Elevated p16 at senescence and loss of p16 at immortalization in human papillomavirus 16 E6, but not E7, transformed human uroepithelial cells.

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

1993 • 3,680 citations

A Cell Cycle Regulator Potentially Involved in Genesis of Many Tumor Types

1994 • 2,821 citations

5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers

1995 • 2,000 citations

E2F: a Link Between the Rb Tumor Suppressor Protein and Viral Oncoproteins

1992 • 1,552 citations

Analysis of the p16 gene (CDKN2) as a candidate for the chromosome 9p melanoma susceptibility locus

1994 • 860 citations

Regulation of p16^CDKN2 Expression and Its Implications for Cell Immortalization and Senescence

1996 • 713 citations

Methylation of the 5' CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing.

1995 • 713 citations

Increased Risk of Pancreatic Cancer in Melanoma-Prone Kindreds withp16^INK4Mutations

1995 • 620 citations

Inhibition of Ras-Induced Proliferation and Cellular Transformation by p16 ^INK4

1995 • 382 citations

Homozygotes for CDKN2 (p16) germline mutation in Dutch familial melanoma kindreds

1995 • 316 citations

Allelotype of human bladder cancer.

1994 • 265 citations

Differential expression and cell cycle regulation of the cyclin-dependent kinase 4 inhibitor p16Ink4.

1994 • 231 citations

Initiation of bladder cancer may involve deletion of a tumour-suppressor gene on chromosome 9.

1993 • 187 citations

p16 (CDKN2) is a major deletion target at 9p21 in bladder cancer

1995 • 178 citations

Cell cycle arrest and inhibition of tumor cell proliferation by the p16INK4 gene mediated by an adenovirus vector.

1995 • 160 citations

Evidence for two bladder cancer suppressor loci on human chromosome 9.

1993 • 143 citations

The reactivation of telomerase activity in cancer progression

1996 • 134 citations

Long-term genome stability and minimal genotypic and phenotypic alterations in HPV16 E7-, but not E6-, immortalized human uroepithelial cells.

1994 • 130 citations

Increased p16 levels correlate with pRb alterations in human urothelial cells.

1995 • 120 citations

Genetic evidence in melanoma and bladder cancers that p16 and p53 function in separate pathways of tumor suppression.

1995 • 118 citations

Characterization of human uroepithelial cells immortalized in vitro by simian virus 40.

1987 • 112 citations

Is telomerase activity in cancer due to selection of stem cells and differentiation arrest?

1996 • 96 citations

Growth kinetics and differentiation in vitro of normal human uroepithelial cells on collagen gel substrates in defined medium

1987 • 88 citations

High Frequency of Chromosome 9p Allelic Loss and CDKN2 Tumor Suppressor Gene Alterations in Squamous Cell Carcinoma of the Bladder

1995 • 74 citations

The 9p21 region in bladder cancer cell lines: large homozygous deletions inactivate the CDKN2, CDKN2B and MTAP genes

1996 • 46 citations

Quantitative assessments of the cytotoxicity of bladder carcinogens towards cultured normal human uroepithelial cells

1986 • 14 citations

Immortalization of human uroepithelial cells by human papillomavirus 16 E6 or E7

1995 • 7 citations