E2Fs and the Retinoblastoma Protein Family

The retinoblastoma protein and cell cycle control

1995 • 4,873 citations

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1992 • 4,648 citations

The Human Papilloma Virus-16 E7 Oncoprotein Is Able to Bind to the Retinoblastoma Gene Product

1989 • 3,036 citations

A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma

1986 • 2,968 citations

p53: puzzle and paradigm.

1996 • 2,363 citations

G ₁ Events and Regulation of Cell Proliferation

1989 • 2,203 citations

Amplification of a gene encoding a p53-associated protein in human sarcomas

1992 • 1,959 citations

Expression of recessive alleles by chromosomal mechanisms in retinoblastoma

1983 • 1,952 citations

Effects of an Rb mutation in the mouse

1992 • 1,779 citations

SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene

1988 • 1,490 citations

The E2F transcription factor is a cellular target for the RB protein

1991 • 1,461 citations

Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

1993 • 1,445 citations

Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product

1988 • 1,440 citations

Life, death, and the pursuit of apoptosis.

1996 • 1,333 citations

Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis

1992 • 1,285 citations

Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4

1993 • 1,258 citations

Complex formation of human papillomavirus E7 proteins with the retinoblastoma tumor suppressor gene product.

1989 • 1,186 citations

Cell cycle control in mammalian cells: role of cyclins, cyclin dependent kinases (CDKs), growth suppressor genes and cyclin-dependent kinase inhibitors (CKIs).

1995 • 1,117 citations

Functional interactions of the retinoblastoma protein with mammalian D-type cyclins

1993 • 1,047 citations

Regulation of retinoblastoma protein functions by ectopic expression of human cyclins

1992 • 1,031 citations

The retinoblastoma protein is phosphorylated during specific phases of the cell cycle

1989 • 1,031 citations

Requirement for a functional Rb-1 gene in murine development

1992 • 1,015 citations

Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiation

1989 • 990 citations

Expression of transcription factor E2F1 induces quiescent cells to enter S phase

1993 • 960 citations

The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory element

1989 • 931 citations

Cellular Targets for Activation by the E2F1 Transcription Factor Include DNA Synthesis- and G₁/S-Regulatory Genes

1995 • 910 citations

Identification and properties of an atypical catalytic subunit (p34PSK-J3/cdk4) for mammalian D type G1 cyclins

1992 • 906 citations

Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16

1995 • 894 citations

Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties

1992 • 846 citations

p53 and E2F-1 cooperate to mediate apoptosis.

1994 • 844 citations

Suppression of the Neoplastic Phenotype by Replacement of the RB Gene in Human Cancer Cells

1988 • 832 citations

Identification of G1 kinase activity for cdk6, a novel cyclin D partner.

1994 • 798 citations

Physical interaction of the retinoblastoma protein with human D cyclins

1993 • 780 citations

Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis.

1994 • 772 citations

E2F-1 Functions in Mice to Promote Apoptosis and Suppress Proliferation

1996 • 765 citations

Genetic Alterations of Cyclins, Cyclin-Dependent Kinases, and Cdk Inhibitors in Human Cancer

1996 • 751 citations

A role for both RB and p53 in the regulation of human cellular senescence*1

1991 • 737 citations

Interaction of myogenic factors and the retinoblastoma protein mediates muscle cell commitment and differentiation

1993 • 734 citations

The retinoblastoma gene product regulates progression through the G1 phase of the cell cycle

1991 • 708 citations

Tumor Induction and Tissue Atrophy in Mice Lacking E2F-1

1996 • 704 citations

Cdc25 cell-cycle phosphatase as a target of c-myc

1996 • 691 citations

Retinoblastoma protein switches the E2F site from positive to negative element

1992 • 663 citations

A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F

1992 • 652 citations

The retinoblastoma susceptibility gene encodes a nuclear phosphoprotein associated with DNA binding activity

1987 • 649 citations

Regulation of the cyclin E gene by transcription factor E2F1.

1995 • 634 citations

The retinoblastoma protein and BRG1 form a complex and cooperate to induce cell cycle arrest

1994 • 625 citations

p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens

1994 • 617 citations

Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product.

1992 • 617 citations

Interaction between the retinoblastoma protein and the oncoprotein MDM2

1995 • 592 citations

The transcription factor E2F interacts with the retinoblastoma product and a p107-cyclin A complex in a cell cycle-regulated manner

1992 • 588 citations

The interaction of RB with E2F coincides with an inhibition of the transcriptional activity of E2F.

1992 • 587 citations

Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein.

1993 • 531 citations

Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis.

1994 • 515 citations

Tumour-derived p16 alleles encoding proteins defective in cell-cycle inhibition

1995 • 515 citations

Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation.

1993 • 498 citations

Mechanism of active transcriptional repression by the retinoblastoma protein

1995 • 494 citations

Negative regulation of the growth-promoting transcription factor E2F-1 by a stably bound cyclin A-dependent protein kinase

1994 • 493 citations

Autoregulatory control of E2F1 expression in response to positive and negative regulators of cell cycle progression.

1994 • 493 citations

A gene therapy strategy using a transcription factor decoy of the E2F binding site inhibits smooth muscle proliferation in vivo.

1995 • 490 citations

Isolation of the Rb-related p130 through its interaction with CDK2 and cyclins.

