The role of cortical connectivity in Alzheimer's disease pathogenesis: A review and model system

Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures.

1981 • 14,396 citations

The Association Between Quantitative Measures of Dementia and of Senile Change in the Cerebral Grey Matter of Elderly Subjects

1968 • 4,041 citations

Alzheimer's Disease and Senile Dementia: Loss of Neurons in the Basal Forebrain

1982 • 3,563 citations

Diagnosis of Alzheimer's Disease

1985 • 2,482 citations

Alzheimer's Disease: Cell-Specific Pathology Isolates the Hippocampal Formation

1984 • 2,199 citations

Observations on the brains of demented old people

1970 • 2,066 citations

AN ANATOMICAL STUDY OF CONVERGING SENSORY PATHWAYS WITHIN THE CEREBRAL CORTEX OF THE MONKEY

1970 • 1,701 citations

The connections of the middle temporal visual area (MT) and their relationship to a cortical hierarchy in the macaque monkey

1983 • 1,621 citations

APRIORITY

1961 • 1,293 citations

NEUROTRANSMITTER-RELATED ENZYMES AND INDICES OF HYPOXIA IN SENILE DEMENTIA AND OTHER ABIOTROPHIES

1976 • 1,272 citations

The Neocortex of Macaca mulatta

1948 • 1,187 citations

Clinical, pathological, and neurochemical changes in dementia: A subgroup with preserved mental status and numerous neocortical plaques

1988 • 1,186 citations

Cortico-cortical connections in the rhesus monkey

1969 • 1,086 citations

Laminar origins and terminations of cortical connections of the occipital lobe in the rhesus monkey

1979 • 1,061 citations

Anatomical correlates of the distribution of the pathological changes in the neocortex in Alzheimer disease.

1985 • 979 citations

Cortical connections of visual area MT in the macaque

1986 • 967 citations

Hierarchical organization and functional streams in the visual cortex

1983 • 962 citations

Paired Helical Filaments in Electron Microscopy of Alzheimer's Disease

1963 • 956 citations

Functional organization of the extrinsic and intrinsic circuitry of the parahippocampal region

1989 • 897 citations

Reduced somatostatin-like immunoreactivity in cerebral cortex from cases of Alzheimer disease and Alzheimer senile dementa

1980 • 866 citations

Functional specialisation in the visual cortex of the rhesus monkey

1978 • 851 citations

Senile dementia of the Alzheimer type

1983 • 835 citations

Some morphometric aspects of the brain in senile dementia of the alzheimer type

1981 • 803 citations

Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport.

1990 • 735 citations

共やくエクイン・エストロゲン(Premarin)服用閉経婦人の血清エクイリン,エストロン,エストラジオール値

1980 • 725 citations

Neurotransmitter enzyme abnormalities in senile dementia

1977 • 710 citations

A unifying hypothesis for the cause of amyotrophic lateral sclerosis, parkinsonism, and alzheimer disease

1981 • 698 citations

The origin of efferent pathways from the primary visual cortex, area 17, of the macaque monkey as shown by retrograde transport of horseradish peroxidase

1975 • 684 citations

Loss of neurons of origin of the adrenergic projection to cerebral cortex (nucleus locus ceruleus) in senile dementia

1982 • 677 citations

Perforant pathway changes and the memory impairment of Alzheimer's disease

1986 • 665 citations

Observations on the brains of non-demented old people

1968 • 656 citations

The parahippocampal gyrus: New observations regarding its cortical connections in the monkey

1982 • 628 citations

Neuronal loss, neurofibrillary tangles and granulovacuolar degeneration in the hippocampus with ageing and dementia

1977 • 628 citations

Plaques, tangles and dementia

1982 • 603 citations

Architecture and Connections of Cortical Association Areas

1985 • 583 citations

Laminar and regional distributions of neurofibrillary tangles and neuritic plaques in Alzheimer's disease: a quantitative study of visual and auditory cortices

1987 • 569 citations

Regional pattern of degeneration in Alzheimer's disease: neuronal loss and histopathological grading

1981 • 567 citations

Alzheimer's disease

1982 • 538 citations

Size, laminar and columnar distribution of efferent cells in the sensory‐motor cortex of monkeys

1977 • 497 citations

The colour centre in the cerebral cortex of man

1989 • 446 citations

Cell loss in the locus coeruleus in senile dementia of Alzheimer type

1981 • 443 citations

Reduced amounts of immunoreactive somatostatin in the temporal cortex in senile dementia of Alzheimer type

