Analysis of γc-Family Cytokine Target Genes

Cluster analysis and display of genome-wide expression patterns

1998 • 16,410 citations

Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling

2000 • 9,712 citations

JAKS AND STATS: Biological Implications

1998 • 1,788 citations

Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice.

1994 • 1,572 citations

THE IL-4 RECEPTOR: Signaling Mechanisms and Biologic Functions

1999 • 1,532 citations

Interleukin-2 receptor γ chain mutation results in X-linked severe combined immunodeficiency in humans

1993 • 1,317 citations

Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function

2000 • 1,191 citations

Relation of Gene Expression Phenotype to Immunoglobulin Mutation Genotype in B Cell Chronic Lymphocytic Leukemia

2001 • 1,110 citations

Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment

1995 • 1,079 citations

Homeostasis and Self-Tolerance in the Immune System: Turning Lymphocytes off

1998 • 989 citations

A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors.

1995 • 761 citations

Defective Thymocyte Maturation in p44 MAP Kinase (Erk 1) Knockout Mice

1999 • 641 citations

Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase

1997 • 534 citations

RETRACTED: Uncoupling IL-2 Signals that Regulate T Cell Proliferation, Survival, and Fas-Mediated Activation-Induced Cell Death

1999 • 443 citations

Contrasting Roles of IL-2 and IL-15 in the Life and Death of Lymphocytes Implications for Immunotherapy

2001 • 441 citations

Human immune disorder arising from mutation of the α chain of the interleukin-2 receptor

1997 • 402 citations

A lymphokine, provisionally designated interleukin T and produced by a human adult T-cell leukemia line, stimulates T-cell proliferation and the induction of lymphokine-activated killer cells.

1994 • 396 citations

Cytokines and immunodeficiency diseases

2001 • 380 citations

Interleukin‐2 receptor common γ‐chain signaling cytokines regulate activated T cell apoptosis in response to growth factor withdrawal: Selective induction of anti‐apoptotic (bcl‐2, bcl‐x_L) but not pro‐apoptotic (bax, bcl‐x_S) gene expression

1996 • 367 citations

The Earliest T Lineage–Committed Cells Depend on IL-7 for Bcl-2 Expression and Normal Cell Cycle Progression

1997 • 338 citations

IL-9-Deficient Mice Establish Fundamental Roles for IL-9 in Pulmonary Mastocytosis and Goblet Cell Hyperplasia but Not T Cell Development

2000 • 324 citations

An Indirect Effect of Stat5a in IL-2–Induced Proliferation: A Critical Role for Stat5a in IL-2–Mediated IL-2 Receptor α Chain Induction

1997 • 275 citations

New Role for Shc in Activation of the Phosphatidylinositol 3-Kinase/Akt Pathway

2000 • 269 citations

The Lymphochip: A Specialized cDNA Microarray for the Genomic-scale Analysis of Gene Expression in Normal and Malignant Lymphocytes

1999 • 254 citations

Cloning of Human Stat5B

1996 • 210 citations

Interleukin 7 is a T-cell growth factor.

1989 • 206 citations

Different interleukin 2 receptor beta-chain tyrosines couple to at least two signaling pathways and synergistically mediate interleukin 2-induced proliferation.

1996 • 202 citations

IL-15 mimics T cell receptor crosslinking in the induction of cellular proliferation, gene expression, and cytotoxicity in CD8⁺memory T cells

2002 • 199 citations

Interleukin 2 induces tyrosine phosphorylation and activation of p72-74 Raf-1 kinase in a T-cell line.

1991 • 165 citations

Signaling from the IL-2 receptor to the nucleus

1997 • 157 citations

An IL-2 response element in the human IL-2 receptor alpha chain promoter is a composite element that binds Stat5, Elf-1, HMG-I(Y) and a GATA family protein.

1996 • 152 citations

The Basis for IL-2-Induced IL-2 Receptor α Chain Gene Regulation

2001 • 152 citations

Up-regulation of interleukin 4/B-cell stimulatory factor 1 receptor expression.

1988 • 145 citations

Isolation of interleukin 2-induced immediate-early genes.

1993 • 144 citations

A novel dual specificity phosphatase induced by serum stimulation and heat shock.

1994 • 143 citations

Thymic lymphomas in interleukin 9 transgenic mice.

1994 • 143 citations

Regulation of pim and myb mRNA accumulation by interleukin 2 and interleukin 3 in murine hematopoietic cell lines.

1988 • 141 citations

JAB/SOCS1/SSI-1 is an interleukin-2–induced inhibitor of IL-2 signaling

2001 • 140 citations

Identification of a novel receptor/signal transduction pathway for IL-15/T in mast cells.

1996 • 139 citations

Multiple Dual Specificity Protein Tyrosine Phosphatases Are Expressed and Regulated Differentially in Liver Cell Lines

1995 • 117 citations

Signal transduction by MAP kinases in T lymphocytes

2001 • 117 citations

Elf-1 and Stat5 Bind to a Critical Element in a New Enhancer of the Human Interleukin-2 Receptor α Gene

1996 • 117 citations

Interleukin-4-induced STAT6 Recognizes and Activates a Target Site in the Promoter of the Interleukin-4 Receptor Gene

1996 • 110 citations

The Prolactin Receptor and Severely Truncated Erythropoietin Receptors Support Differentiation of Erythroid Progenitors

1997 • 101 citations

The IL-15Rα Chain Signals Through Association with Syk in Human B Cells

2001 • 84 citations

Distinct Tyrosine Residues within the Interleukin-2 Receptor β Chain Drive Signal Transduction Specificity, Redundancy, and Diversity

1996 • 75 citations

Permissive role of thrombopoietin and granulocyte colony-stimulating factor receptors in hematopoietic cell fate decisions in vivo

1999 • 66 citations

Mouse Interleukin-2 Receptor α Gene Expression

1995 • 62 citations

Phosphatidylinositol 3-Kinase Potentiates, but Does Not Trigger, T Cell Proliferation Mediated by the IL-2 Receptor

2001 • 61 citations

Absence of cytokine receptor-dependent specificity in red blood cell differentiation in vivo

1998 • 42 citations

Novel CD28-Responsive Enhancer Activated by CREB/ATF and AP-1 Families in the Human Interleukin-2 Receptor α-Chain Locus

2001 • 33 citations

Rapamycin Blocks IL-2-Driven T Cell Cycle Progression While Preserving T Cell Survival

2001 • 31 citations

IL-2-Dependent Expression of Genes Involved in Cytoskeleton Organization, Oncogene Regulation, and Transcriptional Control

1999 • 27 citations

Role of the common cytokine receptor γ chain (γc) in thymocyte selection

2000 • 21 citations