Cytokines and immunodeficiency diseases

NF-κB AND REL PROTEINS: Evolutionarily Conserved Mediators of Immune Responses

1998 • 5,178 citations

STATs and Gene Regulation

1997 • 3,927 citations

Gene Therapy of Human Severe Combined Immunodeficiency (SCID)-X1 Disease

2000 • 2,632 citations

NEW EMBO MEMBERS REVIEW: Transcriptional control by the TGF-beta/Smad signaling system

2000 • 1,935 citations

JAKS AND STATS: Biological Implications

1998 • 1,788 citations

Targeted Disruption of the Stat1 Gene in Mice Reveals Unexpected Physiologic Specificity in the JAK–STAT Signaling Pathway

1996 • 1,648 citations

Stat6 Is Required for Mediating Responses to IL-4 and for the Development of Th2 Cells

1996 • 1,618 citations

Reversible Defects in Natural Killer and Memory Cd8 T Cell Lineages in Interleukin 15–Deficient Mice

2000 • 1,578 citations

Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice.

1994 • 1,572 citations

Targeted Disruption of the Mouse Stat1 Gene Results in Compromised Innate Immunity to Viral Disease

1996 • 1,560 citations

Interleukin-2 receptor γ chain mutation results in X-linked severe combined immunodeficiency in humans

1993 • 1,317 citations

Stat5a and Stat5b Proteins Have Essential and Nonessential, or Redundant, Roles in Cytokine Responses

1998 • 1,316 citations

Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality

1997 • 1,306 citations

Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted State6 gene

1996 • 1,304 citations

IL-15 Receptor Maintains Lymphoid Homeostasis by Supporting Lymphocyte Homing and Proliferation

1998 • 1,293 citations

Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice

1996 • 1,277 citations

Generation and Analysis of Interleukin-4 Deficient Mice

1991 • 1,266 citations

JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin

1993 • 1,223 citations

Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells

1996 • 1,182 citations

Jak2 Is Essential for Signaling through a Variety of Cytokine Receptors

1998 • 1,155 citations

Interleukin-2 Receptor γ Chain: a Functional Component of the Interleukin-7 Receptor

1993 • 1,128 citations

Stat5a is mandatory for adult mammary gland development and lactogenesis.

1997 • 1,106 citations

Signal transduction through NF-κB

1998 • 1,103 citations

Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment

1995 • 1,079 citations

Defective lymphoid development in mice lacking expression of the common cytokine receptor γ chain

1995 • 1,024 citations

Fundamental Immunology

1999 • 1,011 citations

Utilization of the beta and gamma chains of the IL-2 receptor by the novel cytokine IL-15.

1994 • 1,008 citations

Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression

1997 • 989 citations

Identification of JAK2 as a growth hormone receptor-associated tyrosine kinase

1993 • 988 citations

Jak2 Deficiency Defines an EssentialDevelopmental Checkpoint in DefinitiveHematopoiesis

1998 • 904 citations

Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting

1991 • 892 citations

Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor gamma chain.

1995 • 881 citations

Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID)

1995 • 875 citations

Deregulated T Cell Activation and Autoimmunity in Mice Lacking Interleukin-2 Receptor β

1995 • 868 citations

Impairment of Mycobacterial Immunity in Human Interleukin-12 Receptor Deficiency

1998 • 837 citations

Cloning of the γ Chain of the Human IL-2 Receptor

1992 • 835 citations

Disruption of the Jak1 Gene Demonstrates Obligatory and Nonredundant Roles of the Jaks in Cytokine-Induced Biologic Responses

1998 • 827 citations

Severe Mycobacterial and Salmonella Infections in Interleukin-12 Receptor-Deficient Patients

1998 • 812 citations

Defective IL7R expression in T-B+NK+ severe combined immunodeficiency

1998 • 805 citations

Mutation of Jak3 in a Patient with SCID: Essential Role of Jak3 in Lymphoid Development

1995 • 800 citations

Sharing of the Interleukin-2 (IL-2) Receptor γ Chain Between Receptors for IL-2 and IL-4

1993 • 734 citations

Hematopoietic Stem-Cell Transplantation for the Treatment of Severe Combined Immunodeficiency

1999 • 713 citations

Fetal Anemia and Apoptosis of Red Cell Progenitors in Stat5a−/−5b−/− Mice

1999 • 710 citations

Defective Lymphoid Development in Mice Lacking Jak3

1995 • 650 citations

Interaction of IL-2Rβ and γ _c Chains with Jak1 and Jak3: Implications for XSCID and XCID

