IGF System in Periimplantation Uterus and Embryonic Development

Handbook of Physiology.

1960 • 10,428 citations

Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)

1993 • 2,880 citations

Role of insulin-like growth factors in embryonic and postnatal growth

1993 • 2,349 citations

Blastocyst implantation depends on maternal expression of leukaemia inhibitory factor

1992 • 2,004 citations

A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting

1990 • 1,650 citations

Developmental Expression of PDGF, TGF-α, and TGF-β Genes in Preimplantation Mouse Embryos

1988 • 688 citations

Preimplantation embryo development in vitro: cooperative interactions among embryos and role of growth factors.

1990 • 685 citations

Insulin-like growth factor binding protein 1 stimulates cell migration and binds to the alpha 5 beta 1 integrin by means of its Arg-Gly-Asp sequence.

1993 • 515 citations

Growth factors and growth modulators in human uterine endometrium: their potential relevance to reproductive medicine

1994 • 327 citations

Peptide growth factors elicit estrogen receptor-dependent transcriptional activation of an estrogen-responsive element.

1993 • 322 citations

Expression of growth factor ligand and receptor genes in the preimplantation bovine embryo

1992 • 318 citations

Stromal-epithelial interactions in adult organs

1985 • 315 citations

Uterine Insulin-Like Growth Factor-1: Regulation of Expression and Its Role in Estrogen-Induced Uterine Proliferation*

1990 • 314 citations

Insulin-like growth factor II acts through an endogenous growth pathway regulated by imprinting in early mouse embryos.

1992 • 289 citations

Estrogen Regulates the Synthesis of Epidermal Growth Factor in Mouse Uterine Epithelial Cells

1990 • 288 citations

Insulin-Like Growth Factor-I Stimulates Terminal Myogenic Differentiation by Induction of Myogenin Gene Expression

1991 • 258 citations

Cell Type-Specific Expression of Transforming Growth Factor-β 1 in the Mouse Uterus during the Periimplantation Period

1990 • 234 citations

Progesterone Receptor Regulation in Uterine Cells:Stimulation by Estrogen, Cyclic Adenosine 3′,5′-Monophosphate, and Insulin-Like Growth Factor I andSuppression by Antiestrogens and Protein KinaseInhibitors*

1991 • 203 citations

Expression of Insulin-Like Growth Factor-I (IGF-l) and its Receptor in the Peri-Implantation Mouse Uterus, and Cell-Specific Regulation of IGF-l Gene Expression by Estradiol and Progesterone1

1992 • 187 citations

IGF binding proteins: regulation of cellular actions.

1992 • 176 citations

Estrogen Regulation of Epidermal Growth Factor Receptor Messenger Ribonucleic Acid

1988 • 168 citations

Peptide growth factors elicit estrogen receptor-dependent transcriptional activation of an estrogen-responsive element

1993 • 146 citations

Insulin‐like growth factor‐1 stimulates growth of mouse preimplantation embryos in vitro

1992 • 141 citations

Porcine Insulin-Like Growth Factor-I (pIGF-I): Complementary Deoxyribonucleic Acid Cloning and Uterine Expression of Messenger Ribonucleic Acid Encoding Evolutionary Conserved IGF-I Peptides*

1988 • 136 citations

Uterine Insulin-Like Growth Factor-I Receptors: Regulation by Estrogen and Variation throughout the Estrous Cycle*

1989 • 136 citations

Expression of Messenger RNAs Encoding Insulin-like Growth Factor-I, -II, and Insulin-like Growth Factor Binding Protein-2 in Bovine Endometrium during the Estrous Cycle and Early Pregnancy1

1991 • 135 citations

Hormonal Regulation of Insulin-Like Growth Factor Gene Expression in Pig Uterus*

1990 • 128 citations

Regulation of polypeptide growth factor synthesis and growth factor-related gene expression in the rat and mouse uterus before and after implantation

1990 • 126 citations

Effects of epidermal growth factor and insulin-like growth factor I on the levels of mRNA encoding aromatase cytochrome P-450 of human ovarian granulosa cells

1988 • 121 citations

A Growth Factor Phenotype Map for Ovine Preimplantation Development1

1994 • 113 citations

Localization of the Sites of Synthesis and Action of Insulin-Like Growth Factor-I in the Rat Uterus

1990 • 111 citations

Insulin and insulin-like growth factor I regulate a thyroid-specific nuclear protein that binds to the thyroglobulin promoter.

