HOW CELLS RESPOND TO INTERFERONS

Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

1994 • 5,932 citations

Functional diversity of helper T lymphocytes

1996 • 4,512 citations

NITRIC OXIDE AND MACROPHAGE FUNCTION

1997 • 4,106 citations

STATs and Gene Regulation

1997 • 3,927 citations

Virus interference. I. The interferon

1957 • 3,331 citations

Development of T _H 1 CD4 ⁺ T Cells Through IL-12 Produced by Listeria -Induced Macrophages

1993 • 3,140 citations

CELLULAR RESPONSES TO INTERFERON-γ

1997 • 2,885 citations

Interleukin-12: A Proinflammatory Cytokine with Immunoregulatory Functions that Bridge Innate Resistance and Antigen-Specific Adaptive Immunity

1995 • 2,437 citations

Inflammation. Basic principles and clinical correlates

1989 • 2,424 citations

A cytokine-responsive IκB kinase that activates the transcription factor NF-κB

1997 • 2,137 citations

Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

1995 • 2,115 citations

A family of cytokine-inducible inhibitors of signalling

1997 • 2,055 citations

Maximal activation of transcription by statl and stat3 requires both tyrosine and serine phosphorylation

1995 • 1,960 citations

Interferon-γ and B Cell Stimulatory Factor-1 Reciprocally Regulate Ig Isotype Production

1987 • 1,936 citations

INTERFERONS AND THEIR ACTIONS

1987 • 1,838 citations

TRANSCRIPTIONAL RESPONSES TO POLYPEPTIDE LIGANDS: The JAK-STAT Pathway

1995 • 1,826 citations

Multiple Defects of Immune Cell Function in Mice with Disrupted Interferon-γ Genes

1993 • 1,753 citations

Targeted Disruption of the Stat1 Gene in Mice Reveals Unexpected Physiologic Specificity in the JAK–STAT Signaling Pathway

1996 • 1,648 citations

The Cell Biology of Macrophage Activation

1984 • 1,623 citations

Immune Response in Mice that Lack the Interferon-γ Receptor

1993 • 1,570 citations

Targeted Disruption of the Mouse Stat1 Gene Results in Compromised Innate Immunity to Viral Disease

1996 • 1,560 citations

STATs: Signal Transducers and Activators of Transcription

1996 • 1,414 citations

A new protein containing an SH2 domain that inhibits JAK kinases

1997 • 1,413 citations

The Molecular Cell Biology of Interferon-gamma and its Receptor

1993 • 1,323 citations

Interleukin-6 family of cytokines and gp130

1995 • 1,314 citations

Structure and function of a new STAT-induced STAT inhibitor

1997 • 1,308 citations

Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors

1997 • 1,305 citations

A Mutation in the Interferon-γ –Receptor Gene and Susceptibility to Mycobacterial Infection

1996 • 1,174 citations

Caspase-1 processes IFN-γ-inducing factor and regulates LPS-induced IFN- γ production

1997 • 1,172 citations

Identification and Characterization of an IκB Kinase

1997 • 1,166 citations

Activation of Interferon-γ Inducing Factor Mediated by Interleukin-1β Converting Enzyme

1997 • 1,137 citations

Regulation of the Interleukin (IL)-12R β2 Subunit Expression in Developing T Helper 1 (Th1) and Th2 Cells

1997 • 1,022 citations

Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon

1990 • 1,003 citations

THE IFNγ RECEPTOR:A Paradigm for Cytokine Receptor Signaling

1997 • 1,001 citations

Viral inhibition of inflammation: Cowpox virus encodes an inhibitor of the interleukin-1β converting enzyme

1992 • 981 citations

Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes

1989 • 970 citations

Molecular Mimicry of Human Cytokine and Cytokine Response Pathway Genes by KSHV

1996 • 926 citations

Interferon-Dependent Tyrosine Phosphorylation of a Latent Cytoplasmic Transcription Factor

1992 • 906 citations

Jaks and Stats in signaling by the cytokine receptor superfamily

1995 • 902 citations

The Transmembrane Kinase Ire1p Is a Site-Specific Endonuclease That Initiates mRNA Splicing in the Unfolded Protein Response

1997 • 886 citations

Interferon-γ –Receptor Deficiency in an Infant with Fatal Bacille Calmette–Guérin Infection

1996 • 869 citations

Anti-proliferative effect of IFN-gamma in immune regulation. I. IFN-gamma inhibits the proliferation of Th2 but not Th1 murine helper T lymphocyte clones.

1988 • 845 citations

Requirement for Transcription Factor IRF-1 in NO Synthase Induction in Macrophages

1994 • 840 citations

Inhibition of Viral Replication by Interferon-γ-Induced Nitric Oxide Synthase

1993 • 825 citations

Evidence That Hepatitis C Virus Resistance to Interferon Is Mediated through Repression of the PKR Protein Kinase by the Nonstructural 5A Protein

1997 • 824 citations

Dynamin self-assembles into rings suggesting a mechanism for coated vesicle budding

1995 • 816 citations

Mutation of Jak3 in a Patient with SCID: Essential Role of Jak3 in Lymphoid Development

1995 • 800 citations

A Single Phosphotyrosine Residue of Stat91 Required for Gene Activation by Interferon-γ

1993 • 797 citations

pppA2'p5'A2'p5'A: an inhibitor of protein synthesis synthesized with an enzyme fraction from interferon-treated cells.