1980 • 434 citations

Further observations on corticofrontal connections in the rhesus monkey

1976 • 424 citations

A NEW DEFINITION OF ALZHEIMER'S DISEASE: A HIPPOCAMPAL DEMENTIA

1985 • 422 citations

Morphology, distribution, and synaptic relations of somatostatin- and neuropeptide Y-immunoreactive neurons in rat and monkey neocortex

1984 • 415 citations

Quantitative morphology and regional and laminar distributions of senile plaques in Alzheimer's disease

1985 • 414 citations

The Hippocampal Formation of the Primate Brain

1987 • 413 citations

Neuronal loss in different parts of the nucleus basalis is related to neuritic plaque formation in cortical target areas in alzheimer's disease

1985 • 407 citations

Alzheimer's Disease: Insolubility of Partially Purified Paired Helical Filaments in Sodium Dodecyl Sulfate and Urea

1982 • 398 citations

Some connections of the entorhinal (area 28) and perirhinal (area 35) cortices of the rhesus monkey. III. Efferent connections

1975 • 379 citations

The intrinsic architectonic and connectional organization of the superior temporal region of the rhesus monkey

1983 • 374 citations

Quantitative analysis of a vulnerable subset of pyramidal neurons in Alzheimer's disease: I. Superior frontal and inferior temporal cortex

1990 • 367 citations

Neurofibrillary tangles of paired helical filaments

1976 • 366 citations

Alterations in L-Glutamate Binding in Alzheimer's and Huntington's Diseases

1985 • 334 citations

Nucleus raphe dorsalis in Alzheimer's disease: Neurofibrillary tangles and loss of large neurons

1985 • 332 citations

The projections from striate cortex (V1) to areas V2 and V3 in the macaque monkey: Asymmetries, areal boundaries, and patchy connections

1986 • 325 citations

The distribution of tyrosine hydroxylase-immunoreactive fibers in primate neocortex is widespread but regionally specific

1987 • 319 citations

Longitudinal Study of Cerebral Metabolic Asymmetries and Associated Neuropsychological Patterns in Early Dementia of the Alzheimer Type

1990 • 305 citations

Quantitative analysis of a vulnerable subset of pyramidal neurons in Alzheimer's disease: II. Primary and secondary visual cortex

1990 • 302 citations

Distribution of Alzheimer's neurofibrillary changes in the brain stem and hypothalamus of senile dementia

1966 • 299 citations

A double-labeling investigation of the afferent connectivity to cortical areas V1 and V2 of the macaque monkey

1985 • 278 citations

The incidence of cerebral amyloid angiopathy in Alzheimer's disease

1975 • 276 citations

Cortical somatostatin-like immunoreactivity in cases of Alzheimer's disease and senile Dementia of the Alzheimer type

1981 • 274 citations

Senile Dementia of the Alzheimer Type Without Neocortical Neurofibrillary Tangles

1987 • 269 citations

Pattern in the laminar origin of corticocortical connections

1986 • 269 citations

Subcortical projections, cortical associations, and some intrinsic interlaminar connections of the striate cortex in the squirrel monkey (Saimiri)

1970 • 269 citations

The cells of origin of the corpus callosum in rat, cat and rhesus monkey

1974 • 267 citations

Loss of pigmented dopamine-β-hydroxylase positive cells from locus coeruleus in senile dementia of alzheimer's type

1983 • 267 citations

Reduced dopamine-beta-hydroxylase activity in Alzheimer's disease

1981 • 266 citations

Somatostatin immunoreactivity in neuritic plaques of Alzheimer's patients

1985 • 263 citations

Survival of Outpatients with Alzheimer-type Dementia

1990 • 261 citations

Topographic distribution of neurofibrillary tangles and granulovacuolar degeneration in hippocampal cortex of aging and demented patients. A quantitative study

1978 • 252 citations

Cholinergic Innervation in Neuritic Plaques

1982 • 249 citations

Cortical projections from two prestriate areas in the monkey

1971 • 242 citations

Axonal and transneuronal transport in the transmission of neurological disease: Potential role in system degenerations, including alzheimer's disease

1987 • 231 citations

Cortico‐cortical connections of somatic sensory cortex (areas 3, 1 and 2) in the rhesus monkey

1978 • 227 citations

Alzheimer's disease: Glutamate depletion in the hippocampal perforant pathway zone

1987 • 221 citations

Intrinsic connections of the retrohippocampal region in the rat brain: III. The lateral entorhinal area

1988 • 220 citations

Cortical somatostatin, neuropeptide Y, and NADPH diaphorase neurons: Normal anatomy and alterations in alzheimer's disease

1988 • 219 citations

Aspartate and glutamate as possible neurotransmitters in the visual cortex

1981 • 217 citations

Location of neuronal tangles in somatostatin neurones in Alzheimer's disease

1985 • 214 citations

Neuropeptides in Alzheimer type dementia

1983 • 214 citations

Noradrenergic and serotonergic fibers innervate complementary layers in monkey primary visual cortex: an immunohistochemical study.

