The CIS Family: Negative Regulators of JAK–STAT Signaling

Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

1994 • 5,932 citations

STATs and Gene Regulation

1997 • 3,927 citations

A family of cytokine-inducible inhibitors of signalling

1997 • 2,055 citations

Targeted Disruption of the Stat1 Gene in Mice Reveals Unexpected Physiologic Specificity in the JAK–STAT Signaling Pathway

1996 • 1,648 citations

Essential role of Stat6 in IL-4 signalling

1996 • 1,563 citations

Targeted Disruption of the Mouse Stat1 Gene Results in Compromised Innate Immunity to Viral Disease

1996 • 1,560 citations

STATs: Signal Transducers and Activators of Transcription

1996 • 1,414 citations

A new protein containing an SH2 domain that inhibits JAK kinases

1997 • 1,413 citations

Stat5a and Stat5b Proteins Have Essential and Nonessential, or Redundant, Roles in Cytokine Responses

1998 • 1,316 citations

Structure and function of a new STAT-induced STAT inhibitor

1997 • 1,308 citations

Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted State6 gene

1996 • 1,304 citations

Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice

1996 • 1,277 citations

Cytokine receptor signalling

1995 • 1,242 citations

Stat5a is mandatory for adult mammary gland development and lactogenesis.

1997 • 1,106 citations

Identification of SOCS-3 as a Potential Mediator of Central Leptin Resistance

1998 • 1,000 citations

Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression

1997 • 989 citations

Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals

1995 • 956 citations

A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors.

1995 • 761 citations

Twenty proteins containing a C-terminal SOCS box form five structural classes

1998 • 735 citations

Crystal Structure of a Tyrosine Phosphorylated STAT-1 Dimer Bound to DNA

1998 • 696 citations

CIS, a Cytokine Inducible SH2 Protein, Is a Target of the JAK-STAT5 Pathway and Modulates STAT5 Activation

1997 • 538 citations

Regulation of Interferon-γ-Activated STAT1 by the Ubiquitin-Proteasome Pathway

1996 • 405 citations

CD4+ effector cells default to the Th2 pathway in interferon gamma-deficient mice infected with Leishmania major.

1994 • 397 citations

Jaks, STATs, Cytokine Signal Transduction, and Immunoregulation: Are We There Yet?

1997 • 381 citations

Functional domains of the granulocyte colony-stimulating factor receptor.

1991 • 342 citations

The ubiquitin conjugation system is required for ligand-induced endocytosis and degradation of the growth hormone receptor.

1996 • 307 citations

Lack of Interferon γ Receptor β Chain and the Prevention of Interferon γ Signaling in T_H1 Cells

1995 • 292 citations

Hormones, peripherally activated prohormones and regulation of the Th1/Th2 balance

1994 • 286 citations

An Indirect Effect of Stat5a in IL-2–Induced Proliferation: A Critical Role for Stat5a in IL-2–Mediated IL-2 Receptor α Chain Induction

1997 • 275 citations

Naturally Occurring Dominant Negative Variants of Stat5

1996 • 270 citations

Cloning and Characterization of Novel CIS Family Genes

1997 • 259 citations

Interleukin 2 and erythropoietin activate STAT5/MGF via distinct pathways.

1995 • 224 citations

Proteasomes Regulate Erythropoietin Receptor and Signal Transducer and Activator of Transcription 5 (STAT5) Activation

1998 • 193 citations

A Janus Kinase Inhibitor, JAB, Is an Interferon-γ–Inducible Gene and Confers Resistance to Interferons

1998 • 172 citations

Cloning and Functional Analysis of New Members of STAT Induced STAT Inhibitor (SSI) Family: SSI-2 and SSI-3

1997 • 169 citations

Functionally Distinct Isoforms of STAT5 Are Generated by Protein Processing

1997 • 155 citations

Inhibition of cytokines and JAK-STAT activation by distinct signaling pathways.

1996 • 129 citations

Two New EPO Receptor Mutations: Truncated EPO Receptors Are Most Frequently Associated With Primary Familial and Congenital Polycythemias

1997 • 127 citations

SOCS-1/JAB/SSI-1 Can Bind to and Suppress Tec Protein-tyrosine Kinase

1997 • 117 citations

IFN-γ represses ε germline transcription and subsequently down-regulates switch recombination to ε

1994 • 96 citations

CIS3 and JAB have different regulatory roles in interleukin-6 mediated differentiation and STAT3 activation in M1 leukemia cells

1998 • 93 citations

Pituitary Corticotroph SOCS-3: Novel Intracellular Regulation of Leukemia-Inhibitory Factor-Mediated Proopiomelanocortin Gene Expression and Adrenocorticotropin Secretion

1998 • 89 citations

A Novel Ligand for an SH3 Domain of the Adaptor Protein Nck Bears an SH2 Domain and Nuclear Signaling Motifs

1997 • 74 citations

Sequence analysis of the conserved protamine gene cluster shows that it contains a fourth expressed gene

1996 • 49 citations

Distinct downstream signaling mechanism between erythropoietin receptor and interleukin-2 receptor.

1992 • 34 citations

Pituitary Corticotroph SOCS-3: Novel Intracellular Regulation of Leukemia-Inhibitory Factor-Mediated Proopiomelanocortin Gene Expression and Adrenocorticotropin Secretion

1998 • 29 citations

Molecular cloning of CISH, chromosome assignment to 3p21.3, and analysis of expression in fetal and adult tissues

1997 • 25 citations