1993 • 476 citations

Different Roles for Cyclins D1 and E in Regulation of the G₁-to-S Transition

1995 • 469 citations

Molecular cloning, chromosomal mapping, and expression of the cDNA for p107, a retinoblastoma gene product-related protein

1991 • 464 citations

Inhibition of E2F-1 transactivation by direct binding of the retinoblastoma protein.

1993 • 460 citations

Stimulation of E2F1/DP1 transcriptional activity by MDM2 oncoprotein

1995 • 459 citations

Cell Cycle-Dependent Regulation of Phosphorylation of the Human Retinoblastoma Gene Product

1989 • 457 citations

Cyclin E/cdk2 and cyclin A/cdk2 kinases associate with p107 and E2F in a temporally distinct manner.

1992 • 449 citations

The retinoblastoma protein copurifies with E2F-I, an E1A-regulated inhibitor of the transcription factor E2F

1991 • 446 citations

Growth suppression by p16ink4 requires functional retinoblastoma protein.

1995 • 441 citations

The retinoblastoma protein binds to a family of E2F transcription factors.

1993 • 436 citations

Adenovirus E1a prevents the retinoblastoma gene product from complexing with a cellular transcription factor

1991 • 435 citations

Shared role of the pRB-related p130 and p107 proteins in limb development.

1996 • 424 citations

Reverse two-hybrid and one-hybrid systems to detect dissociation of protein-protein and DNA-protein interactions.

1996 • 424 citations

Transducers of life and death: TNF receptor superfamily and associated proteins.

1996 • 423 citations

E2F1 overexpression in quiescent fibroblasts leads to induction of cellular DNA synthesis and apoptosis

1995 • 422 citations

The T/E1A-binding domain of the retinoblastoma product can interact selectively with a sequence-specific DNA-binding protein

1991 • 420 citations

Cdk inhibitors in development and cancer

1996 • 410 citations

Altered cell cycle regulation in the lens of HPV-16 E6 or E7 transgenic mice: implications for tumor suppressor gene function in development.

1994 • 406 citations

The retinoblastoma susceptibility gene product undergoes cell cycle-dependent dephosphorylation and binding to and release from SV40 large T

1990 • 402 citations

Cell cycle regulation of the human cdc2 gene.

1992 • 396 citations

Differential regulation of E2F transactivation by cyclin/cdk2 complexes.

1994 • 393 citations

Regulation of cyclin E transcription by E2Fs and retinoblastoma protein.

1996 • 387 citations

Independent binding of the retinoblastoma protein and p107 to the transcription factor E2F

1992 • 381 citations

Cooperative tumorigenic effects of germline mutations in Rb and p53

1994 • 374 citations

Cell cycle regulation of the E2F transcription factor involves an interaction with cyclin A

1991 • 374 citations

The helix-loop-helix protein Id-2 enhances cell proliferation and binds to the retinoblastoma protein.

1994 • 371 citations

Association of adenovirus early-region 1A proteins with cellular polypeptides.

1986 • 368 citations

Failure to Phosphorylate the Retinoblastoma Gene Product in Senescent Human Fibroblasts

1990 • 367 citations

Cell cycle regulation of the cyclin A gene promoter is mediated by a variant E2F site.

1995 • 363 citations

Inhibition of cyclin D-CDK4/CDK6 activity is associated with an E2F-mediated induction of cyclin kinase inhibitor activity.

1996 • 362 citations

Cyclin A-kinase regulation of E2F-1 DNA binding function underlies suppression of an S phase checkpoint

1995 • 361 citations

A cyclin A-protein kinase complex possesses sequence-specific DNA binding activity: p33cdk2 is a component of the E2F-cyclin A complex

1992 • 361 citations

Adenovirus E1A proteins can dissociate heteromeric complexes involving the E2F transcription factor: A novel mechanism for E1A trans-activation

1990 • 358 citations

E2F-1-mediated transactivation is inhibited by complex formation with the retinoblastoma susceptibility gene product.

1993 • 353 citations

Cell cycle-specific association of E2F with the p130 E1A-binding protein.

1993 • 348 citations

p53-dependent G1 arrest involves pRB-related proteins and is disrupted by the human papillomavirus 16 E7 oncoprotein.

1994 • 347 citations

The retinoblastoma protein is phosphorylated on multiple sites by human cdc2.

1991 • 343 citations

Interaction of Sp1 with the Growth- and Cell Cycle-Regulated Transcription Factor E2F

1996 • 343 citations

An E2F-binding site mediates cell-cycle regulated repression of mouse B-myb transcription.

1993 • 342 citations

The adenovirus E1A-associated 130-kD protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E.

1993 • 341 citations

E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle.

1995 • 336 citations

Apoptosis and the cell cycle

1995 • 334 citations

Targeted disruption of p107: functional overlap between p107 and Rb.

1996 • 333 citations

Molecular cloning of cellular genes encoding retinoblastoma-associated proteins: identification of a gene with properties of the transcription factor E2F.

1992 • 331 citations

E2F-4, a new member of the E2F transcription factor family, interacts with p107.

1994 • 331 citations

E2F-4, a new member of the E2F gene family, has oncogenic activity and associates with p107 in vivo.

1994 • 329 citations

E2F-4 Switches from p130 to p107 and pRB in Response to Cell Cycle Reentry

1996 • 327 citations

The regions of the retinoblastoma protein needed for binding to adenovirus E1A or SV40 large T antigen are common sites for mutations.

