DNA-binding and trans-activation properties of Drosophila E2F and DP proteins.

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase

1988 • 6,107 citations

E2F: a Link Between the Rb Tumor Suppressor Protein and Viral Oncoproteins

1992 • 1,552 citations

Analysis of Sp1 in vivo reveals mutiple transcriptional domains, including a novel glutamine-rich activation motif

1988 • 1,403 citations

Cell lines derived from late embryonic stages of Drosophila melanogaster

1972 • 1,215 citations

Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties

1992 • 846 citations

Transcription activation by the adenovirus E1a protein

1989 • 667 citations

A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F

1992 • 652 citations

The transcription factor E2F interacts with the retinoblastoma product and a p107-cyclin A complex in a cell cycle-regulated manner

1992 • 588 citations

The interaction of RB with E2F coincides with an inhibition of the transcriptional activity of E2F.

1992 • 587 citations

Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein.

1993 • 531 citations

Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation.

1993 • 498 citations

Inhibition of E2F-1 transactivation by direct binding of the retinoblastoma protein.

1993 • 460 citations

Cyclin E/cdk2 and cyclin A/cdk2 kinases associate with p107 and E2F in a temporally distinct manner.

1992 • 449 citations

The retinoblastoma protein binds to a family of E2F transcription factors.

1993 • 436 citations

Sevenless , a Cell-Specific Homeotic Gene of Drosophila , Encodes a Putative Transmembrane Receptor with a Tyrosine Kinase Domain

1987 • 421 citations

A nonchromatographic assay for expression of the chloramphenicol acetyltransferase gene in eucaryotic cells

1986 • 408 citations

Cell cycle regulation of the human cdc2 gene.

1992 • 396 citations

Independent binding of the retinoblastoma protein and p107 to the transcription factor E2F

1992 • 381 citations

A cyclin A-protein kinase complex possesses sequence-specific DNA binding activity: p33cdk2 is a component of the E2F-cyclin A complex

1992 • 361 citations

E2F-1-mediated transactivation is inhibited by complex formation with the retinoblastoma susceptibility gene product.

1993 • 353 citations

Synergistic activation and repression of transcription by Drosophila homeobox proteins

1989 • 353 citations

Cell cycle-specific association of E2F with the p130 E1A-binding protein.

1993 • 348 citations

An E2F-binding site mediates cell-cycle regulated repression of mouse B-myb transcription.

1993 • 342 citations

Molecular cloning of cellular genes encoding retinoblastoma-associated proteins: identification of a gene with properties of the transcription factor E2F.

1992 • 331 citations

A protein synthesis-dependent increase in E2F1 mRNA correlates with growth regulation of the dihydrofolate reductase promoter.

1993 • 315 citations

Cyclin A and the retinoblastoma gene product complex with a common transcription factor

1991 • 296 citations

A new component of the transcription factor DRTF1/E2F

1993 • 293 citations

Transcription Factor E2F Is Required for Efficient Expression of the Hamster Dihydrofolate Reductase Gene In Vitro and In Vivo

1989 • 292 citations

E1A-dependent trans-activation of the human MYC promoter is mediated by the E2F factor.

1989 • 283 citations

Functional synergy between DP-1 and E2F-1 in the cell cycle-regulating transcription factor DRTF1/E2F.

1993 • 267 citations

Nuclear factor E2F mediates basic transcription and trans-activation by E1a of the human MYC promoter.

1989 • 262 citations

Transcriptional repression of the E2-containing promoters EIIaE, c-myc, and RB1 by the product of the RB1 gene.

1992 • 250 citations

Interactions of the p107 and Rb proteins with E2F during the cell proliferation response.

1993 • 235 citations

Interaction of p107 with Cyclin A Independent of Complex Formation with Viral Oncoproteins

1992 • 234 citations

Interaction Between Human Cyclin A and Adenovirus E1A-Associated p107 Protein

1992 • 216 citations

The retinoblastoma protein as a transcriptional repressor

1993 • 176 citations

The HIP1 Binding Site Is Required for Growth Regulation of the Dihydrofolate Reductase Gene Promoter

1992 • 172 citations

Inhibition of E2F-1 Transactivation by Direct Binding of the Retinoblastoma Protein

1993 • 151 citations

An adenovirus E1A-like transcription factor is regulated during the differentiation of murine embryonal carcinoma stem cells

1987 • 149 citations

Functional analysis of NTF-1, a developmentally regulated Drosophila transcription factor that binds neuronal cis elements.

1989 • 141 citations

The Retinoblastoma Protein Binds to a Family of E2F Transcription Factors

1993 • 135 citations

Functional properties of a Drosophila homolog of the E2F1 gene.

1994 • 134 citations

Transcription factor E2F binds DNA as a heterodimer.

1993 • 116 citations

Transcriptional repression by the Rb-related protein p107.

1993 • 102 citations

Molecular Cloning of Cellular Genes Encoding Retinoblastoma-Associated Proteins: Identification of a Gene with Properties of the Transcription Factor E2F

1992 • 82 citations

A Protein Synthesis-Dependent Increase in E2F1 mRNA Correlates with Growth Regulation of the Dihydrofolate Reductase Promoter

1993 • 80 citations

Functional Properties of a Drosophila Homolog of the E2F1 Gene

1994 • 27 citations