1978 • 787 citations

Interleukin 6 and its Receptor: Ten Years Later

1998 • 774 citations

Activation of Transcription by IFN-γ: Tyrosine Phosphorylation of a 91-kD DNA Binding Protein

1992 • 772 citations

Tubular membrane invaginations coated by dynamin rings are induced by GTP-γS in nerve terminals

1995 • 760 citations

Transcriptional and posttranscriptional regulation of interferon-induced gene expression in human cells

1984 • 729 citations

Sequences encoded in the class II region of the MHC related to the 'ABC' superfamily of transporters

1990 • 717 citations

The human interferon $alpha;/$beta; receptor: Characterization and molecular cloning

1994 • 658 citations

Defective Lymphoid Development in Mice Lacking Jak3

1995 • 650 citations

Immunodeficiency and Chronic Myelogenous Leukemia-like Syndrome in Mice with a Targeted Mutation of the ICSBP Gene

1996 • 650 citations

Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase.

1995 • 640 citations

Targeted disruption of IRF-1 or IRF-2 results in abnormal type I IFN gene induction and aberrant lymphocyte development

1993 • 638 citations

ANTIGEN PROCESSING AND PRESENTATION BY THE CLASS I MAJOR HISTOCOMPATIBILITY COMPLEX

1996 • 613 citations

Epstein-Barr virus-coded BHRF1 protein, a viral homologue of Bcl-2, protects human B cells from programmed cell death.

1993 • 602 citations

Identification of a novel serine/threonine kinase and a novel 15-kD protein as potential mediators of the gamma interferon-induced cell death.

1995 • 574 citations

Double-stranded RNA-dependent protein kinase activates transcription factor NF-kappa B by phosphorylating I kappa B.

1994 • 569 citations

Requirement of endogenous interferon-gamma production for resolution of Listeria monocytogenes infection.

1985 • 555 citations

Interferon action and apoptosis are defective in mice devoid of 2',5'-oligoadenylate-dependent RNase L

1997 • 552 citations

Requirement for MAP Kinase (ERK2) Activity in Interferon α- and Interferon β-Stimulated Gene Expression Through STAT Proteins

1995 • 549 citations

Malignant transformation by a mutant of the IFN-inducible dsRNA-dependent protein kinase

1992 • 543 citations

A STAT protein domain that determines DNA sequence recognition suggests a novel DNA-binding domain.

1995 • 531 citations

Expression cloning of 2-5A-dependent RNAase: A uniquely regulated mediator of interferon action

1993 • 509 citations

Defective TNF-α-Induced Apoptosis in STAT1-Null Cells Due to Low Constitutive Levels of Caspases

1997 • 508 citations

Regulation of Interleukin 12 p40 Expression through an NF-κB Half-Site

1995 • 495 citations

Cooperation of Stat2 and p300/CBP in signalling induced by interferon-α

1996 • 492 citations

REGULATION OF MHC CLASS II GENES: Lessons from a Disease

1996 • 488 citations

Two contact regions between Stat1 and CBP/p300 in interferon γ signaling

1996 • 486 citations

Cooperative DNA Binding and Sequence-Selective Recognition Conferred by the STAT Amino-Terminal Domain

1996 • 483 citations

Vaccinia virus encodes a soluble type I interferon receptor of novel structure and broad species soecificity

1995 • 474 citations

Cathepsin D protease mediates programmed cell death induced by interferon-gamma, Fas/APO-1 and TNF-alpha.

1996 • 467 citations

Ligand-induced IFN gamma receptor tyrosine phosphorylation couples the receptor to its signal transduction system (p91).

1994 • 453 citations

Pip, a novel IRF family member, is a lymphoid-specific, PU.1-dependent transcriptional activator.

1995 • 451 citations

Tumor suppressor function of the interferon-induced double-stranded RNA-activated protein kinase.

1993 • 436 citations

Developmental commitment to the Th2 lineage by extinction of IL-12 signaling

1995 • 429 citations

Contribution of STAT SH2 Groups to Specific Interferon Signaling by the Jak-STAT pathway

1995 • 428 citations

Nuclear integration of JAK/STAT and Ras/AP-1 signaling by CBP and p300

1997 • 428 citations

GAS Elements: A Few Nucleotides with a Major Impact on Cytokine-Induced Gene Expression

1997 • 428 citations

Complementation of a mutant cell line: central role of the 91 kDa polypeptide of ISGF3 in the interferon-alpha and -gamma signal transduction pathways.

1993 • 411 citations

DAP-kinase is a Ca2+/calmodulin-dependent, cytoskeletal-associated protein kinase, with cell death-inducing functions that depend on its catalytic activity

1997 • 408 citations

Regulation of Interferon-γ-Activated STAT1 by the Ubiquitin-Proteasome Pathway

1996 • 405 citations

A double-stranded RNA-activated protein kinase-dependent pathway mediating stress-induced apoptosis

1997 • 394 citations

DAP kinase links the control of apoptosis to metastasis

1997 • 394 citations

Virus proteins that counteract host immune defenses

1992 • 392 citations

Tissue-specific Pattern of Stress Kinase Activation in Ischemic/Reperfused Heart and Kidney

1997 • 374 citations

Use of a selectable marker regulated by alpha interferon to obtain mutations in the signaling pathway.

