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Role of Growth Factors of Uterine and Fetal-Placental Origin During Pregnancy

Data up to Jan 2025

Published1998
Citations21
References417

Total Citations Per Year

Abstract

References (417)

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1991 • 589 citations

Mice with a null mutation of the TGFα gene have abnormal skin architecture, wavy hair, and curly whiskers and often develop corneal inflammation

1993 • 578 citations

Heparin-binding EGF-like growth factor gene is induced in the mouse uterus temporally by the blastocyst solely at the site of its apposition: a possible ligand for interaction with blastocyst EGF-receptor in implantation

1994 • 573 citations

Isolation and characterization of a vascular endothelial cell mitogen produced by pituitary-derived folliculo stellate cells.

1989 • 568 citations

Two FGF receptor genes are differentially expressed in epithelial and mesenchymal tissues during limb formation and organogenesis in the mouse

1992 • 552 citations

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1992 • 552 citations

Perlecan, basal lamina proteoglycan, promotes basic fibroblast growth factor-receptor binding, mitogenesis, and angiogenesis

1994 • 541 citations

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1990 • 533 citations

Identification of a new endothelial cell growth factor receptor tyrosine kinase

1991 • 529 citations

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Attachment of smooth muscle cells to collagen and their migration toward platelet-derived growth factor.

1981 • 506 citations

Embryonic gene expression patterns of TGF β1, β2 and β3 suggest different developmental functions in vivo

1991 • 499 citations

Maternal Rescue of Transforming Growth Factor-β 1 Null Mice

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Comparative morphogenesis of the fetal membranes and accessory uterine structures

1991 • 491 citations

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1994 • 471 citations

The Cell Cycle

1989 • 468 citations

Basic fibroblast growth factor, a protein devoid of secretory signal sequence, is released by cells via a pathway independent of the endoplasmic reticulum‐Golgi complex

1992 • 461 citations

Vascular endothelial growth factor receptor expression during embryogenesis and tissue repair suggests a role in endothelial differentiation and blood vessel growth.

1993 • 460 citations

Vascular endothelial growth factor/vascular permeability factor expression in the rat uterus: rapid stimulation by estrogen correlates with estrogen-induced increases in uterine capillary permeability and growth.

1993 • 437 citations

Utero-placental vascular development and placental function

1995 • 419 citations

Developmental expression of two murine fibroblast growth factor receptors, fig and bek

1991 • 397 citations

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1993 • 390 citations

The type 1 (EGFR-related) family of growth factor receptors and their ligands

1992 • 377 citations

Uterine Receptivity for Nidationa

1986 • 371 citations

Insulin-like growth factors and their binding proteins in the term and preterm human fetus and neonate with normal and extremes of intrauterine growth.

1995 • 361 citations

The Amphiregulin Gene Encodes a Novel Epidermal Growth Factor-Related Protein with Tumor-Inhibitory Activity

1990 • 359 citations

Functional Role of Cell Surface Integrins on Human Trophoblast Cell Migration: Regulation by TGF-β, IGF-II, and IGFBP-1

1995 • 358 citations

Localization of Transforming Growth Factor-β at the Human Fetal-Maternal Interface: Role in Trophoblast Growth and Differentiation1

1992 • 357 citations

Persico MG.Isolation of a human placenta cDNA coding for a potein related to the vascular premeability factor

1991 • 352 citations

Developmental expression of c-kit, a proto-oncogene encoded by the W locus

1990 • 349 citations

Structure of heparin-binding EGF-like growth factor. Multiple forms, primary structure, and glycosylation of the mature protein.

1992 • 346 citations

Platelet‐derived growth factor is a chemoattractant for vascular smooth muscle cells

1982 • 340 citations

Angiogenesis in female reproductive system

2001 • 338 citations

Growth factors and growth modulators in human uterine endometrium: their potential relevance to reproductive medicine

1994 • 327 citations

The functions of uterine secretions

1988 • 325 citations

The impact of embryonic development and endometrial maturity on the timing of implantation

1992 • 321 citations

Vascular endothelial growth factor: A new member of the platelet-derived growth factor gene family

1989 • 308 citations

Mechanisms of Angiogenesis

1987 • 304 citations

Purification and Characterization of a Naturally Occurring Vascular Endothelial Growth Factor · Placenta Growth Factor Heterodimer

1995 • 302 citations

A Transforming Growth Factor β Type I Receptor that Signals to Activate Gene Expression

1994 • 296 citations

Phosphorylation of insulin-like growth factor (IGF)-binding protein 1 in cell culture and in vivo: effects on affinity for IGF-I.

1991 • 294 citations

Acute effects of insulin-like growth factor I on glucose and amino acid metabolism in the awake fasted rat. Comparison with insulin.

1989 • 294 citations

Estrogen Regulates the Synthesis of Epidermal Growth Factor in Mouse Uterine Epithelial Cells

1990 • 288 citations

Maternal Recognition of Pregnancy1

1996 • 280 citations

Platelet-derived growth factor: Identification of constituent polypeptide chains

1982 • 275 citations

Collection, description and transfer of embryos from cattle 10-16 days after oestrus

1980 • 264 citations

The related FLT4, FLT1, and KDR receptor tyrosine kinases show distinct expression patterns in human fetal endothelial cells.

1993 • 263 citations

Developmental expression of binding sites and messenger ribonucleic acid for vascular endothelial growth factor suggests a role for this protein in vasculogenesis and angiogenesis.

1993 • 262 citations

Expression of basic fibroblast growth factor in normal human tissues.

1990 • 258 citations

Identification of a human endothelial cell antigen with monoclonal antibody 44G4 produced against a pre-B leukemic cell line.