1990 • 327 citations

Cell cycle regulation of the cyclin A, cdc25C and cdc2 genes is based on a common mechanism of transcriptional repression.

1995 • 324 citations

Activity of RNA polymerase I transcription factor UBF blocked by Rb gene product

1995 • 324 citations

The activation domain of transcription factor PU.1 binds the retinoblastoma (RB) protein and the transcription factor TFIID in vitro: RB shows sequence similarity to TFIID and TFIIB.

1993 • 317 citations

A protein synthesis-dependent increase in E2F1 mRNA correlates with growth regulation of the dihydrofolate reductase promoter.

1993 • 315 citations

Apoptosis or retinoblastoma: alternative fates of photoreceptors expressing the HPV-16 E7 gene in the presence or absence of p53.

1994 • 310 citations

Retinoblastoma cancer suppressor gene product is a substrate of the cell cycle regulator cdc2 kinase.

1991 • 304 citations

Altered Cell Cycle Kinetics, Gene Expression, and G₁ Restriction Point Regulation in Rb-Deficient Fibroblasts

1996 • 301 citations

Functional interaction between E2F-4 and p130: evidence for distinct mechanisms underlying growth suppression by different retinoblastoma protein family members.

1995 • 299 citations

Regulation of the Human hsp70 Promoter by p53

1993 • 297 citations

Deregulated Expression of E2F Family Members Induces S-Phase Entry and Overcomes p16^INK4A-Mediated Growth Suppression

1996 • 297 citations

Deficiency of retinoblastoma protein leads to inappropriate S-phase entry, activation of E2F-responsive genes, and apoptosis.

1995 • 294 citations

Homozygosity of Chromosome 13 in Retinoblastoma

1984 • 294 citations

A new component of the transcription factor DRTF1/E2F

1993 • 293 citations

Transcription Factor E2F Is Required for Efficient Expression of the Hamster Dihydrofolate Reductase Gene In Vitro and In Vivo

1989 • 292 citations

Role of an adenovirus E2 promoter binding factor in E1A-mediated coordinate gene control.

1987 • 290 citations

Dual roles of the retinoblastoma protein in cell cycle regulation and neuron differentiation.

1994 • 286 citations

Inhibition of apoptosis by the retinoblastoma gene product.

1995 • 286 citations

Cell cycle regulted transcription in yeast

1994 • 283 citations

Cyclin A/CDK2 binds directly to E2F-1 and inhibits the DNA-binding activity of E2F-1/DP-1 by phosphorylation.

1994 • 283 citations

E1A-dependent trans-activation of the human MYC promoter is mediated by the E2F factor.

1989 • 283 citations

DNA tumor virus oncoproteins and retinoblastoma gene mutations share the ability to relieve the cell's requirement for cyclin D1 function in G1.

1994 • 279 citations

Altered regulation of G1 cyclins in senescent human diploid fibroblasts: accumulation of inactive cyclin E-Cdk2 and cyclin D1-Cdk2 complexes.

1993 • 277 citations

Binding to DNA and the Retinoblastoma Gene Product Promoted by Complex Formation of Different E2F Family Members

1993 • 271 citations

Cell Cycle-Regulated Association of E2F1 and Sp1 Is Related to Their Functional Interaction

1996 • 268 citations

Three Functional Classes of Transcriptional Activation Domains

1996 • 267 citations

Functional synergy between DP-1 and E2F-1 in the cell cycle-regulating transcription factor DRTF1/E2F.

1993 • 267 citations

Nuclear factor E2F mediates basic transcription and trans-activation by E1a of the human MYC promoter.

1989 • 262 citations

Heterozygous Rb-1 delta 20/+mice are predisposed to tumors of the pituitary gland with a nearly complete penetrance.

1994 • 260 citations

The transcription factor E2F is required for S phase during Drosophila embryogenesis.

1995 • 259 citations

Specific enzymatic dephosphorylation of the retinoblastoma protein.

1993 • 258 citations

Retinoblastoma gene product activates expression of the human TGF-β2 gene through transcription factor ATF-2

1992 • 255 citations

Regulation of the retinoblastoma protein-related p107 by G1 cyclin complexes.

1995 • 254 citations

Oncogenic capacity of the E2F1 gene.

1994 • 254 citations

Developmental rescue of an embryonic-lethal mutation in the retinoblastoma gene in chimeric mice.

1994 • 253 citations

A role for the adenovirus inducible E2F transcription factor in a proliferation dependent signal transduction pathway.

1990 • 253 citations

p107 uses a p21CIP1-related domain to bind cyclin/cdk2 and regulate interactions with E2F.

1995 • 253 citations

Collaboration of G1 cyclins in the functional inactivation of the retinoblastoma protein.

1994 • 253 citations

Functional Interactions between the hBRM/hBRG1 Transcriptional Activators and the pRB Family of Proteins

1996 • 252 citations

A unique role for the Rb protein in controlling E2F accumulation during cell growth and differentiation.

1996 • 251 citations

Repression of cyclin D1: a novel function of MYC.

1994 • 250 citations

Transcription of the E2F-1 Gene Is Rendered Cell Cycle Dependent by E2F DNA-Binding Sites within Its Promoter

1995 • 250 citations

RBF, a novel RB-related gene that regulates E2F activity and interacts with cyclin E in Drosophila.

1996 • 250 citations

Transcriptional repression of the E2-containing promoters EIIaE, c-myc, and RB1 by the product of the RB1 gene.

