THE MULTIFACETED REGULATION OF INTERLEUKIN-15 EXPRESSION AND THE ROLE OF THIS CYTOKINE IN NK CELL DIFFERENTIATION AND HOST RESPONSE TO INTRACELLULAR PATHOGENS

An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs

1987 • 5,139 citations

ROLE OF CYTOKINES IN RHEUMATOID ARTHRITIS

1996 • 2,527 citations

Structural design and molecular evolution of a cytokine receptor superfamily.

1990 • 2,104 citations

An analysis of vertebrate mRNA sequences: intimations of translational control.

1991 • 1,655 citations

Cloning of a T Cell Growth Factor that Interacts with the β Chain of the Interleukin-2 Receptor

1994 • 1,423 citations

Cytokine signal transduction

1994 • 1,358 citations

Potent and Selective Stimulation of Memory-Phenotype CD8+ T Cells In Vivo by IL-15

1998 • 1,262 citations

Severe Herpesvirus Infections in an Adolescent without Natural Killer Cells

1989 • 1,251 citations

Interleukin-2 Receptor γ Chain: a Functional Component of the Interleukin-7 Receptor

1993 • 1,128 citations

Interleukin (IL) 15 is a novel cytokine that activates human natural killer cells via components of the IL-2 receptor.

1994 • 1,079 citations

Defective lymphoid development in mice lacking expression of the common cytokine receptor γ chain

1995 • 1,024 citations

Utilization of the beta and gamma chains of the IL-2 receptor by the novel cytokine IL-15.

1994 • 1,008 citations

Regulation of Lymphokine Messenger RNA Stability by a Surface-Mediated T Cell Activation Pathway

1989 • 910 citations

Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor gamma chain.

1995 • 881 citations

Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID)

1995 • 875 citations

Interleukin-2–Receptor Blockade with Daclizumab to Prevent Acute Rejection in Renal Transplantation

1998 • 875 citations

Cloning of the γ Chain of the Human IL-2 Receptor

1992 • 835 citations

Stimulation of B-cell progenitors by cloned murine interleukin-7

1988 • 826 citations

Mutation of Jak3 in a Patient with SCID: Essential Role of Jak3 in Lymphoid Development

1995 • 800 citations

The role of shared receptor motifs and common stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15

1995 • 760 citations

Transmembrane form of the kit ligand growth factor is determined by alternative splicing and is missing in the SId mutant

1991 • 740 citations

Sharing of the Interleukin-2 (IL-2) Receptor γ Chain Between Receptors for IL-2 and IL-4

1993 • 734 citations

Interleukin-2 Receptor β Chain Gene: Generation of Three Receptor Forms by Cloned Human α and β Chain cDNA's

1989 • 680 citations

Regulation of Interleukin-2 Gene Enhancer Activity by the T Cell Accessory Molecule CD28

1991 • 660 citations

Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor.

1995 • 627 citations

Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells

1994 • 618 citations

Constitutively Activated Jak-STAT Pathway in T Cells Transformed with HTLV-I

1995 • 571 citations

Internal initiation of translation mediated by the 5′ leader of a cellular mRNA

1991 • 554 citations

Interleukin-15 mediates T cell-dependent regulation of tumor necrosis factor-α production in rheumatoid arthritis

1997 • 513 citations

Role of interleukin-15 in the development of human CD56+ natural killer cells from CD34+ hematopoietic progenitor cells

1996 • 495 citations

The role of interleukin–15 in T–cell migration and activation in rheumatoid arthritis

1996 • 492 citations

Immune Responses in Interleukin-2-Deficient Mice

1993 • 476 citations

IL-15: A Pleiotropic Cytokine with Diverse Receptor/Signaling Pathways Whose Expression Is Controlled at Multiple Levels

1996 • 459 citations

IL-15 has stimulatory activity for the induction of B cell proliferation and differentiation.

1995 • 445 citations

The interleukin (IL) 2 receptor beta chain is shared by IL-2 and a cytokine, provisionally designated IL-T, that stimulates T-cell proliferation and the induction of lymphokine-activated killer cells.

1994 • 417 citations

A potential role for interleukin-15 in the regulation of human natural killer cell survival.

1997 • 413 citations

Tyrosine phosphorylation and activation of STAT5, STAT3, and Janus kinases by interleukins 2 and 15.

1995 • 397 citations

A lymphokine, provisionally designated interleukin T and produced by a human adult T-cell leukemia line, stimulates T-cell proliferation and the induction of lymphokine-activated killer cells.

