Mechanisms and Biological Consequences of STAT Signaling by Cytokines that Share the Common Cytokine Receptor γ Chain, γc

HOW CELLS RESPOND TO INTERFERONS

1998 • 3,937 citations

Selective in Vitro Growth of T Lymphocytes from Normal Human Bone Marrows

1976 • 2,458 citations

Structural design and molecular evolution of a cytokine receptor superfamily.

1990 • 2,104 citations

Maximal activation of transcription by statl and stat3 requires both tyrosine and serine phosphorylation

1995 • 1,960 citations

Lymphocyte responses and cytokines

1994 • 1,860 citations

JAKS AND STATS: Biological Implications

1998 • 1,788 citations

Stat6 Is Required for Mediating Responses to IL-4 and for the Development of Th2 Cells

1996 • 1,618 citations

Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo

2000 • 1,596 citations

Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice.

1994 • 1,572 citations

THE IL-4 RECEPTOR: Signaling Mechanisms and Biologic Functions

1999 • 1,532 citations

Interleukin-2 receptor γ chain mutation results in X-linked severe combined immunodeficiency in humans

1993 • 1,317 citations

Stat5a and Stat5b Proteins Have Essential and Nonessential, or Redundant, Roles in Cytokine Responses

1998 • 1,316 citations

Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted State6 gene

1996 • 1,304 citations

IL-15 Receptor Maintains Lymphoid Homeostasis by Supporting Lymphocyte Homing and Proliferation

1998 • 1,293 citations

Potent and Selective Stimulation of Memory-Phenotype CD8+ T Cells In Vivo by IL-15

1998 • 1,262 citations

Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function

2000 • 1,191 citations

Interleukin-2 Receptor γ Chain: a Functional Component of the Interleukin-7 Receptor

1993 • 1,128 citations

Stat5a is mandatory for adult mammary gland development and lactogenesis.

1997 • 1,106 citations

Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment

1995 • 1,079 citations

lnterleukin-2 programs mouse αβ T lymphocytes for apoptosis

1991 • 1,027 citations

Defective lymphoid development in mice lacking expression of the common cytokine receptor γ chain

1995 • 1,024 citations

Utilization of the beta and gamma chains of the IL-2 receptor by the novel cytokine IL-15.

1994 • 1,008 citations

Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression

1997 • 989 citations

Specific Inhibition of Stat3 Signal Transduction by PIAS3

1997 • 971 citations

A Critical Role for IL-21 in Regulating Immunoglobulin Production

2002 • 955 citations

Control of Inflammation, Cytokine Expression, and Germinal Center Formation by BCL-6

1997 • 921 citations

Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor gamma chain.

1995 • 881 citations

Control of Homeostasis of CD8 ⁺ Memory T Cells by Opposing Cytokines

2000 • 847 citations

Disruption of the Jak1 Gene Demonstrates Obligatory and Nonredundant Roles of the Jaks in Cytokine-Induced Biologic Responses

1998 • 827 citations

Stimulation of B-cell progenitors by cloned murine interleukin-7

1988 • 826 citations

CD4 Regulatory T Cells Prevent Lethal Autoimmunity in IL-2Rβ-Deficient Mice

2002 • 783 citations

Interleukin (IL)-15 and IL-7 Jointly Regulate Homeostatic Proliferation of Memory Phenotype CD8+ Cells but Are Not Required for Memory Phenotype CD4+ Cells

2002 • 783 citations

The role of shared receptor motifs and common stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15

1995 • 760 citations

Inhibition of Stat1-mediated gene activation by PIAS1

1998 • 760 citations

Twenty proteins containing a C-terminal SOCS box form five structural classes

1998 • 735 citations

Sharing of the Interleukin-2 (IL-2) Receptor γ Chain Between Receptors for IL-2 and IL-4

1993 • 734 citations

THE MULTIFACETED REGULATION OF INTERLEUKIN-15 EXPRESSION AND THE ROLE OF THIS CYTOKINE IN NK CELL DIFFERENTIATION AND HOST RESPONSE TO INTRACELLULAR PATHOGENS

1999 • 712 citations

Functional interactions between Stat5 and the glucocorticoid receptor

1996 • 681 citations

Defective Lymphoid Development in Mice Lacking Jak3

1995 • 650 citations

Interaction of IL-2Rβ and γ _c Chains with Jak1 and Jak3: Implications for XSCID and XCID

1994 • 647 citations

Biochemical Mechanisms of IL-2–Regulated Fas-Mediated T Cell Apoptosis

1998 • 644 citations

Interleukin-3, granulocyte-macrophage colony stimulating factor and interleukin-5 transduce signals through two STAT5 homologs.