1989 • 373 citations

An IRF-1-dependent pathway of DNA damage-induced apoptosis in mitogen-activated T lymphocytes

1997 • 364 citations

Adenovirus VAI RNA antagonizes the antiviral action of interferon by preventing activation of the interferon-induced eIF-2α kinase

1986 • 358 citations

Interferon Action: RNA Cleavage Pattern of a (2′-5′)Oligoadenylate—Dependent Endonuclease

1981 • 357 citations

Multistage Regulation of Th1-Type Immune Responses by the Transcription Factor IRF-1

1997 • 354 citations

Deficient cytokine signaling in mouse embryo fibroblasts with a targeted deletion in the PKR gene: role of IRF-1 and NF-kappa B

1997 • 353 citations

Antiviral defense in mice lacking both alpha/beta and gamma interferon receptors

1995 • 353 citations

Crystal structure of a complex between interferon-γ and its soluble high-affinity receptor

1995 • 350 citations

Early interleukin 12 production by macrophages in response to mycobacterial infection depends on interferon gamma and tumor necrosis factor alpha.

1995 • 348 citations

Differential Regulation of the Alpha/Beta Interferon-Stimulated Jak/Stat Pathway by the SH2 Domain-Containing Tyrosine Phosphatase SHPTP1

1995 • 346 citations

Jak-STAT Signaling Induced by the v- abl oncogene

1995 • 341 citations

A role for the proteasome regulator PA28α in antigen presentation

1996 • 341 citations

Human p68 kinase exhibits growth suppression in yeast and homology to the translational regulator GCN2.

1992 • 325 citations

The Interferon-induced Double-Stranded RNA-Activated Protein Kinase Induces Apoptosis

1994 • 322 citations

Interferon action—sequence specificity of the ppp(A2′p)nA-dependent ribonuclease

1981 • 321 citations

The rapid inactivation of nuclear tyrosine phosphorylated Stat1 depends upon a protein tyrosine phosphatase.

1996 • 320 citations

Interferon gamma stimulation modulates the proteolytic activity and cleavage site preference of 20S mouse proteasomes.

1994 • 314 citations

IFN-gamma stimulates IgG2a secretion by murine B cells stimulated with bacterial lipopolysaccharide.

1988 • 308 citations

Stat recruitment by tyrosine-phosphorylated cytokine receptors: An ordered reversible affinity-driven process

1995 • 303 citations

DNA binding of in vitro activated Stat1 alpha, Stat1 beta and truncated Stat1: interaction between NH2-terminal domains stabilizes binding of two dimers to tandem DNA sites.

1996 • 302 citations

Regulation of STAT‐dependent pathways by growth factors and cytokines

1996 • 297 citations

Lack of Interferon γ Receptor β Chain and the Prevention of Interferon γ Signaling in T_H1 Cells

1995 • 292 citations

Interferon response element of the human gene 6-16.

1988 • 292 citations

Direct Association with and Dephosphorylation of Jak2 Kinase by the SH2-Domain-Containing Protein Tyrosine Phosphatase SHP-1

1996 • 291 citations

Human and mouse Mx proteins inhibit different steps of the influenza virus multiplication cycle

1992 • 291 citations

Interferon Regulatory Factor-1 Is Required for a T Helper 1 Immune Response In Vivo

1997 • 286 citations

A dominant negative mutant of 2-5A-dependent RNase suppresses antiproliferative and antiviral effects of interferon.

1993 • 273 citations

Stat1 Depends on Transcriptional Synergy with Sp1

1995 • 272 citations

Identification and sequence of an accessory factor required for activation of the human interferon γ receptor

1994 • 266 citations

A single DNA response element can confer inducibility by both alpha- and gamma-interferons.

1989 • 262 citations

2-5A synthetase: assay, distribution and variation with growth or hormone status

1979 • 260 citations

2-5A-dependent RNase Molecules Dimerize during Activation by 2-5A

1995 • 259 citations

Interferon gamma inhibits apoptotic cell death in B cell chronic lymphocytic leukemia.

1993 • 258 citations

Induction of IgG3 secretion by interferon gamma: a model for T cell-independent class switching in response to T cell-independent type 2 antigens.

1992 • 258 citations

Critical role of a common transcription factor, IRF-1, in the regulation of IFN-beta and IFN-inducible genes.

1992 • 247 citations

Mutant U5A cells are complemented by an interferon-alpha beta receptor subunit generated by alternative processing of a new member of a cytokine receptor gene cluster.

1995 • 247 citations

Growth Hormone, Interferon-γ, and Leukemia Inhibitory Factor Promoted Tyrosyl Phosphorylation of Insulin Receptor Substrate-1

1995 • 246 citations

α and α Interferons and Their Receptor and Their Friends and Relations

1995 • 243 citations

Cloning and Characterization of a RNase L Inhibitor.

