lewy bodies

1996 • 211 citations

Patterns of neuronal degeneration in the motor cortex of amyotrophic lateral sclerosis patients

1993 • 210 citations

Preserved learning in monkeys with medial temporal lesions: sparing of motor and cognitive skills

1984 • 209 citations

Dementia of frontal lobe type: neuropathology and immunohistochemistry.

1993 • 209 citations

Alzheimer changes in nondemented patients younger than sixty‐five: Possible early stages of Alzheimer's disease and senile dementia of Alzheimer type

1985 • 209 citations

Differential distribution of neurofibrillary tangles in the cerebral cortex of dementia pugilistica and Alzheimer's disease cases

1992 • 208 citations

Local circuit neurons in the medial prefrontal cortex (areas 24a,b,c, 25 and 32) in the monkey: II. Quantitative areal and laminar distributions

1996 • 206 citations

Progress in Neuropathology

1972 • 203 citations

Diffuse Lewy body disease

1987 • 203 citations

Visual Disturbances With Focal Progressive Dementing Disease

1985 • 201 citations

Classic and generalized variants of Pick's disease: A clinicopathological, ultrastructural, and immunocytochemical comparative study

1984 • 200 citations

Re-examination of ex-boxers' brains using immunohistochemistry with antibodies to amyloid ?-protein and tau protein

1991 • 200 citations

Alterations of the GluR-B AMPA receptor subunit flip/flop expression in kainate-induced epilepsy and ischemia

1993 • 196 citations

Relationships between Regional Neuronal Loss and Neurofibrillary Changes in the Hippocampal Formation and Duration and Severity of Alzheimer Disease

1997 • 195 citations

Down's dyndrome and Alzheimer's disease: dendritic spine counts in the hippocampus

1990 • 194 citations

Degeneration of pyramidal projection neurons in Huntington's disease cortex

1990 • 193 citations

Neocortical morphometry, lesion counts, and choline acetyltransferase levels in the age spectrum of Alzheimer's disease

1988 • 192 citations

Brain Damage in Modern Boxers

1984 • 190 citations

Neocortical neuronal subpopulations labeled by a monoclonal antibody to calbindin exhibit differential vulnerability in Alzheimer's disease

1991 • 189 citations

A low expressor line of transgenic mice carrying a mutant human Cu,Zn superoxide dismutase ( SOD1 ) gene develops pathological changes that most closely resemble those in human amyotrophic lateral sclerosis

1997 • 189 citations

Reduced apolipoprotein ϵ4 allele frequency in the oldest old Alzheimer's patients and cognitively normal individuals

1994 • 189 citations

Encephalitis and Parkinsonism

1965 • 187 citations

Ultrastructure of Neurofibrillary Tangles in Steele-Richardson-Olszewski Syndrome

1973 • 185 citations

The Epidemiology of Dementia.

1981 • 184 citations

Predominant deposition of amyloid-beta 42(43) in plaques in cases of Alzheimer's disease and hereditary cerebral hemorrhage associated with mutations in the amyloid precursor protein gene.

1996 • 183 citations

Ultrastructure and biochemical composition of paired helical filaments in corticobasal degeneration.

1994 • 183 citations

Ophthalmologic manifestations of Alzheimer's disease

1989 • 183 citations

Pick's disease versus Alzheimer's disease

1993 • 182 citations

Recognition of tau epitopes by anti-neurofilament antibodies that bind to Alzheimer neurofibrillary tangles.

1987 • 181 citations

Diffuse Lewy body disease and progressive dementia

1988 • 181 citations

Parvalbumin-lmmunoreactive Neurons in the Neocortex are Resistant to Degeneration in Alzheimerʼs Disease

1991 • 180 citations

Quantitative histological studies on the aged human brain

1970 • 178 citations

Progressive biparietal atrophy: an atypical presentation of Alzheimer's disease.

1996 • 177 citations

Circuit-specific alterations of N-methyl-D-aspartate receptor subunit 1 in the dentate gyrus of aged monkeys.

1996 • 177 citations

The Organization of Connections between Areas V5 and V2 in Macaque Monkey Visual Cortex

1989 • 176 citations

Biopsy‐proved Alzheimer disease presenting as a right parietal lobe syndrome

1982 • 176 citations

Studien zur Pathologie der Hirngefäße II

1938 • 175 citations

Hereditary frontotemporal dementia is linked to chromosome 17q21—q22: A genetic and clinicopathological study of three dutch families

1997 • 175 citations

Relative sparing of nitric oxide synthase–containing neurons in the hippocampal formation in Alzheimer's disease

1992 • 175 citations

Neuropathology and apolipoprotein E profile of aged chimpanzees: implications for Alzheimer disease.

1994 • 174 citations

Balit's syndrome in Alzheimer's disease: specific disruption of the occipito-parietal visual pathway

1989 • 174 citations

Clinical Picture of Frontal Lobe Degeneration of Non-Alzheimer Type

1993 • 172 citations

Calretinin-immunoreactive neocortical interneurons are unaffected in Alzheimer's disease

1993 • 171 citations

Cerebral cortex pathology in aging and Alzheimer's disease: a quantitative survey of large hospital-based geriatric and psychiatric cohorts

1997 • 171 citations

Ubiquitin in Neurodegenerative Diseases

1993 • 171 citations

Which clinical features differentiate progressive supranuclear palsy (Steele-Richardson-Olszewski syndrome) from related disorders? A clinicopathological study

1997 • 170 citations

Posterior Cortical Atrophy

1994 • 169 citations

Differential involvement of protein kinase C isozymes in Alzheimer's disease

1990 • 168 citations

Lactotransferrin immunocytochemistry in Alzheimer and normal human brain.

1993 • 167 citations

Local circuit neurons in the medial prefrontal cortex (areas 24a,b,c, 25 and 32) in the monkey: I. Cell morphology and morphometrics

1996 • 166 citations

Neurochemical phenotype of corticocortical connections in the macaque monkey: Quantitative analysis of a subset of neurofilament protein‐immunoreactive projection neurons in frontal, parietal, temporal, and cingulate cortices

1995 • 166 citations

Synaptic pathology and glial responses to neuronal injury precede the formation of senile plaques and amyloid deposits in the aging cerebral cortex.

1994 • 166 citations

Dementia with Lewy Bodies Versus Pure Alzheimer Disease

1997 • 165 citations

Sequestration of RNA in Alzheimer's disease neurofibrillary tangles and senile plaques

1997 • 165 citations

Familial non-specific dementia maps to chromosome 3

1995 • 165 citations

A comparative study of histological and immunohistochemical methods for neurofibrillary tangles and senile plaques in Alzheimer's disease

1992 • 164 citations

Distribution and synaptic localization of immunocytochemically identified NMDA receptor subunit proteins in sensory-motor and visual cortices of monkey and human

1994 • 163 citations

The significance of morphometric procedures in the investigation of age changes in cytoarchitectonic structures of human brain.

1984 • 163 citations

Morbus Alzheimer and Morbus Pick: A Genetic, Clinical and Patho-anatomical Study

1953 • 162 citations

A monoclonal antibody to non-phosphorylated neurofilament protein marks the vulnerable cortical neurons in Alzheimer's disease

1987 • 161 citations

Epitope map of neurofilament protein domains in cortical and peripheral nervous system Lewy bodies.

1991 • 161 citations

Corticodentatonigral degeneration with neuronal achromasia: a progressive disorder of late adult life.