1995 • 641 citations

Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells

1994 • 618 citations

Phosphorylation and activation of the Jak-3 Janus kinase in response to interleukin-2

1994 • 598 citations

Interleukin-2 Receptor γ Chain: a Functional Component of the Interleukin-4 Receptor

1993 • 593 citations

Constitutively Activated Jak-STAT Pathway in T Cells Transformed with HTLV-I

1995 • 571 citations

Cloning and expression of Stat5 and an additional homologue (Stat5b) involved in prolactin signal transduction in mouse mammary tissue.

1995 • 556 citations

Stat5 Is Required for IL-2-Induced Cell Cycle Progression of Peripheral T Cells

1999 • 554 citations

Defects in B Lymphocyte Maturation and T Lymphocyte Activation in Mice Lacking Jak3

1995 • 551 citations

CIS, a Cytokine Inducible SH2 Protein, Is a Target of the JAK-STAT5 Pathway and Modulates STAT5 Activation

1997 • 538 citations

Cutting Edge: The Common γ-Chain Is an Indispensable Subunit of the IL-21 Receptor Complex

2001 • 535 citations

A STAT protein domain that determines DNA sequence recognition suggests a novel DNA-binding domain.

1995 • 531 citations

Developmental defects of lymphoid cells in Jak3 kinase-deficient mice

1995 • 493 citations

Cooperation of Stat2 and p300/CBP in signalling induced by interferon-α

1996 • 492 citations

Two contact regions between Stat1 and CBP/p300 in interferon γ signaling

1996 • 486 citations

Cooperative DNA Binding and Sequence-Selective Recognition Conferred by the STAT Amino-Terminal Domain

1996 • 483 citations

IL-21 Limits NK Cell Responses and Promotes Antigen-Specific T Cell Activation

2002 • 470 citations

IL-15: A Pleiotropic Cytokine with Diverse Receptor/Signaling Pathways Whose Expression Is Controlled at Multiple Levels

1996 • 459 citations

RETRACTED: Uncoupling IL-2 Signals that Regulate T Cell Proliferation, Survival, and Fas-Mediated Activation-Induced Cell Death

1999 • 443 citations

Contrasting Roles of IL-2 and IL-15 in the Life and Death of Lymphocytes Implications for Immunotherapy

2001 • 441 citations

IL-2-induced activation-induced cell death is inhibited in IL-15 transgenic mice

2000 • 419 citations

Regulation of Interferon-γ-Activated STAT1 by the Ubiquitin-Proteasome Pathway

1996 • 405 citations

Human immune disorder arising from mutation of the α chain of the interleukin-2 receptor

1997 • 402 citations

Cytokines and immunodeficiency diseases

2001 • 380 citations

SOCS3 Is Essential in the Regulation of Fetal Liver Erythropoiesis

1999 • 372 citations

The Roles of Costimulation and Fas in T Cell Apoptosis and Peripheral Tolerance

1996 • 367 citations

Cooperative transcriptional activity of Jun and Stat3 beta, a short form of Stat3.

1995 • 363 citations

Functional Participation of the IL-2 Receptor γ Chain in IL-7 Receptor Complexes

1994 • 342 citations

Cytoplasmic domains of the interleukin-2 receptor β and γ chains mediate the signal for T-cell proliferation

1994 • 340 citations

Heterodimerization of the IL-2 receptor β- and γ-chain cytoplasmic domains is required for signalling

1994 • 338 citations

How Stat1 mediates constitutive gene expression: a complex of unphosphorylated Stat1 and IRF1 supports transcription of the LMP2 gene

2000 • 337 citations

Induction and regulation of the IgE response

1999 • 328 citations

Cytokine and Cytokine Receptor Pleiotropy and Redundancy

2002 • 328 citations

IL-9-Deficient Mice Establish Fundamental Roles for IL-9 in Pulmonary Mastocytosis and Goblet Cell Hyperplasia but Not T Cell Development

2000 • 324 citations

Stat5b Is Essential for Natural Killer Cell–mediated Proliferation and Cytolytic Activity

1998 • 323 citations

Cloning of a type I cytokine receptor most related to the IL-2 receptor β chain

2000 • 322 citations

The rapid inactivation of nuclear tyrosine phosphorylated Stat1 depends upon a protein tyrosine phosphatase.