1992 • 250 citations

Introduction to the E2F Family: Protein Structure and Gene Regulation

1996 • 249 citations

Cell Cycle Regulation of the Murine Cyclin E Gene Depends on an E2F Binding Site in the Promoter

1996 • 248 citations

A potent transrepression domain in the retinoblastoma protein induces a cell cycle arrest when bound to E2F sites.

1995 • 248 citations

The WT1 gene product stabilizes p53 and inhibits p53-mediated apoptosis.

1995 • 247 citations

Retinoblastoma in transgenic mice

1990 • 246 citations

In Vivo Association of E2F and DP Family Proteins

1995 • 246 citations

Identification of a Myc-dependent step during the formation of active G1 cyclin-cdk complexes.

1995 • 243 citations

Growth arrest by induction of p53 in DNA damaged keratinocytes is bypassed by human papillomavirus 16 E7.

1994 • 243 citations

Multiple DNA elements are required for the growth regulation of the mouse E2F1 promoter.

1994 • 242 citations

Binding and Suppression of the Myc Transcriptional Activation Domain by p107

1994 • 242 citations

Association of cdk2 Kinase with the Transcription Factor E2F During S Phase

1992 • 239 citations

The retinoblastoma-susceptibility gene product becomes phosphorylated in multiple stages during cell cycle entry and progression.

1992 • 239 citations

Interactions of the p107 and Rb proteins with E2F during the cell proliferation response.

1993 • 235 citations

Cyclin D1 expression is regulated by the retinoblastoma protein.

1994 • 235 citations

Cloning of a new member of the retinoblastoma gene family (pRb2) which binds to the E1A transforming domain.

1993 • 235 citations

E2F and Cell Proliferation: A World Turned Upside Down

1996 • 234 citations

Interaction of p107 with Cyclin A Independent of Complex Formation with Viral Oncoproteins

1992 • 234 citations

E2F-5, a New E2F Family Member That Interacts with p130 In Vivo

1995 • 232 citations

Human DNA polymerase alpha gene: sequences controlling expression in cycling and serum-stimulated cells.

1991 • 231 citations

Developmental control of the G1 to S transition in Drosophila: cyclin Eis a limiting downstream target of E2F.

1995 • 229 citations

Detection of cellular proteins associated with human adenovirus type 5 early region 1A polypeptides

1985 • 227 citations

Regulation of the Ets-Related Transcription Factor Elf-1 by Binding to the Retinoblastoma Protein

1993 • 220 citations

Overexpression of E2F-1 in rat embryo fibroblasts leads to neoplastic transformation.

1994 • 214 citations

Bilateral retinal and brain tumors in transgenic mice expressing simian virus 40 large T antigen under control of the human interphotoreceptor retinoid-binding protein promoter.

1992 • 213 citations

Retinoblastoma protein directly interacts with and activates the transcription factor NF-IL6.

1996 • 213 citations

Functional interactions between the retinoblastoma (Rb) protein and Sp-family members: superactivation by Rb requires amino acids necessary for growth suppression.

1995 • 212 citations

p130/pRb2 has growth suppressive properties similar to yet distinctive from those of retinoblastoma family members pRb and p107.

1994 • 211 citations

The Retinoblastoma Protein: More than a Tumor Suppressor

1994 • 205 citations

Sp-1 binds promoter elements regulated by the RB protein and Sp-1-mediated transcription is stimulated by RB coexpression.

1993 • 203 citations

Definition of the minimal simian virus 40 large T antigen- and adenovirus E1A-binding domain in the retinoblastoma gene product.

1990 • 197 citations

Multiple members of the E2F transcription factor family are the products of oncogenes.

1995 • 197 citations

Cloning and characterization of E2F-2, a novel protein with the biochemical properties of transcription factor E2F.

1993 • 196 citations

Sequential activation of cyclin E and cyclin A gene expression by human papillomavirus type 16 E7 through sequences necessary for transformation

1995 • 195 citations

A central role for SWI6 in modulating cell cycle Start-specific transcription in yeast

1992 • 191 citations

A role for retinoblastoma protein in potentiating transcriptional activation by the glucocorticoid receptor

1995 • 188 citations

Absence of cyclin D/cdk complexes in cells lacking functional retinoblastoma protein.

1994 • 185 citations

Mice deficient in both p53 and Rb develop tumors primarily of endocrine origin.

1995 • 181 citations

Direct Transcriptional Repression by pRB and Its Reversal by Specific Cyclins

1995 • 179 citations

Elevated p16 at senescence and loss of p16 at immortalization in human papillomavirus 16 E6, but not E7, transformed human uroepithelial cells.

1996 • 176 citations

Genetic characterization of a mammalian protein-protein interaction domain by using a yeast reverse two-hybrid system.

1996 • 174 citations

E2F-1:DP-1 Induces p53 and Overrides Survival Factors To Trigger Apoptosis

1995 • 167 citations

Inhibition of cyclin-dependent kinase activity triggers neuronal differentiation of mouse neuroblastoma cells.

1995 • 166 citations

In Vivo Structure of the Human cdc2 Promoter: Release of a p130–E2F-4 Complex from Sequences Immediately Upstream of the Transcription Initiation Site Coincides with Induction of cdc2 Expression

1995 • 165 citations

PRAD1/lCyclin D1 proto‐oncogene: Genomic organization, 5′ dna sequence, and sequence of a tumor‐specific rearrangement breakpoint

1993 • 165 citations

Expression of the E2F1 transcription factor overcomes type beta transforming growth factor-mediated growth suppression.

