The role of cytokine receptor signaling in lymphocyte development

HIV-1 Entry Cofactor: Functional cDNA Cloning of a Seven-Transmembrane, G Protein-Coupled Receptor

1996 • 4,184 citations

Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development

1998 • 2,496 citations

Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1

1996 • 2,374 citations

Identification of Clonogenic Common Lymphoid Progenitors in Mouse Bone Marrow

1997 • 2,205 citations

The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry

1996 • 1,973 citations

JAKS AND STATS: Biological Implications

1998 • 1,788 citations

Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice

1998 • 1,687 citations

Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow.

1991 • 1,622 citations

Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice.

1994 • 1,572 citations

The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract

1998 • 1,535 citations

Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine.

1995 • 1,447 citations

Cloning of a T Cell Growth Factor that Interacts with the β Chain of the Interleukin-2 Receptor

1994 • 1,423 citations

The Chemokine SDF-1 Is a Chemoattractant for Human CD34+ Hematopoietic Progenitor Cells and Provides a New Mechanism to Explain the Mobilization of CD34+ Progenitors to Peripheral Blood

1997 • 1,414 citations

Cytokine receptor signalling

1995 • 1,242 citations

Hereditary Anemias of the Mouse: A Review for Geneticists

1979 • 1,141 citations

The HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T lymphocytes

1997 • 1,124 citations

Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment

1995 • 1,079 citations

Interleukin (IL) 15 is a novel cytokine that activates human natural killer cells via components of the IL-2 receptor.

1994 • 1,079 citations

Defective lymphoid development in mice lacking expression of the common cytokine receptor γ chain

1995 • 1,024 citations

Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor gamma chain.

1995 • 881 citations

A developmental pathway involving four phenotypically and functionally distinct subsets of CD3-CD4-CD8- triple-negative adult mouse thymocytes defined by CD44 and CD25 expression.

1993 • 833 citations

Molecular cloning and structure of a pre-B-cell growth-stimulating factor.

1994 • 818 citations

Expression and function of c-kit in hemopoietic progenitor cells.

1991 • 756 citations

The kit Ligand, Stem Cell Factor

1993 • 653 citations

The Chemokine Receptor CXCR-4 Is Expressed on CD34+Hematopoietic Progenitors and Leukemic Cells and Mediates Transendothelial Migration Induced by Stromal Cell-Derived Factor-1

1998 • 642 citations

A receptor tyrosine kinase specific to hematopoietic stem and progenitor cell-enriched populations

1991 • 606 citations

Bcl-2 Rescues T Lymphopoiesis in Interleukin-7 Receptor–Deficient Mice

1997 • 603 citations

Targeted disruption of the flk2/flt3 gene leads to deficiencies in primitive hematopoietic progenitors

1995 • 596 citations

Molecular cloning of a ligand for the flt3flk-2 tyrosine kinase receptor: A proliferative factor for primitive hematopoietic cells

1993 • 546 citations

Bcl-2 Can Rescue T Lymphocyte Development in Interleukin-7 Receptor–Deficient Mice but Not in Mutant rag-1 −/− Mice

1997 • 503 citations

Role of interleukin-15 in the development of human CD56+ natural killer cells from CD34+ hematopoietic progenitor cells

1996 • 495 citations

Developmental defects of lymphoid cells in Jak3 kinase-deficient mice

1995 • 493 citations

Immune Responses in Interleukin-2-Deficient Mice

1993 • 476 citations

IL-15: A Pleiotropic Cytokine with Diverse Receptor/Signaling Pathways Whose Expression Is Controlled at Multiple Levels

1996 • 459 citations

Ligand for FLT3/FLK2 receptor tyrosine kinase regulates growth of haematopoietic stem cells and is encoded by variant RNAs

1994 • 453 citations

In Vitro Behavior of Hematopoietic Progenitor Cells Under the Influence of Chemoattractants: Stromal Cell–Derived Factor-1, Steel Factor, and the Bone Marrow Environment

1998 • 417 citations

A potential role for interleukin-15 in the regulation of human natural killer cell survival.