1995 • 243 citations

Constitutive expression of human double-stranded RNA-activated p68 kinase in murine cells mediates phosphorylation of eukaryotic initiation factor 2 and partial resistance to encephalomyocarditis virus growth

1992 • 238 citations

Molecular cloning ofLSIRF, a lymphoid-specific member of the interferon regulatory factor family that binds the interferon-stimulated response element (ISRE)

1995 • 237 citations

Inhibition of bunyaviruses, phleboviruses, and hantaviruses by human MxA protein

1996 • 237 citations

Essential and non‐redundant roles of p48 (ISGF3γ) and IRF‐1 in both type I and type II interferon responses, as revealed by gene targeting studies

1996 • 235 citations

Antigen processing and recognition

1992 • 234 citations

Tyrosine-phosphorylated Stat1 and Stat2 plus a 48-kDa protein all contact DNA in forming interferon-stimulated-gene factor 3.

1995 • 231 citations

Four different forms of interferon-induced 2',5'-oligo(A) synthetase identified by immunoblotting in human cells.

1987 • 229 citations

Mammalian eukaryotic initiation factor 2 alpha kinases functionally substitute for GCN2 protein kinase in the GCN4 translational control mechanism of yeast.

1993 • 227 citations

Roles of JAKs in Activation of STATs and Stimulation of c-fos Gene Expression by Epidermal Growth Factor

1996 • 221 citations

Ligand-Induced Autoregulation of IFN-γ Receptor β Chain Expression in T Helper Cell Subsets

1995 • 219 citations

Blockage of NF-κB Signaling by Selective Ablation of an mRNA target by 2-5A Antisense Chimeras

1994 • 217 citations

A JAK1/JAK2 Chimera Can Sustain Alpha and Gamma Interferon Responses

1997 • 216 citations

Interferon-gamma induces tyrosine phosphorylation of interferon-gamma receptor and regulated association of protein tyrosine kinases, Jak1 and Jak2, with its receptor.

1994 • 213 citations

DAP-kinase loss of expression in various carcinoma and B-cell lymphoma cell lines: possible implications for role as tumor suppressor gene

1997 • 207 citations

A novel member of the interferon receptor family complements functionality of the murine interferon γ receptor in human cells

1994 • 205 citations

Transcriptional induction by interferon. New protein(s) determine the extent and length of the induction.

1986 • 204 citations

Inhibitory activity for the interferon-induced protein kinase is associated with the reovirus serotype 1 sigma 3 protein.

1988 • 204 citations

Interactions between STAT and Non-STAT Proteins in the Interferon-Stimulated Gene Factor 3 Transcription Complex

1996 • 203 citations

Interferon-α Engages the Insulin Receptor Substrate-1 to Associate with the Phosphatidylinositol 3′-Kinase

1995 • 201 citations

The role of the growth hormone (GH) receptor and JAK1 and JAK2 kinases in the activation of Stats 1, 3, and 5 by GH.

1996 • 198 citations

A Novel Interferon Regulatory Factor Family Transcription Factor, ICSAT/Pip/LSIRF, That Negatively Regulates the Activity of Interferon-Regulated Genes

1996 • 197 citations

Formation of STAT1-STAT2 Heterodimers and Their Role in the Activation of IRF-1 Gene Transcription by Interferon-α

1996 • 196 citations

Regulation by interferon alpha of immunoglobulin isotype selection and lymphokine production in mice.

1991 • 193 citations

Reversal of the interferon-sensitive phenotype of a vaccinia virus lacking E3L by expression of the reovirus S4 gene

1995 • 193 citations

A Genetic Tool Used to Identify Thioredoxin as a Mediator of a Growth Inhibitory Signal

1991 • 189 citations

Interferon consensus sequence-binding protein, a member of the interferon regulatory factor family, suppresses interferon-induced gene transcription.

1993 • 189 citations

Kinase-negative mutants of JAK1 can sustain interferon-gamma-inducible gene expression but not an antiviral state.

1996 • 188 citations

Functional Subdomains of STAT2 Required for Preassociation with the Alpha Interferon Receptor and for Signaling

1997 • 187 citations

Mice devoid of interferon regulatory factor 1 (IRF-1) show normal expression of type I interferon genes.

1994 • 186 citations

The cellular 68,000-Mr protein kinase is highly autophosphorylated and activated yet significantly degraded during poliovirus infection: implications for translational regulation

1989 • 184 citations

Direct binding to and tyrosine phosphorylation of the alpha subunit of the type I interferon receptor by p135tyk2 tyrosine kinase.

1994 • 183 citations

Preassociation of STAT1 with STAT2 and STAT3 in Separate Signalling Complexes Prior to Cytokine Stimulation

1996 • 182 citations

Characterization of β-R1, a Gene That Is Selectively Induced by Interferon β (IFN-β) Compared with IFN-α

1996 • 181 citations

A functional GTP-binding motif is necessary for antiviral activity of Mx proteins

1993 • 181 citations

Interferon-α-dependent Activation of Tyk2 Requires Phosphorylation of Positive Regulatory Tyrosines by Another Kinase

1996 • 176 citations

Physical association between STAT1 and the interferon-inducible protein kinase PKR and implications for interferon and double-stranded RNA signaling pathways

1997 • 174 citations

Phosphorylated interferon-alpha receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 kDa STAT2 protein.