1995 • 164 citations

Domains of the adenovirus E1A protein required for oncogenic activity are also required for dissociation of E2F transcription factor complexes.

1991 • 161 citations

DNA-binding and trans-activation properties of Drosophila E2F and DP proteins.

1994 • 155 citations

Cell Cycle Regulation of E2F Site Occupation in Vivo

1996 • 152 citations

Control of growth regulatory and differentiation-specific genes in human epidermal keratinocytes by interferon gamma. Antagonism by retinoic acid and transforming growth factor beta 1.

1994 • 151 citations

Induction of Sp1-p53 DNA-binding heterocomplexes during granulocyte/macrophage colony-stimulating factor-dependent proliferation in human erythroleukemia cell line TF-1.

1993 • 151 citations

Expression and state of phosphorylation of the retinoblastoma susceptibility gene product in cycling and noncycling human hematopoietic cells.

1990 • 149 citations

An adenovirus E1A-like transcription factor is regulated during the differentiation of murine embryonal carcinoma stem cells

1987 • 149 citations

Distinct sub-populations of the retinoblastoma protein show a distinct pattern of phosphorylation.

1994 • 148 citations

Phosphorylation of E2F-1 modulates its interaction with the retinoblastoma gene product and the adenoviral E4 19 kDa protein

1994 • 143 citations

Biological Function of the Retinoblastoma Protein Requires Distinct Domains for Hyperphosphorylation and Transcription Factor Binding

1992 • 143 citations

Role of E2F transcription factor in E1A-mediated trans activation of cellular genes

1991 • 142 citations

Independent regions of adenovirus E1A are required for binding to and dissociation of E2F-protein complexes.

1993 • 141 citations

Promoter interaction of the E1A-inducible factor E2F and its potential role in the formation of a multi-component complex.

1987 • 140 citations

Regions of the Retinoblastoma Gene Product Required for its Interaction with the E2F Transcription Factor are Necessary for E2 Promoter Repression and pRb-Mediated Growth Suppression

1993 • 140 citations

Expression of Dominant-Negative Mutant DP-1 Blocks Cell Cycle Progression in G₁

1996 • 139 citations

Role of pRb-Related Proteins in Simian Virus 40 Large-T-Antigen-Mediated Transformation

1995 • 139 citations

Interaction of c-Myc with the pRb-related protein p107 results in inhibition of c-Myc-mediated transactivation.

1994 • 139 citations

Activity of the Retinoblastoma Family Proteins, pRB, p107, and p130, during Cellular Proliferation and Differentiation

1996 • 138 citations

p53-mediated apoptosis in HeLa cells can be overcome by excess pRB.

1995 • 136 citations

Inhibition of E2F Activity by the Cyclin-Dependent Protein Kinase Inhibitor p21 in Cells Expressing or Lacking a Functional Retinoblastoma Protein

1996 • 136 citations

Origins of G₁ arrest in senescent human fibroblasts

1995 • 134 citations

Functional properties of a Drosophila homolog of the E2F1 gene.

1994 • 134 citations

The retinoblastoma protein binds E2F residues required for activation in vivo and TBP bindingin vitro

1993 • 131 citations

Protein domains governing interactions between E2F, the retinoblastoma gene product, and human papillomavirus type 16 E7 protein.

1993 • 128 citations

Different regulation of thymidine kinase during the cell cycle of normal versus DNA tumor virus-transformed cells.

1994 • 126 citations

HPV16 E7 oncoprotein deregulates B-myb expression: correlation with targeting of p107/E2F complexes.

1994 • 124 citations

Differential transcriptional regulation of c-myc promoter through the same DNA binding sites targeted by Sp1-like proteins.

1995 • 124 citations

The transcription factor E2F-1 mediates the autoregulation of RB gene expression

1994 • 122 citations

Regulation of two E2F-related genes in presenescent and senescent human fibroblasts.

1994 • 121 citations

Disruption of RB/E2F-1 interaction by single point mutations in E2F-1 enhances S-phase entry and apoptosis.

1996 • 120 citations

Dual control of myc expression through a single DNA binding site targeted by ets family proteins and E2F-1.

1994 • 120 citations

Developmental control of a promoter-specific factor that is also regulated by the E1A gene product

1987 • 120 citations

The human papillomavirus E7 oncoprotein and the cellular transcription factor E2F bind to separate sites on the retinoblastoma tumor suppressor protein

1993 • 118 citations

Ectopic expression of dE2F and dDP induces cell proliferation and death in the Drosophila eye.

1996 • 118 citations

Transcription factor E2F binds DNA as a heterodimer.

1993 • 116 citations

E2F mediates dihydrofolate reductase promoter activation and multiprotein complex formation in human cytomegalovirus infection.

1992 • 115 citations

Differential effects of cdk2 and cdk3 on the control of pRb and E2F function during G1 exit.

1996 • 115 citations

The Retinoblastoma Susceptibility Gene Product Represses Transcription When Directly Bound to the Promoter

1995 • 115 citations

老化ヒト二倍体線維芽細胞におけるG1サイクリン調節の変化 不活性サイクリンE‐Cdk2及びサイクリンD1‐Cdk2複合体

1993 • 115 citations

Differential Roles of Two Tandem E2F Sites in Repression of the Human p107 Promoter by Retinoblastoma and p107 Proteins

1995 • 114 citations

Analysis of p107-associated proteins: p107 associates with a form of E2F that differs from pRB-associated E2F-1

1993 • 113 citations

Identification of distinct roles for separate E1A domains in disruption of E2F complexes.