1982 • 209 citations

Areal and laminar distribution of neurons interconnecting the central visual cortical areas 17, 18, 19, and MT in squirrel monkey (Saimiri)

1981 • 209 citations

Comparison of the efferents of the amygdala and the hippocampal formation in the rhesus monkey: II. Reciprocal and non‐reciprocal connections

1988 • 206 citations

Progress in Neuropathology

1972 • 203 citations

Alzheimer's disease: Neurofibrillary tangles in nuclei that project to the cerebral cortex

1987 • 199 citations

GLUCOSE METABOLISM AND ACETYLCHOLINE SYNTHESIS IN RELATION TO NEURONAL ACTIVITY IN ALZHEIMER'S DISEASE

1980 • 196 citations

Evidence for high affinity choline transport in synaptosomes prepared from hippocampus and neocortex of patients with Alzheimer's disease

1983 • 194 citations

An integrative hypothesis concerning the pathogenesis and progression of Alzheimer's disease

1986 • 192 citations

Possible neurotransmitter basis of behavioral changes in alzheimer's disease

1988 • 190 citations

Projections to the superior temporal sulcus from the central and peripheral field representations of V1 and V2

1986 • 188 citations

NON-CHOLINERGIC NEUROTRANSMITTER ABNORMALITIES IN ALZHEIMER'S DISEASE

1986 • 188 citations

A comparison of the efferents of the amygdala and the hippocampal formation in the rhesus monkey: I. Convergence in the entorhinal, prorhinal, and perirhinal cortices

1988 • 181 citations

The Biological Substrates of Alzheimerʼs Disease

1987 • 180 citations

Laminar, tangential and regional organization of the noradrenergic innervation of monkey cortex: Dopamine-β-hydroxylase immunohistochemistry

1982 • 179 citations

Retinotopic patterns of connections of area 17 with visual areas V‐II and MT in macaque monkeys

1983 • 174 citations

Anatomical organization of primate visual cortex area VII

1981 • 174 citations

Balit's syndrome in Alzheimer's disease: specific disruption of the occipito-parietal visual pathway

1989 • 174 citations

Organization of corticocortical connections in human visual cortex.

1989 • 167 citations

Topography of the afferent connectivity of area 17 in the macaque monkey: A double‐labelling study

1986 • 163 citations

Neuropeptides in neurological disease

1986 • 162 citations

Neuronal pathology in the nucleus basalis and associated cell groups in senile dementia of the Alzheimer's type

1985 • 157 citations

Circumscribed changes of the cerebral cortex in neuropsychiatric disorders of later life.

1989 • 148 citations

II. Cortical neurons immunoreactive with antisera against neuropeptide Y are altered in Alzheimer's‐type dementia

1985 • 146 citations

Non-hippocampal cortical projections from the entorhinal cortex in the rat and rhesus monkey

1982 • 146 citations

Cortical Substance P‐Like Immunoreactivity in Cases of Alzheimer's Disease and Senile Dementia of the Alzheimer Type

1982 • 141 citations

Clinical Neurology of Aging

1985 • 141 citations

Evidence for Cholinergic Neurites in Senile Plaques

1984 • 140 citations

RECENT ADVANCES IN NEUROPATHOLOGY

1986 • 133 citations

Correlation between senile plaque and neurofibrillary tangle counts in cerebral cortex and neuronal counts in cortex and subcortical structures in Alzheimer's disease

1985 • 127 citations

Age-related changes in the density and morphology of plaques and neurofibrillary tangles in Down syndrome brain

1989 • 125 citations

Retrograde cell degeneration in the basal nucleus in monkey and man

1983 • 125 citations

Cortical Sensory Organization

1982 • 118 citations

Excitatory amino acid-releasing and cholinergic neurones in Alzheimer's disease

1986 • 118 citations

Hippocampal Neurons Predisposed to Neurofibrillary Tangle Formation Are Enriched in Type II Calcium/Calmodulin-Dependent Protein Kinase

1990 • 112 citations

Acetylcholine and choline levels in post-mortem human brain tissue: Preliminary observations in Alzheimer's disease

1980 • 104 citations

Elevation of neuropeptide Y (NPY) in substantia innominata in Alzheimer's type dementia

1984 • 101 citations

Distribution of precursor amyloid-beta-protein messenger RNA in human cerebral cortex: relationship to neurofibrillary tangles and neuritic plaques.