1994 • 647 citations

Haemopoietic receptors and helical cytokines

1990 • 642 citations

Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells

1994 • 618 citations

Bcl-2 Rescues T Lymphopoiesis in Interleukin-7 Receptor–Deficient Mice

1997 • 603 citations

Phosphorylation and activation of the Jak-3 Janus kinase in response to interleukin-2

1994 • 598 citations

Interleukin-2 Receptor γ Chain: a Functional Component of the Interleukin-4 Receptor

1993 • 593 citations

Functional Activation of Jak1 and Jak3 by Selective Association with IL-2 Receptor Subunits

1994 • 581 citations

Stat3 Activation Is Responsible for IL-6-Dependent T Cell Proliferation Through Preventing Apoptosis: Generation and Characterization of T Cell-Specific Stat3-Deficient Mice

1998 • 571 citations

Stat5 Is Required for IL-2-Induced Cell Cycle Progression of Peripheral T Cells

1999 • 554 citations

Human severe combined immunodeficiency: Genetic, phenotypic, and functional diversity in one hundred eight infants

1997 • 543 citations

Cutting Edge: The Common γ-Chain Is an Indispensable Subunit of the IL-21 Receptor Complex

2001 • 535 citations

Impairment of Mycobacterial But Not Viral Immunity by a Germline Human STAT1 Mutation

2001 • 507 citations

Bcl-2 Can Rescue T Lymphocyte Development in Interleukin-7 Receptor–Deficient Mice but Not in Mutant rag-1 −/− Mice

1997 • 503 citations

Suppression of epithelial apoptosis and delayed mammary gland involution in mice with a conditional knockout of Stat3

1999 • 481 citations

Three-dimensional structure of recombinant human interferon-gamma

1991 • 420 citations

Partial Impairment of Cytokine Responses in Tyk2-Deficient Mice

2000 • 412 citations

Inherited interleukin 12 deficiency in a child with bacille Calmette-Guérin and Salmonella enteritidis disseminated infection.

1998 • 405 citations

Human immune disorder arising from mutation of the α chain of the interleukin-2 receptor

1997 • 402 citations

Immune Response in Stat2 Knockout Mice

2000 • 399 citations

Partial interferon-gamma receptor 1 deficiency in a child with tuberculoid bacillus Calmette-Guérin infection and a sibling with clinical tuberculosis.

1997 • 383 citations

Functional Participation of the IL-2 Receptor γ Chain in IL-7 Receptor Complexes

1994 • 342 citations

Roles of STAT3 defined by tissue-specific gene targeting

2000 • 341 citations

Interleukin-3 signals through multiple isoforms of Stat5.

1995 • 327 citations

Complex roles of Stat1 in regulating gene expression

2000 • 326 citations

IL-9-Deficient Mice Establish Fundamental Roles for IL-9 in Pulmonary Mastocytosis and Goblet Cell Hyperplasia but Not T Cell Development

2000 • 324 citations

Stat5b Is Essential for Natural Killer Cell–mediated Proliferation and Cytolytic Activity

1998 • 323 citations

Prevention of T Cell Anergy by Signaling Through the γ _c Chain of the IL-2 Receptor

1994 • 311 citations

Tyk2 Plays a Restricted Role in IFNα Signaling, Although It Is Required for IL-12-Mediated T Cell Function

2000 • 310 citations

DNA binding of in vitro activated Stat1 alpha, Stat1 beta and truncated Stat1: interaction between NH2-terminal domains stabilizes binding of two dimers to tandem DNA sites.

1996 • 302 citations

Manipulating Immune Responses with Immunosuppressive Agents that Target NFAT

2000 • 279 citations

Overlapping elements in the guanylate-binding protein gene promoter mediate transcriptional induction by alpha and gamma interferons.

1991 • 278 citations

An Indirect Effect of Stat5a in IL-2–Induced Proliferation: A Critical Role for Stat5a in IL-2–Mediated IL-2 Receptor α Chain Induction

1997 • 275 citations

Modulation of hematopoiesis in mice with a truncated mutant of the interleukin-2 receptor gamma chain

1996 • 268 citations

Structure of the Amino-Terminal Protein Interaction Domain of STAT-4

1998 • 267 citations

Bcl-2 Rescues T Lymphopoiesis, but Not B or NK Cell Development, in Common γ Chain–Deficient Mice

1997 • 220 citations

The Significance of Tetramerization in Promoter Recruitment by Stat5

1999 • 213 citations

The state of the STATs: recent developments in the study of signal transduction to the nucleus

1997 • 212 citations

Cloning of Human Stat5B

1996 • 210 citations

Crystal Structure of the IL-10/IL-10R1 Complex Reveals a Shared Receptor Binding Site