1993 • 113 citations

Regulation of the retinoblastoma protein-related protein p107 by G1 cyclin-associated kinases.

1996 • 110 citations

Functional analysis of pRb2/p130 interaction with cyclins.

1996 • 109 citations

Phosphorylation of E2F-1 by cyclin A-cdk2.

1995 • 109 citations

Regulation of BALB/c 3T3 fibroblast proliferation by B-myb is accompanied by selective activation of cdc2 and cyclin D1 expression.

1992 • 108 citations

Interleukin 1 alpha stimulates nuclear phospholipase C in human osteosarcoma SaOS-2 cells.

1994 • 108 citations

Cyclin A Expression Is under Negative Transcriptional Control during the Cell Cycle

1996 • 107 citations

Transcriptional repression by the Rb-related protein p107.

1993 • 102 citations

E2F-dependent regulation of human MYC: trans-activation by cyclins D1 and A overrides tumour suppressor protein functions.

1994 • 102 citations

Effect of Tumor Suppressors on Cell Cycle-Regulatory Genes: RB Suppresses p34cdc2 Expression and Normal p53 Suppresses Cyclin A Expression

1994 • 102 citations

Suppression of cyclin-dependent kinase 4 during induced differentiation of erythroleukemia cells.

1994 • 102 citations

Binding of the Rb1 protein to E1A products is required for adenovirus transformation.

1989 • 101 citations

Thymidine kinase transcription is regulated at G1/S phase by a complex that contains retinoblastoma-like protein and a cdc2 kinase.

1992 • 101 citations

Functional interactions within adenovirus E1A protein complexes.

1994 • 100 citations

Molecular and Cellular Biology

2001 • 98 citations

Domains A and B in the Rb Pocket Interact To Form a Transcriptional Repressor Motif

1996 • 98 citations

Association of p107 with Sp1: Genetically Separable Regions of p107 Are Involved in Regulation of E2F- and Sp1-Dependent Transcription

1995 • 98 citations

G1/S-regulated E2F-containing protein complexes bind to the mouse thymidine kinase gene promoter.

1994 • 98 citations

Physical and functional interactions between p53 and cell cycle co-operating transcription factors, E2F1 and DP1.

1995 • 96 citations

Periodic cdc25C transcription is mediated by a novel cell cycle-regulated repressor element (CDE).

1995 • 95 citations

Cell Cycle Analysis of E2F in Primary Human T Cells Reveals Novel E2F Complexes and Biochemically Distinct Forms of Free E2F

1993 • 94 citations

Disruption of retinoblastoma protein function by coexpression of its C pocket fragment.

1995 • 92 citations

A binding site for transcription factor E2F is a target for trans activation of murine thymidine kinase by polyomavirus large T antigen and plays an important role in growth regulation of the gene

1993 • 91 citations

Multiple Changes in E2F Function and Regulation Occur upon Muscle Differentiation

1995 • 91 citations

Cloning, chromosomal location, and characterization of mouse E2F1.

1994 • 90 citations

DP-1: a cell cycle-regulated and phosphorylated component of transcription factor DRTF1/E2F which is functionally important for recognition by pRb and the adenovirus E4 orf 6/7 protein.

1994 • 90 citations

Transcriptional regulation of the dihydrofolate reductase gene

1996 • 89 citations

p21 Disrupts the Interaction between cdk2 and the E2F-p130 Complex

1996 • 86 citations

Amplification of the E2F1 transcription factor gene in the HEL erythroleukemia cell line

1995 • 85 citations

Correlation between E2F-1 requirement in the S phase and E2F-1 transactivation of cell cycle-related genes in human cells.

1994 • 84 citations

Essential Role of E2F Recognition Sites in Regulation of the Proliferating Cell Nuclear Antigen Gene Promoter during Drosophila Development

1995 • 82 citations

Characterization of transcription factor E2F complexes during muscle and neuronal differentiation.

1995 • 82 citations

Cloning and characterization of human DP2, a novel dimerization partner of E2F.

1995 • 81 citations

G1 cyclin/CDK-independent phosphorylation and accumulation of p130 during the transition from G1 to G0 lead to its association with E2F-4.

1996 • 77 citations

MDM2 transformation in the absence of p53 and abrogation of the p107 G1 cell-cycle arrest.

1995 • 76 citations

E2F-1 but not E2F-4 can overcome p16-induced G1 cell-cycle arrest

1996 • 76 citations

High-Frequency Illegitimate Integration of Transfected DNA at Preintegrated Target Sites in a Mammalian Genome

1996 • 75 citations

Regulation of E2F-1 gene expression by p130 (Rb2) and D-type cyclin kinase activity.

1995 • 74 citations

Cell-cycle regulation of human B-myb transcription

1995 • 72 citations

Retinoblastoma protein inhibits IFN-gamma induced apoptosis.

1996 • 71 citations

Requirements for dE2F function in proliferating cells and in post-mitotic differentiating cells.