1988 • 256 citations

The Role of Cytokines in Gestation

1994 • 254 citations

Amphiregulin is an implantation-specific and progesterone-regulated gene in the mouse uterus.

1995 • 248 citations

Interleukin-1β, human leukocyte antigen HLA-DRα, and transforming growth factor-β expression in endom trium, placenta, and placental membranes

1990 • 248 citations

Vascular Endothelial Growth Factor Receptor Localization and Activation in Human Trophoblast and Choriocarcinoma Cells1

1994 • 246 citations

Expression of mRNA for vascular endothelial growth factor in human placenta

1993 • 245 citations

A Heparin-Binding Form of Placenta Growth Factor (PlGF-2) is Expressed in Human Umbilical Vein Endothelial Cells and in Placenta

1993 • 245 citations

Embryonic Mortality in Domestic Species

1994 • 243 citations

Regulation and role of PDGF receptor a-subunit expression during embryogenesis

1992 • 239 citations

Platelet-derived growth factor-A and its receptor are expressed in separate, but adjacent cell layers of the mouse embryo

1992 • 238 citations

Human cytotrophoblast invasion is up-regulated by epidermal growth factor: Evidence that paracrine factors modify this process

1994 • 237 citations

A heparin sulfate-regulated human keratinocyte autocrine factor is similar or identical to amphiregulin.

1991 • 236 citations

Transforming growth factor-beta 1 knockout mice. A mutation in one cytokine gene causes a dramatic inflammatory disease.

1993 • 235 citations

Cell Type-Specific Expression of Transforming Growth Factor-β 1 in the Mouse Uterus during the Periimplantation Period

1990 • 234 citations

Immune dysregulation in TGF-beta 1-deficient mice.

1994 • 231 citations

Sex Steroids and Growth Factors Differentially Regulate the Growth and Differentiation of Cultured Human Endometrial Stromal Cells*

1991 • 222 citations

Selective expression of PDGF A and its receptor during early mouse embryogenesis

1990 • 215 citations

DEVELOPMENT OF THE VASCULAR SYSTEM

1983 • 207 citations

Expression of endothelial cell-specific receptor tyrosine kinases and growth factors in human brain tumors.

1995 • 205 citations

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1950 • 205 citations

The preimplantation pig embryo: cell number and allocation to trophectoderm and inner cell mass of the blastocyst in vivo and in vitro

1988 • 197 citations

In the human fetus, vascular endothelial growth factor is expressed in epithelial cells and myocytes, but not vascular endothelium: implications for mode of action.

1994 • 196 citations

Endoglin forms a heteromeric complex with the signaling receptors for transforming growth factor-beta.

1994 • 193 citations

Proteinase expression in early mouse embryos is regulated by leukaemia inhibitory factor and epidermal growth factor

1995 • 192 citations

Developmental expression of the α receptor for platelet-derived growth factor, which is deleted in the embryonic lethal Patch mutation

1992 • 191 citations

Expression of Insulin-Like Growth Factor-I (IGF-l) and its Receptor in the Peri-Implantation Mouse Uterus, and Cell-Specific Regulation of IGF-l Gene Expression by Estradiol and Progesterone1

1992 • 187 citations

Placental Steroid Hormone Synthesis: Unique Features and Unanswered Questions1

1996 • 186 citations

Isolation and characterization of a macrophage-derived heparin-binding growth factor.

1990 • 186 citations

Identification of distinct epitopes of endoglin, an RGD-containing glycoprotein of endothelial cells, leukemic cells, and syncytiotrophoblasts

1992 • 186 citations

In vivo proteolysis of serum insulin-like growth factor (IGF) binding protein-3 results in increased availability of IGF to target cells.

1994 • 184 citations

Progesterone-dependent expression of keratinocyte growth factor mRNA in stromal cells of the primate endometrium: keratinocyte growth factor as a progestomedin.

1994 • 182 citations

Fibroblast growth factors in mammalian development

1995 • 182 citations

Localization of two angiogenic growth factors (PDECGF and VEGF) in human placentae throughout gestation

1994 • 177 citations

Tumor Necrosis Factors: Pivotal Components of Pregnancy?1

1996 • 173 citations

Protein tyrosine phosphatases in signaling

1996 • 170 citations

Insulinlike growth factors. Their regulation of glucose and amino acid transport in placental trophoblasts isolated from first-trimester chorionic villi.

1994 • 170 citations

Embryonic Mortality in Farm Animals

1986 • 168 citations

Growth Factor Effects on Cells of the Vascular Wall: A Survey

1993 • 166 citations

Differential expression of vascular endothelial growth factor and its receptor mRNAs in the mouse uterus around the time of implantation

1995 • 166 citations

A confined variable region confers ligand specificity on fibroblast growth factor receptors: implications for the origin of the immunoglobulin fold.

1992 • 165 citations

Receptors for the TGF-β superfamily: multiple polypeptides and serine/threonine kinases

1993 • 164 citations

Angiogenesis during human extraembryonic development involves the spatiotemporal control of PDGF ligand and receptor gene expression

1991 • 164 citations

HAIRPIN-TAIL: A CASE OF POST-REDUCTIONAL GENE ACTION IN THE MOUSE EGG?

1974 • 163 citations

Expression of Rat Transforming Growth Factor Alpha mRNA during Development Occurs Predominantly in the Maternal Decidua

1987 • 162 citations

Transforming growth factor-alpha is a potential mediator of estrogen action in the mouse uterus.

1992 • 160 citations

Differentiation and proliferation patterns in human trophoblast revealed by c-erbB-2 oncogene product and EGF-R.

1993 • 160 citations

Murine pregnancy decidua produces a unique immunosuppressive molecule related to transforming growth factor beta-2.

1990 • 157 citations

Gene knockouts of c-src, transforming growth factor beta 1, and tenascin suggest superfluous, nonfunctional expression of proteins.

