Activity of the Retinoblastoma Family Proteins, pRB, p107, and p130, during Cellular Proliferation and Differentiation

Mutation and Cancer: Statistical Study of Retinoblastoma

1971 • 7,335 citations

Inhibitors of mammalian G1 cyclin-dependent kinases.

1995 • 3,258 citations

Checkpoints: Controls That Ensure the Order of Cell Cycle Events

1989 • 3,036 citations

The Human Papilloma Virus-16 E7 Oncoprotein Is Able to Bind to the Retinoblastoma Gene Product

1989 • 3,036 citations

A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma

1986 • 2,968 citations

Universal control mechanism regulating onset of M-phase

1990 • 2,882 citations

G1 phase progression: Cycling on cue

1994 • 2,706 citations

Cyclins and cancer II: Cyclin D and CDK inhibitors come of age

1994 • 2,122 citations

Mammalian G1 cyclins

1993 • 1,990 citations

Effects of an Rb mutation in the mouse

1992 • 1,779 citations

Molecular themes in oncogenesis

1991 • 1,663 citations

Cyclin: A protein specified by maternal mRNA in sea urchin eggs that is destroyed at each cleavage division

1983 • 1,506 citations

SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene

1988 • 1,490 citations

Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product

1988 • 1,440 citations

Cyclin A is required at two points in the human cell cycle.

1992 • 1,380 citations

A novel cyclin encoded by a bcl1-linked candidate oncogene

1991 • 1,286 citations

Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis

1992 • 1,285 citations

Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4

1993 • 1,258 citations

Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle

1991 • 1,190 citations

Complex formation of human papillomavirus E7 proteins with the retinoblastoma tumor suppressor gene product.

1989 • 1,186 citations

Human Cyclin E, a Nuclear Protein Essential for the G₁-to-S Phase Transition

1995 • 1,132 citations

Functional interactions of the retinoblastoma protein with mammalian D-type cyclins

1993 • 1,047 citations

Formation and Activation of a Cyclin E-cdk2 Complex During the G ₁ Phase of the Human Cell Cycle

1992 • 1,046 citations

Regulation of retinoblastoma protein functions by ectopic expression of human cyclins

1992 • 1,031 citations

The retinoblastoma protein is phosphorylated during specific phases of the cell cycle

1989 • 1,031 citations

Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiation

1989 • 990 citations

Expression of transcription factor E2F1 induces quiescent cells to enter S phase

1993 • 960 citations

The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory element

1989 • 931 citations

Cellular Targets for Activation by the E2F1 Transcription Factor Include DNA Synthesis- and G₁/S-Regulatory Genes

1995 • 910 citations

Identification and properties of an atypical catalytic subunit (p34PSK-J3/cdk4) for mammalian D type G1 cyclins

1992 • 906 citations

Association of human cyclin E with a periodic G1-S phase protein kinase

1992 • 900 citations

Cyclin a is required for the onset of DNA replication in mammalian fibroblasts

1991 • 884 citations

Isolation of three novel human cyclins by rescue of G1 cyclin (cln) function in yeast

1991 • 846 citations

Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties

1992 • 846 citations

Suppression of the Neoplastic Phenotype by Replacement of the RB Gene in Human Cancer Cells

1988 • 832 citations

Identification of G1 kinase activity for cdk6, a novel cyclin D partner.

1994 • 798 citations

Physical interaction of the retinoblastoma protein with human D cyclins

1993 • 780 citations

Dominoes and Clocks: the Union of Two Views of the Cell Cycle

1989 • 750 citations

Human D-type cyclin

1991 • 712 citations

Cyclins and cancer

1991 • 701 citations

Cyclin activation of p34cdc2

1990 • 690 citations

Retinoblastoma protein switches the E2F site from positive to negative element

1992 • 663 citations

The human papillomavirus type 16 E7 gene encodes transactivation and transformation functions similar to those of adenovirus E1A

1988 • 657 citations

Human cyclin E, a new cyclin that interacts with two members of the CDC2 gene family

1991 • 656 citations

A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F

1992 • 652 citations

The retinoblastoma susceptibility gene encodes a nuclear phosphoprotein associated with DNA binding activity

1987 • 649 citations

The transcription factor E2F interacts with the retinoblastoma product and a p107-cyclin A complex in a cell cycle-regulated manner

1992 • 588 citations

The interaction of RB with E2F coincides with an inhibition of the transcriptional activity of E2F.

