Sequestration of tau by granulovacuolar degeneration in Alzheimer's disease.

Clinical diagnosis of Alzheimer's disease

1984 • 27,279 citations

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology.

1986 • 3,430 citations

Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease

1989 • 2,308 citations

Progressive Supranuclear Palsy

1964 • 1,864 citations

Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease.

1986 • 1,387 citations

Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau.

1988 • 1,073 citations

Cloning and sequencing of the cDNA encoding an isoform of microtubule-associated protein tau containing four tandem repeats: differential expression of tau protein mRNAs in human brain.

1989 • 989 citations

Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease.

1988 • 920 citations

Ubiquitin Is a Component of Paired Helical Filaments in Alzheimer's Disease

1987 • 834 citations

Neurofibrillary tangles of Alzheimer disease share antigenic determinants with the axonal microtubule-associated protein tau (tau)

1986 • 729 citations

Neuronal loss, neurofibrillary tangles and granulovacuolar degeneration in the hippocampus with ageing and dementia

1977 • 628 citations

Ubiquitin is detected in neurofibrillary tangles and senile plaque neurites of Alzheimer disease brains.

1987 • 606 citations

A Neuronal Antigen in the Brains of Alzheimer Patients

1986 • 577 citations

Structural characterization of the core of the paired helical filament of Alzheimer disease.

1988 • 566 citations

Epitopes that span the tau molecule are shared with paired helical filaments

1988 • 494 citations

PARKINSONISM-DEMENTIA COMPLEX, AN ENDEMIC DISEASE ON THE ISLAND OF GUAM

1961 • 412 citations

One of the Antigenic Determinants of Paired Helical Filaments Is Related to Tau Protein1

1986 • 336 citations

Alzheimer's disease: Tau proteins, the promoting factors of microtubule assembly, are major components of paired helical filaments

1986 • 310 citations

The fine structure of some intraganglionic alterations. Neurofibrillary tangles, granulovacuolar bodies and "rod-like" structures as seen in Guam amyotrophic lateral sclerosis and parkinsonism-dementia complex.

1968 • 298 citations

PARKINSONISM-DEMENTIA COMPLEX, AN ENDEMIC DISEASE ON THE ISLAND OF GUAM

1961 • 244 citations

Microtubule-associated protein 2: monoclonal antibodies demonstrate the selective incorporation of certain epitopes into Alzheimer neurofibrillary tangles.

1984 • 227 citations

Subunit structure of paired helical filaments in Alzheimer's disease.

1985 • 224 citations

Paired helical filaments from Alzheimer disease patients contain cytoskeletal components.

1985 • 220 citations

Difference between the tau protein of Alzheimer paired helical filament core and normal tau revealed by epitope analysis of monoclonal antibodies 423 and 7.51.

1991 • 214 citations

Ubiquitin is associated with abnormal cytoplasmic filaments characteristic of neurodegenerative diseases.

1988 • 201 citations

Granulovacuolar degeneration of hippocampal pyramidal cells

1972 • 125 citations

Molecular analysis of neurofibrillary degeneration in Alzheimer's disease. An immunohistochemical study.

1990 • 119 citations

GRANULOVACUOLAR DEGENERATION IN THE AGEING BRAIN AND IN DEMENTIA

1977 • 107 citations

Alzheimer neurofibrillary tangles: Monoclonal antibodies to inherent antigen(s)

1984 • 106 citations

Neurofibrillary Changes in Human Brain

1983 • 103 citations

Tau Epitopes are Incorporated into a Range of Lesions in Alzheimerʼs Disease

1987 • 97 citations

Ubiquitin-protein conjugates in Alzheimer's lesions

1987 • 97 citations

Neurofibrillary tangles in senile dementia of the Alzheimer type share an antigenic determinant with intermediate filaments of the vimentin class.

1983 • 85 citations

A monoclonal antibody that recognizes a phosphorylated epitope in Alzheimer neurofibrillary tangles, neurofilaments and tau proteins immunostains granulovacuolar degeneration

1987 • 78 citations

Measurement of distinct immunochemical presentations of tau protein in Alzheimer disease.

1991 • 72 citations

Immunochemical Properties of Ubiquitin Conjugates in the Paired Helical Filaments of Alzheimer Disease

1989 • 68 citations

TOPOGRAPHY OF NEUROFIBRILLARY TANGLES AND GRANULOVACUOLES IN HIPPOCAMPI OF PATIENTS WITH DOWN'S SYNDROME: QUANTITATIVE COMPARISON WITH NORMAL AGEING AND ALZHEIMER'S DISEASE

1981 • 62 citations

Ubiquitin and microtubule-associated protein tau immunoreactivity each define distinct structures with differing distributions and solubility properties in Alzheimer brain.

1988 • 58 citations

Neurofibrillary changes, granulovacuolar bodies and argentophilic globules observed in tuberous sclerosis

1968 • 54 citations

Sequestration of Tubulin in Neurons in Alzheimer's disease

1986 • 53 citations

Immunochemical demonstration of tropomyosin in the neurofibrillary pathology of Alzheimer's disease.

1990 • 47 citations

Two Monoclonal Antibodies Recognize Alzheimer's Neurofibrillary Tangles, Neurofilament, and Microtubule‐Associated Proteins

1987 • 45 citations

Characterisation of the first monoclonal antibody against the pronase resistant core of the Alzheimer PHF.

1989 • 44 citations

Immunohistological study of granulovacuolar degeneration using monoclonal antibodies to neurofilaments.

1985 • 41 citations

Immunoaffinity demonstration that paired helical filaments of Alzheimer disease share epitopes with neurofilaments, MAP2 and tau

1989 • 30 citations

Cell biology of the Alzheimer tangle

1989 • 26 citations