1993 • 157 citations

Insulin-like growth factors and their binding proteins in the term and preterm human fetus and neonate with normal and extremes of intrauterine growth

1995 • 154 citations

Expression of the fibroblast growth factor receptor FGFR-1/flg during gastrulation and segmentation in the mouse embryo

1992 • 153 citations

The effects of infusion of insulinlike growth factor (IGF) I, IGF-II, and insulin on glucose and protein metabolism in fasted lambs.

1991 • 152 citations

Differential inhibition of transforming growth factor beta 1 and beta 2 activity by alpha 2-macroglobulin.

1990 • 148 citations

Differential expression of epidermal growth factor receptor (EGF-R) gene and regulation of EGF-R bioactivity by progesterone and estrogen in the adult mouse uterus.

1994 • 145 citations

Differential expression of the two VEGF receptors flt and KDR in placenta and vascular endothelial cells

1994 • 144 citations

Rescue of the T-associated maternal effect in mice carrying null mutations in Igf-2 and Igf2r, two reciprocally imprinted genes

1993 • 144 citations

The gene structure of the insulin-like growth factor family

1989 • 143 citations

Expression of transforming growth factor-beta isoforms (beta 2 and beta 3) in the mouse uterus: analysis of the periimplantation period and effects of ovarian steroids.

1992 • 142 citations

Differential expression of messenger ribonucleic acids encoding insulin-like growth factors and their receptors in human uterine endometrium and decidua.

1993 • 139 citations

The control of apoptosis in mammalian cells

1993 • 139 citations

Expression of Messenger RNAs Encoding Insulin-like Growth Factor-I, -II, and Insulin-like Growth Factor Binding Protein-2 in Bovine Endometrium during the Estrous Cycle and Early Pregnancy1

1991 • 135 citations

Development of the Vascular System

2014 • 134 citations

Transforming Growth Factor β1 Inhibits Placental Differentiation and Human Chorionic Gonadotropin and Human Placental Lactogen Secretion

1991 • 134 citations

Molecular characterization and in situ localization of murine endoglin reveal that it is a transforming growth factor-beta binding protein of endothelial and stromal cells.

1994 • 133 citations

Insulin-like growth factor 2 and short-range stimulatory loops in control of human placental growth.

1989 • 130 citations

Hormonal Regulation of Insulin-Like Growth Factor Gene Expression in Pig Uterus*

1990 • 128 citations

The trophoblast as an integral component of a macrophage‐cytokine network

1993 • 127 citations

Immunohistochemical Localization of Epidermal Growth Factor in Human Endometrium, Decidua, and Placenta*

1991 • 127 citations

Regulation of polypeptide growth factor synthesis and growth factor-related gene expression in the rat and mouse uterus before and after implantation

1990 • 126 citations

Insulin-like growth factor binding protein-3 is functionally altered in pregnancy plasma.

1994 • 126 citations

Platelet-derived growth factor (PDGF), epidermal growth factor (EGF), and EGF and PDGF beta-receptors in human endometrial tissue: localization and in vitro action.

1992 • 125 citations

Effect of increasing doses of recombinant human insulin-like growth factor-I on glucose, lipid, and leucine metabolism in man.

1992 • 125 citations

Circulating insulin-like growth factors-I and -II and substrates in fetal sheep following restriction of placental growth

1994 • 123 citations

Circulating levels of IGF-I and IGF-binding protein-1 throughout pregnancy: relation to birthweight and maternal weight

1996 • 120 citations

Expression of TGF-βs and Their Receptors during Implantation and Organogenesis of the Mouse Embryo

1994 • 119 citations

Immunohistochemical localization of acidic and basic fibroblast growth factors in normal human endometrium and endometriosis and the detection of their mRNA by polymerase chain reaction

1993 • 118 citations

Vascular endothelial growth factor/vascular permeability factor expression in the rat uterus: rapid stimulation by estrogen correlates with estrogen-induced increases in uterine capillary permeability and growth

1993 • 118 citations

Insulin-like growth factors and their binding proteins in normal and abnormal human fetal growth.

1994 • 117 citations

Cell-Type-Specific Expression of Transforming Growth Factor-α in the Mouse Uterus during the Peri-implantation Period1

1991 • 115 citations

Vascular endothelial growth factor gene expression in ovine placenta and fetal membranes

1995 • 115 citations

Insulin-like growth factor-II and its binding proteins in placental development.

1992 • 114 citations

Insulin‐like growth factor‐1 stimulates amino acid uptake by the cultured human placental trophoblast

1995 • 113 citations

Experimental Diabetes Increases Insulinlike Growth Factor I and II Receptor Concentration and Gene Expression in Kidney

1990 • 112 citations

Insulin-like growth factor binding proteins: gene structure and expression.

1992 • 110 citations

Placental-fetal hormonal interactions: impact on fetal growth

1995 • 106 citations

Platelet-derived growth factor promotes survival of rat and human mesencephalic dopaminergic neurons in culture

1993 • 105 citations

Blastocyst implantation precedes induction of insulin-like growth factor II gene expression in human trophoblasts

1989 • 101 citations

Mitogenicity and transforming activity of the insulin-like growth factor-I receptor with mutations in the tyrosine kinase domain.

1994 • 101 citations

ELEVATING MATERNAL INSULIN-LIKE GROWTH FACTOR-I IN MICE AND RATS ALTERS THE PATTERN OF FETAL GROWTH BY REMOVING MATERNAL CONSTRAINT

1992 • 100 citations

Ontogeny of the porcine insulin-like growth factor system

1993 • 100 citations

The molecular and cellular biology of insulin-like growth factor II

1992 • 100 citations

Structural aspects of the IGFBP family.