1992 • 109 citations

Insulin-Like Growth Factor I (IGF-I), IGF-I Receptors, and IGF Binding Proteins 1–4 in Human Uterine Tissue: Tissue Localization and IGF-I Action in Endometrial Stromal and Myometrial Smooth Muscle Cells in Vitro

1994 • 104 citations

Msx1 (Hox-7.1) in the adult mouse uterus: cellular interactions underlying regulation of expression

1994 • 100 citations

Insulin-like growth factor regulation of human endometrial stromal cell function: coordinate effects on insulin-like growth factor binding protein-1, cell proliferation and prolactin secretion

1993 • 99 citations

Differential expression, during the estrous cycle and pre- and postimplantation conceptus development, of messenger ribonucleic acids encoding components of the pig uterine insulin-like growth factor system.

1992 • 98 citations

Insulin-Like Growth Factors in Sheep Uterine Fluids: Concentrations and Relationship to Ovine Trophoblast Protein-1 Production during Early Pregnancy1

1991 • 95 citations

Insulin, insulin-like growth factors and glucose transporters: temporal patterns of gene expression in early murine and bovine embryos

1992 • 91 citations

Peptide Growth Factors and Proto-oncogenes in Mammalian Conceptus Development1

1991 • 88 citations

IGF-I is a mitogen involved in differentiation-related gene expression in fetal rat brown adipocytes.

1993 • 87 citations

Localization of insulin-like growth factor-I (IGF-I) and -II messenger ribonucleic acid and type 1 IGF receptors in the ovine uterus during the estrous cycle and early pregnancy.

1994 • 85 citations

Changes in oestrogen receptor protein, mRNA expression and localization in the endometrium of cyclic and pregnant gilts

1993 • 84 citations

Differentiation of ovarian theca-interstitial cells in vitro: regulation of 17 alpha-hydroxylase messenger ribonucleic acid expression by luteinizing hormone and insulin-like growth factor-I.

1993 • 81 citations

Effects of Growth Factors and Growth Factor-Extracellular Matrix Interactions on Mouse Trophoblast Outgrowth in Vitro1

1993 • 80 citations

Expression of genes for insulin and insulin‐like growth factors and receptors in early postimplantation mouse embryos and embryonal carcinoma cells

1990 • 77 citations

Receptors for epidermal growth factor and insulin-like growth factor-I on preimplantation trophoderm of the pig

1990 • 75 citations

Mouse Preimplantation Embryos Exhibit Receptor-Mediated Binding and Transcytosis of Maternal Insulin-Like Growth Factor I1

1993 • 75 citations

Expression of the genes for TGF α, EGF and the EGF receptor during early pig development

1992 • 73 citations

Insulin-Like Growth Factor-I Stimulates the Expression of 3β-Hydroxysteroid Dehydrogenase Messenger Ribonucleic Acid in Ovarian Theca-Interstitial Cells1

1993 • 72 citations

Insulin-Like Growth Factor-I Expression during Early Conceptus Development in the Pig1

1989 • 72 citations

Insulin-Like Growth Factor Binding Protein-1 Inhibits the Mitogenic Effect of Insulin-Like Growth Factors and Progestins in Human Endometrial Stromal Cells1

1993 • 68 citations

Regulation of insulin-like growth factor-binding proteins in the baboon (Papio anubis) uterus during early pregnancy.

1992 • 66 citations

Embryo-uterine interactions in pigs during week 2 of pregnancy.

