Quantitative immunocytochemical analysis of the spinal cord in G86R superoxide dismutase transgenic mice: Neurochemical correlates of selective vulnerability

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

1993 • 6,762 citations

Motor Neuron Degeneration in Mice that Express a Human Cu,Zn Superoxide Dismutase Mutation

1994 • 3,959 citations

Oxidative Stress, Glutamate, and Neurodegenerative Disorders

1993 • 3,746 citations

Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator

1991 • 2,982 citations

Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures.

1991 • 2,173 citations

Calbindin D-28k and parvalbumin in the rat nervous system

1990 • 2,068 citations

Peroxynitrite-mediated tyrosine nitration catalyzed by superoxide dismutase

1992 • 1,499 citations

An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria

1995 • 1,424 citations

NMDA-dependent superoxide production and neurotoxicity

1993 • 1,188 citations

Monoclonal antibodies distinguish phosphorylated and nonphosphorylated forms of neurofilaments in situ.

1983 • 1,162 citations

New stereological methods for counting neurons

1993 • 951 citations

The slow component of axonal transport. Identification of major structural polypeptides of the axon and their generality among mammalian neurons.

1975 • 937 citations

Altered Reactivity of Superoxide Dismutase in Familial Amyotrophic Lateral Sclerosis

1996 • 718 citations

Calcium-binding proteins: selective markers of nerve cells

1993 • 699 citations

Transgenic mice expressing an altered murine superoxide dismutase gene provide an animal model of amyotrophic lateral sclerosis.

1995 • 694 citations

Pathological implications of nitric oxide, superoxide and peroxynitrite formation

1993 • 679 citations

Abnormal excitatory amino acid metabolism in amyotrophic lateral sclerosis

1990 • 630 citations

Chronic inhibition of glutamate uptake produces a model of slow neurotoxicity.

1993 • 623 citations

Atlas of the Mouse Brain and Spinal Cord

1971 • 582 citations

Increased expression of neurofilament subunit NF-L produces morphological alterations that resemble the pathology of human motor neuron disease

1993 • 550 citations

Progressive neuronopathy in transgenic mice expressing the human neurofilament heavy gene: A mouse model of amyotrophic lateral sclerosis

1993 • 549 citations

ATLAS OF THE MOUSE BRAIN AND SPINAL CORD

1972 • 537 citations

Evidence for calcium-reducing and excitoprotective roles for the calcium-binding protein calbindin-1328k in cultured hippocampal neurons

1991 • 518 citations

Two classes of cortical GABA neurons defined by differential calcium binding protein immunoreactivities

1989 • 514 citations

Monoclonal antibodies distinguish several differentially phosphorylated states of the two largest rat neurofilament subunits (NF-H and NF-M) and demonstrate their existence in the normal nervous system of adult rats

1987 • 490 citations

Calretinin in rat brain: An immunohistochemical study

1992 • 479 citations

Variants of the heavy neurofilament subunit are associated with the development of amyotrophic lateral sclerosis

1994 • 458 citations

Control of axonal caliber by neurofilament transport.

1984 • 439 citations

Transgenic mice carrying a human mutant superoxide dismutase transgene develop neuronal cytoskeletal pathology resembling human amyotrophic lateral sclerosis lesions.

1996 • 397 citations

Development of central nervous system pathology in a murine transgenic model of human amyotrophic lateral sclerosis.

1994 • 397 citations

Quantitative analysis of a vulnerable subset of pyramidal neurons in Alzheimer's disease: I. Superior frontal and inferior temporal cortex

1990 • 367 citations

Monoclonal antibody to neurofilament protein (SMI‐32) labels a subpopulation of pyramidal neurons in the human and monkey neocortex

1989 • 366 citations

Motor neuron columns in the lumbar spinal cord of the rat

1983 • 364 citations

The role of calcium‐binding proteins in selective motoneuron vulnerability in amyotrophic lateral sclerosis

1994 • 360 citations

A mutant neurofilament subunit causes massive, selective motor neuron death: Implications for the pathogenesis of human motor neuron disease

1994 • 356 citations

Calcium buffering properties of calbindin D28k and parvalbumin in rat sensory neurones.

1993 • 348 citations

Motor neuron disease.

1994 • 330 citations

Superoxide dismutase is an abundant component in cell bodies, dendrites, and axons of motor neurons and in a subset of other neurons.