1967 • 161 citations

Localization of heparan sulfate glycosaminoglycan and proteoglycan core protein in aged brain and Alzheimer's disease

1992 • 161 citations

Human orbitofrontal cortex: Cytoarchitecture and quantitative immunohistochemical parcellation

1995 • 159 citations

THE TOPOGRAPHY OF PLAQUES AND TANGLES IN DOWN'S SYNDROME PATIENTS OF DIFFERENT AGES

1986 • 159 citations

Ca²⁺-Permeable AMPA/Kainate and NMDA Channels: High Rate of Ca²⁺Influx Underlies Potent Induction of Injury

1996 • 156 citations

4-Hydroxy-2-Nonenal Pyrrole Adducts in Human Neurodegenerative Disease

1997 • 155 citations

ENCEPHALITIS LETHARGICA

1987 • 155 citations

Selective distribution of kainate receptor subunit immunoreactivity in monkey neocortex revealed by a monoclonal antibody that recognizes glutamate receptor subunits GluR5/6/7

1993 • 155 citations

Corticobasal degeneration: etiopathological significance of the cytoskeletal alterations

1994 • 155 citations

Laminar distribution of neocortical senile plaques in senile dementia of the alzheimer type

1986 • 154 citations

Dementia pugilistica mit anatomischem Befund

1954 • 154 citations

Cellular and synaptic localization of NMDA and non-NMDA receptor subunits in neocortex: organizational features related to cortical circuitry, function and disease

1994 • 153 citations

Brain injury and neurologic sequelae

1991 • 151 citations

AD2, a phosphorylation-dependent monoclonal antibody directed against tau proteins found in Alzheimer's disease

1996 • 150 citations

Amyotrophic lateral sclerosis and parkinson's disease complex on Guam linked to an environmental neurotoxin

1988 • 148 citations

Neuropil Threads Occur in Dendrites of Tangle—Bearing Nerve Cells

1988 • 147 citations

Neuropathological Changes in Down's Syndrome Hippocampal Formation

1995 • 146 citations

Quantitative localization of AMPA/kainate and kainate glutamate receptor subunit immunoreactivity in neurochemically identified subpopulations of neurons in the prefrontal cortex of the macaque monkey

1993 • 146 citations

Distribution of β‐amyloid protein in the brain following severe head injury

1995 • 145 citations

βA4 deposits are constant in the brain of the oldest old: An immunocytochemical study of 20 french centenarians

1993 • 145 citations

Neuropathological observations in a case of autism presenting with self-injury behavior

1991 • 144 citations

Geriatric neuropsychology.

1981 • 144 citations

Specific tau variants in the brains of patients with myotonic dystrophy

1996 • 144 citations

Relationship of aluminum to Alzheimer's disease.

1985 • 143 citations

Neocortical Lewy Body Counts Correlate with Dementia in the Lewy Body Variant of Alzheimerʼs Disease

1996 • 143 citations

Alzheimer's disease: areal and laminar pathology in the occipital isocortex

1989 • 141 citations

Alzheimer's disease and Lewy body disease: A comparative clinicopathological study

1994 • 141 citations

The new neuropathology of degenerative frontotemporal dementias

1996 • 139 citations

Spatial Vision in Alzheimer's Disease

1985 • 137 citations

DNA Damage Distribution in the Human Brain as Shown by In Situ End Labeling; Area-specific Differences in Aging and Alzheimer Disease in the Absence of Apoptotic Morphology

1997 • 136 citations

Hyperphosphorylated tau proteins differentiate corticobasal degeneration and Pick's disease

1996 • 135 citations

The neurology of aging

1983 • 135 citations

A motion area in human visual cortex.

1995 • 134 citations

Neurodegenerative disorders of the western pacific: the search for mechanisms of pathogenesis

1986 • 134 citations

RECENT ADVANCES IN NEUROPATHOLOGY

1986 • 133 citations

Neurofibrillary tangle densities in the hippocampal formation in a non-demented population define subgroups of patients with differential early pathologic changes

1993 • 133 citations

Alterations in neurofilament protein immunoreactivity in human hippocampal neurons related to normal aging and Alzheimer's disease

1994 • 133 citations

Alzheimer's Disease with Prominent Visual Symptoms

1989 • 132 citations

Distribution of the excitatory amino acid receptor subunits GluR2(4) in monkey hippocampus and colocalization with subunits GluR5-7 and NMDAR1

1995 • 131 citations

Pick's Disease

1982 • 131 citations

Disorders of the visual system in Alzheimer's disease.

1990 • 131 citations

Distribution of cortical neurofibrillary tangles in progressive supranuclear palsy: A quantitative analysis of six cases

1992 • 130 citations

Filaments of Lewy bodies contain insoluble cytoskeletal elements.

1992 • 130 citations

The iron-binding protein lactotransferrin is present in pathologic lesions in a variety of neurodegenerative disorders: a comparative immunohistochemical analysis

1994 • 129 citations

Controlled induction of paired helical filaments of the Alzheimer type in cultured human neurons, by glutamate and aspartate

1985 • 128 citations

α1-Antitrypsin and α1-antichymotrypsin are in the lesions of Alzheimerʼs disease

1992 • 128 citations

Protein kinase C alteration is an early biochemical marker in Alzheimer's disease

1991 • 127 citations

Calcium-binding proteins are concentrated in the CA2 field of the monkey hippocampus: a possible key to this region's resistance to epileptic damage

1991 • 126 citations

Amyotrophic lateral sclerosis and parkinsonism‐dementia on Guam

1986 • 125 citations

Positron emission tomography and histopathology in Pick's disease

1987 • 125 citations

Age-related changes in the density and morphology of plaques and neurofibrillary tangles in Down syndrome brain

1989 • 125 citations

Content of the neurotoxins cycasin (methylazoxymethanol β‐D‐glucoside) and BNLAA (β‐ N ‐methylamino‐L‐alanine) in cycad flour prepared by Guam Chamorros

1992 • 125 citations

Granulovacuolar degeneration of hippocampal pyramidal cells

1972 • 125 citations

Lewy Bodies Contain Epitopes Both Shared and Distinct from Alzheimer Neurofibrillary Tangles

1988 • 124 citations

Neurofibrillary degeneration in amyotrophic lateral sclerosis/parkinsonism-dementia complex of Guam. Immunochemical characterization of tau proteins.

1995 • 124 citations

Neurofibrillary changes confined to the entorhinal region and an abundance of cortical amyloid in cases of presenile and senile dementia

1990 • 124 citations

Tau in Alzheimer's disease and Down's syndrome is insoluble and abnormally phosphorylated

1991 • 123 citations

Absolute number of neurons and thickness of the cerebral cortex during aging, senile and vascular dementia, and Pick's and Alzheimer's diseases

1973 • 123 citations

Un type particulier d'angiopathie sénile du système nerveux central: l'angiopathie congophile. Topographie et fréquence; pp. 219–237

1954 • 123 citations

Pathological proteins Tau 64 and 69 are specifically expressed in the somatodendritic domain of the degenerating cortical neurons during Alzheimer's disease

1990 • 122 citations

Smooth pursuit dysfunction in Alzheimer's disease

1988 • 122 citations

Amyotrophic lateral sclerosis among chamorro migrants from guam

1980 • 121 citations

Lack of association of apolipoprotein E allele ϵ4 with late‐onset Alzheimer's disease among Finnish centenarians

1995 • 121 citations

Alzheimer's disease and aging: Effects on perforant pathway perikarya and synapses

1992 • 120 citations

Frontotemporal dementia and Alzheimer's disease: retrospective differentiation using information from informants.

1995 • 119 citations

Preserved Number of Entorhinal Cortex Layer II Neurons in Aged Macaque Monkeys

1997 • 119 citations

AMYOTROPHIC LATERAL SCLEROSIS

1953 • 118 citations

β-Amyloid (Aβ) Deposition in the Brains of Aged Orangutans

1997 • 118 citations

Corticonigral degeneration with neuronal achromasia and basal neurofibrillary tangles

1990 • 117 citations

Evidence for Early Vulnerability of the Medial and Inferior Aspects of the Temporal Lobe in an 82-Year-Old Patient With Preclinical Signs of Dementia

1992 • 117 citations

Quantitative neuropathologic analysis of Pick's disease cases: cortical distribution of Pick bodies and coexistence with Alzheimer's disease

1994 • 117 citations

Ubiquitin, and B-Crystallin Immunohistochemistry Define the Principal Causes of Degenerative Frontotemporal Dementia

1995 • 117 citations

Synaptic Distribution of the AMPA-GluR2 Subunit and Its Colocalization with Calcium-Binding Proteins in Rat Cerebral Cortex: An Immunohistochemical Study Using a GluR2-Specific Monoclonal Antibody

1996 • 116 citations

Recognition memory span in rhesus monkeys of advanced age

1997 • 116 citations

Loss of calbindin-28K immunoreactive neurones from the cortex in Alzheimer-type dementia

1988 • 116 citations

Post-encephalitic Parkinsonism: current experience

1981 • 114 citations

Chromosome 17 and hereditary dementia

1997 • 114 citations

Neurofibrillary tangles, but not Alzheimer‐type pathology, in a young boxer

1996 • 114 citations

SYNAPSES, AXONAL AND DENDRITIC PATTERNS OF GABA-IMMUNOREACTIVE NEURONS IN HUMAN CEREBRAL CORTEX

1990 • 114 citations

Regions with abundant neurofibrillary pathology in human brain exhibit a selective reduction in levels of binding-competent tau and accumulation of abnormal tau-isoforms (A68 proteins).