1994 • 396 citations

Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation

1995 • 372 citations

Functional Characterization of the Human Interleukin-15 Receptor αChain and Close Linkage of IL15RA and IL2RA Genes

1995 • 363 citations

Abnormal Development of Intestinal Intraepithelial Lymphocytes and Peripheral Natural Killer Cells in Mice Lacking the IL-2 Receptor β Chain

1997 • 359 citations

Endogenous production of interleukin 15 by activated human monocytes is critical for optimal production of interferon-gamma by natural killer cells in vitro.

1995 • 357 citations

Requirement for IRF-1 in the microenvironment supporting development of natural killer cells

1998 • 352 citations

Interleukin-15 protects from lethal apoptosis in vivo

1997 • 339 citations

Induction and regulation of IL-15 expression in murine macrophages.

1996 • 327 citations

Chemoattraction of human blood T lymphocytes by interleukin-15.

1995 • 303 citations

Subcellular fate of the lnt-2 oncoprotein is determined by choice of initiation codon

1990 • 293 citations

Soluble IL-15 receptor alpha-chain administration prevents murine collagen-induced arthritis: a role for IL-15 in development of antigen-induced immunopathology.

1998 • 292 citations

Negative feedback regulation of wild-type p53 biosynthesis.

1995 • 281 citations

Interleukin-15: a novel anabolic cytokine for skeletal muscle.

1995 • 259 citations

Radioimmunotherapy of interleukin-2R alpha-expressing adult T-cell leukemia with Yttrium-90-labeled anti-Tac [see comments]

1995 • 253 citations

A cis-acting element is necessary and sufficient for translational regulation of human ferritin expression in response to iron.

1987 • 250 citations

Intestinal epithelial cells both express and respond to interleukin 15

1996 • 244 citations

Interleukin 15 is produced by endothelial cells and increases the transendothelial migration of T cells In vitro and in the SCID mouse-human rheumatoid arthritis model In vivo.

1998 • 234 citations

The p75 peptide is the receptor for interleukin 2 expressed on large granular lymphocytes and is responsible for the interleukin 2 activation of these cells.

1987 • 226 citations

Interleukin (IL) 15/IL-T production by the adult T-cell leukemia cell line HuT-102 is associated with a human T-cell lymphotrophic virus type I region /IL-15 fusion message that lacks many upstream AUGs that normally attenuates IL-15 mRNA translation.

1996 • 218 citations

The interleukin-2 receptor: a target for monoclonal antibody treatment of human T-cell lymphotrophic virus I-induced adult T-cell leukemia

1993 • 207 citations

Soluble IL-15 Receptor α-Chain Administration Prevents Murine Collagen-Induced Arthritis: A Role for IL-15 in Development of Antigen-Induced Immunopathology

1998 • 206 citations

Generation of secretable and nonsecretable interleukin 15 isoforms through alternate usage of signal peptides

1997 • 201 citations

Interleukin-2, Interleukin-15, and Their Receptors

1998 • 198 citations

Transactivation of interleukin 2 and its receptor induces immune activation in human T-cell lymphotropic virus type I-associated myelopathy: pathogenic implications and a rationale for immunotherapy.

1990 • 194 citations

The IL-2/IL-2 receptor system: a target for rational immune intervention

1993 • 194 citations

Selective translation initiation by ribosome jumping in adenovirus-infected and heat-shocked cells.

1996 • 192 citations

The 5′ Untranslated Region, Signal Peptide, and the Coding Sequence of the Carboxyl Terminus of IL-15 Participate in Its Multifaceted Translational Control

1998 • 189 citations

Translational control of insulin biosynthesis. Evidence for regulation of elongation, initiation and signal-recognition-particle-mediated translational arrest by glucose

1986 • 187 citations

The Transcription Factor Interferon Regulatory Factor 1 (IRF-1) Is Important during the Maturation of Natural Killer 1.1+ T Cell Receptor–α/β+ (NK1+ T) Cells, Natural Killer Cells, and Intestinal Intraepithelial T Cells

1998 • 185 citations

Activation of naive and memory T cells by interleukin-15

1996 • 183 citations

Regulation of IL-15 secretion via the leader peptide of two IL-15 isoforms.

1997 • 182 citations

Identification of an RNA binding site for human thymidylate synthase.

1993 • 178 citations

Role of IL-15, IL-2, and their receptors in the development of T cell alveolitis in pulmonary sarcoidosis.

1996 • 177 citations

Human T cell lymphotropic virus type I Tax protein trans-activates interleukin 15 gene transcription through an NF-κB site

1998 • 176 citations

Serum levels of IL-10, IL-15 and soluble tumour necrosis factor-alpha (TNF-α) receptors in type C chronic liver disease

1997 • 172 citations

Induction of IL-15 messenger RNA and protein in human blood-derived dendritic cells: a role for IL-15 in attraction of T cells.

