Advanced Maillard reaction end products are associated with Alzheimer disease pathology.

Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families

1993 • 8,888 citations

Amyloid plaque core protein in Alzheimer disease and Down syndrome.

1985 • 4,276 citations

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology.

1986 • 3,430 citations

Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease.

1993 • 1,329 citations

Aminoguanidine Prevents Diabetes-Induced Arterial Wall Protein Cross-Linking

1986 • 1,154 citations

Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease.

1988 • 920 citations

Nonenzymatic Browning in Vivo: Possible Process for Aging of Long-Lived Proteins

1981 • 754 citations

Formation of pentosidine during nonenzymatic browning of proteins by glucose. Identification of glucose and other carbohydrates as possible precursors of pentosidine in vivo

1991 • 534 citations

An in vivo model for the neurodegenerative effects of beta amyloid and protection by substance P.

1991 • 516 citations

Mechanism of formation of the Maillard protein cross-link pentosidine. Glucose, fructose, and ascorbate as pentosidine precursors

1991 • 451 citations

Enzymatic and nonenzymatic cross‐linking of collagen and elastin

1992 • 444 citations

The abnormal phosphorylation of tau protein at Ser-202 in Alzheimer disease recapitulates phosphorylation during development.

1993 • 439 citations

beta 2-Microglobulin modified with advanced glycation end products is a major component of hemodialysis-associated amyloidosis.

1993 • 405 citations

Alzheimer's Disease: Insolubility of Partially Purified Paired Helical Filaments in Sodium Dodecyl Sulfate and Urea

1982 • 398 citations

Amyloidogenicity of beta A4 and beta A4-bearing amyloid protein precursor fragments by metal-catalyzed oxidation.

1992 • 344 citations

End-stage renal disease and diabetes catalyze the formation of a pentose-derived crosslink from aging human collagen.

1990 • 288 citations

High correlation between pentosidine protein crosslinks and pigmentation implicates ascorbate oxidation in human lens senescence and cataractogenesis.

1991 • 250 citations

Modification of human low-density lipoprotein by the lipid peroxidation product 4-hydroxynonenal

1986 • 241 citations

Immunohistochemical detection of advanced glycosylation end products in diabetic tissues using monoclonal antibody to pyrraline.

1992 • 218 citations

The Alzheimer‐like phosphorylation of tau protein reduces microtubule binding and involves Ser‐Pro and Thr‐Pro motifs

1992 • 210 citations

Oxidative Glycation and Free Radical Production: A Causal Mechanism of Diabetic Complications

1991 • 179 citations

Pyrrole formation from 4-hydroxynonenal and primary amines

1993 • 172 citations

Neuropil threads of Alzheimer's disease show a marked alteration of the normal cytoskeleton

1991 • 138 citations

Detection of d-glucose-derived pyrrole compounds during maillard reaction under physiological conditions

1987 • 126 citations

Neurofibrillary tangles and β-amyloid deposits in Alzheimer's disease

1991 • 116 citations

Selective modification of aspartic acid-101 in lysozyme by carbodiimide reaction

1981 • 108 citations

Effects of age and diabetes mellitus on the solubility of collagen from human skin, tracheal cartilage and dura mater

1982 • 97 citations

Beta protein immunoreactivity is found in the majority of neurofibrillary tangles of Alzheimer's disease.

1992 • 67 citations

Racemized D-aspartate in Alzheimer neurofibrillary tangles

1992 • 38 citations

Altered aspartate in Alzheimer neurofibrillary tangles

1992 • 38 citations

Dopaminergic Neurotoxicity In Vivo and Inhibition of Mitochondrial Respiration In Vitro by Possible Endogenous Pyridinium‐Like Substances

1991 • 35 citations

α1-Trypsin Immunoreactivity in Alzheimer Disease

1993 • 28 citations

Inhibition of mitochondrial respiration by analogues of the dopaminergic neurotoxin 1-methyl-4-phenylpyridinium: Structural requirements for accumulation-dependent enhanced inhibitory potency on intact mitochondria

1990 • 18 citations

The effects of polymers on the shrinkage temperature of tendon

1982 • 3 citations