1992 • 99 citations

Amphiregulin is an implantation-specific and progesterone-regulated gene in the mouse uterus

1995 • 99 citations

VEGF Receptor Subtypes KDR and FLT1 Show Different Sensitivities to Heparin and Placenta Growth Factor

1994 • 98 citations

Insulin-like growth factor binding protein-3: biochemistry and physiology.

1992 • 98 citations

Differential expression, during the estrous cycle and pre- and postimplantation conceptus development, of messenger ribonucleic acids encoding components of the pig uterine insulin-like growth factor system.

1992 • 98 citations

Synthetic fibronectin peptides interrupt inflammatory cell infiltration in transforming growth factor beta 1 knockout mice.

1994 • 96 citations

Wound Healing: The Role of Platelet‐Derived Growth Factor and Transforming Growth Factor Beta

1993 • 95 citations

Onset and progression of pathological lesions in transforming growth factor-beta 1-deficient mice.

1995 • 95 citations

Transforming growth factor-beta stimulates trophoblast oncofetal fibronectin synthesis in vitro: implications for trophoblast implantation in vivo.

1994 • 93 citations

Macrophages: Important Physiologic and Pathologic Sources of Polypeptide Growth Factors

1990 • 90 citations

Effect of restriction of placental growth on fetal and utero-placental metabolism.

1987 • 89 citations

A Subset of Patients With Recurrent Spontaneous Abortion Is Deficient in Transforming Growth Factor β‐2‐Producing “Suppressor Cells” in Uterine Tissue Near the Placental Attachment Site

1995 • 88 citations

Early embryo development and paracrine relationships

1989 • 88 citations

Further observations on the hairpin-tail (Thp) mutation in the mouse

1974 • 88 citations

Peptide Growth Factors and Proto-oncogenes in Mammalian Conceptus Development1

1991 • 88 citations

Protein synthesis and secretion by the human endometrium and decidua during early pregnancy

1985 • 87 citations

Regulation of uterine epidermal growth factor (EGF) receptors by estrogen in the mature rat and during the estrous cycle

1989 • 86 citations

Transforming growth factor-beta stimulates endometrial stromal apoptosis in vitro.

1994 • 86 citations

Localization of insulin-like growth factor-I (IGF-I) and -II messenger ribonucleic acid and type 1 IGF receptors in the ovine uterus during the estrous cycle and early pregnancy.

1994 • 85 citations

Sex hormones modulate the synthesis of basic fibroblast growth factor in human endometrial adenocarcinoma cells: Implications for the neovascularization of normal and neoplastic endometrium

1988 • 84 citations

Differential localization of TGF-β2 in mouse preimplantation and early postimplantation development

1991 • 83 citations

Specificity of Vascular Endothelial Cell Growth Factor Receptor Ligand Binding Domains

1994 • 83 citations

Platelet-Derived Growth Factor Structure, function and implications in normal and malignant cell growth

1993 • 83 citations

Expression and regulation of the tumour necrosis factor-alpha gene in the female reproductive tract

1993 • 82 citations

Progesterone regulation of heparin-binding epidermal growth factor-like growth factor gene expression during sensitization and decidualization in the rat uterus: effects of the antiprogestin, ZK 98.299.

1994 • 81 citations

Proteolysis of IGFBP-3 may be a common regulatory mechanism of IGF action in vivo.

1993 • 81 citations

In the human fetus, vascular endothelial growth factor is expressed in epithelial cells and myocytes, but not vascular endothelium: implications for mode of action

1994 • 80 citations

Localization of Transforming Growth Factor in the Human Placenta and Decidua: Role in Trophoblast Growth1

1993 • 80 citations

Both homodimeric isoforms of PDGF (AA and BB) have mitogenic and chemotactic activity and stimulate phosphoinositol turnover

1989 • 78 citations

Insulin-Like Growth Factor-I Messenger Ribonucleic Acid in the Developing Human Placenta and in Term Placenta of Diabetics

1988 • 77 citations

Transforming growth factor-β1 expression during placental development

1991 • 77 citations

CHARACTERIZATION OF A RECOMBINANT MOUSE t HAPLOTYPE THAT EXPRESSES A DOMINANT LETHAL MATERNAL EFFECT

1984 • 76 citations

Nuclear tyrosine kinases: from Abl to WEE1

1996 • 75 citations

Developmental expression of binding sites and messenger ribonucleic acid for vascular endothelial growth factor suggests a role for this protein in vasculogenesis and angiogenesis

1993 • 74 citations

Heparin-binding epidermal growth factor-like growth factor is differentially regulated by progesterone and estradiol in rat uterine epithelial and stromal cells.

1994 • 74 citations

Expression of the genes for TGF α, EGF and the EGF receptor during early pig development

1992 • 73 citations

Colocalization of Acidic and Basic Fibroblast Growth Factor (FGF) in Human Placenta and the Cellular Effects of bFGF in Trophoblast Cell Line JEG-3

1994 • 73 citations

Embryonic mortality in cattle

1981 • 70 citations

Expression of mouse PDGF-A and PDGF α-receptor genes during pre- and post-implantation development: Evidence for a developmental shift from an autocrine to a paracrine mode of action

1992 • 69 citations

Differential cytokine regulation of type I and type VII collagen gene expression in cultured human dermal fibroblasts.

1994 • 69 citations

Effect of increasing doses of recombinant human insulin-like growth factor-I on glucose, lipid, and leucine metabolism in man

1992 • 68 citations

Insulin-Like Growth Factor Binding Protein-1 Inhibits the Mitogenic Effect of Insulin-Like Growth Factors and Progestins in Human Endometrial Stromal Cells1

1993 • 68 citations

Developmental regulation of steroidogenic enzyme gene expression in the periimplantation porcine conceptus: a paracrine role for insulin-like growth factor-I.