1997 • 167 citations

Differential effects of interleukin-15 and interleukin-2 on differentiation of bipotential T/natural killer progenitor cells.

1996 • 162 citations

Interleukin‐15‐induced maturation of human natural killer cells from early thymic precursors: selective expression of CD94/NKG2‐A as the only HLA class I‐specific inhibitory receptor

1997 • 162 citations

IL-15 is a novel growth factor for murine gamma delta T cells induced by Salmonella infection.

1996 • 158 citations

Role for IL-15/IL-15 receptor beta-chain in natural killer 1.1+ T cell receptor-alpha beta+ cell development.

1997 • 153 citations

Human herpesvirus-6 enhances natural killer cell cytotoxicity via IL-15.

1996 • 148 citations

Still More on NBT Technic

1974 • 145 citations

Activation of naive and memory T cells by interleukin-15

1996 • 141 citations

Identification of a novel receptor/signal transduction pathway for IL-15/T in mast cells.

1996 • 139 citations

A Consideration of Alternative Models for the Initiation of Translation in Eukaryotes

1992 • 137 citations

Interleukin-15 (IL-15) Induces IL-8 and Monocyte Chemotactic Protein 1 Production in Human Monocytes

1997 • 137 citations

Inhibition of translation of transforming growth factor-beta 3 mRNA by its 5' untranslated region.

1991 • 133 citations

Interleukin‐15 preferentially promotes the growth of intestinal intraepithelial lymphocytes bearing γδ T cell receptor in mice

1997 • 131 citations

Preassembly of interleukin 2 (IL-2) receptor subunits on resting Kit 225 K6 T cells and their modulation by IL-2, IL-7, and IL-15: A fluorescence resonance energy transfer study

1997 • 130 citations

IL-15 enhances immune functions during HIV infection.

1997 • 129 citations

Interleukin-15 mRNA Is Expressed by Human Keratinocytes, Langerhans Cells, and Blood-Derived Dendritic Cells and Is Downregulated by Ultraviolet B Radiation

1996 • 129 citations

Immunological findings in neurological diseases associated with antibodies to HTLV-I: Activated lymphocytes in tropical spastic paraparesis

1988 • 127 citations

Targeting the IL-15 Receptor with an Antagonist IL-15 Mutant/Fcγ2a Protein Blocks Delayed-Type Hypersensitivity

1998 • 125 citations

Constitutive activation of different Jak tyrosine kinases in human T cell leukemia virus type 1 (HTLV-1) tax protein or virus-transformed cells.

1995 • 121 citations

IL-15, an immunomodulator of T cell responses in intracellular infection.

1997 • 120 citations

Role of interleukin-2 (IL-2), IL-7, and IL-15 in natural killer cell differentiation from cord blood hematopoietic progenitor cells and from gamma c transduced severe combined immunodeficiency X1 bone marrow cells

1996 • 119 citations

Interleukin-15 Triggers the Proliferation and Cytotoxicity of Granular Lymphocytes in Patients With Lymphoproliferative Disease of Granular Lymphocytes

1997 • 119 citations

Chromosomal assignment and genomic structure of Il15

1995 • 117 citations

INTRAGRAFT IL-15 TRANSCRIPTS ARE INCREASED IN HUMAN RENAL ALLOGRAFT REJECTION1

1996 • 117 citations

Interleukin-15 Promotes Angiogenesisin Vivo

1997 • 115 citations

Interleukin-15 gene expression in human astrocytes and microglia in culture

1996 • 107 citations

Mouse Brain Microglia Express Interleukin-15 and Its Multimeric Receptor Complex Functionally Coupled to Janus Kinase Activity

1997 • 104 citations

Characterization of interleukin-15 (IL-15) and the IL-15 receptor complex

1996 • 101 citations

Identification of a novel interleukin-15 (IL-15) transcript isoform generated by alternative splicing in human small cell lung cancer cell lines.

1996 • 99 citations

Increased numbers of interleukin-15-expressing cells in active ulcerative colitis.

1996 • 97 citations

Gene for T-Cell Growth Factor: Location on Human Chromosome 4q and Feline Chromosome B1

1984 • 97 citations

IL-15 enhances the response of human gamma delta T cells to nonpeptide [correction of nonpetide] microbial antigens.

1998 • 96 citations

IL-15 Enhances the Response of Human γδ T Cells to Nonpetide Microbial Antigens

1998 • 85 citations

Multimeric cytokine receptors: common versus specific functions

1994 • 82 citations

Peripheral blood mononuclear cells stimulated with C5a or lipopolysaccharide to synthesize equivalent levels of IL-1 beta mRNA show unequal IL-1 beta protein accumulation but similar polyribosome profiles.