1997 • 413 citations

Essential functions of Pax5 (BSAP) in pro-B cell development: difference between fetal and adult B lymphopoiesis and reduced V-to-DJ recombination at the IgH locus.

1997 • 411 citations

Analysis and Expression of a Cloned Pre-T Cell Receptor Gene

1994 • 410 citations

B cell precursor growth-promoting activity. Purification and characterization of a growth factor active on lymphocyte precursors.

1988 • 379 citations

Abnormal Development of Intestinal Intraepithelial Lymphocytes and Peripheral Natural Killer Cells in Mice Lacking the IL-2 Receptor β Chain

1997 • 359 citations

Multistage Regulation of Th1-Type Immune Responses by the Transcription Factor IRF-1

1997 • 354 citations

Requirement for IRF-1 in the microenvironment supporting development of natural killer cells

1998 • 352 citations

The chemokine SDF‐1, stromal cell‐derived factor 1, attracts early stage B cell precursors via the chemokine receptor CXCR4

1997 • 339 citations

The Earliest T Lineage–Committed Cells Depend on IL-7 for Bcl-2 Expression and Normal Cell Cycle Progression

1997 • 338 citations

Impaired immunoglobulin gene rearrangement in mice lacking the IL-7 receptor

1998 • 331 citations

Molecular cloning and characterization of a murine pre-B-cell growth-stimulating factor/stromal cell-derived factor 1 receptor, a murine homolog of the human immunodeficiency virus 1 entry coreceptor fusin

1996 • 322 citations

Interleukin 7 receptor-deficient mice lack gammadelta T cells.

1996 • 316 citations

Inhibition of gamma delta T cell development and early thymocyte maturation in IL-7 -/- mice.

1996 • 301 citations

Murine Flt3, a gene encoding a novel tyrosine kinase receptor of the PDGFR/CSF1R family.

1991 • 300 citations

B Lymphocyte Chemotaxis Regulated in Association with Microanatomic Localization, Differentiation State, and B Cell Receptor Engagement

1998 • 276 citations

Lymphohematopoietic progenitors immortalized by a retroviral vector harboring a dominant-negative retinoic acid receptor can recapitulate lymphoid, myeloid, and erythroid development.

1994 • 275 citations

A novel CXC chemokine PBSF/SDF-1 and its receptor CXCR4: their functions in development, hematopoiesis and HIV infection

1998 • 226 citations

The role of recombinant stem cell factor in early B cell development. Synergistic interaction with IL-7.

1991 • 222 citations

Interleukin-7: a Cofactor For V(D)J Rearrangement of the T Cell Receptor β Gene

1993 • 221 citations

Bcl-2 Rescues T Lymphopoiesis, but Not B or NK Cell Development, in Common γ Chain–Deficient Mice

1997 • 220 citations

The interleukin-7 receptor alpha chain transmits distinct signals for proliferation and differentiation during B lymphopoiesis.

1996 • 213 citations

Interleukin-7 receptor alpha is essential for the development of gamma delta + T cells, but not natural killer cells.

1996 • 211 citations

Intrathymically expressed c-kit ligand (stem cell factor) is a major factor driving expansion of very immature thymocytes in vivo

1995 • 201 citations

Pro-Thymocyte Expansion by c-kit and the Common Cytokine Receptor γ Chain Is Essential for Repertoire Formation

1997 • 195 citations

The Trophic Action of IL-7 on Pro-T Cells: Inhibition of Apoptosis of Pro-T1, -T2, and -T3 Cells Correlates with Bcl-2 and Bax Levels and Is Independent of Fas and p53 Pathways

1998 • 186 citations

The status of Ig loci rearrangements in single cells from different stages of B cell development

1995 • 186 citations

The Transcription Factor Interferon Regulatory Factor 1 (IRF-1) Is Important during the Maturation of Natural Killer 1.1+ T Cell Receptor–α/β+ (NK1+ T) Cells, Natural Killer Cells, and Intestinal Intraepithelial T Cells

1998 • 185 citations

Selective long-term elimination of natural killer cells in vivo by an anti-interleukin 2 receptor beta chain monoclonal antibody in mice.