1996 • 172 citations

An essential role for the interferon-inducible, double-stranded RNA-activated protein kinase PKR in the tumor necrosis factor-induced apoptosis in U937 cells.

1996 • 171 citations

Ligand-Induced Association of the Type I Interferon Receptor Components

1995 • 166 citations

Comparison of the Antiviral Activities of Various Cloned Human Interferon- Subtypes in Mammalian Cell Cultures

1981 • 164 citations

Binding of Epstein-Barr virus small RNA EBER-1 to the double-stranded RNA-activated protein kinase DAI

1991 • 162 citations

Interaction between the Components of the Interferon γ Receptor Complex

1995 • 160 citations

An alternative pathway for STAT activation that is mediated by the direct interaction between JAK and STAT

1997 • 158 citations

Stat2 Is a Transcriptional Activator That Requires Sequence-specific Contacts Provided by Stat1 and p48 for Stable Interaction with DNA

1997 • 156 citations

p135tyk2, an interferon-alpha-activated tyrosine kinase, is physically associated with an interferon-alpha receptor.

1994 • 156 citations

Control of the Interferon-Induced 68-Kilodalton Protein Kinase by the HIV-1 tat Gene Product

1990 • 155 citations

Regulation of LMP2 and TAP1 Genes by IRF-1 Explains the Paucity of CD8+ T Cells in IRF-1−/− Mice

1996 • 152 citations

Combinatorial association and abundance of components of interferon-stimulated gene factor 3 dictate the selectivity of interferon responses.

1995 • 150 citations

Ligand-Induced Assembly and Activation of the Gamma Interferon Receptor in Intact Cells

1996 • 149 citations

HIV-1 Tat Directly Interacts with the Interferon-Induced, Double-Stranded RNA-Dependent Kinase, PKR

1995 • 149 citations

Distinct Domains of the Protein Tyrosine Kinase tyk2 Required for Binding of Interferon-α/β and for Signal Transduction

1995 • 148 citations

Isolation and characterization of a new mutant human cell line unresponsive to alpha and beta interferons.

1991 • 147 citations

Expression of Platelet Glycoprotein (GP) V in Heterologous Cells and Evidence for Its Association with GP Ibα in Forming a GP Ib-IX-V Complex on the Cell Surface

1995 • 144 citations

Possible involvement of double-stranded RNA-activated protein kinase in cell death by influenza virus infection

1996 • 144 citations

STAM, Signal Transducing Adaptor Molecule, Is Associated with Janus Kinases and Involved in Signaling for Cell Growth and c-myc Induction

1997 • 144 citations

The Jak Kinases Differentially Associate with the α and β (Accessory Factor) Chains of the Interferon γ Receptor to Form a Functional Receptor Unit Capable of Activating STAT Transcription Factors

1995 • 143 citations

Human MxA protein inhibits tick-borne Thogoto virus but not Dhori virus

1995 • 142 citations

Differential tyrosine phosphorylation of the IFNAR chain of the type I interferon receptor and of an associated surface protein in response to IFN-alpha and IFN-beta.

1994 • 141 citations

Interferon Regulatory Factor 1 Is Required for Mouse Gbp Gene Activation by Gamma Interferon

1995 • 140 citations

Molecular Characterization of Specific Interactions between SHP-2 Phosphatase and JAK Tyrosine Kinases

1997 • 140 citations

Mutants of the RNA-Dependent Protein Kinase (PKR) Lacking Double-Stranded RNA Binding Domain I Can Act as Transdominant Inhibitors and Induce Malignant Transformation

1995 • 139 citations

Interferon-gamma suppresses B cell stimulation factor (BSF-1) induction of class II MHC determinants on B cells.

1986 • 138 citations

Overlapping sites for constitutive and induced DNA binding factors involved in interferon-stimulated transcription.

1989 • 134 citations

MxA-dependent inhibition of measles virus glycoprotein synthesis in a stably transfected human monocytic cell line

1993 • 133 citations

DAP-5, a Novel Homolog of Eukaryotic Translation Initiation Factor 4G Isolated as a Putative Modulator of Gamma Interferon-Induced Programmed Cell Death

1997 • 130 citations

mRNA metabolism and post-transcriptional gene regulation

1997 • 129 citations

Characterization of the Solution Complex between the Interferon-induced, Double-stranded RNA-activated Protein Kinase and HIV-I Trans-activating Region RNA

1997 • 128 citations

Activation of the ppp(A2'p)nA system in interferon-treated, Herpes simplex virus-infected cells and evidence for novel inhibitors of the ppp(A2'p)nA-dependent RNase

1984 • 127 citations

Involvement of the double-stranded-RNA-dependent kinase PKR in interferon expression and interferon-mediated antiviral activity.