1993 • 65 citations

Comparative placentation in ungulates

1993 • 64 citations

IGF-2 stimulates growth and metabolism of early mouse embryos

1992 • 61 citations

The signaling potential of the receptors for insulin and insulin‐like growth factor I (IGF‐I) in 3t3‐l1 adipocytes: Comparison of glucose transport activity, induction of oncogene c‐fos, glucose transporter mRNA, and DNA‐synthesis

1991 • 60 citations

Changes in morphology, cell number, cell size and cellular estrogen content of individual littermate pig conceptuses on days 9 to 13 of gestation.

1990 • 60 citations

Insulin-like growth factors and blastocyst development

1993 • 60 citations

Identification of a specific pattern of "immediate-early" gene activation induced by estrogen during mitogenic stimulation of rat uterine cells.

1993 • 58 citations

Regulation of uterine and conceptus secretory activity in the pig.

1990 • 57 citations

Insulin-Like Growth Factor (IGF)-I Stimulates Proliferation and Migration of Mouse Ectoplacental Cone Cells, While IGF-II Transforms them into Trophoblastic Giant Cells in Vitro1

1993 • 54 citations

IGF-2 receptors are first expressed at the 2-cell stage of mouse development

1991 • 52 citations

Distribution of Transforming Growth Factor a Precursors in the Mouse Uterus during the Periimplantation Period and after Steroid Hormone Treatments1

1994 • 52 citations

Insulin and insulin-like growth factor I regulate a thyroid-specific nuclear protein that binds to the thyroglobulin promoter

1992 • 51 citations

Insulin-Like Growth Factor I Induces c-fos Messenger Ribonucleic Acid in L6 Rat Skeletal Muscle Cells*

1987 • 49 citations

Human embryos produce transforming growth factors α activity and insulin-like growth factors II

1992 • 48 citations

Insulin-like growth factor I regulates c-myc and GAP-43 messenger ribonucleic acid expression in SH-SY5Y human neuroblastoma cells.

1993 • 47 citations

Epidermal Growth Factor-Specific Protein Tyrosine Phosphorylation in Preimplantation Embryo Development1

1991 • 45 citations

Differential expression, during the estrous cycle and pre- and postimplantation conceptus development, of messenger ribonucleic acids encoding components of the pig uterine insulin-like growth factor system

1992 • 44 citations

Complementary DNA Cloning and Regulation of Expression of the Messenger RNA Encoding a Pregnancy-Associated Porcine Uterine Protein Related to Human Antileukoproteinase

1990 • 43 citations

Epidermal Growth Factor Receptors in Porcine Endometrium: Binding Characteristics and the Regulation of Prostaglandin E and F2α Production 1

1992 • 39 citations

Characterization, Localization, and Regulation of Receptors for Insulin-Like Growth Factor I in the Baboon Uterus during the Cycle and Pregnancy1

1994 • 38 citations

Transient expression of the cytochrome P450 aromatase gene in elongating porcine blastocysts is correlated with uterine insulin-like growth factor levels during peri-implantation development

1994 • 38 citations

The role of growth factors in embryo production

1993 • 38 citations

Constitutive Expression of Uterine Receptors for Insulin-Like Growth Factor-I during the Peri-Implantation Period in the Pig1

1991 • 36 citations

A Uterine Cell Mitogen Distinct from Epidermal Growth Factor in Porcine Uterine Luminal Fluids: Characterization and Partial Purification1

1988 • 34 citations

Insulin-like growth factor binding proteins are transcribed by preimplantation mouse embryos.

