Tau in Alzheimer's disease and Down's syndrome is insoluble and abnormally phosphorylated

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

2013 • 47,043 citations

Clinical diagnosis of Alzheimer's disease

1984 • 27,279 citations

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology.

1986 • 3,430 citations

A protein factor essential for microtubule assembly.

1975 • 2,863 citations

The distribution of tau in the mammalian central nervous system.

1985 • 1,518 citations

Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease.

1986 • 1,387 citations

Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease.

1988 • 920 citations

Physical and chemical properties of purified tau factor and the role of tau in microtubule assembly

1977 • 834 citations

Accumulation of abnormally phosphorylated τ precedes the formation of neurofibrillary tangles in Alzheimer's disease

1989 • 783 citations

Neurofibrillary tangles of Alzheimer disease share antigenic determinants with the axonal microtubule-associated protein tau (tau)

1986 • 729 citations

A preparation of Alzheimer paired helical filaments that displays distinct tau proteins by polyacrylamide gel electrophoresis.

1990 • 715 citations

DEFECTIVE BRAIN MICROTUBULE ASSEMBLY IN ALZHEIMER'S DISEASE

1986 • 704 citations

A Neuronal Antigen in the Brains of Alzheimer Patients

1986 • 577 citations

Phosphorylated Tau Protein Is Integrated into Paired Helical Filaments in Alzheimer's Disease1

1986 • 504 citations

Epitopes that span the tau molecule are shared with paired helical filaments

1988 • 494 citations

Phosphorylation determines two distinct species of tau in the central nervous system

1987 • 405 citations

Alzheimer's disease: Tau proteins, the promoting factors of microtubule assembly, are major components of paired helical filaments

1986 • 310 citations

Phosphorylation of tau proteins to a state like that in Alzheimer's brain is catalyzed by a calcium/calmodulin-dependent kinase and modulated by phospholipids.

1987 • 264 citations

Subunit structure of paired helical filaments in Alzheimer's disease.

1985 • 224 citations

Senile Dementia of the Alzheimer Type

1985 • 178 citations

Tau in Alzheimer neurofibrillary tangles. N- and C-terminal regions are differentially associated with paired helical filaments and the location of a putative abnormal phosphorylation site

1991 • 160 citations

ALZHEIMER'S DISEASE: PAIRED HELICAL FILAMENTS AND CYTOMEMBRANES

1987 • 158 citations

Alzheimer disease proteins (A68) share epitopes with tau but show distinct biochemical properties

1990 • 115 citations

Characterization of two pathological Tau protein variants in Alzheimer brain cortices

1989 • 100 citations

Phosphorylation of Tau proteins: a major event during the process of neurofibrillary degeneration. A comparative study between Alzheimer's disease and Down's syndrome

1990 • 83 citations

Spongiform alterations in brain biopsies of presenile dementia

1979 • 74 citations

Abnormal tau species are produced during Alzheimer's disease neurodegenerating process

1989 • 67 citations

A distinct form of tau is selectively incorporated into Alzheimer's paired helical filaments

1989 • 50 citations

[Direct demonstration of abnormal phosphorylation of Tau microtubular proteins in Alzheimer's disease].

1989 • 15 citations

Polypeptide Composition of Paired Helical Filaments

1989 • 9 citations

The Reinterpretation of the Immunochemical Study of Alzheimer Neurofibrillary Tangles

1989 • 8 citations

[Alzheimer's disease: study of the distribution of tau proteins constituting helical filament pairs in human central nervous tissue].

1988 • 8 citations