1995 • 68 citations

Localization of amphiregulin in the human placenta and decidua throughout gestation: Role in trophoblast growth

1995 • 67 citations

Regulation of insulin-like growth factor-binding proteins in the baboon (Papio anubis) uterus during early pregnancy.

1992 • 66 citations

Effect of restriction of placental growth on expression of IGFs in fetal sheep: relationship to fetal growth, circulating IGFs and binding proteins

1995 • 65 citations

Identification of a specific pattern of vascular endothelial growth factor mRNA expression in human placenta and cultured placental fibroblasts

1994 • 65 citations

Effect of restriction of placental growth on oxygen delivery to and consumption by the pregnant uterus and fetus.

1987 • 65 citations

Developmental distribution of platelet-derived growth factor in the mouse central nervous system

1992 • 64 citations

Differential expression of keratinocyte growth factor and its receptor in the human uterus

1993 • 64 citations

Serum insulin-like growth factor-binding protein-3 (IGFBP-3) levels and IGFBP-3 protease activity in normal, abnormal, and multiple human pregnancy.

1995 • 62 citations

Transforming Growth Factor-α and Epidermal Growth Factor Expression in Human Fetal Gastrointestinal Tract

1993 • 62 citations

Developmental expression of the IGF‐II/mannose 6‐phosphate receptor

1993 • 62 citations

Interaction of Heparin-Binding EGF-Like Growth Factor (HB-EGF) with the Epidermal Growth Factor Receptor: Modulation by Heparin, Heparinase, or Synthetic Heparin-Binding HB-EGF Fragments

1992 • 61 citations

Growth factors in reproduction

1995 • 60 citations

Cytologic localization of epidermal growth factor and its receptor in developing human placenta varies over the course of pregnancy

1991 • 60 citations

Insulin-like growth factors and blastocyst development

1993 • 60 citations

Expression of the Genes for the Epidermal Growth Factor Receptor and its Ligands in Porcine Oviduct and Endometrium1

1994 • 59 citations

Impaired estrogen action in the uterus of insulin-like growth factor binding protein-1 transgenic mice.

1996 • 59 citations

Role of the time factor in signaling specificity: Application to mitogenic and metabolic signaling by the insulin and insulin-like growth factor-I receptor tyrosine kinases

1995 • 58 citations

Localization of mRNA for Basic Fibroblast Growth Factor in Human Placenta

1994 • 57 citations

Epidermal growth factor and its receptor in human implantation trophoblast: immunohistochemical evidence for autocrine/paracrine function.

1992 • 56 citations

Tissue-specific expression of insulin-like growth factor binding protein-3 protease activity during rat pregnancy.

1992 • 56 citations

Identification of mRNA for epidermal growth factor and transforming growth factor-α present in low copy number in human endometrium and decidua using reverse transcriptase-polymerase chain reaction

1991 • 56 citations

Immunohistochemical localization of transforming growth factor-beta in human implantation sites.

1994 • 56 citations

Immunohistochemical localization of transforming growth factor-alpha in human endometrium, decidua, and trophoblast.

1993 • 56 citations

PDGF: a multifunctional growth factor

1991 • 55 citations

Phylogeny of the insulin‐like growth factors (IGFS) and receptors: A molecular approach

1993 • 55 citations

Embryonic Modulation of Basic Fibroblast Growth Factor in the Rat Uterus1

1993 • 55 citations

Fetal Effects of Epidermal Growth Factor Deficiency Induced in Rats by Autoantibodies against Epidermal Growth Factor

1995 • 55 citations

Insulin-like growth factors (IGFs), IGF-binding proteins (IGFBPs), and proteolyzed IGFBP-3 in embryonic cavities in early human pregnancy: their potential relevance to maternal-embryonic and fetal interactions.

1994 • 53 citations

Insulin-like growth factor binding protein-3 is functionally altered in pregnancy plasma

1994 • 53 citations

The free form of insulin-like growth factor I increases in circulation during normal human pregnancy.

1995 • 53 citations

Hormonal control of growth in the human fetus

1989 • 53 citations

Up-regulation of insulin-like growth factor-I (IGF-I) receptor gene expression in patients with reduced serum IGF-I levels

1993 • 53 citations

Growth factors in the uterus: steroidal regulation and biological actions

1991 • 51 citations

Transforming growth factor-alpha is a potential mediator of estrogen action in the mouse uterus

1992 • 50 citations

Characterization of an Insulin-Like Growth Factor Binding Protein, Analogous to Human Pregnancy-Associated Secreted Endometrial α1-Globulin, in Decidua of the Baboon (Paplo Anubis) Placenta1

1989 • 50 citations

Growth Factor Control of Cultured Rat Uterine Stromal Cell Proliferation is Progesterone Dependent1

1996 • 50 citations

Inhibition of progesterone receptor function results in loss of basic fibroblast growth factor expression and stromal cell proliferation during uterine remodelling in the pregnant rat

1994 • 49 citations

Platelet-derived growth factor (PDGF), epidermal growth factor (EGF), and EGF and PDGF beta-receptors in human endometrial tissue: localization and in vitro action

1992 • 49 citations

Differential expression of epidermal growth factor receptor (EGF-R) gene and regulation of EGF-R bioactivity by progesterone and estrogen in the adult mouse uterus

1994 • 48 citations

Molecular and Cellular Aspects of Periimplantation Processes

1995 • 47 citations

Immunolocalization of basic fibroblast growth factor (bFGF) in growing and growth-inhibited placental cells: A possible role for bFGF in placental cell development

1991 • 47 citations

Oestrogen and progesterone control basic fibroblast growth factor mRNA in the rat uterus