1992 • 113 citations

Glutamate metabotropic and AMPA binding sites are reduced in Alzheimer's disease: an autoradiographic study of the hippocampus

1991 • 113 citations

The Epidemiology of dementia

1981 • 112 citations

Loss of parvalbumin-immunoreactive neurones from cortex in Alzheimer-type dementia

1987 • 112 citations

Hippocampal Neurons Predisposed to Neurofibrillary Tangle Formation Are Enriched in Type II Calcium/Calmodulin-Dependent Protein Kinase

1990 • 112 citations

Progressive supranuclear palsy: extensive neuropil threads in addition to neurofibrillary tangles

1988 • 112 citations

Differential vulnerability of neurochemically identified subpopulations of retinal neurons in a monkey model of glaucoma

1995 • 111 citations

Pathological overlap in cases of parkinsonism associated with neurofibrillary tangles

1993 • 111 citations

Incomplete achromatopsia in alzheimer's disease

1993 • 110 citations

Posterior cortical atrophy in Alzheimer's disease: analysis of a new case and re-evaluation of a historical report

1993 • 110 citations

Parietal Pick's disease mimicking cortical‐basal ganglionic degeneration

1994 • 109 citations

Protein kinases and phosphorylation in neurologic disorders and cell death.

1991 • 108 citations

Epitopes located in spatially separate domains of each neurofilament subunit are present in parkinson's disease lewy bodies

1991 • 108 citations

Corticobasal degeneration: a disease with widespread appearance of abnormal tau and neurofibrillary tangles, and its relation to progressive supranuclear palsy

1994 • 108 citations

Cross-national comparisons of the occurrence of Alzheimer's and vascular dementias

1991 • 107 citations

Argyrophilic grain disease: widespread hyperphosphorylation of tau protein in limbic neurons

1997 • 107 citations

Neurofilament protein is differentially distributed in subpopulations of corticocortical projection neurons in the macaque monkey visual pathways

1996 • 107 citations

Aberrant casein kinase II in Alzheimer's disease

1990 • 107 citations

Quantitative histological studies on the aged human brain

1970 • 106 citations

Neurofibrillary degeneration and neuronal loss in alzheimer's disease

1989 • 106 citations

Neurochemical, morphologic, and laminar characterization of cortical projection neurons in the cingulate motor areas of the macaque monkey

1996 • 105 citations

Amyotrophic Lateral Sclerosis and Parkinsonism-Dementia Complex of Guam

1966 • 105 citations

Neuropathological background of twenty-seven centenarian brains

1992 • 105 citations

Morphological Changes in Brains of Boxers

1984 • 104 citations

Anatomische beiträge zur lehre von der pickschen umschriebenen gro\hirnrinden-atrophie („picksche krankheit“)

1926 • 104 citations

Diffuse neurofibrillary tangles with calcification: a new presenile dementia.

1994 • 103 citations

PROGRESSIVE SUPRANUCLEAR PALSY

1969 • 103 citations

AMYOTROPHIC LATERAL SCLEROSIS ON GUAM: A CLINICAL STUDY AND REVIEW OF THE LITERATURE

1952 • 103 citations

Reexpression of a developmentally regulated antigen in Down syndrome and Alzheimer disease.

1988 • 103 citations

A subpopulation of primate corticocortical neurons is distinguished by somatodendritic distribution of neurofilament protein

1991 • 102 citations

The neuropathological changes associated with normal brain aging.

1996 • 102 citations

Amyotrophic lateral sclerosis and parkinsonism‐dementia among Filipino migrants to Guam

1981 • 101 citations

Nature of mental retardation and dementia in down syndrome: Study with PET, CT, and neuropsychology

1992 • 101 citations

Hallucinations and signs of parkinsonism help distinguish patients with dementia and cortical Lewy bodies from patients with Alzheimer's disease at presentation: a clinicopathological study.

1997 • 100 citations

Frontal Lobe Degeneration of Non-Alzheimer Type Revisited

1993 • 100 citations

Visual cortical dysfunction in Alzheimer's disease evaluated with a temporally graded "stress test" during PET

1996 • 99 citations

Neuropathological changes in the cerebral cortex of 1258 cases from a geriatric hospital: retrospective clinicopathological evaluation of a 10-year autopsy population

1994 • 99 citations

Encephalitis lethargica: lessons for contemporary neuropsychiatry

1995 • 99 citations

Neurological Sequelae of Boxing

1987 • 98 citations

Dendritic pathology of granule cells in Alzheimer's disease is unrelated to neuritic plaques

1994 • 98 citations

Brain activation associated with visual motion studied by functional magnetic resonance imaging in humans

1994 • 98 citations

Aged Non‐Human Primates: An Animal Model of Age‐Associated Neurodegenerative Disease

1991 • 97 citations

Prevalence and Disease Associations of Argyrophilic Grains of Braak

1997 • 97 citations

Distinct Patterns of Neuronal Loss and Alzheimerʼs Disease Lesion Distribution in Elderly Individuals Older than 90 Years

1996 • 97 citations

Preferential metabolic involvement of visual cortical areas in a subtype of Alzheimer's disease: clinical implications

1996 • 97 citations

Pick's Disease

1972 • 96 citations

Object recognition deficit in Alzheimer's disease: Possible disconnection of the occipito-temporal component of the visual system

1991 • 96 citations

Frontotemporal dementia versus Alzheimer's disease

1996 • 96 citations

Progressive transformation of the cytoskeleton associated with normal aging and Alzheimer's disease

1992 • 96 citations

COMPARATIVE NEUROPATHOLOGY OF AGEING: STUDIES ON THE BRAINS OF 47 SPECIES OF VERTEBRATES

1971 • 95 citations

Lewy body prevalence in the aging brain: relationship to neuropsychiatric disorders, Alzheimer-type pathology and catecholaminergic nuclei

1990 • 94 citations

Epitope expression and hyperphosphorylation of tau protein in corticobasal degeneration: differentiation from progressive supranuclear palsy

1995 • 94 citations

Neurons of the Human Frontal Cortex Display Apolipoprotein E Immunoreactivity

1996 • 94 citations

Parvalbumin-immunoreactive structures in the hippocampus of the human adult

1991 • 93 citations

The Clinical Pathological Correlates of Lobar Atrophy

1993 • 93 citations

Synapse alterations in the hippocampal-entorhinal formation in Alzheimer's disease with and without Lewy body disease

1994 • 92 citations

Neuron loss in the nucleus basalis of meynert in parkinsonism‐dementia complex of Guam

1983 • 92 citations

Mapping of a disease locus for familial rapidly progressive frontotemporal dementia to chromosome 17q12-21

1997 • 92 citations

Parvalbumin-immunoreactive neurons in the human central nervous system are decreased in Alzheimer's disease

1991 • 91 citations

Calretinin-immunoreactive neurons in the normal human temporal cortex and in Alzheimer's disease

1995 • 91 citations

Cortical Degeneration in Progressive Supranuclear Palsy. A Comparison with Cortical-Basal Ganglionic Degeneration

1997 • 91 citations

NMDA and Non‐NMDA Receptor Gene Expression Following Global Brain Ischemia in Rats: Effect of NMDA and Non‐NMDA Receptor Antagonists

1994 • 91 citations

Ultrastructural analysis of somatostatin‐immunoreactive neurons and synapses in the temporal and occipital cortex of the macaque monkey

1989 • 91 citations

Localization of the mitogen activated protein kinase ERK2 in Alzheimer's disease neurofibrillary tangles and senile plaque neurites

1993 • 90 citations

Alzheimer's disease in a patient with posterior cortical atrophy.

1991 • 90 citations

Quantitative immunocytochemical analysis of the spinal cord in G86R superoxide dismutase transgenic mice: Neurochemical correlates of selective vulnerability

1996 • 90 citations

Focal Alzheimer's disease

1990 • 90 citations

The spectrum of imaging and neuropsychological findings in Pick's disease

1989 • 90 citations

Beitrag zur Kenntnis der chronischen cerebralen Krankheitsbilder bei Boxern

1957 • 89 citations

Immunocytochemical characterization of neurofibrillary tangles in amyotrophic lateral sclerosis and parkinsonism‐dementia of guam

1989 • 89 citations

Amyotrophic Lateral Sclerosis

1967 • 89 citations

Possible neuroprotective role of clusterin in Alzheimer's disease: a quantitative immunocytochemical study

1998 • 89 citations

Abnormal processing of multiple proteins in Alzheimer disease.

