Localization of heparan sulfate glycosaminoglycan and proteoglycan core protein in aged brain and Alzheimer's disease

Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures.

1981 • 14,396 citations

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology.

1986 • 3,430 citations

Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease

1989 • 904 citations

Endothelial cell-derived heparan sulfate binds basic fibroblast growth factor and protects it from proteolytic degradation.

1988 • 810 citations

Isolation of brain fibroblast growth factor by heparin-Sepharose affinity chromatography: identity with pituitary fibroblast growth factor.

1984 • 624 citations

Extracellular Matrix Molecules that Influence Neural Development

1989 • 537 citations

The presence of heparan sulfate proteoglycans in the neuritic plaques and congophilic angiopathy in Alzheimer's disease.

1988 • 410 citations

Inhibition of casein kinase II by heparin.

1980 • 341 citations

Diffuse senile plaques occur commonly in the cerebellum in Alzheimer's disease.

1989 • 336 citations

Massive somatodendritic sprouting of cortical neurons in Alzheimer's disease

1988 • 308 citations

β-Amyloid stimulates glial cells in vitro to produce growth factors that accumulate in senile plaques in Alzheimer's disease

1992 • 291 citations

Cell surface heparan sulfate mediates some adhesive responses to glycosaminoglycan-binding matrices, including fibronectin.

1983 • 281 citations

A variety of cerebral amyloid deposits in the brains of the Alzheimer-type dementia demonstrated by? protein immunostaining

1988 • 280 citations

Characterization of a factor that promotes neurite outgrowth: evidence linking activity to a heparan sulfate proteoglycan.

1982 • 265 citations

A unique heparan sulfate in the nuclei of hepatocytes: structural changes with the growth state of the cells.

1986 • 260 citations

Presence of T-cytotoxic suppressor and leucocyte common antigen positive cells in Alzheimer's disease brain tissue

1988 • 248 citations

Early accumulation of heparan sulfate in neurons and in the beta-amyloid protein containing lesions of Alzheimer's disease and Down's syndrome

1990 • 245 citations

Involvement of phosphatidylinositol and insulin in the coordinate regulation of proteoheparan sulfate metabolism and hepatocyte growth.

1987 • 237 citations

Textbook of neuropathology

1986 • 215 citations

Proteoglycans in the pathogenesis of Alzheimer's disease and other amyloidoses

1989 • 211 citations

Isolation of two forms of basement membrane proteoglycans.

1985 • 202 citations

Characterization of an amyloid beta precursor protein that binds heparin and contains tyrosine sulfate.

1989 • 196 citations

Membrane receptors for extracellular matrix macromolecules: relationship to cell adhesion and tumor metastasis

1987 • 184 citations

Acidic fibroblast growth factor enhances regeneration of processes by postnatal mammalian retinal ganglion cells in culture.

1988 • 181 citations

Neuronal and microglial involvement in beta-amyloid protein deposition in Alzheimer's disease.

1990 • 175 citations

Inhibition of Protease Activity Can Lead to Neurite Extension in Neuroblastoma Cells

1983 • 174 citations

Basic fibroblast growth factor in Alzheimer's disease

1990 • 173 citations

Senile plaques as aberrant sprout-stimulating structures

1986 • 161 citations

Purification and properties of human platelet heparitinase.

1982 • 154 citations

Temporal relationship between glycosaminoglycan accumulation and amyloid deposition during experimental amyloidosis. A histochemical study.

1985 • 152 citations

A monoclonal antibody against a laminin-heparan sulfate proteoglycan complex perturbs cranial neural crest migration in vivo.

1988 • 145 citations

Immunopurification and protease inhibitory properties of protease nexin-2/amyloid beta-protein precursor.

1990 • 145 citations

Protease nexin-1, an antithrombin with neurite outgrowth activity, is reduced in Alzheimer disease.

1989 • 144 citations

The Production of a Monoclonal Antibody That Blocks the Action of a Neurite Outgrowth-promoting Factor

1983 • 137 citations

Microangiopathy and the colocalization of heparan sulfate proteoglycan with amyloid in senile plaques of Alzheimer's disease

1990 • 128 citations

A Glia-Derived Nexin Promotes Neurite Outgrowth in Cultured Chick Sympathetic Neurons

1988 • 122 citations

Aggregation of the amyloid precursor protein within degenerating neurons and dystrophic neurites in alzheimer's disease

1992 • 120 citations

Induction of basic Fibroblast Growth Factor in Alzheimerʼs disease pathology

1990 • 112 citations

Amyloid β-protein precursor is associated with extracellular matrix

1990 • 106 citations

Sulfated glycosaminoglycans in Alzheimer's disease

1987 • 98 citations

CHEMICAL STUDIES ON ALZHEIMERʼS DISEASE

1965 • 96 citations

Microglia are associated with the extracellular neurofibrillary tangles of alzheimer disease

1991 • 83 citations

Laminin and heparan sulphate proteoglycan in the lesioned adult mammalian central nervous system and their possible relationship to axonal sprouting

1988 • 82 citations

Studies on Extracellular Matrix Components That Promote Neurite Outgrowth

1983 • 80 citations

Basement membrane proteoglycan in various tissues: characterization using monoclonal antibodies to the Engelbreth-Holm-Swarm mouse tumor low density heparan sulfate proteoglycan.

1988 • 79 citations

Neuronal proteoglycans: biosynthesis and functional interaction with neurons in vitro

1988 • 78 citations

Degradation of sulfated proteoglycans in the subendothelial extracellular matrix by human platelet heparitinase.

1984 • 78 citations

Glycosaminoglycans and glycoproteins associated with rat brain nuclei

1976 • 77 citations

Sulfated glycosaminoglycans modify growth factor‐induced neurite outgrowth in PC12 cells

1988 • 76 citations

Mucopolysaccharides associated with nuclei of cultured mammalian cells.

1975 • 75 citations

Effects of heparan sulfate removal on attachment and reattachment of fibroblasts and endothelial cells

1986 • 64 citations

Different configurational states of beta-amyloid and their distributions relative to plaques and tangles in Alzheimer disease.

1990 • 62 citations

Glycosaminoglycans on fibroblasts accelerate thrombin inhibition by protease nexin-1

1987 • 58 citations

Demonstration of a platelet enzyme, degrading heparan sulphate

1976 • 57 citations

Influences of anionic polysaccharides on DNA synthesis in isolated nuclei and by DNA polymerase α: Correlation of observed effects with properties of the polysaccharides

1983 • 45 citations

Reversal of heparin inhibition of nuclear protein kinase NII by polyamines and histones

1981 • 44 citations

Growth Factors and Alzheimer’s Disease

1991 • 40 citations

In vitro transcription by wheat germ ribonucleic acid polymerase II: effects of heparin and role of template integrity

1979 • 38 citations

Heparin-binding lectin from human placenta: purification and partial molecular characterization and its relationship to basic fibroblast growth factors

1989 • 38 citations

Rat liver phosphorylase kinase. Stimulation by heparin.

1981 • 29 citations

The Role of Misdirected Plasticity in Plaque Biogenesis and Alzheimer’s Disease Pathology

1991 • 27 citations

Inhibition of topoisomerase I by heparin

1982 • 24 citations

Heparan sulphate is a potent inhibitor of DNA synthesis in vitro

1981 • 14 citations

Nuclear bodies in Creutzfeldt-Jakob and Alzheimer's diseases

1975 • 11 citations

Rate Limiting Events in Neurite Outgrowth

1988 • 1 citations