Phylogeny of the insulin‐like growth factors (IGFS) and receptors: A molecular approach

Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity.

1986 • 1,866 citations

Transcriptional activation by Sp1 as directed through TATA or initiator: specific requirement for mammalian transcription factor IID.

1990 • 501 citations

Developmental regulation of the rat insulin-like growth factor I receptor gene.

1989 • 338 citations

Differential expression of alternative 5' untranslated regions in mRNAs encoding rat insulin-like growth factor I.

1987 • 292 citations

Molecular Cloning of Rat Insulin-Like Growth Factor I Complementary Deoxyribonucleic Acids: Differential Messenger Ribonucleic Acid Processing and Regulation by Growth Hormone in Extrahepatic Tissues

1987 • 275 citations

Role of tyrosine kinase activity in signal transduction by the insulin-like growth factor-I (IGF-I) receptor. Characterization of kinase-deficient IGF-I receptors and the action of an IGF-I-mimetic antibody (alpha IR-3).

1993 • 247 citations

Evolution of the insulin superfamily: cloning of a hybrid insulin/insulin-like growth factor cDNA from amphioxus.

1990 • 192 citations

Nucleotide Sequence and Growth Hormone-Regulated Expression of Salmon Insulin-Like Growth Factor I mRNA

1989 • 190 citations

Localization of insulin-like growth factor genes to human chromosomes 11 and 12

1984 • 180 citations

Regulation of Start Site Usage in the Leader Exons of the Rat Insulin-Like Growth Factor-I Gene by Development, Fasting, and Diabetes

1991 • 141 citations

Functional Analysis of the Rat Insulin-Like Growth Factor I Gene and Identification of an IGF-I Gene Promoter

1992 • 135 citations

Isolation of a Drosophila genomic sequence homologous to the kinase domain of the human insulin receptor and detection of the phosphorylated Drosophila receptor with an anti-peptide antibody.

1986 • 123 citations

Isolation of material displaying insulin-like immunological biological activity from the brain of the blowfly Calliphora vomitoria

1979 • 121 citations

Insulin in Insects and Annelids

1981 • 107 citations

Structural and functional analysis of the insulin-like growth factor I receptor gene promoter.

1992 • 98 citations

Evolution of the insulin gene superfamily. Sequence of a preproinsulin-like growth factor cDNA from the Atlantic hagfish

1991 • 95 citations

Nucleotide sequence and tissue distribution of three insulin-like growth factor I prohormones in salmon.

1992 • 93 citations

Analysis of the human type I insulin-like growth factor receptor promoter region

1991 • 90 citations

Acquisition of insulin-dependent protein tyrosine kinase activity during Drosophila embryogenesis.

1985 • 87 citations

Transcription initiation in the two leader exons of the rat IGF-I gene occurs from disperse versus localized sites

1991 • 85 citations

Cloning and characterization of the proximal promoter region of the rat insulin-like growth factor I (IGF-I) receptor gene

1990 • 84 citations

Genes encoding receptors for insulin and insulin-like growth factor I are expressed in Xenopus oocytes and embryos.

1991 • 77 citations

Cloning of a Gene Encoding Bombyxin, an Insulin‐Like Brain Secretory Peptide of the Silkmoth Bombyx mori with Prothoracicotropic Activity

1989 • 75 citations

Cloning of a drosophila cDNA encoding a polypeptide similar to the human insulin receptor precursor

1986 • 73 citations

Structural and functional analysis of the insulin-like growth factor I receptor gene promoter

1992 • 47 citations

Xenopus laevis Contains Two Nonallelic Preproinsulin Genes

1989 • 45 citations

Structure of the Chum Salmon Insulin-Like Growth Factor I Gene

1993 • 45 citations

Nucleotide sequence and tissue distribution of three insulin-like growth factor I prohormones in salmon

1992 • 44 citations

Demonstration of an endocrine signaling circuit for insulin in the sponge Geodia cydonium.

1989 • 42 citations

Insulin in insects and annelids

1981 • 40 citations

Evidence that Xenopus laevis contains two different nonallelic insulin-like growth factor-I genes

1990 • 33 citations

Distinct promoters in the rat insulin-like growth factor-I (IGF-I) gene are active in CHO cells.

1993 • 28 citations

Distinct promoters in the rat insulin-like growth factor-I (IGF-I) gene are active in CHO cells [published erratum appears in Endocrinology 1993 Aug;133(2):792]

1993 • 15 citations