1989 • 89 citations

Ultrastructure of neurofibrillary tangles in progressive supranuclear palsy

1977 • 89 citations

Cortical Degeneration with Swollen Chromatolytic Neurons

1986 • 89 citations

Posttraumatic Premature Alzheimer's Disease

1982 • 89 citations

Verteilungsmuster der senilen Ver�nderungen im Gehirn

1968 • 89 citations

Localization of amyloid precursor protein in GAP43-immunoreactive aberrant sprouting neurites in Alzheimer's disease

1992 • 88 citations

AMPA-selective glutamate receptor subtype immunoreactivity in the entorhinal cortex of non-demented elderly and patients with Alzheimer's disease

1994 • 88 citations

An immunohistochemical study of pro-somatostatin-derived peptides in the human brain

1987 • 88 citations

Preferential localization of copper zinc superoxide dismutase in the vulnerable cortical neurons in Alzheimer's disease

1988 • 88 citations

Towards an understanding of the role of glutamate in neurodegenerative disorders: energy metabolism and neuropathology

1993 • 88 citations

Chandelier cell axons identified by parvalbumin-immunoreactivity in the normal human temporal cortex and in Alzheimer's disease

1993 • 88 citations

Cortical Degeneration in Progressive Supranuclear Palsy. A Comparison with Cortical-Basal Ganglionic Degeneration

1997 • 87 citations

Topographic organization of cortical and subcortical projections to posterior cingulate cortex in the cat: Evidence for somatic, ocular, and complex subregions

1992 • 87 citations

7 Pathological features

1997 • 86 citations

Pacific paradigms of environmentally-induced neurological disorders: clinical, epidemiological and molecular perspectives.

1991 • 86 citations

Biochemical mapping of neurofibrillary degeneration in a case of progressive supranuclear palsy: evidence for general cortical involvement

1994 • 85 citations

The effect of age and Alzheimer's disease on pyramidal neuron density in the individual fields of the hippocampal formation

1992 • 85 citations

Neuropathologic Changes of the Temporal Pole in Alzheimer's Disease and Pick's Disease

1994 • 85 citations

IMMUNOCYTOCHEMISTRY OF NEUROFIBRILLARY TANGLES IN DEMENTIA PUGILISTICA AND ALZHEIMER'S DISEASE: EVIDENCE FOR COMMON GENESIS

1988 • 85 citations

Binding of secreted human neuroblastoma proteoglycans to the Alzheimer's amyloid A4 peptide

1993 • 84 citations

Regional Distribution of Neurofilament and Calcium-binding Proteins in the Cingulate Cortex of the Macaque Monkey

1992 • 83 citations

Phosphorylation of Tau proteins: a major event during the process of neurofibrillary degeneration. A comparative study between Alzheimer's disease and Down's syndrome

1990 • 83 citations

MONOAMNIOTIC TWINS

1974 • 83 citations

Contingent Vulnerability of Entorhinal Parvalbumin-Containing Neurons in Alzheimer’s Disease

1996 • 83 citations

Selective Cortical and Hippocampal Volume Correlates of Mattis Dementia Rating Scale in Alzheimer Disease

1997 • 83 citations

Pathoanatomic Changes in Amyotrophic Lateral Sclerosis on Guam

1961 • 83 citations

Evidence for oxidative stress in Pick disease and corticobasal degeneration

1995 • 83 citations

Dystrophic Neurite Formation Associated with Age-Related β Amyloid Deposition in the Neocortex: Clues to the Genesis of Neurofibrillary Pathology

1996 • 82 citations

ADULT ONSET HALLERVORDEN-SPATZ DISEASE WITH NEUROFIBRILLARY PATHOLOGY

1987 • 81 citations

The basal nucleus of Meynert in patients with progressive supranuclear palsy

1984 • 81 citations

Specificity of changes in cerebral blood flow in patients with frontal lobe dementia.

1994 • 80 citations

Progressive supranuclear palsy

1971 • 80 citations

Nonphosphorylated Neurofilament Protein and Calbindin Immunoreactivity in Layer III Pyramidal Neurons of Human Neocortex

1992 • 80 citations

The topographic distribution of brain atrophy in frontal lobe dementia

1993 • 80 citations

Neurofibrillary tangles in some cases of dementia pugilistica share antigens with amyloid beta-protein of Alzheimer's disease.

1990 • 79 citations

Reduction of AMPA-selective glutamate receptor subunits in the entorhinal cortex of patients with Alzheimer's disease pathology: a biochemical study

1995 • 79 citations

Neurofibrillary tangles in dementia pugilistica are ubiquitinated.

1991 • 79 citations

Different variants of frontotemporal dementia: a neuropathological and immunohistochemical study

1996 • 79 citations

Observations on the Pathology of Insidious Dementia Following Head Injury

1959 • 78 citations

A monoclonal antibody that recognizes a phosphorylated epitope in Alzheimer neurofibrillary tangles, neurofilaments and tau proteins immunostains granulovacuolar degeneration

1987 • 78 citations

Progressive supranuclear palsy: a clinicopathological study of 21 cases

1996 • 77 citations

Neuropsychological functioning in cortical-basal ganglionic degeneration

1996 • 76 citations

Anatomische Beiträge zur Lehre von der Pickschen umschriebenen Großhirnrinden-Atrophie („Picksche Krankheit“)

1926 • 76 citations

Dementia lacking distinctive histopathology: clinicopathological evaluation of 32 cases

1995 • 76 citations

Neurofilament and calcium-binding proteins in the human cingulate cortex

1997 • 76 citations

Neurofibrillary Tangles in Progressive Supranuclear Palsy Contain the Same Tau Epitopes Identified in Alzheimerʼs Disease PHFtau

1996 • 76 citations

Late onset dementia with argyrophilic grains and subcortical tangles or atypical progressive supranuclear palsy?

1991 • 75 citations

Neurotransmitter receptors in Alzheimer disease.

1993 • 75 citations

Prevalence of Dementia and Distribution of ApoE Alleles in Japanese Centenarians: An Almost‐Complete Survey in Yamanashi Prefecture, Japan

1996 • 75 citations

Synaptic Connections of Calretinin-Immunoreactive Neurons in the Human Neocortex

1997 • 75 citations

Glutamate‐, glutaminase‐, and taurine‐immunoreactive neurons develop neurofibrillary tangles in Alzheimer's disease

1991 • 75 citations

Zinc, a neurotoxin to cultured neurons, contaminates cycad flour prepared by traditional guamanian methods

1992 • 74 citations

Laminar distribution of neuron degeneration in posterior cingulate cortex in Alzheimer's disease

1990 • 74 citations

Neurofibrillary tangle distribution in the cerebral cortex of parkinsonism-dementia cases from Guam: differences with Alzheimer's disease

1991 • 74 citations

Quantitative analysis of tau protein-immunoreactive accumulations and β amyloid protein deposits in the cerebral cortex of the mouse lemur, Microcebus murinus

1997 • 74 citations

Neurologic aspects of boxing.

1987 • 74 citations

Rudolph Balint:Seelenlahmung des Schauens,optische Ataxie,raumliche Storung der Aufmerksamkeit(Mschr.Psychiat.Neurol.,25;51-81,1909)-2-

1977 • 73 citations

Clinical Neurology of Aging

1985 • 72 citations

Two‐Dimensional Characterization of Paired Helical Filament‐Tau from Alzheimer's Disease: Demonstration of an Additional 74‐kDa Component and Age‐Related Biochemical Modifications

1997 • 72 citations

Casein kinase II alteration precedes tau accumulation in tangle formation.

