Amyloid A4 Protein and Its Precursor in Down's Syndrome and Alzheimer's Disease

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

1984 • 5,166 citations

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

1987 • 4,544 citations

Amyloid plaque core protein in Alzheimer disease and Down syndrome.

1985 • 4,276 citations

Alzheimer's disease and Down's syndrome: Sharing of a unique cerebrovascular amyloid fibril protein

1984 • 1,633 citations

Amyloid β Protein Gene: cDNA, mRNA Distribution, and Genetic Linkage Near the Alzheimer Locus

1987 • 1,589 citations

Growth hormone receptor and serum binding protein: purification, cloning and expression

1987 • 1,540 citations

A cellular gene encodes scrapie PrP 27-30 protein

1985 • 1,494 citations

Structure and transcription of human papillomavirus sequences in cervical carcinoma cells

1985 • 1,481 citations

Characterization and Chromosomal Localization of a cDNA Encoding Brain Amyloid of Alzheimer's Disease

1987 • 1,316 citations

Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein

1989 • 1,237 citations

Enzymatic iodination of polypeptides with 125I to high specific activity

1971 • 1,170 citations

The Genetic Defect Causing Familial Alzheimer's Disease Maps on Chromosome 21

1987 • 1,149 citations

Occurrence of neuropathological changes and dementia of Alzheimer's disease in Down's syndrome

1985 • 1,125 citations

Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease

1988 • 1,098 citations

Novel precursor of Alzheimer's disease amyloid protein shows protease inhibitory activity

1988 • 1,093 citations

A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors

1988 • 1,052 citations

Neuronal origin of a cerebral amyloid: neurofibrillary tangles of Alzheimer's disease contain the same protein as the amyloid of plaque cores and blood vessels.

1985 • 1,025 citations

Presence and expression of human papillomavirus sequences in human cervical carcinoma cell lines.

1985 • 600 citations

Molecular cloning and characterization of a cDNA encoding the cerebrovascular and the neuritic plaque amyloid peptides.

1987 • 589 citations

Distinct prion proteins in short and long scrapie incubation period mice

1987 • 482 citations

Formic acid pretreatment enhances immunostaining of cerebral and systemic amyloids.

1987 • 469 citations

Alzheimer's disease amyloidogenic glycoprotein: expression pattern in rat brain suggests a role in cell contact.

1988 • 444 citations

Scrapie prion proteins are synthesized in neurons.

1986 • 422 citations

Linkage of prion protein and scrapie incubation time genes

1986 • 405 citations

Identification, transmembrane orientation and biogenesis of the amyloid A4 precursor of Alzheimer's disease.

1988 • 392 citations

A4 amyloid protein deposition and the diagnosis of Alzheimer's disease

1988 • 367 citations

Localization of Amyloid β Protein Messenger RNA in Brains from Patients with Alzheimer's Disease

1987 • 297 citations

Failure of familial Alzheimer's disease to segregate with the A4-amyloid gene in several European families

1987 • 275 citations

The genetic defect in familial Alzheimer's disease is not tightly linked to the amyloid β-protein gene

1987 • 271 citations

THE FAMILIAL OCCURRENCE OF CREUTZFELDT-JAKOB DISEASE AND ALZHEIMER'S DISEASE

1981 • 233 citations

Scrapie PrP 27-30 is a sialoglycoprotein

1985 • 231 citations

Neuronal localization of amyloid beta protein precursor mRNA in normal human brain and in Alzheimer's disease.

1987 • 222 citations

β Amyloid Gene Duplication in Alzheimer's Disease and Karyotypically Normal Down Syndrome

1987 • 187 citations

A generalized computer program for the treatment of data from competitive protein-binding assays including radioimmunoassays.

1972 • 187 citations

In situ hybridization of nucleus basalis neurons shows increased beta-amyloid mRNA in Alzheimer disease.

1988 • 186 citations

Neuritic Plaque Amyloid in Alzheimer's Disease Is Highly Racemized

1988 • 180 citations

Differential regulation of amyloid-beta-protein mRNA expression within hippocampal neuronal subpopulations in Alzheimer disease.

1988 • 176 citations

Gene Dosage of the Amyloid β Precursor Protein in Alzheimer's Disease

1987 • 173 citations

Absence of Duplication of Chromosome 21 Genes in Familial and Sporadic Alzheimer's Disease

1987 • 142 citations

The Amyloid β Protein Gene Is Not Duplicated in Brains from Patients with Alzheimer's Disease

1987 • 139 citations

Physical State and Biological Activity of Human Papillomavirus Genomes in Precancerous Lesions of the Female Genital Tract

1988 • 111 citations

Distribution of precursor amyloid-beta-protein messenger RNA in human cerebral cortex: relationship to neurofibrillary tangles and neuritic plaques.

1988 • 101 citations

Transferrin receptors in rat plasma.

1988 • 101 citations

Down's Syndrome, Aging, and Alzheimer's Disease: A Clinical Review*

1982 • 96 citations

Genital Human Papillomavirus Infection

1987 • 95 citations

Localization of the putative precursor of Alzheimer's disease-specific amyloid at nuclear envelopes of adult human muscle.

1988 • 76 citations

The Neurobiology of Down syndrome

1986 • 68 citations

Down syndrome with duplication of a region of chromosome 21 containing the CuZn superoxide dismutase gene without detectable karyotypic abnormality

1987 • 57 citations

Detection of human papillomavirus deoxyribonucleic acid in exfoliated cervicovaginal cells as a predictor of cervical neoplasia in a high-risk population

1988 • 54 citations

The beta amyloid protein (AD-AP) cDNA hybridizes in normal and Alzheimer individuals near the interface of 21q21 and q22.1.

1987 • 29 citations

High molecular weight Alzheimer's disease amyloid peptide immunoreactivity in human serum and CSF is an immunoglobulin G

1987 • 27 citations

Parathyroid Hormone Radioimmunoassay: The Clinical Evaluation of Assays Using Commercially Available Reagents

1985 • 11 citations