1994 • 34 citations

Regulation of insulin-like growth factor-binding proteins in the baboon (Papio anubis) uterus during early pregnancy

1992 • 33 citations

Regulation of Synthesis of Uterine Secretory Proteins: Evidence for Differential Induction of Porcine Uteroferrin and Antileukoproteinase Gene Expression1

1991 • 31 citations

Effects of insulin-like growth factor-I on aromatase cytochrome P450 activity and oestradiol biosynthesis in preimplantation porcine conceptuses in vitro

1991 • 30 citations

Localization of insulin-like growth factor-I (IGF-I) and -II messenger ribonucleic acid and type 1 IGF receptors in the ovine uterus during the estrous cycle and early pregnancy

1994 • 30 citations

Comparative Aspects of Conceptus Signals for Maternal Recognition of Pregnancy^a

1991 • 29 citations

Potentiation of epidermal growth factor-induced differentiation of cultured human placental cells by insulin-like growth factor-I.

1992 • 27 citations

Secretory and Morphological Changes in the Baboon (Papio Anubis) Uterus and Placenta during Early Pregnancy1

1993 • 26 citations

Spatial distribution of active genes implicated in the regulation of insulin‐like growth factor stimulatory loops in human decidual and placental tissue of first‐trimester pregnancy

1992 • 22 citations

Characterization of uterine sex steroid receptors in the pig and their variation during the oestrous cycle

1990 • 21 citations

Immunohistochemical Localization of Platelet‐Derived Growth Factor Receptors in the Porcine Uterus During the Oestrous Cycle and Pregnancy

1992 • 21 citations

Ontogeny, immunocytochemical localization, and biochemical properties of the pregnancy-associated uterine elastase/cathepsin-G protease inhibitor, antileukoproteinase (ALP): monospecific antibodies to a synthetic peptide recognize native ALP.

1992 • 21 citations

Regulation of the Uterine Expression of Messenger Ribonucleic Acids Encoding the Oestrogen Receptor and IGF–I Peptides in the Pig Uterus

1990 • 21 citations

Insulin-Like Growth Factor-Mediated Phosphorylation and Protooncogene Induction in Madin-Darby Canine Kidney Cells

1991 • 20 citations

Effect of insulin-like growth factor-I on protein synthesis in porcine embryonic discs cultured in vitro

1991 • 20 citations

Characterization of the epidermal growth factor receptor in preimplantation pig conceptuses

1992 • 19 citations

Differentiation of ovarian theca-interstitial cells in vitro: regulation of 17 alpha-hydroxylase messenger ribonucleic acid expression by luteinizing hormone and insulin-like growth factor-I

1993 • 18 citations

Insulin-like growth factor I stimulates transcription of the c-jun proto-oncogene in Balbc 3T3 cells

1992 • 14 citations

The Primate endometrium

1991 • 14 citations

Potentiation of epidermal growth factor-induced differentiation of cultured human placental cells by insulin-like growth factor-I

1992 • 13 citations

Insulin-like growth factor binding proteins are transcribed by preimplantation mouse embryos

1994 • 12 citations

Insulin-like growth factor I regulates c-myc and GAP-43 messenger ribonucleic acid expression in SH-SY5Y human neuroblastoma cells

1993 • 12 citations

Expression of c-fos in Porcine Endometrium during the Estrous Cycle and Early Pregnancy1

1993 • 11 citations

Localization of antigen defined by a monoclonal antibody to human 32-kDa insulin-like growth factor-binding protein in the sheep uterus at preimplantation stages of pregnancy

1990 • 9 citations

Ontogeny, immunocytochemical localization, and biochemical properties of the pregnancy-associated uterine elastase/cathepsin-G protease inhibitor, antileukoproteinase (ALP): monospecific antibodies to a synthetic peptide recognize native ALP

1992 • 9 citations

Relative Potency of Relaxin, Insulin‐like Growth Factors, and Insulin on the Prolactin Production in Progestin‐primed Human Endometrial Stromal Cells in Long‐term Culture^a

1991 • 7 citations

Binding of epidermal growth factor and transforming growth factor-α in mammalian preimplantation embryos

1994 • 6 citations

Epidermal Growth Factor Enhancement of Insulin-Like Growth Factor-I-Induced Down-Regulation of Insulin-Like Growth Factor I Receptor in Cultured Placental Trophoblastic Cells

1991 • 5 citations