1996 • 320 citations

Cloning of p97/Gab2, the Major SHP2-Binding Protein in Hematopoietic Cells, Reveals a Novel Pathway for Cytokine-Induced Gene Activation

1998 • 313 citations

Stat recruitment by tyrosine-phosphorylated cytokine receptors: An ordered reversible affinity-driven process

1995 • 303 citations

Functional Association of Nmi with Stat5 and Stat1 in IL-2- and IFN γ-Mediated Signaling

1999 • 297 citations

Proliferation of adult T cell leukemia/lymphoma cells is associated with the constitutive activation of JAK/STAT proteins

1997 • 278 citations

An Indirect Effect of Stat5a in IL-2–Induced Proliferation: A Critical Role for Stat5a in IL-2–Mediated IL-2 Receptor α Chain Induction

1997 • 275 citations

Stat1 Depends on Transcriptional Synergy with Sp1

1995 • 272 citations

Naturally Occurring Dominant Negative Variants of Stat5

1996 • 270 citations

Suppression of STAT5 Functions in Liver, Mammary Glands, and T Cells in Cytokine-Inducible SH2-Containing Protein 1 Transgenic Mice

1999 • 269 citations

SOCS-3 Is Tyrosine Phosphorylated in Response to Interleukin-2 and Suppresses STAT5 Phosphorylation and Lymphocyte Proliferation

1999 • 267 citations

Structure of the Amino-Terminal Protein Interaction Domain of STAT-4

1998 • 267 citations

Regulated nuclear import of the STAT1 transcription factor by direct binding of importin-alpha

2002 • 266 citations

Components of a stat recognition code: Evidence for two layers of molecular selectivity

1995 • 254 citations

IL-21 Up-Regulates the Expression of Genes Associated with Innate Immunity and Th1 Response

2002 • 248 citations

Interleukin-7: physiological roles and mechanisms of action

1999 • 243 citations

CD25+CD4+ T cells contribute to the control of memory CD8+ T cells

2002 • 241 citations

STAT3 Acts as a Co-activator of Glucocorticoid Receptor Signaling

1997 • 236 citations

Interacting Regions in Stat3 and c-Jun That Participate in Cooperative Transcriptional Activation

1999 • 224 citations

Identification and purification of human stat proteins activated in response to interleukin-2

1995 • 223 citations

Ser727-dependent recruitment of MCM5 by Stat1α in IFN-γ-induced transcriptional activation

1998 • 220 citations

p300/CREB-Binding Protein Enhances the Prolactin-Mediated Transcriptional Induction through Direct Interaction with the Transactivation Domain of Stat5, but Does Not Participate in the Stat5-Mediated Suppression of the Glucocorticoid Response

1998 • 217 citations

The Significance of Tetramerization in Promoter Recruitment by Stat5

1999 • 213 citations

The state of the STATs: recent developments in the study of signal transduction to the nucleus

1997 • 212 citations

Activation of JAK kinases and STAT proteins by interleukin-2 and interferon alpha, but not the T cell antigen receptor, in human T lymphocytes.

1994 • 211 citations

Cloning of Human Stat5B

1996 • 210 citations

A nuclear protein tyrosine phosphatase is required for the inactivation of Stat1

1999 • 207 citations

Different interleukin 2 receptor beta-chain tyrosines couple to at least two signaling pathways and synergistically mediate interleukin 2-induced proliferation.

1996 • 202 citations

STAT4 serine phosphorylation is critical for IL-12-induced IFN-γ production but not for cell proliferation

2002 • 202 citations

Nuclear export signal located within theDNA-binding domain of the STAT1transcription factor

2000 • 197 citations

Distribution of the Mammalian Stat Gene Family in Mouse Chromosomes

1995 • 195 citations

Activation of Stat5 by interleukin 2 requires a carboxyl-terminal region of the interleukin 2 receptor beta chain but is not essential for the proliferative signal transmission.

1995 • 190 citations

DNA Binding Site Selection of Dimeric and Tetrameric Stat5 Proteins Reveals a Large Repertoire of Divergent Tetrameric Stat5a Binding Sites

2000 • 187 citations

A Single Tyrosine of the Interleukin-9 (IL-9) Receptor Is Required for STAT Activation, Antiapoptotic Activity, and Growth Regulation by IL-9

1996 • 182 citations

Requirement for Stat5 in Thymic Stromal Lymphopoietin-Mediated Signal Transduction

1999 • 181 citations

IL-2 negatively regulates IL-7 receptor α chain expression in activated T lymphocytes

2002 • 176 citations

Stat5 Activation Is Uniquely Associated with Cytokine Signaling in Peripheral T Cells

1999 • 171 citations

Cytosolic Tyrosine Dephosphorylation of STAT5

2000 • 170 citations

Suppressor of Cytokine Signaling-1 Is a Critical Regulator of Interleukin-7-Dependent CD8+ T Cell Differentiation

2003 • 169 citations

THE MOLECULAR BASIS OF X-LINKED SEVERE COMBINED IMMUNODEFICIENCY: Defective Cytokine Receptor Signaling

1996 • 168 citations

Interleukin 2 receptor gene expression in normal human T lymphocytes.