1992 • 587 citations

Identification of a cellular transcription factor involved in E1A trans-activation

1986 • 551 citations

Cyclin E controls S phase progression and its down-regulation during Drosophila embryogenesis is required for the arrest of cell proliferation

1994 • 543 citations

The clam embryo protein cyclin A induces entry into M phase and the resumption of meiosis in Xenopus oocytes

1986 • 534 citations

Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein.

1993 • 531 citations

Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis.

1994 • 515 citations

SV40 large T antigen binds preferentially to an underphosphorylated member of the retinoblastoma susceptibility gene product family

1989 • 508 citations

Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation.

1993 • 498 citations

Mechanism of active transcriptional repression by the retinoblastoma protein

1995 • 494 citations

Negative regulation of the growth-promoting transcription factor E2F-1 by a stably bound cyclin A-dependent protein kinase

1994 • 493 citations

Isolation of the Rb-related p130 through its interaction with CDK2 and cyclins.

1993 • 476 citations

Isolation of the human cdk2 gene that encodes the cyclin A- and adenovirus E1A-associated p33 kinase

1991 • 475 citations

Substrates for p34cdc2: In vivo veritas?

1990 • 472 citations

Different Roles for Cyclins D1 and E in Regulation of the G₁-to-S Transition

1995 • 469 citations

Molecular cloning, chromosomal mapping, and expression of the cDNA for p107, a retinoblastoma gene product-related protein

1991 • 464 citations

Inhibition of E2F-1 transactivation by direct binding of the retinoblastoma protein.

1993 • 460 citations

Cell Cycle-Dependent Regulation of Phosphorylation of the Human Retinoblastoma Gene Product

1989 • 457 citations

Cytostatic Gene Therapy for Vascular Proliferative Disorders with a Constitutively Active form of the Retinoblastoma Gene Product

1995 • 455 citations

Retinoblastoma and Subband Deletion of Chromosome 13

1978 • 455 citations

G1-specific cyclins of S. cerevisiae: Cell cycle periodicity, regulation by mating pheromone, and association with the p34CDC28 protein kinase

1990 • 449 citations

Cyclin E/cdk2 and cyclin A/cdk2 kinases associate with p107 and E2F in a temporally distinct manner.

1992 • 449 citations

The retinoblastoma protein copurifies with E2F-I, an E1A-regulated inhibitor of the transcription factor E2F

1991 • 446 citations

The retinoblastoma protein binds to a family of E2F transcription factors.

1993 • 436 citations

A family of cyclin homologs that control the G1 phase in yeast.

1989 • 416 citations

Driving the cell cycle: M phase kinase, its partners, and substrates

1990 • 404 citations

A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle

1993 • 402 citations

The retinoblastoma susceptibility gene product undergoes cell cycle-dependent dephosphorylation and binding to and release from SV40 large T

1990 • 402 citations

Cell cycle regulation of the human cdc2 gene.

1992 • 396 citations

Differential regulation of E2F transactivation by cyclin/cdk2 complexes.

1994 • 393 citations

Independent binding of the retinoblastoma protein and p107 to the transcription factor E2F

1992 • 381 citations

Cell cycle regulation of the E2F transcription factor involves an interaction with cyclin A

1991 • 374 citations

Gene for Hereditary Retinoblastoma Assigned to Human Chromosome 13 by Linkage to Esterase D

1983 • 369 citations

Reversal of Terminal Differentiation Mediated by p107 in Rb ^-/- Muscle Cells

1994 • 369 citations

Association of adenovirus early-region 1A proteins with cellular polypeptides.

1986 • 368 citations

S Phase of the Cell Cycle

1989 • 366 citations

Cyclin A-kinase regulation of E2F-1 DNA binding function underlies suppression of an S phase checkpoint

1995 • 361 citations

Alterations to either c-erbB-2(neu) or c-myc proto-oncogenes in breast carcinomas correlate with poor short-term prognosis.

1987 • 360 citations

E2F-1-mediated transactivation is inhibited by complex formation with the retinoblastoma susceptibility gene product.

1993 • 353 citations

Mutation and childhood cancer: a probabilistic model for the incidence of retinoblastoma.

1975 • 353 citations

Regional Assignment of Genes for Human Esterase D and Retinoblastoma to Chromosome Band 13q14

1980 • 348 citations

Cell cycle-specific association of E2F with the p130 E1A-binding protein.