1993 • 178 citations

Differential Chemotactic Behavior of Developing T Cells in Response to Thymic Chemokines

1998 • 169 citations

Clonal proliferation of murine lymphohemopoietic progenitors in culture.

1992 • 163 citations

The flt3 ligand supports proliferation of lymphohematopoietic progenitors and early B-lymphoid progenitors

1995 • 162 citations

Stepwise progression of B lineage differentiation supported by interleukin 7 and other stromal cell molecules.

1990 • 158 citations

Murine thymocytes proliferate in direct response to interleukin-7

1989 • 157 citations

Identification of a Novel Developmental Stage Marking Lineage Commitment of Progenitor Thymocytes

1997 • 146 citations

Generation of Lytic Natural Killer 1.1+, Ly-49− Cells from Multipotential Murine Bone Marrow Progenitors in a Stroma-free Culture: Definition of Cytokine Requirements and Developmental Intermediates

1997 • 139 citations

CXCR4 and CCR5 on Human Thymocytes: Biological Function and Role in HIV-1 Infection

1998 • 135 citations

The V–J Recombination of T Cell Receptor-γ Genes Is Blocked in Interleukin-7 Receptor–deficient Mice

1996 • 132 citations

Interleukin 7 Receptor Control of T Cell Receptor γ Gene Rearrangement: Role of Receptor-associated Chains and Locus Accessibility

1998 • 131 citations

The transcription factor interferon regulatory factor-1 is essential for natural killer cell function in vivo.

1996 • 128 citations

Expansion of Functional NK Cells in Multiple Tissue Compartments of Mice Treated with Flt3-Ligand: Implications for Anti-Cancer and Anti-Viral Therapy

1998 • 124 citations

Differential roles of stromal cells, interleukin-7, and kit-ligand in the regulation of B lymphopoiesis

1992 • 120 citations

Induction of TCR Gene Rearrangements in Uncommitted Stem Cells by a Subset of IL-7 Producing, MHC Class II–Expressing Thymic Stromal Cells

1997 • 119 citations

CXCR4 expression during lymphopoiesis: implications for human immunodeficiency virus type 1 infection of the thymus

1997 • 116 citations

flk2/flt3 ligand is a potent cofactor for the growth of primitive B cell progenitors.

1996 • 115 citations

Flt3 ligand supports the differentiation of early B cell progenitors in the presence of interleukin‐11 and interleukin‐7

1996 • 115 citations

Characterization of murine bone marrow and spleen-derived stromal cells: analysis of leukocyte marker and growth factor mRNA transcript levels

1989 • 112 citations

CXCR4 and CCR5 Expression Delineates Targets for HIV-1 Disruption of T Cell Differentiation

1998 • 112 citations

The chemokine SDF-1α triggers a chemotactic response and induces cell polarization in human B lymphocytes

1998 • 108 citations

IL-7 Receptor and VDJ Recombination: Trophic Versus Mechanistic Actions

1997 • 108 citations

Expression of Interleukin-7 Receptor by Lineage-Negative Human Bone Marrow Progenitors With Enhanced Lymphoid Proliferative Potential and B-Lineage Differentiation Capacity

1997 • 101 citations

Disturbed CD4+ T Cell Homeostasis and In Vitro HIV-1 Susceptibility in Transgenic Mice Expressing T Cell Line–tropic HIV-1 Receptors

1998 • 101 citations

Requirement for the Thymus in αβ T Lymphocyte Lineage Commitment

1998 • 99 citations

Combined signaling through interleukin-7 receptors and flt3 but not c- kit potently and selectively promotes B-cell commitment and differentiation from uncommitted murine bone marrow progenitor cells

1996 • 90 citations

The FLK2/FLT3 ligand synergizes with interleukin-7 in promoting stromal- cell-independent expansion and differentiation of human fetal pro-B cells in vitro

1996 • 90 citations

Composition and function of T-cell receptor and B-cell receptor complexes on precursor lymphocytes

1996 • 82 citations

Fetal liver contains committed NK progenitors, but is not a site for development of CD34+ cells into T cells.