1997 • 46 citations

Insulin-like growth factor-II and its binding proteins in placental development

1992 • 46 citations

Differential expression of messenger ribonucleic acids encoding insulin- like growth factors and their receptors in human uterine endometrium and decidua

1993 • 44 citations

Modulation of cell migration and vessel formation by vascular endothelial growth factor and basic fibroblast growth factor in cultured embryonic heart

1995 • 44 citations

Differential expression, during the estrous cycle and pre- and postimplantation conceptus development, of messenger ribonucleic acids encoding components of the pig uterine insulin-like growth factor system

1992 • 44 citations

Identification of transforming growth factor-β1 mRNA in virgin and pregnant rat uteri by in situ hybridization

1993 • 44 citations

Analysis of Hornozygous TGFβ1 Null Mouse Embryos Demonstrates Defects in Yolk Sac. Vasculogenesis and Hematopoiesis

1995 • 44 citations

Purification of Heparin-Binding Epidermal Growth Factor-Like Growth Factor from Pig Uterine Luminal Flushings, and its Production by Endometrial Tissues1

1995 • 44 citations

Coordinate regulation by diethylstilbestrol of the platelet-derived growth factor-A (PDGF-A) and -B chains and the PDGF receptor alpha- and beta-subunits in the mouse uterus and vagina: potential mediators of estrogen action.

1995 • 44 citations

Developmental expression of transforming growth factor-? and epidermal growth factor receptor proteins in the human pancreas and digestive tract

1994 • 42 citations

Expression of transforming growth factor-beta isoforms (beta 2 and beta 3) in the mouse uterus: analysis of the periimplantation period and effects of ovarian steroids

1992 • 42 citations

The epidermal growth factor precursor isolated from murine kidney membranes. Chemical characterization and biological properties.

1990 • 41 citations

Basic Fibroblast Growth Factor in Ovulatory Cycle and Postmenopausal Human Endometrium

1990 • 41 citations

Cytologic localization of epidermal growth factor and its receptor in developing human placenta varies over the course of pregnancy

1991 • 41 citations

Heparin-binding epidermal growth factor-like growth factor is differentially regulated by progesterone and estradiol in rat uterine epithelial and stromal cells

1994 • 39 citations

Uterine fibronectin mRNA content and localization are modulated during implantation

1992 • 39 citations

Epidermal Growth Factor Receptors in Porcine Endometrium: Binding Characteristics and the Regulation of Prostaglandin E and F2α Production 1

1992 • 39 citations

Plasma clearance and tissue distribution of labelled insulin-like growth factor-I (IGF-I) and an analogue LR3IGF-I in pregnant rats

1993 • 38 citations

Characterization, Localization, and Regulation of Receptors for Insulin-Like Growth Factor I in the Baboon Uterus during the Cycle and Pregnancy1

1994 • 38 citations

Expression of Transforming Growth Factor-α in Mid-gestation Human Fetal Lung

1993 • 38 citations

Ovine Endometrial Expression of Transforming Growth Factor β Isoforms during the Peri-Implantation Period1

1996 • 37 citations

Transforming growth factor-α and epidermal growth factor messenger ribonucleic acid and protein levels in human placentas from early, mid, and late gestation

1992 • 37 citations

Angiogenic activity of maternal and fetal placental tissues of ewes throughout gestation

1989 • 37 citations

Experimental diabetes increases insulinlike growth factor I and II receptor concentration and gene expression in kidney

1990 • 37 citations

Involvement of epidermal growth factor (EGF)/EGF receptor autocrine and paracrine mechanism in human trophoblast cells: functional differentiation in vitro

1994 • 37 citations

Regulation of the aromatase activity of human placental cytotrophoblasts by insulin, insulin-like growth factor-I, and -II

1993 • 37 citations

Bioavailability: Is this a key event in regulating the actions of peptide growth factors?

1992 • 36 citations

Molecular characterization and in situ localization of murine endoglin reveal that it is a transforming growth factor-beta binding protein of endothelial and stromal cells

1994 • 36 citations

Immunohistochemical localization of basic fibroblast growth factor within the mouse uterus

1992 • 36 citations

Fibroblast Growth Factor-Mediated Growth Regulation and Receptor Expression in Embryonal Carcinoma and Embryonic Stem Cells and Human Germ Cell Tumors

1993 • 35 citations

Identification of the horse epidermal growth factor (EGF) coding sequence and its use in monitoring EGF gene expression in the endometrium of the pregnant mare

1994 • 35 citations

The Expression of PDGF α- and β-Receptors in Subpopulations of PDGF-Producing Cells Implicates Autocrine Stimulatory Loops in the Control of Proliferation in Cytotrophoblasts that Have Invaded the Maternal Endometrium

1992 • 34 citations

9 Hormonal and developmental regulation of pulmonary surfactant synthesis in fetal lung

1990 • 34 citations

Regulation of insulin-like growth factor-binding proteins in the baboon (Papio anubis) uterus during early pregnancy

1992 • 33 citations

Purification and characterization of heparin-binding growth factors from porcine uterus

1990 • 33 citations

Epidermal growth factor (EGF) replaces estradiol for the initiation of embryo implantation in the hypophysectomized rat

1993 • 32 citations

The insulin receptor and type I IGF receptor: Comparison of structure and function

1992 • 32 citations

Secretory proteins and growth factors of the baboon (Papio anubis) uterus: potential roles in pregnancy.

1994 • 32 citations

Characterization of murine pregnancy decidua transforming growth factor beta. I. Transforming growth factor beta 2-like molecules of unusual molecular size released in bioactive form

1995 • 31 citations

Expression of insulin-like growth factors and their binding proteins in the estrogen responsive Ishikawa human endometrial cancer cell line.