1992 • 72 citations

The Cellular Basis for the Relative Resistance of Parvalbumin and Calretinin Immunoreactive Neocortical Neurons to the Pathology of Alzheimer's Disease

1997 • 72 citations

Increased numbers of βAPP-immunoreactive neurones in the entorhinal cortex after head injury

1994 • 72 citations

A quantitative histological study of early clinical and preclinical Alzheimer's disease

1990 • 72 citations

The cerebral cortex in presenil dementia

1973 • 71 citations

Expression of Bcl‐2 in Adult Human Brain Regions with Special Reference to Neurodegenerative Disorders

1997 • 71 citations

Verteilungsmuster der senilen Vernderungen im Gehirn: Die Beteiligung des limbischen Systems bei hirnatrophischen Prozessen des Seniums und bei Morbus Alzheimer

1968 • 70 citations

Excitatory amino acid AMPA receptor mRNA localization in several regions of normal and neurological disease affected human brain. An in situ hybridization histochemistry study

1994 • 70 citations

Modular Organization of Human Extrastriate Visual Cortex: Evidence from Cytochrome Oxidase Pattern in Normal and Macular Degeneration Cases

1994 • 70 citations

Post–traumatic Alzheimer's disease: preponderance of a single plaque type

1991 • 70 citations

Progressive supranuclear palsy (The Steele-Richardson-Olszewski syndrome)

1971 • 70 citations

Parvalbumin immunoreactive neurons in normal human temporal neocortex and in patients with Alzheimer's disease

1991 • 70 citations

Regional Distribution of Neurofibrillary Tangles and Senile Plaques in the Cerebral Cortex of Very Old Patients

1995 • 70 citations

Filaments of Pick's bodies contain altered cytoskeletal elements.

1987 • 69 citations

Age-related changes in expression of ampa-selective glutamate receptor subunits: Is calcium-permeability altered in hippocampal neurons?

1994 • 69 citations

Posterior Cingulate Cortex and Visuospatial Cognition: Properties of Single Neurons in the Behaving Monkey

1993 • 69 citations

PICKʼS DISEASE

1949 • 69 citations

Secondary deposition of beta amyloid within extracellular neurofibrillary tangles in Alzheimer-type dementia.

1991 • 68 citations

Colocalization of parvalbumin and calbindin D-28k in neurons including chandelier cells of the human temporal neocortex

1997 • 68 citations

Neurologic diseases on the island of Guam.

1954 • 68 citations

Pathological τ proteins in postencephalitic parkinsonism: Comparison with Alzheimer's disease and other neurodegenerative disorders

1997 • 68 citations

Multiple Transmitter Systems Contribute Neurites to Individual Senile Plaques

1988 • 67 citations

The cortex of the primary auditory area in Alzheimer's disease

1986 • 67 citations

Allocortical neurofibrillary changes in progressive supranuclear palsy

1992 • 67 citations

Subpopulations of somatostatin 28-immunoreactive neurons display different vulnerability in senile dementia of the Alzheimer type

1989 • 67 citations

Broad-band visual capacities are not selectively impaired in Alzheimer's disease

1994 • 67 citations

What are the obstacles for an accurate clinical diagnosis of Pick's disease? A clinicopathologic study

1997 • 66 citations

Abnormal cytoskeletal pathology peculiar to corticobasal degeneration is different from that of Alzheimer's disease or progressive supranuclear palsy

1994 • 66 citations

Neurologic Aspects of Boxing

1987 • 66 citations

Ischemic disruption of glutamate homeostasis in brain: quantitative immunocytochemical analyses

1996 • 66 citations

Aberrant accumulation of phospholipase C-delta in Alzheimer brains.

1991 • 65 citations

The fine structure of subcortical neurofibrillary tangles in progressive supranuclear palsy

1979 • 65 citations

Pick's disease: An immunocytochemical study of neuronal changes

1983 • 65 citations

Selective impairment of spatial attention during visual search in Alzheimerʼs disease

1995 • 65 citations

Regional Cerebral Glucose Metabolism is Normal in Young Adults with down Syndrome

1990 • 65 citations

Sequestration of tau by granulovacuolar degeneration in Alzheimer's disease.

1991 • 65 citations

Greater relative impairment of object recognition than of visuospatial abilities in Alzheimer's disease.

1996 • 65 citations

Neocortical morphometry and cholinergic neurochemistry in Pick's disease.

1988 • 65 citations

The gene encoding the glutamate receptor subunit GluR5 is located on human chromosome 21q21.1-22.1 in the vicinity of the gene for familial amyotrophic lateral sclerosis.

1993 • 65 citations

Functional Organisation of the Human Visual Cortex

1993 • 65 citations

Cortical neurones with Ca2+permeable AMPA/kainate channels display distinct receptor immunoreactivity and are GABAergic

1994 • 64 citations

Immunohistochemical identification of thrombospondin in normal human brain and in Alzheimer's disease.

1992 • 64 citations

A subset of calretinin-positive neurons are abnormal in Alzheimer's disease

1994 • 64 citations

Cytoskeletal pathology in non-Alzheimer degenerative dementia: new lesions in Diffuse Lewy body disease, Pick’s disease, and Corticobasal Degeneration

1996 • 64 citations

Chapter 12 Ratio of pyramidal cells versus non-pyramidal cells in the human frontal isocortex and changes in ratio with ageing and Alzheimer's disease

1986 • 64 citations

Calbindin-D_ a potential neuroprotective protein.

1994 • 64 citations

Neurofibrillary tangles of Guam parkinson-dementia are associated with reactive microglia and complement proteins

1996 • 63 citations

Localization of ³H‐nicotine, ¹²⁵I‐kappa‐bungarotoxin, and ¹²⁵I‐alpha‐bungarotoxin binding to nicotinic sites in the chicken forebrain and midbrain

1992 • 63 citations

Age-associated and cell-type-specific neurofibrillary pathology in transgenic mice expressing the human midsized neurofilament subunit

1994 • 63 citations

Non-Alzheimer non-Pick dementia with Fahr's syndrome.

1992 • 63 citations

Clinical Characteristics of a Chromosome 17--Linked Rapidly Progressive Familial Frontotemporal Dementia

1997 • 63 citations

Motor neuron disease on Guam: geographic and familial Occurrence, 1956-85

1996 • 63 citations

Substance P and somatostatin coexist within neuritic plaques: Implications for the pathogenesis of Alzheimer's disease

1989 • 62 citations

Presenile Dementia With Lewy Bodies and Neurofibrillary Tangles

1978 • 62 citations

Substance P-like immunoreactive neurons are depleted in Alzheimer's disease cerebral cortex

1991 • 62 citations

Cortical neurones exhibiting kainate-activated Co2+uptake are selectively vulnerable to AMPA/kainate receptor-mediated toxicity

1994 • 62 citations

Quantitative immunohistochemical analysis of the distribution of neurofibrillary tangles and senile plaques in the cerebral cortex of nonagenarians and centenarians

1993 • 61 citations

Cortical Lewy body-containing neurons are pyramidal cells: laser confocal imaging of double-immunolabeled sections with anti-ubiquitin and SMI32

1995 • 61 citations

Amygdaloid Pathology in Alzheimer's Disease: Qualitative and Quantitative Analysis

1990 • 60 citations

Brain evolution and Alzheimer's disease.

1988 • 59 citations

NMDA, AMPA, and benzodiazepine binding site changes in Alzheimer's disease visual cortex

1993 • 59 citations

Synaptic Distribution of GluR2 in Hippocampal GABAergic Interneurons and Pyramidal Cells: A Double-Label Immunogold Analysis

1998 • 59 citations

Identification of Phosphorylation Sites in PHF-TAU from Patients with Guam Amyotrophic Lateral Sclerosis/Parkinsonism-dementia Complex

1996 • 59 citations

Cerebral cortical calbindin D28K and parvalbumin neurones in Down's syndrome

1990 • 58 citations

Amyotrophic lateral sclerosis/parkinsonism-dementia complex of Guam: quantitative neuropathology, immunohistochemical analysis of neuronal vulnerability, and comparison with related neurodegenerative disorders

1994 • 58 citations

Dementia in Parkinson's disease: Biochemical evidence for cortical involvement using the immunodetection of abnormal tau proteins

1993 • 57 citations

The presubicular region in Alzheimer's disease: topography of amyloid deposits and neurofibrillary changes

1989 • 57 citations

Glutamate increases tau phosphorylation in primary neuronal cultures from fetal rat cerebral cortex

1994 • 57 citations

Lewy Bodies in Alzheimer Disease-One or Two Diseases?

1989 • 57 citations

Low glucose metabolism during brain stimulation in older Down's syndrome subjects at risk for Alzheimer's disease prior to dementia

1997 • 57 citations

Ultrastructure of neurofibrillary tangles in progressive supranuclear palsy

1979 • 57 citations

An immunohistochemical study of six biologically active peptides in the human brain.