1997 • 76 citations

Generation of human T lymphocytes from bone marrow CD34+ cells in vitro

1996 • 75 citations

The role of IL-7 in thymic and extrathymic development of TCR gamma delta cells.

1998 • 71 citations

The Common Cytokine Receptor γ Chain Controls Survival of γ/δ T Cells

1997 • 64 citations

The Role of IL-7 in Thymic and Extrathymic Development of TCRγδ Cells

1998 • 63 citations

Differential effects of Flk-2/Flt-3 ligand and stem cell factor on murine thymic progenitor cells.

1997 • 59 citations

Activity of stem cell factor and IL-7 in combination on normal bone marrow B lineage cells.

1993 • 57 citations

Natural killer cell development and function precede alpha beta T cell differentiation in mouse fetal thymic ontogeny.

1998 • 56 citations

Il-7 supports D-J but not V-DJ rearrangement of TCR-beta gene in fetal liver progenitor cells.

1996 • 53 citations

Ex Vivo Culture of CD34+/Lin−/DR− Cells in Stroma-Derived Soluble Factors, Interleukin-3, and Macrophage Inflammatory Protein-1α Maintains Not Only Myeloid But Also Lymphoid Progenitors in a Novel Switch Culture Assay

1998 • 50 citations

Interactions Between c-kit and Stem Cell Factor Are Not Required for B-Cell Development In Vivo

1997 • 50 citations

Loss of SDF-1 receptor expression during positive selection in the thymus

1998 • 48 citations

An interleukin‐7 internet for intestinal intraepithelial T cell development: Knockout of ligand or receptor reveal differences in the immunodeficient state

1997 • 48 citations

Natural Killer Cell Development and Function Precede αβ T Cell Differentiation in Mouse Fetal Thymic Ontogeny

1998 • 48 citations

Cell cycle control of c-kit+IL-7R+ B precursor cells by two distinct signals derived from IL-7 receptor and c-kit in a fully defined medium.

1995 • 41 citations

Fetal Liver Pro-B and Pre-B Lymphocyte Clones: Expression of Lymphoid-Specific Genes, Surface Markers, Growth Requirements, Colonization of the Bone Marrow, and Generation of B Lymphocytes In Vivo and In Vitro

1992 • 39 citations

TCR-gamma genes are rearranged but not transcribed in IL-7R alpha-deficient mice.

1997 • 28 citations

Bidirectional Effect of Interleukin-10 on Early Murine B-Cell Development: Stimulation of flt3-Ligand Plus Interleukin-7–Dependent Generation of CD19− ProB Cells From Uncommitted Bone Marrow Progenitor Cells and Growth Inhibition of CD19+ ProB Cells

1997 • 28 citations

Differential ability of flt3-ligand, interleukin-11, and Steel factor to support the generation of B cell progenitors and myeloid cells from primitive murine fetal liver cells.

1997 • 19 citations

FLT-3 Ligand and Marrow Stroma-Derived Factors Promote CD3γ, CD3δ, CD3ζ, and RAG-2 Gene Expression in Primary Human CD34+LIN−DR− Marrow Progenitors

1998 • 18 citations

Fetal liver pro-B and pre-B lymphocyte clones: expression of lymphoid-specific genes, surface markers, growth requirements, colonization of the bone marrow, and generation of B lymphocytes in vivo and in vitro.

1992 • 18 citations

Flt3/Flk-2 and c-Kit are not essential for the proliferation of B lymphoid progenitor cells in the bone marrow of the adult mouse.

1998 • 17 citations

Role of IL-7 and KL in activating molecules controlling the G₁/S transition of B precursor cells

1996 • 17 citations

Isolation and characterization of primitive hematopoietic progenitors of murine fetal liver.

1996 • 15 citations