1995 • 313 citations

Neurofilament protein defines regional patterns of cortical organization in the macaque monkey visual system: A quantitative immunohistochemical analysis

1995 • 269 citations

The spinothalamic system of the rat. I. Locations of cells of origin

1986 • 247 citations

The localization of the motoneurons supplying the hindlimb muscles of the mouse

1981 • 244 citations

Familial Amyotrophic Lateral Sclerosis

1967 • 235 citations

Accumulation of Phosphorylated Neurofilaments in Anterior Horn Motoneurons of Amyotrophic Lateral Sclerosis Patients

1988 • 223 citations

Serum Antibodies to L-Type Calcium Channels in Patients with Amyotrophic Lateral Sclerosis

1992 • 207 citations

Expression of neurofilament subunits in neurons of the central and peripheral nervous system: an immunohistochemical study with monoclonal antibodies

1986 • 206 citations

Phosphorylation of Neurofilaments Is Altered in Amyotrophic Lateral Sclerosis

1988 • 198 citations

Immunoelectronmicroscopical localization of the three neurofilament triplet proteins along neurofilaments of cultured dorsal root ganglion neurones

1982 • 190 citations

Stable transfection of calbindin-D28k into the GH3 cell line alters calcium currents and intracellular calcium homeostasis

1992 • 187 citations

A comparative study of the calcium-binding proteins calbindin-D28K, calretinin, calmodulin and parvalbumin in the rat spinal cord

1994 • 183 citations

Calretinin-immunoreactive neocortical interneurons are unaffected in Alzheimer's disease

1993 • 171 citations

A monoclonal antibody to non-phosphorylated neurofilament protein marks the vulnerable cortical neurons in Alzheimer's disease

1987 • 161 citations

The cells of origin of the spinothalamic tract of the rat: a quantitative reexamination

1990 • 156 citations

Calcium‐binding proteins, parvalbumin‐ and calbindin‐D 28k‐immunoreactive neurons in the rat spinal cord and dorsal root ganglia: A light and electron microscopic study

1990 • 154 citations

Cortical neurons containing calretinin are selectively resistant to calcium overload and excitotoxicity in vitro

1994 • 152 citations

Synaptic connexions made by horizontal cells within the outer plexiform layer of the retina of the cat and the rabbit

1974 • 141 citations

Motor neurons and neurofilaments in sickness and in health

1993 • 137 citations

The Neuronal Cytoskeleton

1992 • 132 citations

Evidence for autoimmunity in amyotrophic lateral sclerosis

1993 • 121 citations

Cytotoxicity of immunoglobulins from amyotrophic lateral sclerosis patients on a hybrid motoneuron cell line.

1994 • 115 citations

Estimate of the total number of neurons and glial and endothelial cells in the rat spinal cord by means of the optical disector

1993 • 96 citations

CYTOSKELETAL ABNORMALITIES IN MOTOR NEURON DISEASE

1989 • 94 citations

The neurofilament triplet is present in distinct subpopulations of neurons in the central nervous system of the guinea-pig

1992 • 91 citations

Neurofilament protein phosphorylation - where, when and why

1988 • 88 citations

Amyotrophic lateral sclerosis patient antibodies label Ca²⁺ channel α₁ subunit

1994 • 87 citations

Focal accumulation of phosphorylated neurofilaments within anterior horn cell in familial amyotrophic lateral sclerosis

1989 • 84 citations

Vulnerability to excitotoxic stimuli of cultured rat hippocampal neurons containing the calcium-binding proteins calretinin and calbindin D28K

1994 • 78 citations

Amyotrophic Lateral Sclerosis and Other Motor Neuron Diseases

1992 • 69 citations

Disease-specific patterns of neuronal loss in the spinal ventral horn in amyotrophic lateral sclerosis, multiple system atrophy and X-linked recessive bulbospinal neuronopathy, with special reference to the loss of small neurons in the intermediate zone

1994 • 58 citations

Neurofilament and glial alterations in the cerebral cortex in amyotrophic lateral sclerosis

1992 • 55 citations

Calbindin D-28k and parvalbumin immunoreactivity in the frontal cortex in patients with frontal lobe dementia of non-Alzheimer type associated with amyotrophic lateral sclerosis.

1993 • 51 citations

Neurofilament phosphorylation in axons and perikarya: Immunofluorescence study of the rat spinal cord and dorsal root ganglia with monoclonal antibodies

1988 • 45 citations

Distribution of calbindin D28k-like immunoreactivity (LI) in the monkey ventral horn: do Renshaw cells contain calbindin D28k-LI?

1992 • 43 citations

Evidence for sequential degeneration of the neurons in the intermediate zone of the spinal cord in amyotrophic lateral sclerosis: a topographic and quantitative investigation

1989 • 42 citations

The use of the optical disector to estimate the number of neurons, glial and endothelial cells in the spinal cord of the mouse — with a comparative note on the rat spinal cord

1993 • 38 citations

The role of intracellular free calcium in motor neuron disease

1994 • 37 citations

Altered glutamatergic mechanisms and selective motor neuron degeneration in amyotrophic lateral sclerosis: possible role of glycine.

1991 • 22 citations