The Human Papilloma Virus-16 E7 Oncoprotein Is Able to Bind to the Retinoblastoma Gene Product

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

A Film Detection Method for Tritium‐Labelled Proteins and Nucleic Acids in Polyacrylamide Gels

1974 • 8,693 citations

Mutation and Cancer: Statistical Study of Retinoblastoma

1971 • 7,335 citations

A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma

1986 • 2,968 citations

A papillomavirus DNA from a cervical carcinoma and its prevalence in cancer biopsy samples from different geographic regions.

1983 • 2,011 citations

Expression of recessive alleles by chromosomal mechanisms in retinoblastoma

1983 • 1,952 citations

SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene

1988 • 1,490 citations

Structure and transcription of human papillomavirus sequences in cervical carcinoma cells

1985 • 1,481 citations

Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product

1988 • 1,440 citations

Human Retinoblastoma Susceptibility Gene: Cloning, Identification, and Sequence

1987 • 1,436 citations

Monoclonal antibodies specific for simian virus 40 tumor antigens

1981 • 1,110 citations

Abnormalities in Structure and Expression of the Human Retinoblastoma Gene in SCLC

1988 • 905 citations

Structural Evidence for the Authenticity of the Human Retinoblastoma Gene

1987 • 809 citations

Structural and transcriptional analysis of human papillomavirus type 16 sequences in cervical carcinoma cell lines

1987 • 760 citations

Cellular targets for transformation by the adenovirus E1A proteins

1989 • 747 citations

Transcription of human papillomavirus type 16 early genes in a cervical cancer and a cancer-derived cell line and identification of the E7 protein.

1986 • 665 citations

The human papillomavirus type 16 E7 gene encodes transactivation and transformation functions similar to those of adenovirus E1A

1988 • 657 citations

Inactivation of the Retinoblastoma Susceptibility Gene in Human Breast Cancers

1988 • 608 citations

DNA Tumor Viruses

1982 • 550 citations

Retinoblastoma: Clues to Human Oncogenesis

1984 • 495 citations

ADENOVIRUS PROMOTERS AND E1A TRANSACTIVATION

1986 • 460 citations

Point Mutational Inactivation of the Retinoblastoma Antioncogene

1989 • 427 citations

Monoclonal antibodies specific for adenovirus early region 1A proteins: extensive heterogeneity in early region 1A products

1985 • 417 citations

Osteosarcoma and retinoblastoma: a shared chromosomal mechanism revealing recessive predisposition.

1985 • 415 citations

Multiple functional domains in the adenovirus E1A gene

1987 • 361 citations

Human papillomavirus type 16 DNA cooperates with activated ras in transforming primary cells.

1987 • 351 citations

An adenovirus E1a protein region required for transformation and transcriptional repression

1986 • 329 citations

Transcriptional regulation of the human papillomavirus-16 E6-E7 promoter by a keratinocyte-dependent enhancer, and by viral E2 trans-activator and repressor gene products: implications for cervical carcinogenesis.

1987 • 327 citations

A novel type of human papillomavirus associated with genital neoplasias

1986 • 324 citations

Comparison of the in vitro transforming activities of human papillomavirus types.

1988 • 303 citations

The BPV1-E2 trans-acting protein can be either an activator or a repressor of the HPV18 regulatory region.

1987 • 294 citations

Functional domains of adenovirus type 5 E1a proteins

1987 • 283 citations

Human papillomavirus type 16 DNA-induced malignant transformation of NIH 3T3 cells

1986 • 235 citations

Two regions of the adenovirus early region 1A proteins are required for transformation

1988 • 232 citations

Identification of separate domains in the adenovirus E1A gene for immortalization activity and the activation of virus early genes.

1986 • 231 citations

E1a regions of the human adenoviruses and of the highly oncogenic simian adenovirus 7 are closely related

1985 • 213 citations

The major human papillomavirus protein in cervical cancers is a cytoplasmic phosphoprotein

1987 • 203 citations

Mutational analysis of the adenovirus E1a gene: the role of transcriptional regulation in transformation.

1987 • 201 citations

Different functional domains of the adenovirus E1A gene are involved in regulation of host cell cycle products.

1987 • 171 citations

A region of SV40 large T antigen can substitute for a transforming domain of the adenovirus E1A products

1988 • 167 citations

The release of growth arrest by microinjection of adenovirus E1A DNA.

1985 • 154 citations

Human papillomavirus type 16 open reading frame E7 encodes a transforming gene for rat 3Y1 cells

1988 • 143 citations

Adenovirus-induced alterations of the cell growth cycle: a requirement for expression of E1A but not of E1B

1983 • 120 citations

Cloning of monomeric human papillomavirus type 16 DNA integrated within cell DNA from a cervical carcinoma

1986 • 118 citations

Thiol groups of liver alcohol dehydrogenase. Accessibility to general thiol reagents and to potential affinity‐labels

1974 • 118 citations

Prediction of Familial Predisposition to Retinoblastoma

1986 • 117 citations

Characterization of a transcriptional promoter of human papillomavirus 18 and modulation of its expression by simian virus 40 and adenovirus early antigens

1987 • 106 citations

Enhancers and trans-acting E2 transcriptional factors of papillomaviruses

1987 • 102 citations

Induction of cellular DNA synthesis by purified adenovirus E1A proteins

1986 • 75 citations

Human papillomavirus type 16 transformation of rat 3Y1 cells.

1987 • 35 citations

Anti-oncogenes and the Negative Regulation of Cell Growth

1988 • 9 citations