1993 • 348 citations

The retinoblastoma protein is phosphorylated on multiple sites by human cdc2.

1991 • 343 citations

Interaction of Sp1 with the Growth- and Cell Cycle-Regulated Transcription Factor E2F

1996 • 343 citations

The adenovirus E1A-associated 130-kD protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E.

1993 • 341 citations

E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle.

1995 • 336 citations

Molecular cloning of cellular genes encoding retinoblastoma-associated proteins: identification of a gene with properties of the transcription factor E2F.

1992 • 331 citations

E2F-4, a new member of the E2F transcription factor family, interacts with p107.

1994 • 331 citations

An adenovirus E1a protein region required for transformation and transcriptional repression

1986 • 329 citations

E2F-4, a new member of the E2F gene family, has oncogenic activity and associates with p107 in vivo.

1994 • 329 citations

E2F-4 Switches from p130 to p107 and pRB in Response to Cell Cycle Reentry

1996 • 327 citations

The regions of the retinoblastoma protein needed for binding to adenovirus E1A or SV40 large T antigen are common sites for mutations.

1990 • 327 citations

A protein synthesis-dependent increase in E2F1 mRNA correlates with growth regulation of the dihydrofolate reductase promoter.

1993 • 315 citations

The Role of p34 Kinases in the G1 to S-Phase Transition

1992 • 313 citations

Retinoblastoma cancer suppressor gene product is a substrate of the cell cycle regulator cdc2 kinase.

1991 • 304 citations

Functional interaction between E2F-4 and p130: evidence for distinct mechanisms underlying growth suppression by different retinoblastoma protein family members.

1995 • 299 citations

A new component of the transcription factor DRTF1/E2F

1993 • 293 citations

Transcription Factor E2F Is Required for Efficient Expression of the Hamster Dihydrofolate Reductase Gene In Vitro and In Vivo

1989 • 292 citations

Extensive contribution of Rb-deficient cells to adult chimeric mice with limited histopathological consequences.

1994 • 289 citations

Oncogenic Point Mutations in the Human Retinoblastoma Gene: Their Application to Genetic Counseling

1989 • 288 citations

Functional domains of adenovirus type 5 E1a proteins

1987 • 283 citations

Cyclin A/CDK2 binds directly to E2F-1 and inhibits the DNA-binding activity of E2F-1/DP-1 by phosphorylation.

1994 • 283 citations

Chromosomal Deletion and Retinoblastoma

1976 • 283 citations

Metabolism of c-myc gene products: c-myc mRNA and protein expression in the cell cycle.

1985 • 271 citations

Cell Cycle-Regulated Association of E2F1 and Sp1 Is Related to Their Functional Interaction

1996 • 268 citations

Nuclear factor E2F mediates basic transcription and trans-activation by E1a of the human MYC promoter.

1989 • 262 citations

CDK6 (PLSTIRE) and CDK4 (PSK-J3) are a distinct subset of the cyclin-dependent kinases that associate with cyclin D1.

1994 • 260 citations

The transcription factor E2F is required for S phase during Drosophila embryogenesis.

1995 • 259 citations

Regulation of the retinoblastoma protein-related p107 by G1 cyclin complexes.

1995 • 254 citations

Collaboration of G1 cyclins in the functional inactivation of the retinoblastoma protein.

1994 • 253 citations

A role for the adenovirus inducible E2F transcription factor in a proliferation dependent signal transduction pathway.

1990 • 253 citations

p107 uses a p21CIP1-related domain to bind cyclin/cdk2 and regulate interactions with E2F.

1995 • 253 citations

Cyclin A-Associated Kinase Activity Is Rate Limiting for Entrance into S Phase and Is Negatively Regulated in G₁ by p27^Kip1

1995 • 252 citations

Transcriptional repression of the E2-containing promoters EIIaE, c-myc, and RB1 by the product of the RB1 gene.

1992 • 250 citations

Transcription of the E2F-1 Gene Is Rendered Cell Cycle Dependent by E2F DNA-Binding Sites within Its Promoter

1995 • 250 citations

Structure and expression of the murine retinoblastoma gene and characterization of its encoded protein.

1989 • 248 citations

In Vivo Association of E2F and DP Family Proteins

1995 • 246 citations

DNA tumor virus transforming proteins and the cell cycle

1993 • 242 citations

Interactions of the p107 and Rb proteins with E2F during the cell proliferation response.

