Contrasting Roles of IL-2 and IL-15 in the Life and Death of Lymphocytes Implications for Immunotherapy

Reversible Defects in Natural Killer and Memory Cd8 T Cell Lineages in Interleukin 15–Deficient Mice

2000 • 1,578 citations

Cloning of a T Cell Growth Factor that Interacts with the β Chain of the Interleukin-2 Receptor

1994 • 1,423 citations

Control of Homeostasis of CD8 ⁺ Memory T Cells by Opposing Cytokines

2000 • 847 citations

Randomised trial of basiliximab versus placebo for control of acute cellular rejection in renal allograft recipients

1997 • 757 citations

THE MULTIFACETED REGULATION OF INTERLEUKIN-15 EXPRESSION AND THE ROLE OF THIS CYTOKINE IN NK CELL DIFFERENTIATION AND HOST RESPONSE TO INTRACELLULAR PATHOGENS

1999 • 712 citations

Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor.

1995 • 627 citations

IL-15 has stimulatory activity for the induction of B cell proliferation and differentiation.

1995 • 445 citations

RETRACTED: Uncoupling IL-2 Signals that Regulate T Cell Proliferation, Survival, and Fas-Mediated Activation-Induced Cell Death

1999 • 443 citations

The interleukin-2 receptor.

1991 • 354 citations

Soluble IL-15 receptor alpha-chain administration prevents murine collagen-induced arthritis: a role for IL-15 in development of antigen-induced immunopathology.

1998 • 292 citations

Interleukin 15 is produced by endothelial cells and increases the transendothelial migration of T cells In vitro and in the SCID mouse-human rheumatoid arthritis model In vivo.

1998 • 234 citations

The interleukin-2 receptor: a target for monoclonal antibody treatment of human T-cell lymphotrophic virus I-induced adult T-cell leukemia

1993 • 207 citations

Fas and the art of lymphocyte maintenance.

1996 • 196 citations

The 5′ Untranslated Region, Signal Peptide, and the Coding Sequence of the Carboxyl Terminus of IL-15 Participate in Its Multifaceted Translational Control

1998 • 189 citations

Death deflected: IL‐15 inhibits TNF‐α‐mediated apoptosis in fibroblasts by TRAF2 recruitment to the IL‐15Rα chain

1999 • 155 citations

Development and proliferation of lymphocytes in mice deficient for both interleukins‐2 and ‐4

1994 • 146 citations

The use of antibodies against the IL-2 receptor in transplantation

1998 • 138 citations

Targeting the IL-15 Receptor with an Antagonist IL-15 Mutant/Fcγ2a Protein Blocks Delayed-Type Hypersensitivity

1998 • 125 citations

Involvement of IL-15 in the pathogenesis of human T lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis: implications for therapy with a monoclonal antibody directed to the IL-2/15R beta receptor.

1999 • 85 citations

Evidence for the interleukin-2 dependent expansion of leukemic cells in adult T cell leukemia

1987 • 83 citations

Quiescence-Inducing and Antiapoptotic Activities of IL-15 Enhance Secondary CD4+ T Cell Responsiveness to Antigen

1998 • 79 citations

IL-2Ralpha-Directed monoclonal antibodies provide effective therapy in a murine model of adult T-cell leukemia by a mechanism other than blockade of IL-2/IL-2Ralpha interaction.

2000 • 77 citations

Reduction in HTLV‐I proviral load and spontaneous lymphoproliferation in HTLV‐I–associated myelopathy/tropical spastic paraparesis patients treated with humanized anti‐tac

1998 • 76 citations

Humanized antibody directed to the IL-2 receptor beta-chain prolongs primate cardiac allograft survival.

1994 • 47 citations

Interleukin-15 redirects the outcome of a tolerizing T-cell stimulus from apoptosis to anergy

2000 • 21 citations