1995 • 126 citations

Transcription of interferon-stimulated genes is induced by adenovirus particles but is suppressed by E1A gene products

1988 • 124 citations

Participation of JAK and STAT Proteins in Growth Hormone-induced Signaling

1996 • 124 citations

Alpha Interferon Suppresses the Cyclin D3 and cdc25A Genes, Leading to a Reversible G₀-Like Arrest

1996 • 124 citations

The Apoptosis Pathway Triggered by the Interferon-Induced Protein Kinase PKR Requires the Third Basic Domain, Initiates Upstream of Bcl-2, and Involves ICE-like Proteases1

1997 • 124 citations

Dominant-negative mutants of human MxA protein: domains in the carboxy-terminal moiety are important for oligomerization and antiviral activity

1997 • 122 citations

The role of the growth hormone (GH) receptor and JAK1 and JAK2 kinases in the activation of Stats 1, 3, and 5 by GH

1996 • 122 citations

Association of the Interferon-dependent Tyrosine Kinase Tyk-2 with the Hematopoietic Cell Phosphatase

1995 • 121 citations

Tyrosine phosphorylation of the alpha and beta subunits of the type I interferon receptor. Interferon-beta selectively induces tyrosine phosphorylation of an alpha subunit-associated protein.

1994 • 121 citations

Interferons and interleukin 6 suppress phosphorylation of the retinoblastoma protein in growth-sensitive hematopoietic cells.

1992 • 120 citations

Janus Kinase-dependent Activation of Insulin Receptor Substrate 1 in Response to Interleukin-4, Oncostatin M, and the Interferons

1997 • 120 citations

Tick-borne thogoto virus infection in mice is inhibited by the orthomyxovirus resistance gene product Mx1

1995 • 116 citations

Different Relative Activities of Human Cell-Derived Interferon-α Subtypes: IFN-α8 Has Very High Antiviral Potency

1996 • 116 citations

Inhibition of the cellular response to interferons by products of the adenovirus type 5 E1A oncogene

1991 • 115 citations

Isolation of DAP3, a Novel Mediator of Interferon-γ-induced Cell Death

1995 • 115 citations

Cytokines increase transporter in antigen processing-1 expression more rapidly than HLA class I expression in endothelial cells.

1992 • 115 citations

A Bipartite Model of 2-5A-dependent RNase L

1997 • 112 citations

Interferon-γ-dependent Nuclear Import of Stat1 Is Mediated by the GTPase Activity of Ran/TC4

1996 • 112 citations

Identification of 69-kd and 100-kd forms of 2-5A synthetase in interferon-treated human cells by specific monoclonal antibodies.

1987 • 112 citations

A nuclear tyrosine phosphatase downregulates interferon-induced gene expression.

1993 • 112 citations

Targeting RNA for degradation with a (2'-5')oligoadenylate-antisense chimera.

1993 • 109 citations

Beta Interferon and Oncostatin M Activate Raf-1 and Mitogen-Activated Protein Kinase through a JAK1-Dependent Pathway

1997 • 109 citations

The activation of major histocompatibility complex class I genes by interferon regulatory factor-1 (IRF-1)

1992 • 108 citations

Identification of an Interferon-γ Receptor α Chain Sequence Required for JAK-1 Binding

1996 • 105 citations

Differences in Interferon α and β Signaling

1996 • 104 citations

Transcription Stimulation of the Fas-encoding Gene by Nuclear Factor for Interleukin-6 Expression upon Influenza Virus Infection

1995 • 103 citations

The molecular chaperone hsp40 regulates the activity of P58 ^IPK , the cellular inhibitor of PKR

1997 • 103 citations

Interferon-gamma induces receptor dimerization in solution and on cells.

1993 • 102 citations

The SH2 Domain-containing Tyrosine Phosphatase PTP1D Is Required for Interferon α/β-induced Gene Expression

1996 • 100 citations

Roles of Protein-tyrosine Phosphatases in Stat1α-mediated Cell Signaling

1995 • 98 citations

Tec tyrosine kinase links the cytokine receptors to PI-3 kinase probably through JAK

1997 • 97 citations

Antiproliferative and antiviral activities of human leukocyte interferons

1981 • 97 citations

Mx Transgenic Mice — Animal Models of Health

1996 • 96 citations

Reflections on STAT3, STAT5, and STAT6 as fat STATs.

1996 • 96 citations

The 69-kDa 2-5A synthetase is composed of two homologous and adjacent functional domains.

1992 • 95 citations

IFNα induces the expression of the cyclin-dependent kinase inhibitor p21 in human prostate cancer cells

1997 • 95 citations

Environmental signals influencing expression of the IFN-gamma receptor on human T cells control whether IFN-gamma promotes proliferation or apoptosis.

1994 • 94 citations

Regulation of IFN‐α/β genes: evidence for a dual function of the transcription factor complex ISGF3 in the production and action of IFN‐α/β

1996 • 94 citations

Tissue-specific targeting of gytokine unresponsiveness in transgenic mice

1995 • 94 citations

Intracellular signalling: Putting JAKs on the kinase MAP

1996 • 93 citations

Interferon gamma signals via a high-affinity multisubunit receptor complex that contains two types of polypeptide chain.

1995 • 93 citations

Cloning, sequencing, and expression of two murine 2‘-5‘-oligoadenylate synthetases. Structure-function relationships

1991 • 92 citations

Interferon alpha induces the expression of retinoblastoma gene product in human Burkitt lymphoma Daudi cells: role in growth regulation.