1994 • 31 citations

Epidermal growth factor and its receptor in human implantation trophoblast: immunohistochemical evidence for autocrine/paracrine function

1992 • 31 citations

Insulin-like growth factor II gene expression in the fetus and placenta of the horse during the first half of gestation

1995 • 31 citations

Binding of transforming growth factor‐β (TGF‐β) to pregnancy zone protein (PZP)

1994 • 31 citations

Transforming growth factor-beta stimulates trophoblast oncofetal fibronectin synthesis in vitro: implications for trophoblast implantation in vivo

1994 • 31 citations

Effects of insulin-like growth factor-I on aromatase cytochrome P450 activity and oestradiol biosynthesis in preimplantation porcine conceptuses in vitro

1991 • 30 citations

Intrauterine growth retardation and fetal losses are caused by epidermal growth factor deficiency in mice

1993 • 30 citations

Transforming growth factor-beta stimulates endometrial stromal apoptosis in vitro

1994 • 30 citations

Secretion of angiogenic activity by placental tissues of cows at several stages of gestation

1988 • 30 citations

Localization of insulin-like growth factor-I (IGF-I) and -II messenger ribonucleic acid and type 1 IGF receptors in the ovine uterus during the estrous cycle and early pregnancy

1994 • 30 citations

Differential effects of platelet-derived growth factor isoforms on plasminogen activator activity in fetal rat osteoblasts due to isoform-specific receptor functions.

1992 • 29 citations

Transforming Growth Factor-α Gene Expression in Late-Gestation Fetal Rat Lung

1992 • 29 citations

A potential transforming growth factor alpha/epidermal growth factor receptor autocrine circuit in placental cytotrophoblasts.

1993 • 29 citations

Epidermal Growth Factor Receptor and Human Fetoplacental Development

1994 • 28 citations

Localization of epidermal growth factor receptors in first- and third-trimester human placentas.

1994 • 28 citations

Transforming growth factor-alpha in human implantation trophoblast: immunohistochemical evidence for autocrine/paracrine function.

1993 • 27 citations

Developmental and tissue-specific regulation of ovine insulin-like growth factor II (IGF-II) mRNA expression

1991 • 27 citations

Potentiation of epidermal growth factor-induced differentiation of cultured human placental cells by insulin-like growth factor-I.

1992 • 27 citations

Serum insulin-like growth factor-binding protein-3 (IGFBP-3) levels and IGFBP-3 protease activity in normal, abnormal, and multiple human pregnancy

1995 • 27 citations

Localization and characterization of EGF/TGF- receptors on peri-implantation trophoblast in sheep

1993 • 27 citations

The free form of insulin-like growth factor I increases in circulation during normal human pregnancy

1995 • 26 citations

Expression of messenger ribonucleic acids encoding for basic fibroblast growth factor (FGF) and alternatively spliced FGF receptor in human fetal ovary and uterus.

1993 • 26 citations

Epidermal Growth Factor, Transforming Growth Factor-α, and Epidermal Growth Factor Receptor Localization in the Baboon (Papio anubis) Uterus During the Menstrual Cycle and Early Pregnancy

1994 • 26 citations

Growth Factors in Reproduction

1991 • 26 citations

Immunohistochemical localization of transforming growth factor-beta in human implantation sites

1994 • 26 citations

Stimulation of epidermal growth factor gene expression during the fetal mouse reproductive tract differentiation: role of androgen and its receptor.

1996 • 25 citations

IGF System in Periimplantation Uterus and Embryonic Development

1995 • 25 citations

Epidermal growth factor—Induced implantation and decidualization in the rat

1994 • 24 citations

Transformation of NIH3T3 fibroblasts by an expression vector for the human epidermal growth factor precursor.

1990 • 23 citations

Alternative splicing and differential targeting of fibroblast growth factor receptor 1 in the pregnant rat uterus.

1995 • 23 citations

The Immunolocalization of Basic Fibroblast Growth Factor in the Mouse Uterus During the Initial Stages of Embryo Implantation

1994 • 23 citations

Early Gestational Expression of Transforming Growth Factor Beta Isoforms by the Ovine Placenta1

1995 • 23 citations

Dose-related effect of IGF-I on placental prostanoid release

1995 • 23 citations

Growth factor expression during rat development: a comparison of TGF-beta 3, TGF-alpha, bFGF, PDGF and PDGF-R.

1993 • 22 citations

Spatial distribution of active genes implicated in the regulation of insulin‐like growth factor stimulatory loops in human decidual and placental tissue of first‐trimester pregnancy

1992 • 22 citations

Binding of insulin-like growth factor I to human trophoblast cells during differentiation in vitro

1994 • 22 citations

The uterine growth-promoting action of epidermal growth factor and its function in the fertility of mice

1993 • 22 citations

IGF-II and IGF-binding proteins increase dramatically during rabbit pregnancy

1996 • 21 citations

Immunohistochemical Localization of Platelet‐Derived Growth Factor Receptors in the Porcine Uterus During the Oestrous Cycle and Pregnancy

1992 • 21 citations

Role of fibroblast growth factors as inducing agents in early embryonic development

1994 • 21 citations

Progesterone regulation of heparin-binding epidermal growth factor-like growth factor gene expression during sensitization and decidualization in the rat uterus: effects of the antiprogestin, ZK 98.299

1994 • 21 citations

Fibroblast growth factor induces primitive streak formation in rabbit pre-implantation embryos in vitro

1993 • 21 citations

Regulation of 17 beta-hydroxysteroid dehydrogenase type 1 by epidermal growth factor and transforming growth factor-alpha in choriocarcinoma cells.