1985 • 164 citations

Characterization of Stat5a and Stat5b Homodimers and Heterodimers and Their Association with the Glucocortiocoid Receptor in Mammary Cells

1998 • 164 citations

A Sequence of the CIS Gene Promoter Interacts Preferentially with Two Associated STAT5A Dimers: a Distinct Biochemical Difference between STAT5A and STAT5B

1998 • 160 citations

NATURALLY OCCURRING PRIMARY DEFICIENCIES OF THE IMMUNE SYSTEM

1997 • 159 citations

Growth and Gene Expression Are Predominantly Controlled by Distinct Regions of the Human IL-4 Receptor

1996 • 158 citations

Signaling from the IL-2 receptor to the nucleus

1997 • 157 citations

Enhancement of Antiproliferative Activity of Gamma Interferon by the Specific Inhibition of Tyrosine Dephosphorylation of Stat1

1996 • 153 citations

An IL-2 response element in the human IL-2 receptor alpha chain promoter is a composite element that binds Stat5, Elf-1, HMG-I(Y) and a GATA family protein.

1996 • 152 citations

The Basis for IL-2-Induced IL-2 Receptor α Chain Gene Regulation

2001 • 152 citations

Differential Control of the Phosphorylation State of Proline-juxtaposed Serine Residues Ser725 of Stat5a and Ser730 of Stat5b in Prolactin-sensitive Cells

1998 • 143 citations

A novel dual specificity phosphatase induced by serum stimulation and heat shock.

1994 • 143 citations

JAB/SOCS1/SSI-1 is an interleukin-2–induced inhibitor of IL-2 signaling

2001 • 140 citations

Regulation of Stat3 nuclear export

2003 • 139 citations

Primary cellular immunodeficiencies

2002 • 136 citations

Involvement of Proteasomes in Regulating Jak-STAT Pathways upon Interleukin-2 Stimulation

1997 • 133 citations

STAT5 Interaction with the T Cell Receptor Complex and Stimulation of T Cell Proliferation

1999 • 132 citations

Deacetylase Activity Is Required for Recruitment of the Basal Transcription Machinery and Transactivation by STAT5

2003 • 132 citations

Interleukin 9 and its Receptor: An Overview of Structure and Function

1998 • 129 citations

p300/CBP is required for transcriptional induction by interleukin-4 and interacts with Stat6

1999 • 126 citations

Identification of Shp-2 as a Stat5A Phosphatase

2003 • 123 citations

Importance of the MKK6/p38 pathway for interleukin-12–induced STAT4 serine phosphorylation and transcriptional activity

2000 • 122 citations

The role of cytokine receptor signaling in lymphocyte development

1999 • 118 citations

Elf-1 and Stat5 Bind to a Critical Element in a New Enhancer of the Human Interleukin-2 Receptor α Gene

1996 • 117 citations

Multiple Dual Specificity Protein Tyrosine Phosphatases Are Expressed and Regulated Differentially in Liver Cell Lines

1995 • 117 citations

CIS Associates with the Interleukin-2 Receptor β Chain and Inhibits Interleukin-2-dependent Signaling

1999 • 116 citations

Regulation of lymphoid homeostasis by interleukin-15

2002 • 115 citations

Functional interaction of STAT5 and nuclear receptor co-repressor SMRT: implications in negative regulation of STAT5-dependent transcription

2001 • 113 citations

Close linkage of the locus for X chromosome-linked severe combined immunodeficiency to polymorphic DNA markers in Xq11-q13.

1987 • 108 citations

Differentiation-Regulated Serine Phosphorylation of STAT1 Promotes GAF Activation in Macrophages

1995 • 101 citations

Cutting Edge: STAT6 Serves as a Positive and Negative Regulator of Gene Expression in IL-4-Stimulated B Lymphocytes

2002 • 98 citations

Analysis of γc-Family Cytokine Target Genes

2003 • 95 citations

Interleukin-9 is a major anti-apoptotic factor for thymic lymphomas

1995 • 90 citations

Prolactin Stimulates Serine/Tyrosine Phosphorylation and Formation of Heterocomplexes of Multiple Stat5 Isoforms in Nb2 Lymphocytes

1997 • 86 citations

Interaction of STAT5 Dimers on Two Low Affinity Binding Sites Mediates Interleukin 2 (IL-2) Stimulation of IL-2 Receptor α Gene Transcription