1988 • 101 citations

Intralaminar Neurochemical Distributions in Human Midtemporal Cortex: Comparison Between Alzheimer's Disease and the Normal

1984 • 91 citations

NEUROFIBRILLARY TANGLES AND THE PATHOGENESIS OF DEMENTIA: A QUANTITATIVE STUDY

1976 • 90 citations

Somatostatin-like immunoreactivity within neuritic plaques

1985 • 86 citations

A direct demonstration of the perforant pathway terminal zone in Alzheimer's disease using the monoclonal antibody Alz-50

1988 • 84 citations

Glutamate in cortical fibers.

1981 • 83 citations

The Lesser Bushbaby (Galago) as an Animal Model: Selected Topics

2019 • 83 citations

Catecholaminergic neurites in senile plaques in prefrontal cortex of aged nonhuman primates

1985 • 81 citations

Somatostatin- and Neuropeptide Y-immunoreactive neurons in the neocortex in senile dementia of alzheimer's type

1986 • 78 citations

Decreased somatostatin immunoreactivity but not neuropeptide Y immunoreactivity in cerebral cortex in senile dementia of Alzheimer type

1986 • 76 citations

Postnatal development of laminar innervation patterns by monoaminergic fibers in monkey (Macaca fascicularis) primary visual cortex

1984 • 72 citations

Cortical projections of the dorsolateral visual area in owl monkeys: The prestriate relay to inferior temporal cortex

1985 • 70 citations

A DESCRIPTIVE STUDY OF NEURITIC PLAQUES AND NEUROFIBRILLARY TANGLES IN AN AUTOPSY POPULATION

1984 • 70 citations

Subpopulations of somatostatin 28-immunoreactive neurons display different vulnerability in senile dementia of the Alzheimer type

1989 • 67 citations

Neural Systems of the Non‐human Primate Forebrain Implicated in Memory^a

1985 • 61 citations

Neuropeptide Y-like immunoreactivity in neuritic plaques of Alzheimer's disease

1985 • 58 citations

Cortical projections of area 18 in owl monkeys

1977 • 56 citations

Localization and quantitation of 68 kDa neurofilament and superoxide dismutase-1 mRNA in alzheimer brains

1991 • 54 citations

Chapter 20 Cell-specific pathology in neural systems of the temporal lobe in Alzheimer's disease

1986 • 53 citations

Cortical and Subcortical Connections of Visual Cortex in Primates

1981 • 50 citations

The hypothalamic-pituitary-adrenal axis: Physiology, pathophysiology, and psychiatric implications

1988 • 49 citations

Abnormalities in Corticotropin-releasing Hormone (CRH) in Alzheimer's Disease and Other Human Disorders

1987 • 49 citations

Neuropeptides and neuropathology in the amygdala in Alzheimer's disease: relationship between somatostatin, neuropeptide Y and subregional distribution of neuritic plaques

1988 • 48 citations

Alzheimer's Disease

1989 • 47 citations

Selective involvement of large neurons in the neostriatum of Alzheimer's disease and senile dementia: a morphometric investigation

1987 • 45 citations

Substance P immunoreactivity within neuritic plaques

1985 • 42 citations

Anterograde transsynaptic transport of WGA-HRP in the limbic system of rat and monkey

1986 • 35 citations

Quantitative changes in some subcortical nuclei in aging, Alzheimer's disease and Parkinson's disease

1987 • 35 citations

Reduction of neurotensin immunoreactivity in the amygdala in Alzheimer's disease

1990 • 31 citations

The distribution of somatostatin-immunoreactive neurons and fibers in the rat cerebral cortex: light and electron microscopic studies

1987 • 30 citations

Senile plaques are concentrated in the subicular region of the hippocampal formation in Alzheimer's disease

1988 • 27 citations

Pathogenesis of Alzheimer's Disease — Beyond the Cholinergic Hypothesis: Discussion Paper

1986 • 20 citations

Peptides in the neocortex in Alzheimer's disease and ageing

1990 • 14 citations

VISUAL MECHANISMS IN THE TEMPORAL AND PRESTRIATE ASSOCIATION CORTICES OF THE MONKEY

1981 • 11 citations

Thermal Injuries and Formation of Mucopolysaccharides in the Skin

1963 • 6 citations

Advancing frontiers in Alzheimer's disease research

1988 • 4 citations

A quantitative study of the cerebral cortex in Alzheimer's disease and senile dementia using an automatic image analyzing system.

1986 • 4 citations

Understanding the memory loss of Alzheimer's disease

1986 • 2 citations