1996 • 66 citations

Use of the E2F Transcription Factor by DNA Tumor Virus Regulatory Proteins

1996 • 65 citations

A Role for a Bent DNA Structure in E2F-Mediated Transcription Activation

1996 • 65 citations

Transcription of histone H4, H3, and H1 cell cycle genes: promoter factor HiNF-D contains CDC2, cyclin A, and an RB-related protein.

1994 • 64 citations

Three distinct elements within the murine c-myc promoter are required for transcription.

1992 • 62 citations

The embryonal carcinoma stem cell Ela-like activity involves a differentiation-regulated transcription factor

1990 • 62 citations

Modulation of cyclin gene expression by adenovirus E1A in a cell line with E1A-dependent conditional proliferation

1994 • 61 citations

The role of cellular transcription factor E2F in the regulation of cdc2 mRNA expression and cell cycle control of human hematopoietic cells

1994 • 60 citations

Heterodimerization of the transcription factors E2F-1 and DP-1 is required for binding to the adenovirus E4 (ORF6/7) protein

1994 • 59 citations

A new member of the DP family, DP-3, with distinct protein products suggests a regulatory role for alternative splicing in the cell cycle transcription factor DRTF1/E2F.

1995 • 58 citations

v-Abl Activates c-myc Transcription through the E2F Site

1995 • 57 citations

Regulation of Proliferation-Specific and Differentiation-Specific Genes during Senescence of Human Epidermal Keratinocyte and Mammary Epithelial Cells

1993 • 56 citations

Functional Interaction between DP-1 and p53

1996 • 56 citations

An E2F dominant negative mutant blocks E1A induced cell cycle progression.

1994 • 55 citations

Proto-oncogenic properties of the DP family of proteins.

1995 • 55 citations

Phosphorylation of a specific cdk site in E2F-1 affects its electrophoretic mobility and promotes pRB-binding in vitro.

1995 • 55 citations

Protein-DNA Interactions at the Major and Minor Promoters of the Divergently Transcribed dhfr and rep3 Genes during the Chinese Hamster Ovary Cell Cycle

1996 • 55 citations

The Rb-Related p107 Protein Can Suppress E2F Function Independently of Binding to Cyclin A/cdk2

1995 • 54 citations

The E2F Transcription Factor Activates a Replication-Dependent Human H2A Gene in Early S Phase of the Cell Cycle

1996 • 54 citations

The Role of Myb Proteins in Normal and Neoplastic Cell Proliferation

1994 • 53 citations

The mycn/max protein complex in neuroblastoma. Short review

1995 • 52 citations

Role for E2F1 in p210 BCR-ABL downstream regulation of c-myc transcription initiation. Studies in murine myeloid cells.

1995 • 51 citations

Nerve growth factor regulates the expression and activity of p33cdk2 and p34cdc2 kinases in PC12 pheochromocytoma cells.

1994 • 50 citations

Characterization of the human RB1 promoter and of elements involved in transcriptional regulation.

1994 • 50 citations

Increased cyclin A and decreased cyclin D levels in adenovirus 5 E1A-transformed rodent cell lines.

1993 • 49 citations

Regulation of dihydrofolate reductase gene expression and E2F components in human diploid fibroblasts during growth and senescence

1996 • 48 citations

The interactions of E2F with pRB and with p107 are regulated via the phosphorylation of pRB and p107 by a cyclin-dependent kinase.

1995 • 47 citations

Inhibition of cell growth by TGF beta 1 is associated with inhibition of B-myb and cyclin A in both BALB/MK and Mv1Lu cells.

1994 • 47 citations

Coordinated trans activation of DNA synthesis- and precursor-producing enzymes by polyomavirus large T antigen through interaction with the retinoblastoma protein.

1994 • 46 citations

Cell cycle gene expression and E2F transcription factor complexes in human melanoma cells induced to terminally differentiate.

1995 • 46 citations

Differentiation of P19 EC cells leads to differential modulation of cyclin-dependent kinase activities and to changes in the cell cycle profile.

1995 • 46 citations

Identification of a Cell-Type-Specific and E2F-Independent Mechanism for Repression of cdc2 Transcription

1995 • 44 citations

Molecular and functional characterisation of E2F-5, a new member of the E2F family.

1995 • 43 citations

Molecular cloning and characterization of the mouse RB1 promoter.

1993 • 43 citations

The Sequence of Porcine Protein NH2-terminal Asparagine Amidohydrolase

1995 • 42 citations

Regulation of cyclin D1, DNA topoisomerase I, and proliferating cell nuclear antigen promoters during the cell cycle.

1995 • 42 citations

An Inverted Repeat Motif Stabilizes Binding of E2F and Enhances Transcription of the Dihydrofolate Reductase Gene

1995 • 41 citations

A complex between E2F and the pRb-related protein p130 is specifically targeted by the simian virus 40 large T antigen during cell transformation.

1995 • 41 citations

Overexpression of the E2F-1 transcription factor gene mediates cell transformation.

1995 • 40 citations

Positive and Negative Regulation of Cell Proliferation by E2F-1: Influence of Protein Level and Human Papillomavirus Oncoproteins

1994 • 40 citations

Retinoblastoma protein reverses DNA bending by transcription factor E2F.

1994 • 39 citations

An E2F-dependent late-serum-response promoter in a gene that controls glycolysis.