1997 • 86 citations

Both Stat5a and Stat5b are required for antigen-induced eosinophil and T-cell recruitment into the tissue

2000 • 84 citations

A Role of Suppressor of Cytokine Signaling 3 (SOCS3/CIS3/SSI3) in CD28-mediated Interleukin 2 Production

2003 • 83 citations

The Interleukin-4 Receptor Activates STAT5 by a Mechanism That Relies upon Common γ-Chain

1998 • 83 citations

A reinterpretation of the dimerization interface of the N‐terminal Domains of STATs

2003 • 81 citations

Role of serine phosphorylation of Stat5a in prolactin-stimulated β-casein gene expression

2001 • 80 citations

Stat5a Serine Phosphorylation

2000 • 79 citations

A Role for Stat5 in CD8+ T Cell Homeostasis

2003 • 78 citations

Involvement of SHP-2 in multiple aspects of IL-2 signaling: evidence for a positive regulatory role.

1998 • 74 citations

The CIS Family: Negative Regulators of JAK–STAT Signaling

1998 • 72 citations

Delineation of the Regions of Interleukin-2 (IL-2) Receptor β Chain Important for Association of Jak1 and Jak3

1998 • 71 citations

Serine Phosphorylation of GH-Activated Signal Transducer and Activator of Transcription 5a (STAT5a) and STAT5b: Impact on STAT5 Transcriptional Activity

2001 • 68 citations

Growth Signal Transduction by the Human Interleukin-2 Receptor Requires Cytoplasmic Tyrosines of the β Chain and Non-tyrosine Residues of the γc Chain

1995 • 67 citations

Cutting Edge: Suppressor of Cytokine Signaling 3 Inhibits Activation of NFATp

2002 • 66 citations

Structure of the Mouse Stat 3/5 Locus: Evolution from Drosophila to Zebrafish to Mouse

2001 • 66 citations

Cutting Edge: Involvement of SHP-2 in Multiple Aspects of IL-2 Signaling: Evidence for a Positive Regulatory Role

1998 • 63 citations

Mouse Interleukin-2 Receptor α Gene Expression

1995 • 62 citations

Functional Cooperation of the Interleukin-2 Receptor β Chain and Jak1 in Phosphatidylinositol 3-Kinase Recruitment and Phosphorylation

1998 • 55 citations

Immunocompromised tumor-bearing mice show a selective loss of STAT5a/b expression in T and B lymphocytes.

1997 • 54 citations

Cytokine signaling: Inhibitors keep cytokines in check

1999 • 52 citations

The structure of human STAT5A and B genes reveals two regions of nearly identical sequence and an alternative tissue specific STAT5B promoter

2002 • 50 citations

Activation of Stat5 by interleukin 2 requires a carboxyl-terminal region of the interlekin 2 receptor βchain but is not essential for the proliferative signal transmission.

1995 • 48 citations

A New Tyrosine-phosphorylated 97-kDa Adaptor Protein Mediates Interleukin-2-induced Association of SHP-2 with p85-Phosphatidylinositol 3-Kinase in Human T Lymphocytes

1998 • 47 citations

Constitutive activation ofStat5aby retrovirus integration in early pre-B lymphomas of SL/Kh strain mice

2002 • 47 citations

Elf-1 Contributes to the Function of the Complex Interleukin (IL)-2–responsive Enhancer in the Mouse IL-2 Receptor α Gene

1997 • 41 citations

Activation of STAT5 by IL-4 relies on Janus kinase function but not on receptor tyrosine phosphorylation, and can contribute to both cell proliferation and gene regulation

1999 • 40 citations

Interleukin-2 (IL-2)-mediated Induction of the IL-2 Receptor α Chain Gene

1997 • 39 citations

Interleukin-2 family cytokines stimulate phosphorylation of the Pro-Ser-Pro motif of Stat5 transcription factors in human T cells: resistance to suppression of multiple serine kinase pathways

2002 • 35 citations

Deficient surface expression of glycosylphosphatidylinositol-anchored proteins in B cell lines established from patients with paroxysmal nocturnal hemoglobinuria

1992 • 34 citations

IL-2, But Not IL-4 and Other Cytokines, Induces Phosphorylation of a 98-kDa Protein Associated with SHP-2, Phosphatidylinositol 3′-Kinase, and Grb2

1999 • 30 citations

Serine phosphorylation of Stat5 proteins in lymphocytes stimulated with IL-2

2002 • 25 citations

FUNDAMENTAL IMMUNOLOGY, FIFTH EDITION

2004 • 7 citations