Developmental control of the G1 to S transition in Drosophila: cyclin Eis a limiting downstream target of E2F.

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

1993 • 5,680 citations

p21 is a universal inhibitor of cyclin kinases

1993 • 3,408 citations

G1 phase progression: Cycling on cue

1994 • 2,706 citations

A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback

1989 • 2,555 citations

The embryonic development of Drosophila melanogaster

1938 • 2,188 citations

Mammalian G1 cyclins

1993 • 1,990 citations

A major developmental transition in early xenopus embryos: I. characterization and timing of cellular changes at the midblastula stage

1982 • 1,635 citations

E2F: a Link Between the Rb Tumor Suppressor Protein and Viral Oncoproteins

1992 • 1,552 citations

The E2F transcription factor is a cellular target for the RB protein

1991 • 1,461 citations

The Embryonic Development of Drosophila melanogaster

1985 • 1,371 citations

Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4

1993 • 1,258 citations

Functional interactions of the retinoblastoma protein with mammalian D-type cyclins

1993 • 1,047 citations

Formation and Activation of a Cyclin E-cdk2 Complex During the G ₁ Phase of the Human Cell Cycle

1992 • 1,046 citations

Regulation of retinoblastoma protein functions by ectopic expression of human cyclins

1992 • 1,031 citations

Association of human cyclin E with a periodic G1-S phase protein kinase

1992 • 900 citations

Physical interaction of the retinoblastoma protein with human D cyclins

1993 • 780 citations

Inhibition of CDK2 activity in vivo by an associated 20K regulatory subunit

1993 • 778 citations

Gene required in G1 for commitment to cell cycle and in G2 for control of mitosis in fission yeast

1981 • 740 citations

Retinoblastoma protein switches the E2F site from positive to negative element

1992 • 663 citations

Ordering S phase and M phase in the cell cycle

1994 • 596 citations

The transcription factor E2F interacts with the retinoblastoma product and a p107-cyclin A complex in a cell cycle-regulated manner

1992 • 588 citations

The interaction of RB with E2F coincides with an inhibition of the transcriptional activity of E2F.

1992 • 587 citations

An essential G1 function for cyclin-like proteins in yeast

1989 • 574 citations

Genetic control of cell division patterns in the Drosophila embryo

1989 • 567 citations

Endothelial proliferation in tumours and normal tissues: Continuous labelling studies

1984 • 562 citations

Mitotic domains reveal early commitment of cells in Drosophila embryos

1989 • 554 citations

Cyclin E controls S phase progression and its down-regulation during Drosophila embryogenesis is required for the arrest of cell proliferation

1994 • 543 citations

Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation.

1993 • 498 citations

Negative regulation of the growth-promoting transcription factor E2F-1 by a stably bound cyclin A-dependent protein kinase

1994 • 493 citations

Inhibition of E2F-1 transactivation by direct binding of the retinoblastoma protein.

1993 • 460 citations

The retinoblastoma protein copurifies with E2F-I, an E1A-regulated inhibitor of the transcription factor E2F

1991 • 446 citations

DAF1, a mutant gene affecting size control, pheromone arrest, and cell cycle kinetics of Saccharomyces cerevisiae.

1988 • 445 citations

The three postblastoderm cell cycles of Drosophila embryogenesis are regulated in G2 by string

1990 • 434 citations

The roles of Drosophila cyclins A and B in mitotic control

1990 • 429 citations

The T/E1A-binding domain of the retinoblastoma product can interact selectively with a sequence-specific DNA-binding protein

1991 • 420 citations

A family of cyclin homologs that control the G1 phase in yeast.

1989 • 416 citations

Mitotic domains reveal early commitment of cells in Drosophila embryos

1989 • 412 citations

Expression and function of Drosophila cyclin a during embryonic cell cycle progression

1989 • 399 citations

A Role for the Transcription Factors Mbp1 and Swi4 in Progression from G1 to S Phase

1993 • 399 citations

Temporal order of S phase and mitosis in fission yeast is determined by the state of the p34cdc2-mitotic B cyclin complex

1994 • 393 citations

Differential regulation of E2F transactivation by cyclin/cdk2 complexes.