1995 • 39 citations

Interacting domains of E2F1, DP1, and the adenovirus E4 protein

1994 • 37 citations

Inactivation of the retinoblastoma susceptibility protein is not sufficient for the transforming function of the conserved region 2-like domain of simian virus 40 large T antigen

1995 • 36 citations

Detailed analysis of the basic domain of the E2F1 transcription factor indicates that it is unique among bHLH proteins.

1994 • 35 citations

The N-terminal Region of E2F-1 Is Required for Transcriptional Activation of a New Class of Target Promoter

1996 • 35 citations

Loss of Rb and Myc activation co-operate to suppress cyclin D1 and contribute to transformation.

1996 • 35 citations

Retinoblastoma antioncogene is involved in the inhibition of myogenesis by polyomavirus large T antigen.

1994 • 35 citations

Adenovirus E1A activates cyclin A gene transcription in the absence of growth factors through interaction with p107

1996 • 35 citations

The G₁/S Boundary-Specific Enhancer of the Rat cdc2 Promoter

1995 • 34 citations

An E2F binding sequence negatively regulates the response of the insulin-like growth factor 1 (IGF-I) promoter to simian virus 40T antigen and to serum.

1994 • 33 citations

Functional conservation of the cell cycle-regulating transcription factor DRTF1/E2F and its pathway of control in Drosophila melanogaster

1995 • 33 citations

Blocking the transcription factor E2F/DP by dominant-negative mutants in a normal breast epithelial cell line efficiently inhibits apoptosis and induces tumor growth in SCID mice.

1996 • 32 citations

Characterization of cis-regulatory elements of the c-myc promoter responding to human GM-CSF or mouse interleukin 3 in mouse proB cell line BA/F3 cells expressing the human GM-CSF receptor.

1995 • 32 citations

Complexes containing the retinoblastoma gene product recognize different DNA motifs related to the E2F binding site.

1992 • 31 citations

Promoter-dependent Photocross-linking of the Acidic Transcriptional Activator E2F-1 to the TATA-binding Protein

1995 • 30 citations

Expression of the E2F-1/DP-1 transcription factor in murine development.

1996 • 30 citations

Cloning and expression of the Rb-related mouse p130 mRNA.

1996 • 29 citations

Mutually exclusive interaction of the adenovirus E4-6/7 protein and the retinoblastoma gene product with internal domains of E2F-1 and DP-1

1994 • 29 citations

Different Regulation of the Human Thymidine Kinase Promoter in Normal Human Diploid IMR-90 Fibroblasts and HeLa Cells

1995 • 28 citations

Regulation of transcription by E2F1/DP1

1995 • 28 citations

A silencer element in the retinoblastoma tumor-suppressor gene.

1994 • 28 citations

E2F and Its Developmental Regulation in Xenopus laevis

1994 • 24 citations

Cooperative binding of two E2F molecules to an Ela-responsive promoter is triggered by the adenovirus Ela, but not by a cellular Ela-like activity.

1989 • 24 citations

Molecular characterization of Xenopus laevis DP proteins.

1994 • 24 citations

Identification of an Essential Cis-Element Near the Transcription Start Site for Transcriptional Activation of the Proliferating Cell Nuclear Antigen Gene

1996 • 22 citations

E2F-1 and a Cyclin-like DNA Repair Enzyme, Uracil-DNA Glycosylase, Provide Evidence for an Autoregulatory Mechanism for Transcription

1995 • 22 citations

Domains of E1A that bind p105Rb, p130, and p300 are required to block nerve growth factor-induced neurite growth in PC12 cells.

1993 • 22 citations

A direct role of transcription factor E2F in c-myc gene expression during granulocytic and macrophage-like differentiation of HL60 cells.

1995 • 21 citations

Transcriptional repression and activation in the same cell type of the human c-MYC promoter by the retinoblastoma gene protein: antagonisation of both effects by SV40 T antigen.

1994 • 21 citations

Protein phosphorylation required for the formation of E2F complexes regulates N-myc transcription during differentiation of human embryonal carcinoma cells.

1993 • 21 citations

Changes in E2F DNA-binding activity during induced erythroid differentiation.

1996 • 21 citations

Regulation of the Mouse Histone H2A.X Gene Promoter by the Transcription Factor E2F and CCAAT Binding Protein

1995 • 20 citations

Differential Activation of Cyclin and Cyclin-Dependent Kinase Genes by Adenovirus E1A12S cDNA Product

1993 • 18 citations

Transcription from the P2 promoter of human protooncogene myc is suppressed by retinoic acid through an interaction between the E2F element and its binding proteins.

1994 • 18 citations

Activation of the retinoblastoma gene expression by Bcl-3: implication for muscle cell differentiation.

1996 • 16 citations

DNA sequences required for serum-responsive regulation of expression from the mouse thymidine kinase promoter.

1993 • 16 citations

Expression of Rb, E2F1, cdc2, and D, and B cyclins in developing spinal cord

1995 • 14 citations

In vivo footprints between the murine c-myc P1 and P2 promoters.

1992 • 13 citations

Selective repression of growth-regulating cdk2, cyclin E and E2F1 genes in human cell senescence.

1994 • 12 citations

Structural characterization and specificity of expression of E2F-5: a new member of the E2F family of transcription factors.

1995 • 9 citations

Isolation and characterization of a chicken homolog of the E2F-1 transcription factor.

1995 • 8 citations

EIa-mediated transactivation of the adenovirus EIIa early promoter is restricted in undifferentiated F9 cells.

1990 • 5 citations

The flight of the pterosaur

1994 • 4 citations