1992 • 92 citations

In vitro activation of a transcription factor by gamma interferon requires a membrane-associated tyrosine kinase and is mimicked by vanadate.

1993 • 92 citations

Interruption of cytokine networks by poxviruses: lessons from myxoma virus

1995 • 91 citations

The Human Type I Interferon Receptor

1996 • 91 citations

Other Kinases Can Substitute for Jak2 in Signal Transduction by Interferon-γ

1996 • 90 citations

Inhibition of Human Parainfluenza Virus-3 Replication by Interferon and Human MxA

1996 • 90 citations

Involvement of the transcription factor PU.1/Spi-1 in myeloid cell-restricted expression of an interferon-inducible gene encoding the human high-affinity Fc gamma receptor.

1994 • 89 citations

Intracellular Tyrosine Residues of the Human Growth Hormone Receptor Are Not Required for the Signaling of Proliferation or Jak-STAT Activation

1995 • 86 citations

Interferon‐γ arrests proliferation and causes apoptosis in stromal cell/interleukin‐7‐dependent normal murine pre‐B cell lines and clones in vitro, but does not induce differentiation to surface immunoglobulin‐positive B cells

1993 • 86 citations

Restoration of interferon responses of adenovirus E1A-expressing HT1080 cell lines by overexpression of p48 protein

1997 • 85 citations

Interferons, Mx Genes, and Resistance to Influenza Virus

1995 • 84 citations

The role of the dsRNA-activated kinase, PKR, in signal transduction

1995 • 82 citations

Function of the Mouse Mx1 Protein Is Inhibited by Overexpression of the PB2 Protein of Influenza Virus

1993 • 82 citations

Platelet-derived Growth Factor Signal Transduction through the Interferon-inducible Kinase PKR

1995 • 81 citations

Transcription factors induced by interferons α and γ

1990 • 80 citations

Vesicular stomatitis virus transcription inhibited by purified MxA protein

1995 • 80 citations

Adenovirus early region 1A modulation of interferon antiviral activity

1987 • 79 citations

Identification and characterization of an interferon (IFN)-stimulated response element-IFN-stimulated gene factor 3-independent signaling pathway for IFN-alpha.

1994 • 78 citations

Mx-dependent resistance to influenza viruses is induced by mouse interferons α and β but not γ

1984 • 78 citations

Two cis-DNA elements involved in myeloid-cell-specific expression and gamma interferon (IFN-gamma) activation of the human high-affinity Fc gamma receptor gene: a novel IFN regulatory mechanism.

1993 • 76 citations

Constitutive nuclear localization of Janus kinases 1 and 2.

1996 • 76 citations

Stoichiometry of interaction between interferon γ and its receptor

1992 • 76 citations

Characterization of 69- and 100-kDa forms of 2-5A-synthetase from interferon-treated human cells.

1988 • 73 citations

Inducible Expression of the 2-5A Synthetase/RNase L System Results in Inhibition of Vaccinia Virus Replication

1997 • 71 citations

Double-stranded RNA-dependent Protein Kinase Mediates c-Myc Suppression Induced by Type I Interferons

1996 • 71 citations

Virus proteins that bind cytokines, chemokines or interferons

1996 • 71 citations

Structure of mouse Mx1 protein. Molecular assembly and GTP-dependent conformational change

1993 • 71 citations

Targeting RNA decay with 2′,5′ oligoadenylate-antisense in respiratory syncytial virus-infected cells

1997 • 71 citations

Interferon-induced MxA Protein.

1995 • 71 citations

Elongation mechanism and substrate specificity of 2',5'-oligoadenylate synthetase.

1980 • 69 citations

Interferons and interleukin-6 suppress the DNA-binding activity of E2F in growth-sensitive hematopoietic cells.

1993 • 68 citations

A Base Substitution within the GTPase-associated Domain of Mammalian 28 S Ribosomal RNA Causes High Thiostrepton Accessibility

1995 • 67 citations

Activation of the Double‐Stranded‐RNA‐Activated Protein Kinase and Induction of Vascular Cell Adhesion Molecule‐1 by Poly (I) · Poly (C) in Endothelial Cells

1995 • 67 citations

Virus-mediated inhibition of the ppp(A2′p)n A system and its prevention by interferon

1982 • 66 citations

The Epstein-Barr virus encoded cytokine viral interleukin-10 enhances transformation of human B lymphocytes.

1995 • 65 citations

Interferon augments PML and PML/RAR alpha expression in normal myeloid and acute promyelocytic cells and cooperates with all-trans retinoic acid to induce maturation of a retinoid-resistant promyelocytic cell line

1996 • 64 citations

Stoichiometry of 2′,5′-Oligoadenylate-induced Dimerization of Ribonuclease L

1996 • 62 citations

Virus-induced cell death in plants expressing the mammalian 2′,5′ oligoadenylate system

1996 • 62 citations

69‐kDa and 100‐kDa Isoforms of Interferon‐Induced (2′‐5′)Oligoadenylate Synthetase Exhibit Differential Catalytic Parameters

1997 • 61 citations

Cleavage of Oligoribonucleotides by the 2′,5′-Oligoadenylate- dependent Ribonuclease L

1996 • 61 citations

IFN-gamma induces a p91/Stat1 alpha-related transcription factor with distinct activation and binding properties.

