Autoregulatory control of E2F1 expression in response to positive and negative regulators of cell cycle progression.

G ₁ Events and Regulation of Cell Proliferation

1989 • 2,203 citations

Mammalian G1 cyclins

1993 • 1,990 citations

Cyclin D1 is a nuclear protein required for cell cycle progression in G1.

1993 • 1,605 citations

Genetic Control of the Cell Division Cycle in Yeast

1974 • 1,588 citations

E2F: a Link Between the Rb Tumor Suppressor Protein and Viral Oncoproteins

1992 • 1,552 citations

The E2F transcription factor is a cellular target for the RB protein

1991 • 1,461 citations

A novel cyclin encoded by a bcl1-linked candidate oncogene

1991 • 1,286 citations

Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4

1993 • 1,258 citations

Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle

1991 • 1,190 citations

Overexpression of mouse D-type cyclins accelerates G1 phase in rodent fibroblasts.

1993 • 1,057 citations

Functional interactions of the retinoblastoma protein with mammalian D-type cyclins

1993 • 1,047 citations

The retinoblastoma protein is phosphorylated during specific phases of the cell cycle

1989 • 1,031 citations

Regulation of retinoblastoma protein functions by ectopic expression of human cyclins

1992 • 1,031 citations

Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiation

1989 • 990 citations

Expression of transcription factor E2F1 induces quiescent cells to enter S phase

1993 • 960 citations

Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties

1992 • 846 citations

Physical interaction of the retinoblastoma protein with human D cyclins

1993 • 780 citations

Cyclin-Dependent Regulation of G ₁ in Mammalian Fibroblasts

1993 • 767 citations

Gene required in G1 for commitment to cell cycle and in G2 for control of mitosis in fission yeast

1981 • 740 citations

Human D-type cyclin

1991 • 712 citations

Retinoblastoma protein switches the E2F site from positive to negative element

1992 • 663 citations

Human cyclin E, a new cyclin that interacts with two members of the CDC2 gene family

1991 • 656 citations

A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F

1992 • 652 citations

Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product.

1992 • 617 citations

The transcription factor E2F interacts with the retinoblastoma product and a p107-cyclin A complex in a cell cycle-regulated manner

1992 • 588 citations

The interaction of RB with E2F coincides with an inhibition of the transcriptional activity of E2F.

1992 • 587 citations

Negative Regulation of G1 in Mammalian Cells: Inhibition of Cyclin E-Dependent Kinase by TGF-β

1993 • 578 citations

Identification of a cellular transcription factor involved in E1A trans-activation

1986 • 551 citations

DNA Tumor Viruses

1982 • 550 citations

TGFβ inhibition of Cdk4 synthesis is linked to cell cycle arrest

1993 • 544 citations

Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein.

1993 • 531 citations

THE TUMOR SUPPRESSOR GENES

1993 • 509 citations

Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation.

1993 • 498 citations

Isolation of the human cdk2 gene that encodes the cyclin A- and adenovirus E1A-associated p33 kinase

1991 • 475 citations

Function of a human cyclin gene as an oncogene.

1994 • 471 citations

Inhibition of E2F-1 transactivation by direct binding of the retinoblastoma protein.

1993 • 460 citations

PRAD1, a candidate BCL1 oncogene: mapping and expression in centrocytic lymphoma.

1991 • 454 citations

Cyclin E/cdk2 and cyclin A/cdk2 kinases associate with p107 and E2F in a temporally distinct manner.

1992 • 449 citations

The retinoblastoma protein copurifies with E2F-I, an E1A-regulated inhibitor of the transcription factor E2F

1991 • 446 citations

The retinoblastoma protein binds to a family of E2F transcription factors.

1993 • 436 citations

Identification of a growth suppression domain within the retinoblastoma gene product.

1992 • 413 citations

The retinoblastoma susceptibility gene product undergoes cell cycle-dependent dephosphorylation and binding to and release from SV40 large T

1990 • 402 citations

Cell cycle regulation of the E2F transcription factor involves an interaction with cyclin A

1991 • 374 citations

Adenovirus E1A proteins can dissociate heteromeric complexes involving the E2F transcription factor: A novel mechanism for E1A trans-activation

1990 • 358 citations

E2F-1-mediated transactivation is inhibited by complex formation with the retinoblastoma susceptibility gene product.

1993 • 353 citations

Cell cycle-specific association of E2F with the p130 E1A-binding protein.

1993 • 348 citations

An E2F-binding site mediates cell-cycle regulated repression of mouse B-myb transcription.

1993 • 342 citations

Molecular cloning of cellular genes encoding retinoblastoma-associated proteins: identification of a gene with properties of the transcription factor E2F.

1992 • 331 citations

A protein synthesis-dependent increase in E2F1 mRNA correlates with growth regulation of the dihydrofolate reductase promoter.

1993 • 315 citations

Cyclin A and the retinoblastoma gene product complex with a common transcription factor

1991 • 296 citations

Binding to DNA and the Retinoblastoma Gene Product Promoted by Complex Formation of Different E2F Family Members

1993 • 271 citations

Functional synergy between DP-1 and E2F-1 in the cell cycle-regulating transcription factor DRTF1/E2F.

1993 • 267 citations

Interactions of the p107 and Rb proteins with E2F during the cell proliferation response.

1993 • 235 citations

Control of DNA synthesis genes in fission yeast by the cell-cycle gene cdclO+

1992 • 233 citations

Coordination of expression of DNA synthesis genes in budding yeast by a cell-cycle regulated trans factor

1991 • 209 citations

Cloning and characterization of E2F-2, a novel protein with the biochemical properties of transcription factor E2F.

1993 • 196 citations

Gene rearrangement and overexpression of PRAD1 in lymphoid malignancy with t(11;14)(q13;q32) translocation.

1992 • 194 citations

Domains of the adenovirus E1A protein required for oncogenic activity are also required for dissociation of E2F transcription factor complexes.

1991 • 161 citations

Biological Function of the Retinoblastoma Protein Requires Distinct Domains for Hyperphosphorylation and Transcription Factor Binding

1992 • 143 citations

Role of E2F transcription factor in E1A-mediated trans activation of cellular genes

1991 • 142 citations

Regions of the Retinoblastoma Gene Product Required for its Interaction with the E2F Transcription Factor are Necessary for E2 Promoter Repression and pRb-Mediated Growth Suppression

1993 • 140 citations

Functional properties of a Drosophila homolog of the E2F1 gene.

1994 • 134 citations

A genetic analysis of the E2F1 gene distinguishes regulation by Rb, p107, and adenovirus E4.

1993 • 118 citations

Transcriptional repression by the Rb-related protein p107.

1993 • 102 citations

Cell Cycle Analysis of E2F in Primary Human T Cells Reveals Novel E2F Complexes and Biochemically Distinct Forms of Free E2F

1993 • 94 citations

Promoter-specific trans-activation by the adenovirus E1A12S product involves separate E1A domains.

1992 • 73 citations

The ubiquitous octamer-binding protein(s) is sufficient for transcription of immunoglobulin genes.

1990 • 44 citations

RB Associates with an E2F-like, Sequence-specific DNA-binding Protein

1991 • 21 citations