The retinoblastoma protein is phosphorylated during specific phases of the cell cycle

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A Film Detection Method for Tritium‐Labelled Proteins and Nucleic Acids in Polyacrylamide Gels

1974 • 8,693 citations

Mutation and Cancer: Statistical Study of Retinoblastoma

1971 • 7,335 citations

The Human Papilloma Virus-16 E7 Oncoprotein Is Able to Bind to the Retinoblastoma Gene Product

1989 • 3,036 citations

A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma

1986 • 2,968 citations

Expression of recessive alleles by chromosomal mechanisms in retinoblastoma

1983 • 1,952 citations

SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene

1988 • 1,490 citations

Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product

1988 • 1,440 citations

Human Retinoblastoma Susceptibility Gene: Cloning, Identification, and Sequence

1987 • 1,436 citations

Complex formation of human papillomavirus E7 proteins with the retinoblastoma tumor suppressor gene product.

1989 • 1,186 citations

Monoclonal antibodies specific for simian virus 40 tumor antigens

1981 • 1,110 citations

The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory element

1989 • 931 citations

Abnormalities in Structure and Expression of the Human Retinoblastoma Gene in SCLC

1988 • 905 citations

Suppression of the Neoplastic Phenotype by Replacement of the RB Gene in Human Cancer Cells

1988 • 832 citations

The Xenopus cdc2 protein is a component of MPF, a cytoplasmic regulator of mitosis

1988 • 829 citations

Structural Evidence for the Authenticity of the Human Retinoblastoma Gene

1987 • 809 citations

Activation of cdc2 protein kinase during mitosis in human cells: Cell cycle-dependent phosphorylation and subunit rearrangement

1988 • 786 citations

Cellular targets for transformation by the adenovirus E1A proteins

1989 • 747 citations

The retinoblastoma susceptibility gene encodes a nuclear phosphoprotein associated with DNA binding activity

1987 • 649 citations

Isolation and characterization of the c-fos(rat) cDNA and analysis of post-translational modification in vitro.

1987 • 630 citations

Inactivation of the Retinoblastoma Susceptibility Gene in Human Breast Cancers

1988 • 608 citations

SV40 large T antigen binds preferentially to an underphosphorylated member of the retinoblastoma susceptibility gene product family

1989 • 508 citations

Retinoblastoma and Subband Deletion of Chromosome 13

1978 • 455 citations

Point Mutational Inactivation of the Retinoblastoma Antioncogene

1989 • 427 citations

Structural Rearrangement of the Retinoblastoma Gene in Human Breast Carcinoma

1988 • 423 citations

Monoclonal antibodies specific for adenovirus early region 1A proteins: extensive heterogeneity in early region 1A products

1985 • 417 citations

Patient with 13 Chromosome Deletion: Evidence That the Retinoblastoma Gene Is a Recessive Cancer Gene

1983 • 342 citations

Activation at M-phase of a protein kinase encoded by a starfish homologue of the cell cycle control gene cdc2+

1988 • 314 citations

The cellular 107K protein that binds to adenovirus E1A also associates with the large T antigens of SV40 and JC virus

1989 • 307 citations

Homozygosity of Chromosome 13 in Retinoblastoma

1984 • 294 citations

Functional domains of adenovirus type 5 E1a proteins

1987 • 283 citations

Chromosomal Deletion and Retinoblastoma

1976 • 283 citations

Identification of early proteins of the human papilloma viruses type 16 (HPV 16) and type 18 (HPV 18) in cervical carcinoma cells.

1987 • 272 citations

Identification of Germline and Somatic Mutations Affecting the Retinoblastoma Gene

1988 • 270 citations

Altered phosphorylation and activation of PP60c-src during fibroblast mitosis

1988 • 249 citations

In vitro mutagenesis of a putative DNA binding domain of SV40 large-T

1984 • 248 citations

Structure and expression of the murine retinoblastoma gene and characterization of its encoded protein.

1989 • 248 citations

Altered expression of the retinoblastoma (RB) gene in small-cell carcinoma of the lung.

1988 • 247 citations

Somatic inactivation of genes on chromosome 13 is a common event in retinoblastoma

1983 • 234 citations

Identification of separate domains in the adenovirus E1A gene for immortalization activity and the activation of virus early genes.

1986 • 231 citations

Preferential mutation of paternally derived RB gene as the initial event in sporadic osteosarcoma

1989 • 221 citations

Mutational analysis of the adenovirus E1a gene: the role of transcriptional regulation in transformation.

1987 • 201 citations

A region of SV40 large T antigen can substitute for a transforming domain of the adenovirus E1A products

1988 • 167 citations

Familial Retinoblastoma and Chromosome 13 Deletion Transmitted via an Insertional Translocation

1981 • 154 citations

Abnormalities of chromosome #13 in retinoblastomas from individuals with normal constitutional karyotypes

1982 • 130 citations

Cyclic activation of histone H1 kinase during sea urchin egg mitotic divisions

1988 • 126 citations

Tumor suppressors: Recessive mutations that lead to cancer

1988 • 115 citations

Chromosome 13 homozygosity in osteosarcoma without retinoblastoma.

1986 • 106 citations

The retinoblastoma susceptibility gene product: a characteristic pattern in normal cells and abnormal expression in malignant cells.

1989 • 104 citations

Historic Review of Retinoblastoma

1987 • 99 citations

Sporadic bilateral retinoblastoma and 13q‐chromosomal deletion

1976 • 95 citations

Nonrandom chromosomal changes in untreated retinoblastomas

1983 • 93 citations

Separation of simian virus 40 large-T-antigen-transforming and origin-binding functions from the ability to block differentiation.

1988 • 86 citations

The amino-terminal region of the adenovirus serotype 5 E1a protein performs two separate functions when expressed in primary baby rat kidney cells.

1988 • 61 citations

Substrate specificity of ribosomal protein S6 kinase II from Xenopus eggs.

1988 • 43 citations