Oncogenic capacity of the E2F1 gene.

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

1993 • 5,680 citations

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

1993 • 3,680 citations

p21 is a universal inhibitor of cyclin kinases

1993 • 3,408 citations

A Cell Cycle Regulator Potentially Involved in Genesis of Many Tumor Types

1994 • 2,821 citations

Mammalian G1 cyclins

1993 • 1,990 citations

Tumor Suppressor Genes

1991 • 1,784 citations

Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2

1993 • 1,531 citations

The E2F transcription factor is a cellular target for the RB protein

1991 • 1,461 citations

Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture

1983 • 1,358 citations

A novel cyclin encoded by a bcl1-linked candidate oncogene

1991 • 1,286 citations

Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4

1993 • 1,258 citations

Functional interactions of the retinoblastoma protein with mammalian D-type cyclins

1993 • 1,047 citations

D type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNA

1992 • 1,023 citations

Identification and properties of an atypical catalytic subunit (p34PSK-J3/cdk4) for mammalian D type G1 cyclins

1992 • 906 citations

Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties

1992 • 846 citations

Functional dissection of VP16, the trans-activator of herpes simplex virus immediate early gene expression.

1988 • 830 citations

Physical interaction of the retinoblastoma protein with human D cyclins

1993 • 780 citations

A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F

1992 • 652 citations

Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product.

1992 • 617 citations

The interaction of RB with E2F coincides with an inhibition of the transcriptional activity of E2F.

1992 • 587 citations

Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation.

1993 • 498 citations

Malignant transformation of early passage rodent cells by a single mutated human oncogene

1984 • 479 citations

The retinoblastoma protein copurifies with E2F-I, an E1A-regulated inhibitor of the transcription factor E2F

1991 • 446 citations

Identification of a growth suppression domain within the retinoblastoma gene product.

1992 • 413 citations

Proliferating cell nuclear antigen and p21 are components of multiple cell cycle kinase complexes.

1993 • 362 citations

Adenovirus E1A proteins can dissociate heteromeric complexes involving the E2F transcription factor: A novel mechanism for E1A trans-activation

1990 • 358 citations

Molecular cloning of cellular genes encoding retinoblastoma-associated proteins: identification of a gene with properties of the transcription factor E2F.

1992 • 331 citations

Cyclin A and the retinoblastoma gene product complex with a common transcription factor

1991 • 296 citations

Complete transformation by adenovirus 2 requires both E1A proteins

1984 • 243 citations

Tumor suppressor genes

1993 • 147 citations

Biological Function of the Retinoblastoma Protein Requires Distinct Domains for Hyperphosphorylation and Transcription Factor Binding

1992 • 143 citations

Regions of the Retinoblastoma Gene Product Required for its Interaction with the E2F Transcription Factor are Necessary for E2 Promoter Repression and pRb-Mediated Growth Suppression

1993 • 140 citations

Adenovirus E1a prevents the retinoblastoma gene product from repressing the activity of a cellular transcription factor.

1992 • 137 citations

Functional properties of a Drosophila homolog of the E2F1 gene.

1994 • 134 citations

A genetic analysis of the E2F1 gene distinguishes regulation by Rb, p107, and adenovirus E4.

1993 • 118 citations

Molecular Cloning of Cellular Genes Encoding Retinoblastoma-Associated Proteins: Identification of a Gene with Properties of the Transcription Factor E2F

1992 • 82 citations

Promoter-specific trans-activation by the adenovirus E1A12S product involves separate E1A domains.

1992 • 73 citations

Cold-sensitive expression of transformation by a host range mutant of type 5 adenovirus.

1983 • 46 citations

Interacting domains of E2F1, DP1, and the adenovirus E4 protein

1994 • 37 citations

A Genetic Analysis of the E2F1 Gene Distinguishes Regulation by Rb, p107, and Adenovirus E4

1993 • 30 citations

Functional Properties of a Drosophila Homolog of the E2F1 Gene

1994 • 27 citations

Promoter-Specific Zrans-Activation by the Adenovirus E1A_12S Product Involves Separate E1A Domains

1992 • 25 citations

RB Associates with an E2F-like, Sequence-specific DNA-binding Protein

1991 • 21 citations

[31] Use of nude mice for tumorigenicity testing and mass propagation

1979 • 19 citations