The G₁/S Boundary-Specific Enhancer of the Rat cdc2 Promoter

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase

1988 • 17,059 citations

Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mpl8 and pUC19 vectors

1985 • 15,222 citations

A new technique for the assay of infectivity of human adenovirus 5 DNA

1973 • 9,740 citations

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

1982 • 8,069 citations

[19] Rapid and efficient site-specific mutagenesis without phenotypic selection

1987 • 5,413 citations

High-efficiency transformation of mammalian cells by plasmid DNA.

1987 • 5,377 citations

Unidirectional digestion with exonuclease III creates targeted breakpoints for DNA sequencing

1984 • 4,231 citations

Universal control mechanism regulating onset of M-phase

1990 • 2,882 citations

DNAase footprinting a simple method for the detection of protein-DNA binding specificity

1978 • 2,092 citations

Mammalian G1 cyclins

1993 • 1,990 citations

E2F: a Link Between the Rb Tumor Suppressor Protein and Viral Oncoproteins

1992 • 1,552 citations

Cyclin A is required at two points in the human cell cycle.

1992 • 1,380 citations

DNA-dependent transcription of adenovirus genes in a soluble whole-cell extract.

1980 • 1,285 citations

Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4

1993 • 1,258 citations

Complementation used to clone a human homologue of the fission yeast cell cycle control gene cdc2

1987 • 1,153 citations

D-type cyclin-dependent kinase activity in mammalian cells.

1994 • 1,073 citations

Functional interactions of the retinoblastoma protein with mammalian D-type cyclins

1993 • 1,047 citations

Formation and Activation of a Cyclin E-cdk2 Complex During the G ₁ Phase of the Human Cell Cycle

1992 • 1,046 citations

Expression of transcription factor E2F1 induces quiescent cells to enter S phase

1993 • 960 citations

Isolation of a human cyclin cDNA: Evidence for cyclin mRNA and protein regulation in the cell cycle and for interaction with p34cdc2

1989 • 920 citations

Association of human cyclin E with a periodic G1-S phase protein kinase

1992 • 900 citations

Cyclin a is required for the onset of DNA replication in mammalian fibroblasts

1991 • 884 citations

Activation of cdc2 protein kinase during mitosis in human cells: Cell cycle-dependent phosphorylation and subunit rearrangement

1988 • 786 citations

Physical interaction of the retinoblastoma protein with human D cyclins

1993 • 780 citations

Control of the yeast cell cycle by the Cdc28 protein kinase

1993 • 502 citations

Evidence that the G1-S and G2-M transitions are controlled by different cdc2 proteins in higher eukaryotes

1991 • 493 citations

Isolation of the human cdk2 gene that encodes the cyclin A- and adenovirus E1A-associated p33 kinase

1991 • 475 citations

The cdc2 kinase is a nuclear protein that is essential for mitosis in mammalian cells

1989 • 439 citations

Cell cycle regulation of the human cdc2 gene.

1992 • 396 citations

Rat cell line 3y1 and its virogenic polyoma‐ and SV40‐transformed derivatives

1975 • 340 citations

Human cyclin-dependent kinase 2 is activated during the S and G2 phases of the cell cycle and associates with cyclin A.

1992 • 331 citations

Cell Cycle Regulation in the Yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe

1991 • 326 citations

Regulation of the cell cycle by the cdk2 protein kinase in cultured human fibroblasts.

1993 • 325 citations

The cdk2 kinase is required for the G1-to-S transition in mammalian cells.

1993 • 307 citations

Transcription Factor E2F Is Required for Efficient Expression of the Hamster Dihydrofolate Reductase Gene In Vitro and In Vivo

1989 • 292 citations

Cell Cycle Control of DNA Replication by a Homologue from Human Cells of the p34 ^cdc2 Protein Kinase

1990 • 285 citations

Cyclin A is required in S phase in normal epithelial cells

1992 • 273 citations

cdc2 family kinases phosphorylate a human cell DNA replication factor, RPA, and activate DNA replication.

1992 • 272 citations

A new human p34 protein kinase, CDK2, identified by complementation of a cdc28 mutation in Saccharomyces cerevisiae, is a homolog of Xenopus Eg1.

1991 • 265 citations

A 60 kd cdc2-associated polypeptide complexes with the E1A proteins in adenovirus-infected cells

1989 • 262 citations

Human DNA polymerase alpha gene: sequences controlling expression in cycling and serum-stimulated cells.

1991 • 231 citations

CDK2 encodes a 33-kDa cyclin A-associated protein kinase and is expressed before CDC2 in the cell cycle.

1992 • 230 citations

The FT210 cell line is a mouse G2 phase mutant with a temperature-sensitive CDC2 gene product

1990 • 222 citations

cdc2 Gene Expression at the G ₁ to S Transition in Human T Lymphocytes

1990 • 220 citations

Cloning of a human cDNA encoding a CDC2-related kinase by complementation of a budding yeast cdc28 mutation.

1991 • 201 citations

Cyclin A is required for the onset of DNA replication in mammalian fibroblasts

1992 • 185 citations

The HIP1 Binding Site Is Required for Growth Regulation of the Dihydrofolate Reductase Gene Promoter

1992 • 172 citations

c-myb transactivates cdc2 expression via Myb binding sites in the 5'-flanking region of the human cdc2 gene.

1993 • 125 citations

Recognition of the adenovirus type 2 origin of DNA replication by the virally encoded DNA polymerase and preterminal proteins.

1992 • 93 citations

c-Myc cooperates with activated Ras to induce the cdc2 promoter.

1994 • 78 citations

Activation of the p34 CDC2 protein kinase at the start of S phase in the human cell cycle.

1992 • 71 citations

Requirement for p34cdc2 kinase is restricted to mitosis in the mammalian cdc2 mutant FT210

1992 • 65 citations

The role of cellular transcription factor E2F in the regulation of cdc2 mRNA expression and cell cycle control of human hematopoietic cells

1994 • 60 citations

Transcription signals and protein binding sites for sericin gene transcription in vitro

1989 • 56 citations

E1A-responsive elements for repression of rat fibronectin gene transcription.

1992 • 40 citations

Association of p34cdc with Replicating DNA

1991 • 30 citations

Differential Activation of Cyclin and Cyclin-Dependent Kinase Genes by Adenovirus E1A12S cDNA Product

1993 • 18 citations