Abnormal kidney development and hematological disorders in PDGF beta-receptor mutant mice.

The biology of platelet-derived growth factor

1986 • 2,036 citations

Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice

1991 • 2,028 citations

A Platelet-Dependent Serum Factor That Stimulates the Proliferation of Arterial Smooth Muscle Cells In Vitro

1974 • 1,838 citations

Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret

1994 • 1,589 citations

Promoter traps in embryonic stem cells: a genetic screen to identify and mutate developmental genes in mice.

1991 • 1,358 citations

Structure of the receptor for platelet-derived growth factor helps define a family of closely related growth factor receptors

1986 • 1,244 citations

Mice deficient for PDGF B show renal, cardiovascular, and hematological abnormalities.

1994 • 1,123 citations

Use of a recombinant retrovirus to study post-implantation cell lineage in mouse embryos.

1986 • 1,118 citations

Developmental Expression of PDGF, TGF-α, and TGF-β Genes in Preimplantation Mouse Embryos

1988 • 688 citations

Signal Transduction by the Platelet-Derived Growth Factor Receptor

1989 • 653 citations

Two Different Subunits Associate to Create Isoform-Specific Platelet-derived Growth Factor Receptors

1989 • 633 citations

Platelets as a source of fibroblast growth-promoting activity

1974 • 625 citations

Isolation of a Novel Receptor cDNA Establishes the Existence of Two PDGF Receptor Genes

1989 • 610 citations

Two Classes of PDGF Receptor Eecognize Different Isoforms of PDGF

1988 • 603 citations

Binding of different dimeric forms of PDGF to human fibroblasts: evidence for two separate receptor types.

1988 • 514 citations

cDNA cloning and expression of the human A-type platelet-derived growth factor (PDGF) receptor establishes structural similarity to the B-type PDGF receptor.

1989 • 413 citations

PDGF B-chain in neurons of the central nervous system, posterior pituitary, and in a transgenic model

1991 • 410 citations

PDGF A-chain gene is expressed by mammalian neurons during development and in maturity

1991 • 360 citations

Platelet-derived growth factor (PDGF) and PDGF receptor are induced in mesangial proliferative nephritis in the rat.

1991 • 293 citations

A platelet factor stimulating human normal glial cells

1976 • 271 citations

A PDGF receptor mutation in the mouse (Patch) perturbs the development of a non-neuronal subset of neural crest-derived cells

1992 • 259 citations

PDGF alpha- and beta-receptors activate unique and common signal transduction pathways.

1992 • 259 citations

Infusion of platelet-derived growth factor or basic fibroblast growth factor induces selective glomerular mesangial cell proliferation and matrix accumulation in rats.

1993 • 254 citations

Regulation and role of PDGF receptor a-subunit expression during embryogenesis

1992 • 239 citations

Platelet-derived growth factor-A and its receptor are expressed in separate, but adjacent cell layers of the mouse embryo

1992 • 238 citations

Functional overlap in the src gene family: inactivation of hck and fgr impairs natural immunity.

1994 • 232 citations

Selective expression of PDGF A and its receptor during early mouse embryogenesis

1990 • 215 citations

Platelet-derived growth factor receptor alpha-subunit gene (Pdgfra) is deleted in the mouse patch (Ph) mutation.

1991 • 209 citations

Platelet-derived growth factor (PDGF) stimulates PDGF receptor subunit dimerization and intersubunit trans-phosphorylation

1991 • 196 citations

Developmental expression of the α receptor for platelet-derived growth factor, which is deleted in the embryonic lethal Patch mutation

1992 • 191 citations

Receptor tyrosine kinases and their targets

1994 • 177 citations

Angiogenesis during human extraembryonic development involves the spatiotemporal control of PDGF ligand and receptor gene expression

1991 • 164 citations

Rat Brain Capillary Endothelial Cells Express Functional PDGF B-Type Receptors

1989 • 153 citations

Developmental patterns of PDGF B-chain, PDGF-receptor, and α-actin expression in human glomerulogenesis

1992 • 131 citations

Two closely linked genes in the mouse

1960 • 104 citations

Developmental expression of the platelet-derived growth factor alpha-receptor gene in mammalian central nervous system.

1993 • 85 citations

Mouse platelet-derived growth factor receptor alpha gene is deleted in W19H and patch mutations on chromosome 5.

1991 • 84 citations

Differences in substrate specificities of alpha and beta platelet-derived growth factor (PDGF) receptors. Correlation with their ability to mediate PDGF transforming functions

1993 • 79 citations

Expression of the platelet‐derived growth factor β receptor during organogenesis and tissue differentiation in the mouse embryo

1994 • 70 citations

PDGF-AB requires PDGF receptor alpha-subunits for high-affinity, but not for low-affinity, binding and signal transduction.

1993 • 62 citations

Actions of platelet‐derived growth factor isoforms in mesangial cells

1994 • 40 citations

Differential induction of the c‐fos promoter through distinct PDGF receptor‐mediated signaling pathways

1992 • 16 citations