1994 • 20 citations

Tissue-specific expression of insulin-like growth factor binding protein-3 protease activity during rat pregnancy

1992 • 20 citations

Localization and Quantification of Insulin-Like Growth Factor-I (IGF-I) and IGF-II/ Mannose-6-Phosphate (IGF-II/M6P) Receptors in Pig Embryos during Early Pregnancy1

1994 • 19 citations

Impaired estrogen action in the uterus of insulin-like growth factor binding protein-1 transgenic mice

1996 • 19 citations

Insulin-like growth factors (IGFs), IGF-binding proteins (IGFBPs), and proteolyzed IGFBP-3 in embryonic cavities in early human pregnancy: their potential relevance to maternal-embryonic and fetal interactions

1994 • 19 citations

Developmental regulation of steroidogenic enzyme gene expression in the periimplantation porcine conceptus: a paracrine role for insulin-like growth factor-I

1995 • 18 citations

Immunohistochemical localization of transforming growth factor-alpha in human endometrium, decidua, and trophoblast

1993 • 17 citations

Comparative expression of TGF-α and EGF genes in the ovine conceptus and uterine endometrium in the peri-implantation period

1995 • 16 citations

Immunohistochemical localization of two endometrial proteins in the early days of human pregnancy

1994 • 16 citations

Sex-specific differences in rabbit fetal lung maturation in response to epidermal growth factor

1992 • 15 citations

Transforming growth factor-alpha in human implantation trophoblast: immunohistochemical evidence for autocrine/paracrine function

1993 • 15 citations

Analysis of messenger ribonucleic acid and protein for the ligands and receptors of the platelet-derived growth factor signaling pathway in the placenta, extraembryonic membranes, and uterus during the latter half of murine gestation.

1995 • 15 citations

Maternal growth factors as mediators of embryonic and neonatal growth

1989 • 15 citations

Influence of fetal and maternal genotype for circulating insulin-like growth factor I on fetal growth in mice

1994 • 15 citations

Molecular and Cellular Signalling and Embryo Survival

1986 • 14 citations

Ontogeny and characterization of epidermal growth factor receptors on the fetal area of the sheep placenta

1993 • 13 citations

Potentiation of epidermal growth factor-induced differentiation of cultured human placental cells by insulin-like growth factor-I

1992 • 13 citations

Stimulation of epidermal growth factor gene expression during the fetal mouse reproductive tract differentiation: role of androgen and its receptor

1996 • 13 citations

IGF-I and IGF-II receptors in the sheep placenta: evolution during the course of pregnancy

1995 • 13 citations

Epithelial localization of insulin-like growth factor binding protein 1 in the uterus of the rat during pregnancy, deciduoma-bearing pseudopregnancy and hormone treatment

1994 • 12 citations

Accumulation of chromotrope 2R positive cells in equine endometrium during early pregnancy and expression of transforming growth factor- 2 (TGF- 2)

1995 • 12 citations

Fibroblast growth factor enhances the transcription and stability of human chorionic gonadotropin beta-subunit messenger ribonucleic acid in Jar choriocarcinoma cells.

1993 • 11 citations

Alternative splicing and differential targeting of fibroblast growth factor receptor 1 in the pregnant rat uterus

1995 • 10 citations

Expression of insulin-like growth factors and their binding proteins in the estrogen responsive Ishikawa human endometrial cancer cell line

1994 • 10 citations

Differential effects of platelet-derived growth factor isoforms on plasminogen activator activity in fetal rat osteoblasts due to isoform- specific receptor functions

1992 • 9 citations

Coordinate regulation by diethylstilbestrol of the platelet-derived growth factor-A (PDGF-A) and -B chains and the PDGF receptor alpha- and beta-subunits in the mouse uterus and vagina: potential mediators of estrogen action

1995 • 9 citations

Immunosuppressive activity of a porcine high-molecular weight uterine macromolecule is associated with transforming growth factor-β

1995 • 9 citations

Regulation of 17 beta-hydroxysteroid dehydrogenase type 1 by epidermal growth factor and transforming growth factor-alpha in choriocarcinoma cells

1994 • 9 citations

Expression of messenger ribonucleic acids encoding for basic fibroblast growth factor (FGF) and alternatively spliced FGF receptor in human fetal ovary and uterus

1993 • 9 citations

Estrogen Induces Expression of Endometrial Epidermal Growth Factor Receptors Before Implantation

1993 • 9 citations

Epidermal growth factor and transforming growth factor α

1991 • 9 citations

Determinants of fetal and neonatal growth

1994 • 7 citations

Effects of maternally administered epidermal growth factor on placental permeability

1991 • 7 citations

Ontogenesis and Distribution of Epidermal Growth Factor Immunoreactivity and Binding Activity in the Mouse Fetal and Neonatal Tissues.

1993 • 7 citations

Disappearance of labelled IGF-2 from plasma of the ovine fetus in late gestation.

1990 • 6 citations

Fibroblast growth factor enhances the transcription and stability of human chorionic gonadotropin beta-subunit messenger ribonucleic acid in Jar choriocarcinoma cells

1993 • 6 citations

The location and expression of fibroblast growth factor (FGF) in F9 visceral and parietal embryonic cells after retinoic acid-induced differentiation

1992 • 5 citations

Analysis of messenger ribonucleic acid and protein for the ligands and receptors of the platelet-derived growth factor signaling pathway in the placenta, extraembryonic membranes, and uterus during the latter half of murine gestation

1995 • 4 citations

Specific binding sites for 125I-labelled epidermal growth factor in the ovine corpus luteum and human placenta

1992 • 4 citations

Transforming Growth Factor β: A Multifunctional Regulatory Peptide with Actions in the Reproductive System

1991 • 3 citations

Differential Effects of an Antiserum to Epidermal Growth Factor on the Development of Transplanted Rat Embryos and Fetal Structuresin Vivo

1993 • 2 citations

Effects of Epidermal Growth Factor on Mouse Fetal Growth

1993 • 2 citations

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