The human papillomavirus E7 oncoprotein and the cellular transcription factor E2F bind to separate sites on the retinoblastoma tumor suppressor protein

Rapid detection of octamer binding proteins with ‘mini extracts’, prepared from a small number of cells

1989 • 4,279 citations

The E2F transcription factor is a cellular target for the RB protein

1991 • 1,461 citations

The E6 and E7 genes of the human papillomavirus type 16 together are necessary and sufficient for transformation of primary human keratinocytes

1989 • 1,345 citations

Complex formation of human papillomavirus E7 proteins with the retinoblastoma tumor suppressor gene product.

1989 • 1,186 citations

HPV16 E6 and E7 proteins cooperate to immortalize human foreskin keratinocytes.

1989 • 913 citations

Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties

1992 • 846 citations

The human papillomavirus type 16 E7 gene encodes transactivation and transformation functions similar to those of adenovirus E1A

1988 • 657 citations

A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F

1992 • 652 citations

Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product.

1992 • 617 citations

The transcription factor E2F interacts with the retinoblastoma product and a p107-cyclin A complex in a cell cycle-regulated manner

1992 • 588 citations

The retinoblastoma protein copurifies with E2F-I, an E1A-regulated inhibitor of the transcription factor E2F

1991 • 446 citations

The T/E1A-binding domain of the retinoblastoma product can interact selectively with a sequence-specific DNA-binding protein

1991 • 420 citations

Identification of a growth suppression domain within the retinoblastoma gene product.

1992 • 413 citations

Homologous sequences in adenovirus E1A and human papillomavirus E7 proteins mediate interaction with the same set of cellular proteins

1992 • 389 citations

Independent binding of the retinoblastoma protein and p107 to the transcription factor E2F

1992 • 381 citations

Cell cycle regulation of the E2F transcription factor involves an interaction with cyclin A

1991 • 374 citations

A cyclin A-protein kinase complex possesses sequence-specific DNA binding activity: p33cdk2 is a component of the E2F-cyclin A complex

1992 • 361 citations

Adenovirus E1A proteins can dissociate heteromeric complexes involving the E2F transcription factor: A novel mechanism for E1A trans-activation

1990 • 358 citations

Cloning of cDNAs for cellular proteins that bind to the retinoblastoma gene product

1991 • 334 citations

Efficiency of binding the retinoblastoma protein correlates with the transforming capacity of the E7 oncoproteins of the human papillomaviruses.

1992 • 327 citations

The region of the HPV E7 oncoprotein homologous to adenovirus E1a and Sv40 large T antigen contains separate domains for Rb binding and casein kinase II phosphorylation.

1990 • 323 citations

Comparison of the in vitro transforming activities of human papillomavirus types.

1988 • 303 citations

The Role of Papillomaviruses in Human Anogenital Cancer

1987 • 267 citations

A role for the adenovirus inducible E2F transcription factor in a proliferation dependent signal transduction pathway.

1990 • 253 citations

A point mutational analysis of human papillomavirus type 16 E7 protein

1989 • 241 citations

Papillomavirus polypeptides E6 and E7 are zinc-binding proteins

1989 • 239 citations

Association of cdk2 Kinase with the Transcription Factor E2F During S Phase

1992 • 239 citations

The E7 proteins of the nononcogenic human papillomavirus type 6b (HPV-6b) and of the oncogenic HPV-16 differ in retinoblastoma protein binding and other properties

1990 • 238 citations

Structure-function analysis of the human papillomavirus type 16 E7 oncoprotein

1992 • 233 citations

Chromosomal integration sites of human papillomavirus DNA in three cervical cancer cell lines mapped by in situ hybridization

1987 • 184 citations

Regions of human papillomavirus type 16 E7 oncoprotein required for immortalization of human keratinocytes

1992 • 177 citations

Role of E2F transcription factor in E1A-mediated trans activation of cellular genes

1991 • 142 citations

Prediction of similar transforming regions in simian virus 40 large T, adenovirus E1A, and myc oncoproteins

1988 • 124 citations

Biochemical and biological differences between E7 oncoproteins of the high- and low-risk human papillomavirus types are determined by amino-terminal sequences

1991 • 109 citations

Analysis of trans activation by human papillomavirus type 16 E7 and adenovirus 12S E1A suggests a common mechanism

1991 • 108 citations

The E7 protein of human papillomavirus type 16 is phosphorylated by casein kinase II.

1989 • 97 citations

Mutational analysis of human papillomavirus type 16 E7 functions

1990 • 93 citations

Co-transformation by Human Papillomavirus Types 6 and 11

1990 • 53 citations

Chemical synthesis of human papillomavirus type 16 E7 oncoprotein: autonomous protein domains for induction of cellular DNA synthesis and for trans activation

1990 • 50 citations

Human papillomavirus type 16 E7 protein inhibits DNA binding by the retinoblastoma gene product.

1992 • 38 citations

The E7 functions of human papillomaviruses in rat 3Y1 cells

1992 • 23 citations