1993 • 235 citations

Cloning of a new member of the retinoblastoma gene family (pRb2) which binds to the E1A transforming domain.

1993 • 235 citations

Interaction of p107 with Cyclin A Independent of Complex Formation with Viral Oncoproteins

1992 • 234 citations

E2F-5, a New E2F Family Member That Interacts with p130 In Vivo

1995 • 232 citations

Two regions of the adenovirus early region 1A proteins are required for transformation

1988 • 232 citations

Human DNA polymerase alpha gene: sequences controlling expression in cycling and serum-stimulated cells.

1991 • 231 citations

Detection of cellular proteins associated with human adenovirus type 5 early region 1A polypeptides

1985 • 227 citations

Regulation of the Ets-Related Transcription Factor Elf-1 by Binding to the Retinoblastoma Protein

1993 • 220 citations

Trisomy for the Distal End of the Short Arm of Chromosome 3

1978 • 216 citations

Interaction Between Human Cyclin A and Adenovirus E1A-Associated p107 Protein

1992 • 216 citations

Overexpression of E2F-1 in rat embryo fibroblasts leads to neoplastic transformation.

1994 • 214 citations

p130/pRb2 has growth suppressive properties similar to yet distinctive from those of retinoblastoma family members pRb and p107.

1994 • 211 citations

Cell Cycle—Regulated Binding of c-Abl Tyrosine Kinase to DNA

1992 • 202 citations

Definition of the minimal simian virus 40 large T antigen- and adenovirus E1A-binding domain in the retinoblastoma gene product.

1990 • 197 citations

Cloning and characterization of E2F-2, a novel protein with the biochemical properties of transcription factor E2F.

1993 • 196 citations

p34cdc2: the S and M kinase?

1990 • 192 citations

Directing Cell Division During Development

1989 • 186 citations

Direct Transcriptional Repression by pRB and Its Reversal by Specific Cyclins

1995 • 179 citations

Cyclin synthesis, modification and destruction during meiotic maturation of the starfish oocyte

1987 • 176 citations

The HIP1 Binding Site Is Required for Growth Regulation of the Dihydrofolate Reductase Gene Promoter

1992 • 172 citations

A region of SV40 large T antigen can substitute for a transforming domain of the adenovirus E1A products

1988 • 167 citations

DNA-binding and trans-activation properties of Drosophila E2F and DP proteins.

1994 • 155 citations

Mitosis

1989 • 155 citations

Cloning and characterization of human cyclin D3, a cDNA closely related in sequence to the PRAD1/cyclin D1 proto-oncogene.

1992 • 150 citations

Distinct sub-populations of the retinoblastoma protein show a distinct pattern of phosphorylation.

1994 • 148 citations

Sequences within the conserved cyclin box of human cyclin A are sufficient for binding to and activation of cdc2 kinase.

1993 • 147 citations

Transcription factor E2F is required for efficient expression of the hamster dihydrofolate reductase gene in vitro and in vivo.

1989 • 144 citations

Role of E2F transcription factor in E1A-mediated trans activation of cellular genes

1991 • 142 citations

Transcription of the E2F-1 gene is rendered cell cycle dependent by E2F DNA-binding sites within its promoter.

1994 • 141 citations

Promoter interaction of the E1A-inducible factor E2F and its potential role in the formation of a multi-component complex.

1987 • 140 citations

Adenovirus E1a prevents the retinoblastoma gene product from repressing the activity of a cellular transcription factor.

1992 • 137 citations

Retinoblastoma and chromosome 13

1976 • 136 citations

The pRB-related protein p107 contains two growth suppression domains: independent interactions with E2F and cyclin/cdk complexes.

1995 • 135 citations

Cell cycle-dependent phosphorylation of the retinoblastoma-related protein p130.

1995 • 129 citations

Prediction of similar transforming regions in simian virus 40 large T, adenovirus E1A, and myc oncoproteins

1988 • 124 citations

Disruption of RB/E2F-1 interaction by single point mutations in E2F-1 enhances S-phase entry and apoptosis.

1996 • 120 citations

Differential Roles of Two Tandem E2F Sites in Repression of the Human p107 Promoter by Retinoblastoma and p107 Proteins

1995 • 114 citations

Biochemical and biological differences between E7 oncoproteins of the high- and low-risk human papillomavirus types are determined by amino-terminal sequences

1991 • 109 citations

Phosphorylation of E2F-1 by cyclin A-cdk2.