2001 • 199 citations

Sharing of the IL-2 receptor γ chain with the functional IL-9 receptor complex

1995 • 189 citations

The Molecular Basis of X‐Linked Severe Combined Immunodeficiency: The Role of the Interleukin‐2 Receptor γ Chain as a Common γ Chain, γc

1994 • 180 citations

Partial Interferon‐γ Receptor Signaling Chain Deficiency in a Patient with Bacille Calmette‐Guérin andMycobacterium abscessusInfection

2000 • 178 citations

THE MOLECULAR BASIS OF X-LINKED SEVERE COMBINED IMMUNODEFICIENCY: Defective Cytokine Receptor Signaling

1996 • 168 citations

NATURALLY OCCURRING PRIMARY DEFICIENCIES OF THE IMMUNE SYSTEM

1997 • 159 citations

An IL-2 response element in the human IL-2 receptor alpha chain promoter is a composite element that binds Stat5, Elf-1, HMG-I(Y) and a GATA family protein.

1996 • 152 citations

The Basis for IL-2-Induced IL-2 Receptor α Chain Gene Regulation

2001 • 152 citations

Severe Combined Immunodeficiency Due to a Specific Defect in the Production of Interleukin-2

1990 • 146 citations

Thymic lymphomas in interleukin 9 transgenic mice.

1994 • 143 citations

Three-dimensional crystal structure of recombinant murine interferon-beta.

1992 • 130 citations

Janus kinase 3 (Jak3) is essential for common cytokine receptor γ chain (γc)-dependent signaling: comparative analysis of γc, Jak3, and γc and Jak3 double-deficient mice

2000 • 127 citations

Human IL-2 Receptor α Chain Deficiency

2000 • 121 citations

Elf-1 and Stat5 Bind to a Critical Element in a New Enhancer of the Human Interleukin-2 Receptor α Gene

1996 • 117 citations

Interleukin 2 Receptor Signaling Regulates the Perforin Gene through Signal Transducer and Activator of Transcription (Stat)5 Activation of Two Enhancers

1999 • 113 citations

Close linkage of the locus for X chromosome-linked severe combined immunodeficiency to polymorphic DNA markers in Xq11-q13.

1987 • 108 citations

Negative Regulators of Cytokine Signaling

2001 • 106 citations

Interleukin-3, granulocyte-macrophage colony-stimulating factor, and interleukin-5 transduce signals through two forms of STAT5

1995 • 105 citations

Mutations in the gene for the IL-7 receptor result in T–B+NK+ severe combined immunodeficiency disease

2000 • 100 citations

Recombinant interleukin 2 therapy in severe combined immunodeficiency disease.

1989 • 100 citations

Defective expression of the interleukin-2/interleukin-15 receptor β subunit leads to a natural killer cell–deficient form of severe combined immunodeficiency

2001 • 100 citations

Defective IL-2-mediated IL-2 receptor alpha chain expression in Stat3- deficient T lymphocytes

1998 • 92 citations

Both Stat5a and Stat5b are required for antigen-induced eosinophil and T-cell recruitment into the tissue

2000 • 84 citations

The role of Jak3 in lymphoid development, activation, and signaling

1997 • 83 citations

Restoration of Lymphoid Populations in a Murine Model of X-Linked Severe Combined Immunodeficiency by a Gene-Therapy Approach

1999 • 73 citations

Pim1 Reconstitutes Thymus Cellularity in Interleukin 7–And Common γ Chain–Mutant Mice and Permits Thymocyte Maturation in Rag- but Not Cd3γ-Deficient Mice

1999 • 63 citations

Mouse Interleukin-2 Receptor α Gene Expression

1995 • 62 citations

Preface: STAT signaling

2000 • 58 citations

Genomic Sequence, Organization, and Chromosomal Localization of HumanJAK3

1996 • 55 citations

Cytokine signaling: Inhibitors keep cytokines in check

1999 • 52 citations

X-linked severe combined immunodeficiency: localization within the region Xq13.1-q21.1 by linkage and deletion analysis.

1989 • 51 citations

Cytokines and their receptor complexes

1995 • 50 citations

Gene Therapy for Human Severe Combined Immunodeficiencies

2001 • 45 citations

Role of Bcl-2 in alpha beta T cell development in mice deficient in the common cytokine receptor gamma-chain: the requirement for Bcl-2 differs depending on the TCR/MHC affinity.

1999 • 41 citations

Role of Bcl-2 in αβ T Cell Development in Mice Deficient in the Common Cytokine Receptor γ-Chain: The Requirement for Bcl-2 Differs Depending on the TCR/MHC Affinity

1999 • 40 citations