1995 • 59 citations

Interferon-alpha-induced phosphorylation and activation of cytosolic phospholipase A2 is required for the formation of interferon-stimulated gene factor three.

1996 • 58 citations

A mammalian 2-5A system functions as an antiviral pathway in transgenic plants.

1996 • 58 citations

Epstein-Barr virus-encoded small RNAs (EBERs) do not modulate interferon effects in infected lymphocytes

1992 • 57 citations

Oncostatin M induces association of Grb2 with Janus kinase JAK2 in multiple myeloma cells.

1995 • 56 citations

Synthesis, Characterisation and Biological Significance of (2′‐5′)Oiigoadenylate Derivatives of NAD⁺, ADP‐Ribose and Adenosine(5′)Tetraphosph0(5′)Adenosine

1982 • 53 citations

Jak1 kinase is required for cell migrations and anterior specification in zebrafish embryos

1997 • 52 citations

The Short Form of the Interferon α/β Receptor Chain 2 Acts as a Dominant Negative for Type I Interferon Action

1997 • 51 citations

Inhibition of Alpha Interferon but Not Gamma Interferon Signal Transduction by Phorbol Esters Is Mediated by a Tyrosine Phosphatase

1996 • 46 citations

Interaction of p59fynwith Interferon-Activated Jak Kinases

1997 • 45 citations

The Interferon-inducible Protein Kinase PKR Modulates the Transcriptional Activation of Immunoglobulin κ Gene

1995 • 44 citations

Modified subcellular localization of interferon-induced p68 kinase during encephalomyocarditis virus infection

1990 • 43 citations

Reconstitution of a High Affinity Binding Site for Type I Interferons

1995 • 41 citations

Interferon induction of gene expression through the Jak–Stat pathway

1995 • 41 citations

Partial Inhibition of Vesicular Stomatitis Virus by the Interferon-Induced Human 9-27 Protein

1996 • 41 citations

Mx1 but Not MxA Confers Resistance against Tick-Borne Dhori Virus in Mice

1995 • 41 citations

The murine 2-5A synthetase locus: three distinct transcripts from two linked genes

1991 • 38 citations

Enhancement by retinoic acid and dibutyryl cyclic adenosine 3':5'-monophosphate of the differentiation and gene expression of human neuroblastoma cells induced by interferon.

1991 • 36 citations

Protein phosphorylation in cell growth regulation

1996 • 36 citations

Inhibition of apoptotic cell death in B-CLL by interferon gamma correlates with clinical stage.

1996 • 33 citations

The vav proto‐oncogene product (p95^vav) interacts with the Tyk‐2 protein tyrosine kinase

1997 • 33 citations

Two Molecular Weight Forms of Human 2′,5′-Oligoadenylate Synthetase Have Different Activation Requirements

1986 • 33 citations

Activation of RNase L by 2′,5′-Oligoadenylates

1997 • 33 citations

The IL-4-induced tyrosine phosphorylation of the insulin receptor substrate is dependent on JAK1 expression in human fibrosarcoma cells.

1997 • 32 citations

Interaction of thec-cblProto-oncogene Product with the Tyk-2 Protein Tyrosine Kinase

1996 • 31 citations

Nomenclature of the Human Interferon Genes^a

1993 • 27 citations

Ap₃A and Ap₄A are primers for oligoadenylate synthesis catalyzed by interferon‐inducible 2–5A synthetase¹

1997 • 25 citations

Activation of RNase L by 2′,5′-Oligoadenylates

1997 • 25 citations

Viruses Launch their Own 'Star Wars'

1992 • 24 citations

Dimerization of a chimeric CD4-interferon-alpha receptor reconstitutes the signaling events preceding STAT phosphorylation.

1996 • 24 citations

Modulation of interferon signaling in human fibroblasts by phorbol esters.

1992 • 24 citations

Simian Virus 40 Large-T Bypasses the Translational Block Imposed by the Phosphorylation of eIF-2α

1996 • 22 citations

Transcriptional Regulation in the Interferon System

1997 • 21 citations

Occurrence of 2-5A and RNA degradation in the chick oviduct during rapid estrogen withdrawal

1988 • 19 citations

Analysis of 2′,5′-oligoadenylates in cells and tissues

1984 • 17 citations

Specific Binding of the ETS-Domain Protein to the Interferon-Stimulated Response Element

1997 • 14 citations

INDUCTION, PURIFICATION, AND PROPERTIES OF 2′5′-OLIGOADENYLATE SYNTHETASE

1979 • 13 citations

The interferon-induced enzyme 2–5A synthetase adenylates tRNA

1985 • 10 citations

Human papillomavirus type-16 (HPV-16) major transforming proteins functionally interact with interferon signaling mechanisms

1997 • 9 citations

(2′‐5′)A_n‐dependent endoribonuclease: Enzyme levels are regulated by IFNβ, IFNγ, and cell culture conditions

1988 • 9 citations