JAB/SOCS1/SSI-1 is an interleukin-2–induced inhibitor of IL-2 signaling

STATs and Gene Regulation

1997 • 3,927 citations

A family of cytokine-inducible inhibitors of signalling

1997 • 2,055 citations

JAKS AND STATS: Biological Implications

1998 • 1,788 citations

A new protein containing an SH2 domain that inhibits JAK kinases

1997 • 1,413 citations

Interleukin-2 receptor γ chain mutation results in X-linked severe combined immunodeficiency in humans

1993 • 1,317 citations

Structure and function of a new STAT-induced STAT inhibitor

1997 • 1,308 citations

Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment

1995 • 1,079 citations

Specific Inhibition of Stat3 Signal Transduction by PIAS3

1997 • 971 citations

Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor gamma chain.

1995 • 881 citations

Deregulated T Cell Activation and Autoimmunity in Mice Lacking Interleukin-2 Receptor β

1995 • 868 citations

A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors.

1995 • 761 citations

The role of shared receptor motifs and common stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15

1995 • 760 citations

Inhibition of Stat1-mediated gene activation by PIAS1

1998 • 760 citations

Twenty proteins containing a C-terminal SOCS box form five structural classes

1998 • 735 citations

Cytokine Signaling Through Nonreceptor Protein Tyrosine Kinases

1995 • 713 citations

The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop

1999 • 712 citations

Interaction of IL-2Rβ and γ _c Chains with Jak1 and Jak3: Implications for XSCID and XCID

1994 • 647 citations

The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation

1999 • 620 citations

Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells

1994 • 618 citations

Phosphorylation and activation of the Jak-3 Janus kinase in response to interleukin-2

1994 • 598 citations

The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families

1998 • 596 citations

Functional Activation of Jak1 and Jak3 by Selective Association with IL-2 Receptor Subunits

1994 • 581 citations

CIS, a Cytokine Inducible SH2 Protein, Is a Target of the JAK-STAT5 Pathway and Modulates STAT5 Activation

1997 • 538 citations

SOCS1 Deficiency Causes a Lymphocyte-Dependent Perinatal Lethality

1999 • 531 citations

Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction

1999 • 428 citations

Human immune disorder arising from mutation of the α chain of the interleukin-2 receptor

1997 • 402 citations

Tyrosine phosphorylation and activation of STAT5, STAT3, and Janus kinases by interleukins 2 and 15.

1995 • 397 citations

Abnormal Development of Intestinal Intraepithelial Lymphocytes and Peripheral Natural Killer Cells in Mice Lacking the IL-2 Receptor β Chain

1997 • 359 citations

Cytoplasmic domains of the interleukin-2 receptor β and γ chains mediate the signal for T-cell proliferation

1994 • 340 citations

Heterodimerization of the IL-2 receptor β- and γ-chain cytoplasmic domains is required for signalling

1994 • 338 citations

Prevention of T Cell Anergy by Signaling Through the γ _c Chain of the IL-2 Receptor

1994 • 311 citations

Functional Association of Nmi with Stat5 and Stat1 in IL-2- and IFN γ-Mediated Signaling

1999 • 297 citations

Accelerated apoptosis of lymphocytes by augmented induction of Bax in SSI-1 (STAT-induced STAT inhibitor-1) deficient mice

1998 • 290 citations

SOCS-3 Is Tyrosine Phosphorylated in Response to Interleukin-2 and Suppresses STAT5 Phosphorylation and Lymphocyte Proliferation

1999 • 267 citations

Three distinct domains of SSI-1/SOCS-1/JAB protein are required for its suppression of interleukin 6 signaling

1998 • 246 citations

Cloning of Human Stat5B

1996 • 210 citations

Socs1 binds to multiple signalling proteins and suppresses Steel factor-dependent proliferation

1999 • 205 citations

Cutting Edge: SOCS-1 Is a Potent Inhibitor of IL-4 Signal Transduction

1999 • 183 citations

Interferons inhibit activation of STAT6 by interleukin 4 in human monocytes by inducingSOCS-1gene expression

1999 • 173 citations

The Common Cytokine Receptor γ Chain Plays an Essential Role in Regulating Lymphoid Homeostasis

1997 • 168 citations

Interleukin-2 activation of STAT5 requires the convergent action of tyrosine kinases and a serine/threonine kinase pathway distinct from the Raf1/ERK2 MAP kinase pathway.

1996 • 167 citations

Signaling from the IL-2 receptor to the nucleus

1997 • 157 citations

Interleukin‐2 Deficient Mice: A New Model to Study Autoimmunity and Self‐Tolerance

1995 • 151 citations

The SOCS proteins: a new family of negative regulators of signal transduction

1998 • 135 citations

Recruitment of SH2-containing protein tyrosine phosphatase SHP-1 to the interleukin 2 receptor; loss of SHP-1 expression in human T-lymphotropic virus type I-transformed T cells

1998 • 129 citations

Distinct tyrosine phosphorylation sites in JAK3 kinase domain positively and negatively regulate its enzymatic activity

1997 • 118 citations

SOCS-1/JAB/SSI-1 Can Bind to and Suppress Tec Protein-tyrosine Kinase

1997 • 117 citations

CIS Associates with the Interleukin-2 Receptor β Chain and Inhibits Interleukin-2-dependent Signaling

1999 • 116 citations

Janus kinases in interleukin-2-mediated signaling: JAK1 and JAK3 are differentially regulated by tyrosine phosphorylation

1997 • 98 citations

Repression of IL-4-induced gene expression by IFN-gamma requires Stat1 activation.

1999 • 92 citations

Functional cleavage of the common cytokine receptor γ chain (γ_c) by calpain

1997 • 75 citations

The CIS Family: Negative Regulators of JAK–STAT Signaling

1998 • 72 citations

Delineation of the Regions of Interleukin-2 (IL-2) Receptor β Chain Important for Association of Jak1 and Jak3

1998 • 71 citations

Repression of IL-4-Induced Gene Expression by IFN-γ Requires Stat1 Activation

1999 • 71 citations

Interleukin‐2 induces tyrosine phosphorylation and nuclear translocation of stat3 in human T lymphocytes

1994 • 69 citations

Control of hsp70 RNA levels in human lymphocytes.

1987 • 46 citations