Isolation of the Rb-related p130 through its interaction with CDK2 and cyclins.

Basic local alignment search tool

1990 • 87,358 citations

Basic Local Alignment Search Tool

1990 • 12,947 citations

Mammalian G1 cyclins

1993 • 1,990 citations

Eukaryotic proteins expressed in Escherichia coli: An improved thrombin cleavage and purification procedure of fusion proteins with glutathione S-transferase

1991 • 1,779 citations

Cyclin D1 is a nuclear protein required for cell cycle progression in G1.

1993 • 1,605 citations

The myoD Gene Family: Nodal Point During Specification of the Muscle Cell Lineage

1991 • 1,564 citations

The E2F transcription factor is a cellular target for the RB protein

1991 • 1,461 citations

Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4

1993 • 1,258 citations

Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle

1991 • 1,190 citations

Functional interactions of the retinoblastoma protein with mammalian D-type cyclins

1993 • 1,047 citations

Purification of a RAS-responsive adenylyl cyclase complex from Saccharomyces cerevisiae by use of an epitope addition method.

1988 • 983 citations

Physical interaction of the retinoblastoma protein with human D cyclins

1993 • 780 citations

Cyclin-Dependent Regulation of G ₁ in Mammalian Fibroblasts

1993 • 767 citations

Interaction of myogenic factors and the retinoblastoma protein mediates muscle cell commitment and differentiation

1993 • 734 citations

Retinoblastoma protein switches the E2F site from positive to negative element

1992 • 663 citations

The interaction of RB with E2F coincides with an inhibition of the transcriptional activity of E2F.

1992 • 587 citations

An essential G1 function for cyclin-like proteins in yeast

1989 • 574 citations

Identification of cellular proteins that can interact specifically with the T/ElA-binding region of the retinoblastoma gene product

1991 • 541 citations

Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein.

1993 • 531 citations

Allelotype of breast cancer: cumulative allele losses promote tumor progression in primary breast cancer.

1990 • 511 citations

Isolation of the human cdk2 gene that encodes the cyclin A- and adenovirus E1A-associated p33 kinase

1991 • 475 citations

Molecular cloning, chromosomal mapping, and expression of the cDNA for p107, a retinoblastoma gene product-related protein

1991 • 464 citations

Cyclin E/cdk2 and cyclin A/cdk2 kinases associate with p107 and E2F in a temporally distinct manner.

1992 • 449 citations

Using the two-hybrid system to detect protein-protein interactions

1993 • 414 citations

p13suc1 acts in the fission yeast cell division cycle as a component of the p34cdc2 protein kinase.

1987 • 387 citations

Cell cycle regulation of the E2F transcription factor involves an interaction with cyclin A

1991 • 374 citations

Association of adenovirus early-region 1A proteins with cellular polypeptides.

1986 • 368 citations

Cell cycle control in eukaryotes: molecular mechanisms of cdc2 activation

1990 • 364 citations

A cyclin A-protein kinase complex possesses sequence-specific DNA binding activity: p33cdk2 is a component of the E2F-cyclin A complex

1992 • 361 citations

The regions of the retinoblastoma protein needed for binding to adenovirus E1A or SV40 large T antigen are common sites for mutations.

1990 • 327 citations

Characterization of four B-type cyclin genes of the budding yeast Saccharomyces cerevisiae.

1992 • 310 citations

Cyclin-B homologs in Saccharomyces cerevisiae function in S phase and in G2.

1992 • 281 citations

Growth-regulated expression of D-type cyclin genes in human diploid fibroblasts.

1992 • 277 citations

A new human p34 protein kinase, CDK2, identified by complementation of a cdc28 mutation in Saccharomyces cerevisiae, is a homolog of Xenopus Eg1.

1991 • 265 citations

Genomic organization, chromosomal localization, and independent expression of human cyclin D genes

1992 • 264 citations

Interaction of p107 with Cyclin A Independent of Complex Formation with Viral Oncoproteins

1992 • 234 citations

Accumulation of genetic alterations and progression of primary breast cancer.

1991 • 229 citations

Interaction Between Human Cyclin A and Adenovirus E1A-Associated p107 Protein

1992 • 216 citations

A single amino acid substitution results in a retinoblastoma protein defective in phosphorylation and oncoprotein binding.

1990 • 204 citations

Two distinct and frequently mutated regions of retinoblastoma protein are required for binding to SV40 T antigen.

1990 • 204 citations

A third Wilms' tumor locus on chromosome 16q.

1992 • 201 citations

Definition of the minimal simian virus 40 large T antigen- and adenovirus E1A-binding domain in the retinoblastoma gene product.

1990 • 197 citations

A- and B-type cyclins differentially modulate substrate specificity of cyclin-cdk complexes.

1993 • 190 citations

Human cDNAs encoding homologs of the small p34Cdc28/Cdc2-associated protein of Saccharomyces cerevisiae and Schizosaccharomyces pombe.

1990 • 181 citations

Association of Adenovirus Early-Region 1A Proteins with Cellular Polypeptides

1986 • 166 citations

Molecular characterization of the retinoblastoma susceptibility gene

1993 • 161 citations

Antibodies specific for the human retinoblastoma protein identify a family of related polypeptides.

1991 • 131 citations

Loss of heterozygosity on 6q, 16q, and 17p in human central nervous system primitive neuroectodermal tumors.

1991 • 117 citations

Frequent Loss of Heterozygosity on Chromosomes 16 and 4 in Human Hepatocellular Carcinoma

1990 • 116 citations

Signals and genes in the control of cell-cycle progression

1993 • 113 citations

The retinoblastoma gene and gene product.

1992 • 111 citations

Correlation of chromosome abnormalities with histological and clinical features in Wilms' and other childhood renal tumors.

1991 • 103 citations

Cytogenetics and molecular genetics of Wilms' Tumor of childhood

1992 • 103 citations

The adenovirus E1A-associated kinase consists of cyclin E-p33cdk2 and cyclin A-p33cdk2

1993 • 80 citations

A transcriptional tryst

1991 • 69 citations

1P13 is the most frequently involved band in structural chromosomal rearrangements in human breast cancer

1990 • 56 citations

Definition of the Minimal Simian Virus 40 Large Τ Antigen- and Adenovirus E1A-Binding Domain in the Retinoblastoma Gene Product

1990 • 54 citations

Conservation of function and regulation within the Cdc28/cdc2 protein kinase family: characterization of the human Cdc2Hs protein kinase in Saccharomyces cerevisiae.

1989 • 50 citations

Transcription of a nematode trans-spliced leader RNA requires internal elements for both initiation and 3′ end-formation.

1990 • 46 citations

Antibodies Specific for the Human Retinoblastoma Protein Identify a Family of Related Polypeptides

1991 • 41 citations

Genetic changes associated with prostate cancer in humans.

1991 • 31 citations

Chromosome Mapping of Human CDC25A and CDC25B Phosphatases

1993 • 20 citations

Chromosomal localization of putative tumor-suppressor genes in several human cancers.

1991 • 6 citations