AD2, a phosphorylation-dependent monoclonal antibody directed against tau proteins found in Alzheimer's disease

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease

1989 • 2,308 citations

Microtubule-associated protein tau. A component of Alzheimer paired helical filaments.

1986 • 1,709 citations

The distribution of tau in the mammalian central nervous system.

1985 • 1,518 citations

A68: a Major Subunit of Paired Helical Filaments and Derivatized Forms of Normal Tau

1991 • 1,397 citations

Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease.

1986 • 1,387 citations

Tau proteins of alzheimer paired helical filaments: Abnormal phosphorylation of all six brain isoforms

1992 • 1,058 citations

Paired Helical Filaments in Electron Microscopy of Alzheimer's Disease

1963 • 956 citations

Abnormal tau phosphorylation at Ser396 in alzheimer's disease recapitulates development and contributes to reduced microtubule binding

1993 • 856 citations

Expression of separate isoforms of human tau protein: correlation with the tau pattern in brain and effects on tubulin polymerization.

1990 • 849 citations

A preparation of Alzheimer paired helical filaments that displays distinct tau proteins by polyacrylamide gel electrophoresis.

1990 • 715 citations

Glycogen synthase kinase-3 induces Alzheimer's disease-like phosphorylation of tau: Generation of paired helical filament epitopes and neuronal localisation of the kinase

1992 • 709 citations

Mitogen activated protein (MAP) kinase transforms tau protein into an Alzheimer-like state.

1992 • 563 citations

Biopsy-derived adult human brain tau is phosphorylated at many of the same sites as Alzheimer's disease paired helical filament tau

1994 • 561 citations

Monoclonal antibody AT8 recognises tau protein phosphorylated at both serine 202 and threonine 205

1995 • 551 citations

Proline-directed and Non-proline-directed Phosphorylation of PHF-tau

1995 • 549 citations

Hydrofluoric acid-treated tau PHF proteins display the same biochemical properties as normal tau.

1992 • 509 citations

Phosphorylated Tau Protein Is Integrated into Paired Helical Filaments in Alzheimer's Disease1

1986 • 504 citations

Abnormal Alzheimer‐like phosphorylation of tau‐protein by cyclin‐dependent kinases cdk2 and cdk5

1993 • 470 citations

The switch of tau protein to an Alzheimer-like state includes the phosphorylation of two serine-proline motifs upstream of the microtubule binding region.

1992 • 468 citations

Monoclonal antibody PHF‐1 recognizes tau protein phosphorylated at serine residues 396 and 404

1994 • 451 citations

The abnormal phosphorylation of tau protein at Ser-202 in Alzheimer disease recapitulates phosphorylation during development.

1993 • 439 citations

Protein sequence and mass spectrometric analyses of tau in the Alzheimer's disease brain.

1992 • 415 citations

Epitope mapping of monoclonal antibodies to the paired helical filaments of Alzheimer's disease: identification of phosphorylation sites in tau protein

1994 • 349 citations

Detection of Phosphorylated Ser262 in Fetal Tau, Adult Tau, and Paired Helical Filament Tau

1995 • 345 citations

Aberrant neurofilament phosphorylation in Alzheimer disease.

1985 • 339 citations

Monoclonal antibodies with selective specificity for Alzheimer Tau are directed against phosphatase-sensitive epitopes

1992 • 334 citations

Alzheimer's disease : basic mechanisms, diagnosis and therapeutic strategies

1991 • 327 citations

Alzheimer's disease: Tau proteins, the promoting factors of microtubule assembly, are major components of paired helical filaments

1986 • 310 citations

In vivo phosphorylation sites in fetal and adult rat tau.

1993 • 233 citations

Specific Pathological Tau Protein Variants Characterize Pickʼs Disease

1996 • 218 citations

Fetal‐Type Phosphorylation of the τ in Paired Helical Filaments

1992 • 217 citations

The Alzheimer‐like phosphorylation of tau protein reduces microtubule binding and involves Ser‐Pro and Thr‐Pro motifs

1992 • 210 citations

Mise en évidence immunologique de la protéine tau au niveau des lésions de dégénérescence neurofibrillaire de la maladie d'Alzheimer

1985 • 163 citations

Proline-directed phosphorylation of human Tau protein.

1992 • 162 citations

Phosphorylation-dependent epitopes of neurofilament antibodies on tau protein and relationship with Alzheimer tau.

1992 • 157 citations

Assembly of Alzheimer‐like filaments from full‐length tau protein

1994 • 154 citations

Alzheimer's neurofibrillary tangles contain unique epitopes and epitopes in common with the heat-stable microtubule associated proteins tau and MAP2.

1987 • 147 citations

The phosphorylation state of tau in the developing rat brain is regulated by phosphoprotein phosphatases.

1994 • 138 citations

Alterations in neurofilament protein immunoreactivity in human hippocampal neurons related to normal aging and Alzheimer's disease

1994 • 133 citations

Neurofibrillary degeneration in amyotrophic lateral sclerosis/parkinsonism-dementia complex of Guam. Immunochemical characterization of tau proteins.

1995 • 124 citations

Pathological proteins Tau 64 and 69 are specifically expressed in the somatodendritic domain of the degenerating cortical neurons during Alzheimer's disease

1990 • 122 citations

Alzheimer disease proteins (A68) share epitopes with tau but show distinct biochemical properties

1990 • 115 citations

Characterization of Two Distinct Monoclonal Antibodies to Paired Helical Filaments: Further Evidence for Fetal‐Type Phosphorylation of the τ in Paired Helical Filaments

1993 • 104 citations

Characterization of two pathological Tau protein variants in Alzheimer brain cortices

1989 • 100 citations

Detection of a Cdc2-related kinase associated with Alzheimer paired helical filaments.

1995 • 76 citations

τ Phosphorylation in Human, Primate, and Rat Brain: Evidence that a Pool of τ Is Highly Phosphorylated In Vivo and Is Rapidly Dephosphorylated In Vitro

1994 • 71 citations

Mapping of neurofibrillary degeneration in Alzheimer's disease: evaluation of heterogeneity using the quantification of abnormal tau proteins

1992 • 50 citations

Production and Characterization of Monoclonal Antibodies Against Human Thyroglobulin

1985 • 50 citations

Phosphorylated Tau Epitope of Alzheimer's Disease Is Coupled to Axon Development in the Avian Central Nervous System

1993 • 48 citations

Presence of abnormally phosphorylated Tau proteins in the entorhinal cortex of aged non-demented subjects

1992 • 42 citations

Dementia in the Oldest-Old:Quantitative Analysis of 12 Cases from a Psychiatric Hospital

1994 • 24 citations

Mechanism-based fragmentation of coenzyme A transferase. Comparison of alpha 2-macroglobulin and coenzyme A transferase thiol ester reactions.

1986 • 20 citations

[Demonstration of a specific profile of pathological Tau proteins in frontotemporal dementia cases].

1995 • 13 citations

Immunogold labelling of paired helical filaments and amyloid fibrils by specific monoclonal and polyclonal antibodies

1995 • 12 citations

New immunoassay for the mapping of neurofibrillary degeneration in Alzheimer's disease using two monoclonal antibodies against human paired helical filament tau proteins

1995 • 11 citations