1986 • 55 citations

Balint's Syndrome in Alzheimer's Disease: Visuospatial Functions

1990 • 55 citations

L'angiopathie dyshorique (Morel) de l'�corce c�r�brale

1961 • 54 citations

Altered distribution of the α-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor subunit GluR2(4) and the N -methyl- d -aspartate receptor subunit NMDAR1 in the hippocampus of patients with temporal lobe epilepsy

1996 • 54 citations

Simultanagnosia as the Initial Sign of Degenerative Dementia

1993 • 54 citations

Frequency of Alzheimer's neurofibrillary tangles in the cerebral cortex in progressive supranuclear palsy (subcortical argyrophilic dystrophy)

1976 • 54 citations

Overview of Dementia Lacking Distinctive Histology: Pathological Designation of a Progressive Dementia

1993 • 54 citations

Frontal lobe degeneration: novel ubiquitin‐immunoreactive neurites within frontotemporal cortex

1995 • 53 citations

Presenilin-1-immunoreactive neurons are preserved in late-onset Alzheimer's disease.

1997 • 53 citations

The elderly brain. A quantitative analysis in the cerebral cortex of two cases.

1972 • 53 citations

Vulnerability of the hippocampus to kainate excitotoxicity in the aged, mature and young adult rat

1995 • 53 citations

Posterior Cingulate Cortex: Sensory and Oculomotor Properties of Single Neurons in Behaving Cat

1992 • 53 citations

Calbindin D-28k and parvalbumin immunoreactivity in the frontal cortex in patients with frontal lobe dementia of non-Alzheimer type associated with amyotrophic lateral sclerosis.

1993 • 51 citations

Distinct Pathological Features of the Gallyas- and Tau-positive Glia in the Parkinsonism-Dementia Complex and Amyotrophic Lateral Sclerosis of Guam

1997 • 51 citations

Correlation between microscopical changes and Tau 64 and 69 biochemical detection in senile dementia of the Alzheimer type

1990 • 50 citations

Mapping of neurofibrillary degeneration in Alzheimer's disease: evaluation of heterogeneity using the quantification of abnormal tau proteins

1992 • 50 citations

Loss of calbindin-immunoreactivity in CA1 hippocampal stratum radiatum and stratum lacunosum-moleculare interneurons in the aged rat

1994 • 50 citations

Gene dosage of CuZnSOD and Down's syndrome: diminished prostaglandin synthesis in human trisomy 21, transfected cells and transgenic mice.

1991 • 50 citations

Senile plaques, amyloid ?-protein, and acetylcholinesterase fibres: laminar distributions in Alzheimer's disease striate cortex

1992 • 49 citations

Late Progression of Post-Encephalitic Parkinson's Syndrome

1988 • 49 citations

Modifications of neuronal phosphorylated τ immunoreactivity induced by NMDA toxicity

1996 • 49 citations

Calretinin-immunoreactive neurons are resistant to β-amyloid toxicity in vitro

1995 • 48 citations

Galanin-like immunoreactivity is present in human substantia innominata and in senile plaques in Alzheimer's disease

1989 • 48 citations

Morphological overlap between corticobasal degeneration and Pick's disease: A clinicopathological report

1995 • 48 citations

[Neuropathological study of 12 centenarians: the incidence of Alzheimer type senile dementia is not particularly increased in this group of very old patients].

1986 • 48 citations

The Neurochemistry of Prion Diseases

1993 • 47 citations

Amyotrophic lateral sclerosis among Guamanians in California.

1957 • 47 citations

Non Alzheimer's disease forms of cerebral atrophy.

1990 • 47 citations

α-Calcium-Calmodulin-Dependent Kinase II is Associated with Paired Helical Filaments of Alzheimerʼs Disease

1996 • 46 citations

Imaging, Cerebral Topography and Alzheimer’s Disease

1990 • 46 citations

Alzheimer dementia and Pick's disease: neurofibrillary tangles and Pick bodies are associated with identical phosphorylated neurofilament epitopes

1987 • 46 citations

Corticobasal degeneration: widespread argentophilic threads and glia in addition to neurofibrillary tangles. Similarities of cytoskeletal abnormalities in corticobasal degeneration and progressive supranuclear palsy

1996 • 45 citations

Presenilin‐1 protein expression in familial and sporadic Alzheimer's disease

1997 • 45 citations

Dissociation between the detection and perception of motion in Alzheimer's disease

1994 • 45 citations

Distribution of tangles and threads in the cerebral cortex in progressive supranuclear palsy

1995 • 45 citations

Quantitative localization of NMDAR1 receptor subunit immunoreactivity in inferotemporal and prefrontal association cortices of monkey and human

1997 • 45 citations

Potential role of an additive genetic component in the cause of amyotrophic lateral sclerosis and parkinsonism‐dementia in the western Pacific

1993 • 45 citations

Association and intrinsic connections of human extrastriate visual cortex

1994 • 44 citations

Microzonal decreases in the immunostaining for non-NMDA ionotropic excitatory amino acid receptor subunits GluR 2/3 and GluR 5/6/7 in the human epileptogenic neocortex

1994 • 43 citations

Neuronal Ultrastructural Abnormalities in a Patient with Frontotemporal Dementia and Motor Neuron Disease

1995 • 43 citations

The cerebral vasculature in dementia pugilistica.

1989 • 43 citations

Parvalbumin‐immunoreactive cortical neurons in Creutzfeldt‐Jakob disease

1993 • 43 citations

Visual-Spatial Deficits Explain Visual Symptoms in Alzheimer's Disease

1996 • 43 citations

Dementia in Down's syndrome

1988 • 43 citations

Presence of abnormally phosphorylated Tau proteins in the entorhinal cortex of aged non-demented subjects

1992 • 42 citations

An update on long-term in vivo and in vitro studies designed to identify a virus as the cause of amyotrophic lateral sclerosis, parkinsonism dementia, and Parkinson's disease.

1982 • 42 citations

Amyotrophic lateral sclerosis and parkinsonism-dementia from Guam: differences in neurofibrillary tangle distribution and density in the hippocampal formation and neocortex

1994 • 42 citations

Cholinesterases colocalize with sites of neurofibrillary degeneration in aged and Alzheimer's brains

1994 • 42 citations

Morphology and Neurochemical Characteristics of the Vulnerable Neurons in Brain Aging and Alzheimer’s Disease

1997 • 41 citations

Constructional apraxia in Alzheimer's disease correlates with neuritic neuropathology in occipital cortex

1996 • 41 citations

Distribution of AMPA-selective glutamate receptor subunits in the human hippocampus and cerebellum

1995 • 41 citations

Reorganization of Cingulate Cortex in Alzheimer's Disease: Neuron Loss, Neuritic Plaques, and Muscarinic Receptor Binding

1992 • 41 citations

Distribution of neurofibrillary tangles and senile plaques in the cerebral cortex in postencephalitic parkinsonism

1992 • 40 citations

Alz‐50 immunoreactive neuropil differentiates hippocampal complex subfields in Alzheimer's disease

1991 • 40 citations

Antibodies to presenilin proteins detect neurofibrillary tangles in Alzheimer's disease.

1996 • 40 citations

Ultrastructural localization of butyrylcholinesterase on neurofibrillary degeneration sites in the brains of aged and Alzheimer's disease patients

1994 • 40 citations

Ultrastructural localization of acetylcholinesterase in neurofibrillary tangles, neuropil threads and senile plaques in aged and Alzheimer's brain

1992 • 40 citations

Supranuclear disturbances of ocular motility in Lytico‐Bodig

1988 • 40 citations

Distribution and ultrastructure of Alzheimer's neurofibrillary tangles in postencephalitic parkinsonism of Economo type

1981 • 40 citations

Aluminum Neurotoxicity — Potential Role in the Pathogenesis of Neurofibrillary Tangle Formation

1986 • 40 citations

Histochemical and X-ray microanalytical localization of aluminum in amyotrophic lateral sclerosis and parkinsonism-dementia of Guam

1988 • 40 citations

"A CONTRIBUTION TO THE LOCALIZATION OF CEREBRAL FUNCTION, BASED ON THE CLINICO-PATHOLOGICAL STUDY OF MENTAL DISEASE."

1910 • 39 citations

Ophthalmological aspects of Alzheimer??s disease

1994 • 38 citations

The progression of idiopathic Parkinson's disease is not explained by age-related changes. Clinical and pathological comparisons with post-encephalitic parkinsonian syndrome

1987 • 38 citations

AMPA‐selective glutamate receptor subtype immunoreactivity in the aged human hippocampal formation

1995 • 37 citations

Senile dementia of the Alzheimer type: is there a correlation between entorhinal cortex and dentate gyrus lesions?

