Heparin-induced oligomerization of FGF molecules is responsible for FGF receptor dimerization, activation, and cell proliferation

High-efficiency transformation of mammalian cells by plasmid DNA.

1987 • 5,377 citations

Rapid measurement of binding constants and heats of binding using a new titration calorimeter

1989 • 2,603 citations

Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor

1991 • 2,437 citations

Human Growth Hormone and Extracellular Domain of Its Receptor: Crystal Structure of the Complex

1992 • 2,236 citations

Requirement of Heparan Sulfate for bFGF-Mediated Fibroblast Growth and Myoblast Differentiation

1991 • 1,507 citations

Transformation of mammalian cells with genes from procaryotes and eucaryotes

1979 • 1,474 citations

Growth factor signaling by receptor tyrosine kinases

1992 • 1,450 citations

Proteoglycans as modulators of growth factor activities

1991 • 1,338 citations

The Fgf Family of Growth Factors and Oncogenes

1992 • 1,164 citations

A Heparin-Binding Growth Factor Secreted by Macrophage-Like Cells That Is Related to EGF

1991 • 1,135 citations

Identification of Heregulin, a Specific Activator of p185 ^erbB2

1992 • 963 citations

Dimerization of the Extracellular Domain of the Human Growth Hormone Receptor by a Single Hormone Molecule

1991 • 879 citations

Purification and Complementary DNA Cloning of a Receptor for Basic Fibroblast Growth Factor

1989 • 660 citations

Cloning and expression of two distinct high-affinity receptors cross-reacting with acidic and basic fibroblast growth factors.

1990 • 635 citations

Heparin is required for cell-free binding of basic fibroblast growth factor to a soluble receptor and for mitogenesis in whole cells.

1992 • 634 citations

Rational Design of Potent Antagonists to the Human Growth Hormone Receptor

1992 • 633 citations

A dual receptor system is required for basic fibroblast growth factor activity

1991 • 589 citations

An Essential Heparin-Binding Domain in the Fibroblast Growth Factor Receptor Kinase

1993 • 520 citations

The binding of vascular endothelial growth factor to its receptors is dependent on cell surface-associated heparin-like molecules.

1992 • 495 citations

Three-Dimensional Structures of the Ligand-Binding Domain of the Bacterial Aspartate Receptor with and Without a Ligand

1991 • 411 citations

The human fibroblast growth factor receptor genes: a common structural arrangement underlies the mechanisms for generating receptor forms that differ in their third immunoglobulin domain.

1991 • 406 citations

Dimerization of B-type Platelet-derived Growth Factor Receptors Occurs After Ligand Binding and Is Closely Associated with Receptor Kinase Activation

1989 • 366 citations

The structural basis of insulin and insulin-like growth factor-I receptor binding and negative co-operativity, and its relevance to mitogenic versus metabolic signalling

1994 • 282 citations

Heparin increases the affinity of basic fibroblast growth factor for its receptor but is not required for binding.

1994 • 262 citations

Genetic analysis of proteoglycan structure, function and metabolism

1991 • 230 citations

Fibroblast Growth Factor Receptors from Liver Vary in Three Structural Domains

1991 • 227 citations

Receptor for acidic fibroblast growth factor is related to the tyrosine kinase encoded by the fms-like gene (FLG).

1989 • 203 citations

Nature of the interaction of heparin with acidic fibroblast growth factor

1993 • 192 citations

Epidermal growth factor binding induces a conformational change in the external domain of its receptor.

1989 • 175 citations

Aspartate receptors of Escherichia coli and Salmonella typhimurium bind ligand with negative and half-of-the-sites cooperativity

1994 • 135 citations

Real-time measurements of kinetics of EGF binding to soluble EGF receptor monomers and dimers support the dimerization model for receptor activation

1993 • 129 citations

Epidermal growth factor (EGF) induces oligomerization of soluble, extracellular, ligand-binding domain of EGF receptor. A low resolution projection structure of the ligand-binding domain

1991 • 105 citations

EGF induces increased ligand binding affinity and dimerization of soluble epidermal growth factor (EGF) receptor extracellular domain.

1991 • 100 citations

The three-dimensional structure of the ligand-binding domain of a wild-type bacterial chemotaxis receptor. Structural comparison to the cross-linked mutant forms and conformational changes upon ligand binding

1993 • 99 citations

The Fibroblast Growth Factors: An Emerging Family of Neural Growth Factors

1991 • 96 citations

Structural studies of the binding of the anti-ulcer drug sucrose octasulfate to acidic fibroblast growth factor

1993 • 89 citations

Transformation of mammalian cells with genes from prokaryotes and eukaryotes. 1979.

1992 • 76 citations

Biological equivalence of natural bovine and recombinant human alpha-endothelial cell growth factors.

1987 • 63 citations

Structural organization of the human insulin receptor ectodomain

1992 • 62 citations

A recombinant ectodomain of the receptor for the stem cell factor (SCF) retains ligand-induced receptor dimerization and antagonizes SCF-stimulated cellular responses.

1992 • 57 citations