1994 • 393 citations

Parameters controlling transcriptional activation during early drosophila development

1986 • 377 citations

The role of SWI4 and SWI6 in the activity of G1 cyclins in yeast

1991 • 354 citations

E2F-1-mediated transactivation is inhibited by complex formation with the retinoblastoma susceptibility gene product.

1993 • 353 citations

A potential positive feedback loop controlling CLN1 and CLN2 gene expression at the start of the yeast cell cycle

1991 • 341 citations

DRTF1/E2F: an expanding family of heterodimeric transcription factors implicated in cell-cycle control

1994 • 323 citations

Transcriptional activation of CLN1, CLN2, and a putative new G1 cyclin (HCS26) by SWI4, a positive regulator of G1-specific transcription

1991 • 313 citations

Distinct molecular mechanism regulate cell cycle timing at successive stages of Drosophila embryogenesis.

1994 • 301 citations

Cyclin A/CDK2 binds directly to E2F-1 and inhibits the DNA-binding activity of E2F-1/DP-1 by phosphorylation.

1994 • 283 citations

Cell cycle-dependent expression of mammalian ribonucleotide reductase. Differential regulation of the two subunits.

1985 • 283 citations

The transcription factor E2F is required for S phase during Drosophila embryogenesis.

1995 • 259 citations

The regulation of the cell cycle during Drosophila embryogenesis: the transition to polyteny

1991 • 259 citations

Rules to replicate by

1994 • 252 citations

Neurogenesis of the peripheral nervous system in Drosophila embryos: DNA replication patterns and cell lineages

1989 • 248 citations

Control of DNA synthesis genes in fission yeast by the cell-cycle gene cdclO+

1992 • 233 citations

Positive feedback in the activation of Gl cyclins in yeast

1991 • 202 citations

Directing Cell Division During Development

1989 • 186 citations

Requirements for autosomal gene activity during precellular stages of Drosophila melanogaster

1988 • 183 citations

S-Phase-specific expression of mammalian ribonucleotide reductase R1 and R2 subunit mRNAs

1990 • 178 citations

The pattern of proliferation of the neuroblasts in the wild-type embryo of Drosophila melanogaster

1987 • 160 citations

DNA-binding and trans-activation properties of Drosophila E2F and DP proteins.

1994 • 155 citations

DP and E2F proteins: components of a heterodimeric transcription factor implicated in cell cycle control

1994 • 152 citations

Requirements for X-linked zygotic gene activity during cellularization of early Drosophila embryos

1988 • 138 citations

A Drosophila G1-specific cyclin E homolog exhibits different modes of expression during embryogenesis

1993 • 137 citations

Mutagen sensitivity and suppression of position-effect variegation result from mutations in mus209, the Drosophila gene encoding PCNA.

1994 • 134 citations

Functional properties of a Drosophila homolog of the E2F1 gene.

1994 • 134 citations

Cip1 blocks the initiation of DNA replication in Xenopus extracts by inhibition of cyclin-dependent kinases

1994 • 130 citations

Changing spatial patterns of DNA replication in the developing wing of Drosophila

1987 • 127 citations

Developmental control of a G1-S transcriptional program in Drosophila

1994 • 113 citations

Ribonucleotide reductase M1 subunit in cellular proliferation, quiescence, and differentiation.

1988 • 107 citations

Transcriptional repression by the Rb-related protein p107.

1993 • 102 citations

Regulation of cell cycle-dependent gene expression in yeast.

1990 • 91 citations

The genetics of a small autosomal region of Drosophila melanogaster containing the structural gene for alcohol dehydrogenase. VII. Characterization of the region around the snail and cactus loci.

1990 • 83 citations

pRB, p107 and the regulation of the E2F transcription factor

1994 • 61 citations

Transcriptional regulation in the eukaryotic cell cycle

1991 • 56 citations

G1 events and the regulation of genes for S-phase enzymes

1992 • 46 citations

A cell cycle analysis of growth-related genes expressed during T lymphocyte maturation.

1990 • 32 citations

Identification of genomic regions required for DNA replication during Drosophila embryogenesis.

1993 • 30 citations