1991 • 36 citations

Connections, Cognition and Alzheimerʼs Disease

1998 • 36 citations

Differential vulnerability, connectivity, and cell typology

1993 • 36 citations

Amyloid β-protein (Aβ) Accumulation in the Leptomeninges during Aging and in Alzheimer Disease

1997 • 35 citations

The Morphologic and Neurochemical Basis of Dementia: Aging, Hierarchical Patterns of Lesion Distribution and Vulnerable Neuronal Phenotype

1995 • 35 citations

AMPA-Selective glutamate receptor subtype immunoreactivity in the hippocampal dentate gyrus of patients with Alzheimer disease

1996 • 34 citations

Motor Cortex Involvement in Presenile Dementia: Report of a Case

1992 • 34 citations

Neurofibrillary tangles in the dentate granule cells of patients with Alzheimer's disease, Lewy body disease and progressive supranuclear palsy

1997 • 34 citations

Immunocytochemical profile of neurofibrillary tangles in Down's syndrome patients of different ages

1989 • 34 citations

Alzheimer's disease with asymmetric atrophy of the cerebral hemispheres: morphometric analysis of four cases

1994 • 33 citations

A Cellular Mechanism for the Neuronal Changes Underlying Alzheimer‘s Disease

1997 • 33 citations

Callosally projecting neurons in the macaque monkey V1/V2 border are enriched in nonphosphorylated neurofilament protein

1997 • 33 citations

Regional Cerebral Blood Flow in Frontal Lobe Dementia of Non-Alzheimer Type

1993 • 33 citations

Isolated senile plaque cores in Alzheimer's disease and Down's syndrome show differences in morphology.

1986 • 32 citations

Foci of motor neuron disease in high incidence in isolated populations of East Asia and the Western Pacific.

1982 • 32 citations

Monoclonal antibodies to a 100-kd protein reveal abundant A beta-negative plaques throughout gray matter of Alzheimer's disease brains.

1997 • 32 citations

Pyramidal neurons are immunoreactive for calbindin D28k in the CA1 subfield of the human hippocampus

1992 • 32 citations

Topography of Pick body distribution in Pick's disease: a contribution to understanding the relationship between Pick's and Alzheimer's diseases.

1989 • 32 citations

Progress in Neuropathology

1987 • 31 citations

Geographic Patterns of Parkinsonism-Dementia Complex on Guam

1990 • 31 citations

Patterns of Acquiring Parkinsonism-Dementia Complex on Guam

1990 • 31 citations

Tau antigenic changes induced by glutamate in rat primary culture model: A biochemical approach

1992 • 31 citations

Localization of non–N‐methyl‐<scp>D</scp>‐aspartate glutamate receptors in normal and Alzheimer hippocampal formation

1994 • 30 citations

Neurochemical organization of the primate visual cortex

1998 • 30 citations

Recent neuropathologic observations in amyotrophic lateral sclerosis and parkinsonism‐dementia of Guam

1971 • 30 citations

Alzheimer's disease, Lewy body disease and aging: a comparative study of the perforant pathway

1997 • 30 citations

Substance P Immunoreactivity in Alzheimer Disease

1990 • 30 citations

Chapter VIII Primate cingulate cortex chemoarchitecture and its disruption in Alzheimer's disease

1997 • 29 citations

Acetylcholinesterase-rich pyramidal neurons in alzheimer's disease

1992 • 29 citations

Frontotemporal dementia: a clinicopathological review of four postmortem studies

1996 • 29 citations

VII. Neurologic Disease in the Western Pacific Islands, with a Report on the Focus of Amyotrophic Lateral Sclerosis Found in the Kii Peninsula, Japan

1970 • 29 citations

Amyotrophic lateral sclerosis and parkinsonism dementia in a migrant population from Guam

1969 • 28 citations

Severe cerebral atrophy in progressive supranuclear palsy: a case report.

1989 • 28 citations

Presenilin-1 Immunoreactivity Is Localized Intracellularly in Alzheimer's Disease Brain, but Not Detected in Amyloid Plaques

1997 • 27 citations

Calbindin D-28k immunoreactivity in the temporal neocortex in patients with Alzheimer's disease.

1993 • 27 citations

Calcium-Binding Proteins Define Subpopulations of Interneurons in Cingulate Cortex

1993 • 27 citations

Astrogliosis in von Economo's and postencephalitic Parkinson's diseases support probable viral etiology

1991 • 27 citations

Apolipoprotein E in Guamanian amyotrophic lateral sclerosis/ parkinsonism-dementia complex: genotype analysis and relationships to neuropathological changes

1996 • 27 citations

Molecular pathology of Alzheimer amyloid and neurofibrillary tangles

1990 • 27 citations

Relationship of amyloid ?/A4 protein to the neurofibrillary tangles in Guamanian parkinsonism-dementia

1995 • 27 citations

Non-Alzheimer fronto-temporal degenerative dementia. A neurobehavioral and pathologic study.

1994 • 26 citations

Smooth Pursuit Eye Movements in Dementia of the Alzheimer Type

1989 • 26 citations

AMPA glutamate receptors and their flip and flop mRIMAs in human hippocampus

1994 • 26 citations

The globus pallidus in post-encephalitic parkinsonism

1965 • 26 citations

Presenilin-1 is associated with Alzheimer's disease amyloid.

1997 • 25 citations

Ubiquitin-related cytoskeletal abnormality in frontotemporal dementia: immunohistochemical and immunoelectron microscope studies

1997 • 25 citations

Selective loss of calbindin D28K-immunoreative neurons in the cortical layer II in brains of Alzheimer's disease: a morphometric study

1993 • 25 citations

Corticotropin-releasing factor immunoreactive neurons persist throughout the brain in Alzheimer's disease

1989 • 25 citations

Demonstration of β amyloid protein‐containing neurofibrillary tangles in parkinsonism‐dementia complex on Guam

1991 • 25 citations

Immunocytochemical localization of non-NMDA ionotropic excitatory amino acid receptor subunits in human neocortex

1995 • 25 citations

Dementia in the Oldest-Old:Quantitative Analysis of 12 Cases from a Psychiatric Hospital

1994 • 24 citations

Severe panencephalic Pick's disease with Alzheimer's disease-like neuropil threads and synaptophysin immunoreactivity

1994 • 24 citations

Neurodegeneration in the limbic and paralimbic system in progressive supranuclear palsy

1995 • 24 citations

Distribution of glutamate receptor subunit proteins G1uR2(4), GluR5/6/7, and NMDAR1 in the canine and primate cerebral cortex: a comparative immunohistochemical analysis

1996 • 24 citations

Neuronal inclusions in the dentate fascia in patients with multiple system atrophy

1997 • 24 citations

Diagnostic différentiel histologique de la maladie d'Alzheimer et de la démence sénile

1947 • 23 citations

Early-onset dementias: clinical, neuropathological and genetic characteristics

1996 • 23 citations

Parvalbumin-immunoreactive neurons in the cortex in Pick's disease

1991 • 23 citations

Olfactory Frontal Cortex and Multiple Olfactory Processing in Primates

1991 • 23 citations

Single glutamate channels in CA1 pyramidal neurones after transient ischaemia

1995 • 22 citations

Regional neuronal loss in aging and Alzheimer's disease: a brief review

1994 • 22 citations

SMI-32 antibody against non-phosphorylated neurofilaments identifies a subpopulation of cultured cortical neurons hypersensitive to kainate toxicity

1995 • 22 citations

Parkinsonism-Dementia Complex

1962 • 22 citations

Comparative Investigation of Neurofibrillary Damage in the Temporal Lobe in Alzheimer's Disease, Down's Syndrome and Dementia Pugilistica

1996 • 22 citations

[A parietal form of Pick's disease: clinical and pathological study (author's transl)].

1981 • 22 citations

Parvalbumin-immunoreactive dystrophic neurites and aberrant sprouts in the cerebral cortex of patients with Alzheimer's disease

1993 • 21 citations

The neuropathologic diagnostic criteria of frontal lobe dementia revisited. A study of ten consecutive cases

1996 • 21 citations

[Oculo-facio-cervical dystonia (Steele-Richardson-Olszewski progressive supranuclear paralysis). Ophthalmic pseudo-paralysis, visuo-spatial disorders, pseudo-dementia and neuronal changes].

