E2F-1-mediated transactivation is inhibited by complex formation with the retinoblastoma susceptibility gene product.

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

1982 • 8,069 citations

Recombinant Genomes Which Express Chloramphenicol Acetyltransferase in Mammalian Cells

1982 • 3,106 citations

E2F: a Link Between the Rb Tumor Suppressor Protein and Viral Oncoproteins

1992 • 1,552 citations

SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene

1988 • 1,490 citations

The E2F transcription factor is a cellular target for the RB protein

1991 • 1,461 citations

Regulation of retinoblastoma protein functions by ectopic expression of human cyclins

1992 • 1,031 citations

Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties

1992 • 846 citations

Suppression of the Neoplastic Phenotype by Replacement of the RB Gene in Human Cancer Cells

1988 • 832 citations

The retinoblastoma gene product regulates progression through the G1 phase of the cell cycle

1991 • 708 citations

Retinoblastoma protein switches the E2F site from positive to negative element

1992 • 663 citations

A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F

1992 • 652 citations

Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product.

1992 • 617 citations

The interaction of RB with E2F coincides with an inhibition of the transcriptional activity of E2F.

1992 • 587 citations

Identification of cellular proteins that can interact specifically with the T/ElA-binding region of the retinoblastoma gene product

1991 • 541 citations

The retinoblastoma protein copurifies with E2F-I, an E1A-regulated inhibitor of the transcription factor E2F

1991 • 446 citations

Adenovirus E1a prevents the retinoblastoma gene product from complexing with a cellular transcription factor

1991 • 435 citations

The T/E1A-binding domain of the retinoblastoma product can interact selectively with a sequence-specific DNA-binding protein

1991 • 420 citations

Identification of a growth suppression domain within the retinoblastoma gene product.

1992 • 413 citations

Molecular cloning of cellular genes encoding retinoblastoma-associated proteins: identification of a gene with properties of the transcription factor E2F.

1992 • 331 citations

The regions of the retinoblastoma protein needed for binding to adenovirus E1A or SV40 large T antigen are common sites for mutations.

1990 • 327 citations

A new component of the transcription factor DRTF1/E2F

1993 • 293 citations

A role for the adenovirus inducible E2F transcription factor in a proliferation dependent signal transduction pathway.

1990 • 253 citations

A single amino acid substitution results in a retinoblastoma protein defective in phosphorylation and oncoprotein binding.

1990 • 204 citations

Two distinct and frequently mutated regions of retinoblastoma protein are required for binding to SV40 T antigen.

1990 • 204 citations

Definition of the minimal simian virus 40 large T antigen- and adenovirus E1A-binding domain in the retinoblastoma gene product.

1990 • 197 citations

A cellular protein that competes with SV40 T antigen for binding to the retinoblastoma gene product

1991 • 153 citations

Biological Function of the Retinoblastoma Protein Requires Distinct Domains for Hyperphosphorylation and Transcription Factor Binding

1992 • 143 citations

Adenovirus E1a prevents the retinoblastoma gene product from repressing the activity of a cellular transcription factor.

1992 • 137 citations

Molecular Cloning of Cellular Genes Encoding Retinoblastoma-Associated Proteins: Identification of a Gene with Properties of the Transcription Factor E2F

1992 • 82 citations

Characterization of the Epstein-Barr virus BZLF1 protein transactivation domain

1992 • 80 citations

Transcriptional activation by viral regulatory proteins

1991 • 57 citations

Retinoblastoma-repression of E2F-dependent transcription depends on the ability of the retinoblastoma protein to interact with E2F and is abrogated by the adenovirus E1A oncoprotein

1992 • 56 citations

Definition of the Minimal Simian Virus 40 Large Τ Antigen- and Adenovirus E1A-Binding Domain in the Retinoblastoma Gene Product

1990 • 54 citations

Rapid site-specific mutagenesis in plasmids

1987 • 44 citations