1995 • 109 citations

SV40 T antigen binds specifically to a cellular 53 K protein in vitro

1981 • 107 citations

Speculations on the roles of RB1 in tissue‐specific differentiation, tumor initiation, and tumor progression

1993 • 107 citations

Intraocular and Extraocular Retinoblastoma

1987 • 106 citations

Transcriptional repression by the Rb-related protein p107.

1993 • 102 citations

The Adenovirus EIIA Enhancer

1989 • 100 citations

Isochromosome 6p, a unique chromosomal abnormality in retinoblastoma: Verification by standard staining techniques, new densitometric methods, and somatic cell hybridization

1984 • 96 citations

Sporadic bilateral retinoblastoma and 13q‐chromosomal deletion

1976 • 95 citations

Cell Cycle Analysis of E2F in Primary Human T Cells Reveals Novel E2F Complexes and Biochemically Distinct Forms of Free E2F

1993 • 94 citations

Multiple Changes in E2F Function and Regulation Occur upon Muscle Differentiation

1995 • 91 citations

Characterization of transcription factor E2F complexes during muscle and neuronal differentiation.

1995 • 82 citations

Cloning and characterization of human DP2, a novel dimerization partner of E2F.

1995 • 81 citations

Retinoblastoma and the progression of tumor genetics

1988 • 80 citations

Expression and activity of the retinoblastoma protein (pRB)-family proteins, p107 and p130, during L6 myoblast differentiation.

1995 • 79 citations

Regulated expression of the retinoblastoma gene in differentiating embryonal carcinoma cells.

1993 • 76 citations

Failure of RB1 to reverse the malignant phenotype of human tumor cell lines.

1992 • 71 citations

The Vin-1 gene, identified by provirus insertional mutagenesis, is the cyclin D2.

1993 • 64 citations

Three distinct elements within the murine c-myc promoter are required for transcription.

1992 • 62 citations

The Genetics of Retinoblastoma: Relevance to the Patient

1991 • 61 citations

Regions controlling hyperphosphorylation and conformation of the retinoblastoma gene product are independent of domains required for transcriptional repression.

1992 • 60 citations

Multiple karyotypic changes in retinoblastoma tumor cells: Presence of normal chromosome No. 13 in most tumors

1982 • 59 citations

The Rb-Related p107 Protein Can Suppress E2F Function Independently of Binding to Cyclin A/cdk2

1995 • 54 citations

Retinoblastoma Gene Product Rb Accumulates during Myogenic Differentiation and Is Deinduced by the Expression of SV40 Large T Antigen1

1992 • 53 citations

The HIP1 binding site is required for growth regulation of the dihydrofolate reductase gene promoter.

1992 • 51 citations

The retinoblastoma-susceptibility gene product binds directly to the human TATA-binding protein-associated factor TAFII250.

1995 • 51 citations

Retinoblastoma in a Patient with a 13qxp Translocation

1977 • 49 citations

Molecular and functional characterisation of E2F-5, a new member of the E2F family.

1995 • 43 citations

Cell cycle analysis of E2F in primary human T cells reveals novel E2F complexes and biochemically distinct forms of free E2F.

1993 • 42 citations

An Inverted Repeat Motif Stabilizes Binding of E2F and Enhances Transcription of the Dihydrofolate Reductase Gene

1995 • 41 citations

Expression of a deletion mutant of the E2F1 transcription factor in fibroblasts lengthens S phase and increases sensitivity to S phase-specific toxins.

1995 • 37 citations

Co-purification of p34cdc2/p58cyclin A proline-directed protein kinase and the retinoblastoma tumor susceptibility gene product: interaction of an oncogenic serine/threonine protein kinase with a tumor-suppressor protein.

1992 • 31 citations

Molecular characterization of Xenopus laevis DP proteins.

1994 • 24 citations

Why Don’t Germline Mutations in RB1 Predispose to Leukemia?

1992 • 21 citations

Editorial overview oncogenes and the cell cycle

1993 • 13 citations

The Molecular Basis of Retinoblastomas

2007 • 12 citations

Diverse mutations lead to inactivation of the retinoblastoma gene.

1991 • 2 citations

The cell cycle : abstracts of papers presented at the LVI Cold Spring Harbor Symposium on Quantitative Biology, May 29-June 5, 1991

1991 • 1 citations