1970 • 21 citations

Quantitative analysis of neuropathologic changes in the cerebral cortex of centenarians

1995 • 21 citations

Aluminium and calcium in soil and food from Guam, Palau and Jamaica: Implications for amyotrophic lateral sclerosis and parkinsonism-dementia syndromes of Guam

1989 • 21 citations

Calretinin-immunoreactivity in organotypic cultures of the rat cerebral cortex: effects of serum deprivation

1996 • 21 citations

DISTRIBUTION OF THE BRAIN STEM LESIONS IN POSTENCEPHALITIC PARKINSONISM

2009 • 21 citations

Parkinsonism‐dementia in a Filipino migrant

1982 • 21 citations

Immunohistochemical Study of the Hippocampus in Parkinsonism-Dementia Complex on Guam

1991 • 20 citations

Visual variant of Alzheimer's disease: Distinctive neuropsychological features.

1996 • 20 citations

Callosal Connections and Functional Subdivision of the Human Occipital Cortex

1993 • 20 citations

Determinants of the calcium permeation of ligand-gated cation channels

1992 • 20 citations

GERIATRIC BIOSCIENCE: Hippocampal and Neocortical Involvement in Normal Brain Aging and Dementia: Morphological and Neurochemical Profile of the Vulnerable Circuits

1996 • 20 citations

An immunohistochemical study of neurofibrillary tangle formation in post-encephalitic Parkinsonism.

1996 • 20 citations

Characterization of the association of phospholipase C-δ with Alzheimer neurofibrillary tangles

1995 • 19 citations

Phosphorylated and non-phosphorylated neurofilament proteins: distribution in the rat hippocampus and early changes after kainic acid induced seizures

1995 • 19 citations

Intraperikaryal Neurofilamentous Accumulations in a Subset of Retinal Ganglion Cells in Aged Mice That Express a Human Neurofilament Gene

1995 • 19 citations

Down's syndrome: occurrence of ALZ-50 reactive neurons and the formation of senile plaques

1992 • 19 citations

Patterns of Amyotrophic Lateral Sclerosis and Parkinsonism-Dementia on Guam.

1975 • 18 citations

Patterns of glial cell activity in fronto‐temporal dementia (lobar atrophy)

1996 • 18 citations

REGIONAL AND LAMINAR SYNAPTIC PATHOLOGY IN FRONTAL LOBE DEGENERATION OF NON-ALZHEIMER TYPE

1996 • 17 citations

Patterns of glial cell activity in fronto-temporal dementia (lobar atrophy).

1996 • 17 citations

Morphology and kainate-receptor immunoreactivity of identified neurons within the entorhinal cortex projecting to superior temporal sulcus in the cynomolgus monkey

1995 • 17 citations

Perceptuospatial Disorder in Alzheimer's Disease

1987 • 17 citations

The topographic distribution of brain atrophy in cortical Lewy body disease: comparison with Alzheimer's disease

1995 • 17 citations

Regional distribution of the AMPA glutamate receptor subunits GluR2(4) in human hippocampus

1995 • 16 citations

A light and electron microscopic study of GluR4-positive cells in human cerebral cortex

1996 • 16 citations

The organization of the cerebral cortex: From molecules to circuits

1992 • 16 citations

Neurofibrillary tangles of Guamanian amyotrophic lateral sclerosis, parkinsonism-dementia and neurologically normal Guamanians contain a 4-to 4.5-kilodalton protein which is immunoreactive to anti-amyloid ?/A4-protein antibodies

1993 • 16 citations

An unusual case of Pick's disease

1983 • 16 citations

Developmental trends within memory‐deficient reading‐disability subtypes

1988 • 15 citations

Topography of Alzheimer’s Disease: Involvement of Association Neocortices and Connected Regions; Pathological, Metabolic and Cognitive Correlations; Relation to Evolution

1990 • 15 citations

Zur pathologischen Anatomie der Pickschen Krankheit

1960 • 14 citations

Endemic amyotrophic lateral sclerosis on Guam; epidemiological data; a preliminary report.

1953 • 14 citations

Down's syndrome

1987 • 14 citations

The Impact of Alzheimer’s Disease in the United States Population

1992 • 14 citations

[Posterior cortical atrophy: anatomo-clinical variant of Alzheimer's disease].

1990 • 13 citations

[Absolute number of nerve cells and thickness of the cerebral cortex during aging and in disease (senile and vascular dementia, Pick's and Alzheimer's diseases)].

1972 • 13 citations

Amyotrophic lateral sclerosis of the Guam type in a U.S. veteran

1973 • 13 citations

Les aires striée, parastriée et péristriée dans les troubles de la fonction visuelle au cours de la maladie d'Alzheimer

1944 • 13 citations

Étude statistique des altérations dégénératives cérébrales apparaissant au cours du vieillissement; pp. 41–53

1964 • 12 citations

Margin to Craton Expansion of Late Ordovician Benthic Marine Invertebrates

1985 • 12 citations

Does Alzheimer's disease start early in life?

1997 • 12 citations

Zur pathologischen Anatomie der Pickschen Krankheit

1961 • 11 citations

Age vs. Aging in the Pathogenesis of Senile Dementia of the Alzheimer Type: Electrophysiological Evidence

1996 • 11 citations

Distribution of glutamate receptor subunit GluR1 and GABA in human cerebral neocortex: a double immunolabelling and electron microscopic study

1996 • 11 citations

■ REVIEW : Glutamate Receptors: Emerging Links Between Subunit Proteins and Specific Excitatory Circuits in Primate Hippocampus and Neocortex

1996 • 11 citations

Motor neuron disease on Guam: temporal xcurrence, 1941-85

2009 • 11 citations

Frequency of Alzheimer's Neurofibrillary Tangle in the Brains of Progressive Supranuclear Palsy, Postencephalitic Parkinsonism, Alzheimer's Disease, Senile Dementia and Non‐Demented Elderly Person

1981 • 10 citations

Molecular and cellular mechanisms of neuronal plasticity in normal aging and Alzheimer's disease

1990 • 10 citations

Down Syndrome

1991 • 10 citations

Contribution à l'étude histologique différentielle de la démence sénile et de la maladie d'Alzheimer

1958 • 9 citations

The incredible shrinking brain

1995 • 8 citations

CORTICOBASAL DEGENERATION

1995 • 7 citations

Is progression in postencephalitic parkinson's disease late and age-related?

1991 • 7 citations

Morphologic and Neurochemical Characteristics of Corticocortical Projections: Emergence of Circuit-specific Features and Relationships to Degenerative Changes in Alzheimer’s Disease

1997 • 7 citations

Post-encephalitic parkinsonism

1998 • 7 citations

Amyloid plaque: morphology, evolution, and etiology.

1992 • 7 citations

[Hippocampal pathology as one of the possible factors in the pathogenesis of several dementias of old age].

1976 • 7 citations

Alzheimer's disease-type neurofibrillary degeneration in verrucose dysplasias of the cerebral cortex

1995 • 6 citations

Species differences in the distribution of the glutamate receptor subunit, GluR1, in the rat and monkey entorhinal cortex.

1997 • 6 citations

[On the pathological anatomy of Pick's disease. II. Histological changes of the fine structures and the problem of localization of onset at the neuron].

1961 • 6 citations

[Neuropathologic study of 50 cases of senile dementia].

1990 • 6 citations

A Phylogenetic Hypothesis for Alzheimer’s Disease

1988 • 6 citations

Neurological disease on Guam. A review of past and present investigations.

1967 • 5 citations

Alzheimer's Disease or Plaque Disease? Two Cases at the Frontier of a Definition

1992 • 5 citations

Cortical Mapping of Pathological Tau Proteins in Several Neurodegenerative Disorders

1997 • 5 citations

Angiopathie topistique

1943 • 5 citations

The cortical degeneration in Pick's syndrome; a quantitative analysis.

1955 • 4 citations

Un type particulier d'angiopathie sénile du système nerveux central: l'angiopathie congophile. Topographie et fréquence; pp. 238–256

1954 • 4 citations

Abnormal Neuritic Architecture Identified by Di-I in Pickʼs Disease

1993 • 4 citations

Parvalbumin Neurons in the Hippocampus in Senile Dementia of the Alzheimer Type, Parkinson's Disease and Multi-Infarct Dementia (Part 1 of 2)

1991 • 3 citations

Étude statistique des altérations dégénératives cérébrales apparaissant au cours du vieillissement; pp. 54–68

1964 • 2 citations

The Geniculocalcarine Pathway in Man, and Some Putative Visual Areas Involved in Visuo-spatial Attention

1993 • 2 citations

Deleted Work

1955 • 0 citations