1994 • 76 citations

Interleukin-15 Augments Superoxide Production and Microbicidal Activity of Human Monocytes againstCandida albicans

1998 • 75 citations

Translational Efficiency Is Up-Regulated by Alternative Exon in Murine IL-15 mRNA

1998 • 72 citations

The NF-κB binding site is essential for transcriptional activation of the IL-15 gene

1998 • 72 citations

IL-15 mRNA expression is up-regulated in blood and cerebrospinal fluid mononuclear cells in multiple sclerosis (MS)

1998 • 72 citations

Interleukin-15 Stimulates C2 Skeletal Myoblast Differentiation

1997 • 71 citations

Cytokines: Shared receptors, distinct functions

1997 • 71 citations

Enhancement of natural killer cell cytotoxicity by the human herpesvirus-7 via IL-15 induction.

1997 • 69 citations

Biosynthesis of human fibroblast growth factor-5.

1991 • 68 citations

Interleukin-15 Induces the Expression of mRNAs of Cytolytic Mediators and Augments Cytotoxic Activities in Primary Murine Lymphocytes

1996 • 68 citations

High-dose IL-2 and IL-15 enhance the in vitro priming of naive CD4+ T cells for IFN-gamma but have differential effects on priming for IL-4.

1996 • 66 citations

Two Cases of T-Cell Chronic Lymphocytic Leukemia in Japan

1974 • 63 citations

Internal initiation of translation

1993 • 63 citations

Interleukin (IL)-15 Promotes the Growth of Murine Epidermal γδ T Cells by a Mechanism Involving the β- and γc-Chains of the IL-2 Receptor

1995 • 59 citations

DIFFERENTIAL REGULATION OF HUMAN T LYMPHOBLAST FUNCTIONS BY IL-2 AND IL-15

1997 • 58 citations

HSP70 mRNA translation in chicken reticulocytes is regulated at the level of elongation.

1988 • 55 citations

Interleukin-15 (IL-15) Can Replace the IL-2 Signal in IL-2–Dependent Adult T-Cell Leukemia (ATL) Cell Lines: Expression of IL-15 Receptor α on ATL Cells

1998 • 54 citations

Role of IL-15 in HIV-1-associated hypergammaglobulinaemia

1997 • 51 citations

IL-15 is produced by a subset of human melanomas, and is involved in the regulation of markers of melanoma progression through juxtacrine loops

1998 • 48 citations

Humanized antibody directed to the IL-2 receptor beta-chain prolongs primate cardiac allograft survival.

1994 • 47 citations

Activation of antigen-induced lymphocyte proliferation by interleukin-15 without the mitogenic effect of interleukin-2 that may induce human immunodeficiency virus-1 expression.

1996 • 43 citations

Interleukin-15: A Novel Cytokine with Regulatory Properties on Normal and Neoplastic B Lymphocytes

1997 • 42 citations

Interleukin-15 and the Growth of Tumor Derived Activated T-Cells

1995 • 40 citations

The Role of the La Autoantigen in Internal Initiation

1995 • 37 citations

Differential regulation of interleukin‐12‐and interleukin‐15‐induced natural killer cell activation by interleukin‐4

1996 • 37 citations

Interleukin‐15 Induces Antimicrobial Activity after Release byCryptococcus neoformans‐StimulatedMonocytes

1998 • 35 citations

Ontogeny of NK cells and the bone marrow microenvironment: Where does IL15 fit in?

1997 • 23 citations

IL-2 receptor (Tac antigen) protein expression is down-regulated by the 5'-untranslated region of the mRNA.

1990 • 21 citations

Interleukin-15 gene transcripts are present in rejecting islet allografts

1997 • 20 citations

Interleukin 15: A Potential Player during the Innate Immune Response to Infection

1996 • 16 citations

Genetic construction and characterization of the diphtheria toxin-related interleukin 15 fusion protein DAB³⁸⁹ sIL-15

1995 • 13 citations

Activation of leukemic large granular lymphocytes by interleukin-2 via the p75 interleukin-2 receptor.

1990 • 12 citations

Release of sIL-2Rα from and Activation of Native Human Peripheral Blood Mononuclear Cells by Recombinant IL-15

1996 • 11 citations

IL-15 Induces the Release of Soluble IL-2Rα from Human Peripheral Blood Mononuclear Cells

1996 • 11 citations

Molecular cloning of cDNA encoding porcine interleukin-15

1997 • 10 citations

Bispecific humanized anti-IL-2 receptor alpha beta antibodies inhibitory for both IL-2- and IL-15-mediated proliferation.

1997 • 9 citations

Deleted Work

1955 • 0 citations