In Vivo Association of E2F and DP Family Proteins

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Antibodies, a laboratory manual

1989 • 12,929 citations

A new technique for the assay of infectivity of human adenovirus 5 DNA

1973 • 9,740 citations

Firefly luciferase gene: structure and expression in mammalian cells.

1987 • 3,088 citations

Current Protocols in Molecular Biology

1989 • 1,916 citations

Suppression of Human Colorectal Carcinoma Cell Growth by Wild-Type p53

1990 • 1,796 citations

E2F: a Link Between the Rb Tumor Suppressor Protein and Viral Oncoproteins

1992 • 1,552 citations

The E2F transcription factor is a cellular target for the RB protein

1991 • 1,461 citations

Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4

1993 • 1,258 citations

Monoclonal antibodies specific for simian virus 40 tumor antigens

1981 • 1,110 citations

D-type cyclin-dependent kinase activity in mammalian cells.

1994 • 1,073 citations

Purification of a RAS-responsive adenylyl cyclase complex from Saccharomyces cerevisiae by use of an epitope addition method.

1988 • 983 citations

Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties

1992 • 846 citations

Identification of G1 kinase activity for cdk6, a novel cyclin D partner.

1994 • 798 citations

A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F

1992 • 652 citations

Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product.

1992 • 617 citations

The transcription factor E2F interacts with the retinoblastoma product and a p107-cyclin A complex in a cell cycle-regulated manner

1992 • 588 citations

The interaction of RB with E2F coincides with an inhibition of the transcriptional activity of E2F.

1992 • 587 citations

Frequent inactivation of the retinoblastoma anti-oncogene is restricted to a subset of human tumor cells.

1990 • 543 citations

Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein.

1993 • 531 citations

Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation.

1993 • 498 citations

ADENOVIRUS PROMOTERS AND E1A TRANSACTIVATION

1986 • 460 citations

Inhibition of E2F-1 transactivation by direct binding of the retinoblastoma protein.

1993 • 460 citations

Cyclin E/cdk2 and cyclin A/cdk2 kinases associate with p107 and E2F in a temporally distinct manner.

1992 • 449 citations

The retinoblastoma protein binds to a family of E2F transcription factors.

1993 • 436 citations

Adenovirus E1a prevents the retinoblastoma gene product from complexing with a cellular transcription factor

1991 • 435 citations

Independent binding of the retinoblastoma protein and p107 to the transcription factor E2F

1992 • 381 citations

Cell cycle regulation of the E2F transcription factor involves an interaction with cyclin A

1991 • 374 citations

A cyclin A-protein kinase complex possesses sequence-specific DNA binding activity: p33cdk2 is a component of the E2F-cyclin A complex

1992 • 361 citations

Adenovirus E1A proteins can dissociate heteromeric complexes involving the E2F transcription factor: A novel mechanism for E1A trans-activation

1990 • 358 citations

Cell cycle-specific association of E2F with the p130 E1A-binding protein.

1993 • 348 citations

The retinoblastoma protein is phosphorylated on multiple sites by human cdc2.

1991 • 343 citations

Molecular cloning of cellular genes encoding retinoblastoma-associated proteins: identification of a gene with properties of the transcription factor E2F.

1992 • 331 citations

E2F-4, a new member of the E2F transcription factor family, interacts with p107.

1994 • 331 citations

E2F-4, a new member of the E2F gene family, has oncogenic activity and associates with p107 in vivo.

1994 • 329 citations

Retinoblastoma cancer suppressor gene product is a substrate of the cell cycle regulator cdc2 kinase.

1991 • 304 citations

A new component of the transcription factor DRTF1/E2F

1993 • 293 citations

E1A-dependent trans-activation of the human MYC promoter is mediated by the E2F factor.

1989 • 283 citations

Binding to DNA and the Retinoblastoma Gene Product Promoted by Complex Formation of Different E2F Family Members

1993 • 271 citations

Functional synergy between DP-1 and E2F-1 in the cell cycle-regulating transcription factor DRTF1/E2F.

1993 • 267 citations

Collaboration of G1 cyclins in the functional inactivation of the retinoblastoma protein.

1994 • 253 citations

Transcriptional repression of the E2-containing promoters EIIaE, c-myc, and RB1 by the product of the RB1 gene.

1992 • 250 citations

Interactions of the p107 and Rb proteins with E2F during the cell proliferation response.

1993 • 235 citations

Cloning and characterization of E2F-2, a novel protein with the biochemical properties of transcription factor E2F.

1993 • 196 citations

Domains of the adenovirus E1A protein required for oncogenic activity are also required for dissociation of E2F transcription factor complexes.

1991 • 161 citations

Role of E2F transcription factor in E1A-mediated trans activation of cellular genes

1991 • 142 citations

Independent regions of adenovirus E1A are required for binding to and dissociation of E2F-protein complexes.

1993 • 141 citations

Adenovirus E1a prevents the retinoblastoma gene product from repressing the activity of a cellular transcription factor.

1992 • 137 citations

Antibodies specific for the human retinoblastoma protein identify a family of related polypeptides.

1991 • 131 citations

Analysis of p107-associated proteins: p107 associates with a form of E2F that differs from pRB-associated E2F-1

1993 • 113 citations

DP-1: a cell cycle-regulated and phosphorylated component of transcription factor DRTF1/E2F which is functionally important for recognition by pRb and the adenovirus E4 orf 6/7 protein.

1994 • 90 citations

Transactivation by the adenovirus E1A gene

1988 • 24 citations

Molecular characterization of Xenopus laevis DP proteins.

1994 • 24 citations

Growth Suppression by Members of the Retinoblastoma Protein Family

1994 • 17 citations