Sp-1 binds promoter elements regulated by the RB protein and Sp-1-mediated transcription is stimulated by RB coexpression.

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase

1988 • 6,107 citations

Isolation of cDNA encoding transcription factor Sp1 and functional analysis of the DNA binding domain

1987 • 1,640 citations

The E2F transcription factor is a cellular target for the RB protein

1991 • 1,461 citations

Analysis of Sp1 in vivo reveals mutiple transcriptional domains, including a novel glutamine-rich activation motif

1988 • 1,403 citations

Oncogenes, antioncogenes, and the molecular bases of multistep carcinogenesis.

1989 • 961 citations

[71] Use of eukaryotic expression technology in the functional analysis of cloned genes

1987 • 834 citations

Retinoblastoma protein switches the E2F site from positive to negative element

1992 • 663 citations

The interaction of RB with E2F coincides with an inhibition of the transcriptional activity of E2F.

1992 • 587 citations

Adenovirus E1a prevents the retinoblastoma gene product from complexing with a cellular transcription factor

1991 • 435 citations

Point Mutational Inactivation of the Retinoblastoma Antioncogene

1989 • 427 citations

The T/E1A-binding domain of the retinoblastoma product can interact selectively with a sequence-specific DNA-binding protein

1991 • 420 citations

Monoclonal antibodies specific for adenovirus early region 1A proteins: extensive heterogeneity in early region 1A products

1985 • 417 citations

Transient expression of genes introduced into cultured cells of Drosophila.

1983 • 370 citations

Cloning of cDNAs for cellular proteins that bind to the retinoblastoma gene product

1991 • 334 citations

Negative regulation of human c-fos expression by thes retinoblastoma gene product

1990 • 298 citations

Retinoblastoma gene product activates expression of the human TGF-β2 gene through transcription factor ATF-2

1992 • 255 citations

The retinoblastoma gene product regulates Sp1-mediated transcription.

1992 • 253 citations

Regulation of transforming growth factor beta 1 gene expression by the product of the retinoblastoma-susceptibility gene.

1991 • 159 citations

A cellular protein that competes with SV40 T antigen for binding to the retinoblastoma gene product

1991 • 153 citations

Functional analysis of GC element binding and transcription in the hamster dihydrofolate reductase gene promoter

1989 • 123 citations

Factor-binding element in the human c-myc promoter involved in transcriptional regulation by transforming growth factor beta 1 and by the retinoblastoma gene product.

1991 • 120 citations

The Retinoblastoma Gene Product Regulates Sp1-Mediated Transcription

1992 • 55 citations

An enhancer element responsive to ras and fms signaling pathways is composed of two distinct nuclear factor binding sites.

1992 • 50 citations

A naturally occurring gamma globin gene mutation enhances SP1 binding activity.

1990 • 43 citations

The retinoblastoma gene product suppresses neu oncogene-induced transformation via transcriptional repression of neu.

1992 • 36 citations

Regulation of transcription by the retinoblastoma protein

1993 • 36 citations

A common set of nuclear factors bind to promoter elements regulated by the retinoblastoma protein.

1992 • 30 citations